1. Point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical validation trial and implementation study
- Author
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Dami A. Collier, Sonny M. Assennato, Ben Warne, Nyarie Sithole, Katherine Sharrocks, Allyson Ritchie, Pooja Ravji, Matthew Routledge, Dominic Sparkes, Jordan Skittrall, Anna Smielewska, Isobel Ramsey, Neha Goel, Martin Curran, David Enoch, Rhys Tassell, Michelle Lineham, Devan Vaghela, Clare Leong, Hoi Ping Mok, John Bradley, Kenneth G.C. Smith, Vivienne Mendoza, Nikos Demiris, Martin Besser, Gordon Dougan, Paul J. Lehner, Mark J. Siedner, Hongyi Zhang, Claire S. Waddington, Helen Lee, Ravindra K. Gupta, Stephen Baker, Ian Goodfellow, Paul Lyons, Nicholas J. Matheson, Mark Toshner, Michael P. Weekes, Nick Brown, Surendra Palmar, Daniel Chapman, Ashley Shaw, Vivien Mendoza, Sherly Jose, Areti Bermperi, Julie Ann Zerrudo, Evgenia Kourampa, Caroline Saunders, Ranalie de Jesus, Jason Domingo, Ciro Pasquale, Bensi Vergese, Phoebe Vargas, Marivic Fabiculana, Marlyn Perales, Richard Skells, Lee Mynott, Elizabeth Blake, Amy Bates, Anne-laure Vallier, Alexandra Williams, David Phillips, Edmund Chiu, Alex Overhill, Nicola Ramenante, Jamal Sipple, Steven Frost, Helena Knock, Richard Hardy, Emily Foster, Fiona Davidson, Viona Rundell, Purity Bundi, Richmond Abeseabe, Sarah Clark, Isabel Vicente, Warne, Ben [0000-0003-1326-0373], Sithole, Nyarie [0000-0002-8020-223X], Routledge, Matthew [0000-0003-0423-6857], Skittrall, Jordan [0000-0002-8228-3758], Smielewska, Anna Alexandra [0000-0002-6200-6876], Bradley, John [0000-0002-7774-8805], Dougan, Gordon [0000-0003-0022-965X], Gupta, Ravindra [0000-0001-9751-1808], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Isolation (health care) ,Hospitalized patients ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Nucleic Acid Testing ,General Biochemistry, Genetics and Molecular Biology ,Article ,Throat ,medicine ,COVID-19 ,POC ,point of care ,diagnostic test ,nosocomial ,infection control ,SARS-CoV-2 ,Infection control ,Humans ,Point of care ,Aged ,Cross Infection ,lcsh:R5-920 ,business.industry ,Middle Aged ,Hospitalization ,medicine.anatomical_structure ,Point-of-Care Testing ,COVID-19 Nucleic Acid Testing ,Emergency medicine ,Female ,business ,lcsh:Medicine (General) - Abstract
Summary There is urgent need for rapid SARS-CoV-2 testing in hospital to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined nasal/throat swabbing for POC versus standard lab RT-PCR testing. Median time to result is 2.6 (IQR 2.3 to 4.8) versus 26.4 hours (IQR 21.4 to 31.4, p, Graphical Abstract, Highlights • Point of care (POC) test highly sensitive and specific against RT-PCR • Time to result 2.6hrs for POC v 26.4hrs for standard lab RT-PCR. • SARS-CoV-2 POC test reduces median time-to-bed placement by approximately six hours • SARS-CoV-2 POC improves indices of hospital functioning and patient care, Collier et al report testing and implementation of an accurate SARS-CoV-2 point of care nucleic acid amplification test that leads to faster time to definitive bed placement from the ER, release of isolation rooms, avoidance of bed closures, and expedited discharges to care homes and access to hospital investigations/procedures.
- Published
- 2020