1. Regional cerebral oxygen saturation monitoring for predicting interventional outcomes in patients following out-of-hospital cardiac arrest of presumed cardiac cause: A prospective, observational, multicentre study
- Author
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Tomoyuki Endo, Noriaki Yamada, Takeshi Hatada, Satoru Beppu, Migaku Kikuchi, Kei Hayashida, Yuka Tsujimura, Masahiro Mizobuchi, Tomohiko Orita, Noritoshi Ito, Hideo Himeno, Hideto Yasuda, Toshiaki Mochizuki, Kei Nishiyama, Kazuo Okuchi, Takashi Unoki, Akira Murai, Kazuhiro Shiga, Hideki Arimoto, Ken Nagao, Mitsuru Abe, and Tetsuo Hatanaka
- Subjects
Male ,medicine.medical_specialty ,Heart Diseases ,Cerebral oxygen saturation ,Emergency Nursing ,Out of hospital cardiac arrest ,Oxygen Consumption ,Japan ,Clinical endpoint ,medicine ,Humans ,In patient ,Oximetry ,Prospective Studies ,Aged ,Cardiopulmonary resuscitation ,Spectroscopy, Near-Infrared ,Receiver operating characteristic ,business.industry ,Area under the curve ,Brain ,Prognoses ,Prognosis ,Cardiac arrest ,Surgery ,Survival Rate ,Oxygen ,Anesthesia ,Emergency ,Emergency Medicine ,Female ,Observational study ,Cardiology and Cardiovascular Medicine ,business ,Out-of-Hospital Cardiac Arrest ,Cerebrovascular circulation ,Follow-Up Studies - Abstract
[Aim] This study investigated the value of regional cerebral oxygen saturation (rSO2) monitoring upon arrival at the hospital for predicting post-cardiac arrest intervention outcomes. [Methods] We enrolled 1195 patients with out-of-hospital cardiac arrest of presumed cardiac cause from the Japan-Prediction of Neurological Outcomes in Patients Post-cardiac Arrest Registry. The primary endpoint was a good neurologic outcome (cerebral performance categories 1 or 2 [CPC1/2]) 90 days post-event. [Results] A total of 68 patients (6%) had good neurologic outcomes. We found a mean rSO2 of 21% ± 13%. A receiver operating characteristic curve analysis indicated an optimal rSO2cut-off of ≥40% for good neurologic outcomes (area under the curve 0.92, sensitivity 0.81, specificity 0.96). Good neurologic outcomes were observed in 53% (55/103) and 1% (13/1092) of patients with high (≥40%) and low (
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