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A facile synthesis of novel 3-functionalized pyridine derivatives has been accomplished through the reaction of 4-hydroxy-3-benzoylpyridin-2(1H)-ones and β-nitrostyrenes in the presence of catalytic amount of pyrrolidine (10 mol%). In this process, the desired products were obtained with 72–87% yields using ethanol as solvent at 80 °C for 4 h. In addition, a total of 19 examples were obtained, which exhibited the broad substrate scope of the transformation. The reaction process may involve the formation of an unstable enamine intermediate and then undergo hydrolysis to afford 4-hydroxy-3-benzoylpyridin-2(1H)-one derivatives. [ABSTRACT FROM AUTHOR]

Background: The medication adherence of psoriasis patients may be influenced by a series combined internal and external factors. Effective methods for improving adherence could improve treatment outcomes. Objective: To characterize medication adherence in psoriasis patients in China and to test an intervention to improve psoriasis patients' adherence. Methods: We investigated 200 patients with psoriasis using questionnaires to determine their medication adherence and the factors that influence adherence. In 117 patients, low medication adherence was identified; we randomized 96 of these patients into intervention group and control groups. The intervention group received health education during 6-month therapy. One-way analysis of variance (one-way ANOVA) was used to analyze the influence factors of medication adherence to further obtain the variables. Logistic regression was used to analyze these data. Results: Adherence of psoriasis patients was poor (41.5%). Factors associated with adherence included sociological characteristics, disease characteristics, medicine type, the cognitive level toward psoriasis, care indicators, and social environment. Patients in the intervention group exhibited greater adherence improvement (83.7%) compared with the control group (6.4%). Conclusions: Medication adherence of the psoriasis patients is poor but can be improved by a health education intervention. [ABSTRACT FROM AUTHOR]

A one-pot three-component reaction for the synthesis of 4- thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton. [ABSTRACT FROM AUTHOR]