1. Ganonorsterone A, a norsteroid from the medicinal fungus Ganoderma lingzhi.
- Author
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Du, Jia-Hui, Zhao, Xuan, Zhang, Fei, Wang, Yan, Du, Kun, Ding, Si-Yi, Feng, Wei-Sheng, and Zhao, Zhen-Zhu
- Subjects
STEROID drugs ,STEROIDS ,HIGH performance liquid chromatography ,MACROPHAGES ,NITRIC oxide ,RESEARCH funding ,TERPENES ,FUNGI ,CELL lines ,EXPERIMENTAL design ,ASIAN medicine ,MOLECULAR structure ,BIOAVAILABILITY ,BIOLOGICAL assay ,REGRESSION analysis - Abstract
Phytochemical investigation on the fruiting bodies of the medicinal fungus Ganoderma lingzhi led to the isolation of a new norsteroid, namely ganonorsterone A (1), together with one known steroid, cyathisterol (2). The structure and absolute configuration of compound 1 were assigned by extensive analysis of MS, NMR data, and quantum-chemical calculations including electronic circular dichroism (ECD) and calculated
13 C NMR-DP4+ analysis. Bioassay results showed that compound 1 displayed moderate inhibition on NO production in RAW 264.7 macrophages. [ABSTRACT FROM AUTHOR]- Published
- 2024
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