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The relationship between serum total cholesterol (TC) and triglyceride (TG) levels and mortality in maintenance hemodialysis (MHD) patients remains inconsistent. We aimed to explore the individual and combined association of TC and TG levels with the risk of mortality in Chinese MHD patients. 1036 MHD patients were enrolled in this multicenter, prospective cohort study. The serum levels of total cholesterol and triglycerides were measured at baseline. The primary outcome was all-cause mortality and secondary outcome was cardiovascular disease (CVD) mortality. During a median follow-up duration of 4.4 years (IQR= 2.0–7.9 years), 549 (53.0%) patients died, and 297 (28.7%) deaths were attributed to CVD. Compared with patients with TC levels in the first three quartiles (<182.5 mg/dL), a significantly higher risk of all-cause mortality was found in participants with TC in the fourth quartile (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.17–1.76). However, a significantly lower risk of all-cause mortality was observed in participants with TG in the fourth quartile (≥193.9 mg/dL) (HR, 0.78; 95%CI: 0.63–0.98), compared with participants with TG in the first three quartiles. Similar trends were observed in CVD mortality. When analyzed jointly, patients with lower TC (<182.5 mg/dL) and higher TG (≥193.9 mg/dL) levels had the lowest risk of all-cause mortality and CVD mortality. Conclusions: In MHD patients in southern China, higher TC levels were associated with higher risk of mortality, while higher TG levels were related to lower risk of mortality. Patients with lower TC and higher TG levels had the best survival prognosis. [ABSTRACT FROM AUTHOR]

Forty cows suffered from ketosis at post-parturient period were used in the current study together with 10 healthy cows who served as a control. Blood samples were collected from diseased and healthy animals and the harvested serum were used for determination of biochemical, the profiles of lipids and liver enzymes. The obtained results declared that serum insulin had highly significant decrease (P < 0.01) in group C (5.02 ± 0.46 µIU/ml), also there was a highly significant decrease in serum cortisol (P < 0.01) of both A and B groups (3.74 ± 0.15 and 3.98 ± 0.14 ng/ml), as compared to healthy cows (5.39 ± 0.27 ng/ml). The values of serum cholesterol, serum triglyceride and serum total lipids were significantly increased (P < 0.01) in groups A, B and C 146.54 ± 7.71, 153.22 ± 6.04 and 150.50 ± 6.02 mg/dl; 74.85 ± 0.95, 76.43 ± 1.85 and 80.05 ± 4.68 mg/dl and 271.31 ± 4.34, 281.76 ± 3.50 and 266.64 ± 4.26 mg/dl, respectively; also, the values of serum aspartate aminotransferase and alanine aminotransferase were highly significantly increased (P < 0.01) in ketotic cows of groups A, B and C (94.13 ± 1.05, 94.42 ± 1.29 and 88.30 ± 88.30 ± 3.44 IU/L, respectively, and 57.07 ± 3.97, 54.29 ± 4.40 and 64.20 ± 4.70 IU/L, respectively). There was a highly significant decrease (P < 0.01) in serum calcium of groups A, B and C (7.20 ± 0.23, 7.15 ± 0.14 and 8.95 ± 0.33 mg/dl, respectively). [ABSTRACT FROM AUTHOR]

Purpose: We investigated which obesity-associated parameters can better predict the risk of anastomotic leakage (AL) in rectal cancer patients that underwent anterior resection of the rectum. Method: Patients (n = 589) who underwent anterior resection of the rectum with a primary anastomosis were included in this study, including 44 patients with AL and 545 without AL. Univariate analysis was used to compare demographic characteristics and to select risk factors that were used in one-to-one propensity score matching (PSM). Obesity-associated parameters, including preoperative body mass index (BMI), visceral fat area (VFA), subcutaneous fat area (SFA), total fat area (TFA), VFA/TFA ratio, serum cholesterol, and triglycerides, were compared between the two groups after PSM. Results: Sex, neoadjuvant chemotherapy, operation time, and anastomosis level from the anal verge were risk factors for AL (p <.05). After the PSM, BMI, VFA, SFA, TFA, VFA/TFA, and serum cholesterol showed no significant difference between the two group (p >.05). However, the level of serum triglycerides was an independent risk factor for AL (p =.024, odds ratio = 2.95). Conclusions: Serum triglycerides have potential as a predictive indicator for AL, which may improve the treatment and outcomes of patients with AL. [ABSTRACT FROM AUTHOR]

Background: There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related. The purpose of this study was to evaluate the influence of alcohol consumption on the association between serum cholesterol levels and colorectal adenoma. Methods: The subjects were 1,349 male patients who underwent both barium enema examination and total colonoscopy. They answered a questionnaire regarding their alcohol consumption history, and their blood samples were analysed. The subjects were divided into three groups: those with no tumour (with neither adenoma nor adenocarcinoma), those with adenoma and those with adenocarcinoma. Among the groups, the serum total cholesterol and triglyceride levels were compared in all the patients, in the patients who did not drink daily and in the patients who did. Results: In all the patients, the serum cholesterol and triglyceride levels did not differ between the patients with and those without adenoma. In the daily drinkers, the serum cholesterol and triglyceride levels were significantly lower in patients with adenoma than in those without. Conclusions: Significantly lower levels of serum cholesterol and triglycerides were found in daily drinkers with adenoma than in those without. [ABSTRACT FROM AUTHOR]