1. Cavoaortic shunt improves hemodynamics with preserved oxygen delivery in experimental right ventricular failure during left ventricular assist device therapy
- Author
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Jakob Johansson, Laila Hellgren, Per Vikholm, and Petter Schiller
- Subjects
Pulmonary and Respiratory Medicine ,Cardiac output ,medicine.medical_specialty ,Mean arterial pressure ,Vena Cava, Superior ,Central Venous Pressure ,Swine ,medicine.medical_treatment ,Ventricular Dysfunction, Right ,Hemodynamics ,Ventricular Function, Left ,Atrial Pressure ,Oxygen Consumption ,Internal medicine ,Medicine ,Animals ,Arterial Pressure ,Cardiac Output ,Aorta ,Heart Failure ,business.industry ,Central venous pressure ,Right Ventricular Assist Device ,Oxygen ,Disease Models, Animal ,Blood pressure ,Ventricular assist device ,Cardiology ,Ventricular Function, Right ,Surgery ,Heart-Assist Devices ,Blood Gas Analysis ,business ,Cardiology and Cardiovascular Medicine ,Shunt (electrical) - Abstract
ObjectiveRight heart failure is a major cause of morbidity and mortality after left ventricular assist device (LVAD) implantation. This study evaluated the approach of a cavoaortic shunt included in the LVAD circuit, which would aim to relieve venous congestion and improve hemodynamics with preserved oxygen delivery during induced right ventricular failure.MethodsRight ventricular failure was induced by coronary ligation in 10 pigs. An LVAD was implanted and a cavoaortic shunt was created from the right atrium and included in the assist circuit. Hemodynamic measures and blood gas analyses were analyzed. Oxygen delivery and oxygen consumption were estimated.ResultsRight atrial pressure decreased from more than 20 mm Hg to 17.2 mm Hg (14.8-18.4) with the LVAD and to 14.1 mm Hg (11.2-15.5) (P
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