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Regional landscape ecological risk (LER) assessment is of great significance for coordinating the relationship between land use and ecological environment, and for promoting the rational allocation of resources, and it is the basis and guarantee for achieving sustainable development. By assessing the landscape ecological risk of the Huaihe River ecological and economic zone, it can promote the development of ecological risk assessment theory, provide a scientific basis for the formulation of ecological civilization construction planning and policies, and help to strengthen environmental monitoring, planning and management, and promote the construction of ecological civilization. Based on the remote sensing image data of land use from 1985 to 2020, the spatiotemporal evolution characteristics of land use and LER in the Anhui section of the Huaihe River Ecological and Economic Belt in China were explored. The results showed that: (1) The construction land showed an increasing trend, with an increased area of 4753.35 km2, whereas the cultivated land showed a negative growth trend, with a reduced area of 4487.58 km2. (2) During the past 35 years, the ecological risks in the research area showed a decreasing trend as a whole, with medium-low and medium-risk areas ranking as the main; medium-high and high-risk areas are mainly distributed on both sides of the Huaihe River and in the northern-central part of Suzhou City. (3) Moran's I values of LER in each period were showing significant spatial autocorrelation and tending to converge spatially. In the future, the ecological security pattern should be optimized for local high-risk deterioration areas. [ABSTRACT FROM AUTHOR]

The aim of our study was to investigate the therapeutic effect of Mesenchymal stem cell-derived exosomes (MSC-exs) on eczema mice model. Eczema mice were established by 2, 4-two nitrochlorobenzene. Human umbilical cords cells and exosomes were harvested. In eczema mice model, the effect of MSC-ex on eczema was evaluated by severity score, atopic dermatitis score and histopathological analysis of dermis. MTT tests were performed to assess PBMC proliferation. Treg was identified by flow cytometry. The angiogenesis was analyzed by endothelial cell tube formation assay. Compared with PBS, the wound closure of animals treated with MSC-exs was faster. After MSC-exs treatment, there were more new epidermis and dermis, and less scar formation of the lesion. There were significant differences in the integral score of skin injury and the number of lymphocyte infiltration in the skin between the treatment group and the PBS group (p <.01). MSC-exs significantly inhibit Peripheral blood mononuclear cell proliferation, promote the transformation of Treg and the formation of endothelial tube. MSC-ex accelerated wounds healing in mice eczema model by inhibiting inflammatory cell infiltration and promoting vascular formation. [ABSTRACT FROM AUTHOR]

Coilia ectenes is a commercially important fishery species. In this study, genetic diversity and population structure of C. ectenes were examined by using mitochondrial DNA control region sequences in 246 individuals sampled from 10 localities in China. One hundred and ninety-five polymorphic sites defined 184 distinct haplotypes, revealing a moderately high haplotype diversity (Hd) and a relatively low nucleotide diversity (π) in the 10 localities. An excess of unique haplotypes at most sample locations were detected, which might influence the genetic structure of the C. ectenes populations. Hd ranged from 0.939 to 1.000 and π ranged from 0.26% to 1.15%. The Dongting fish population had the highest π level. The genetic distances ranged from 0.26% to 1.03% within populations and from 0.56% to 4.90% between populations. The distances between the Fuzhou (FZ) population and other populations were mostly >4.8%. Neighbor-joining tree indicated distinct patterns of phylogeographic structure among haplotypes from FZ population and those from other populations. Analyses of molecular variance and Fst statistics suggested that the divergence existed among populations from 10 localities, indicating that gene flow might be restricted among those regions, despite the wide dispersal. In addition, neutral tests and analysis of mismatch distribution suggested that C. ectenes might have undergone a population expansion. Our study revealed the extant population genetic diversity and structure of the C. ectenes, and was in favor of the related fishery management issues including fishery stock identification and conservation. [ABSTRACT FROM AUTHOR]