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Your search keyword '"Earnshaw, William C."' showing total 23 results
Start Over Author "Earnshaw, William C." Publisher the company of biologists
23 results on '"Earnshaw, William C."'

3. APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit

Author

Tsunematsu, Takaaki, Arakaki, Rieko, Kawai, Hidehiko, Ruppert, Jan, Tsuneyama, Koichi, Ishimaru, Naozumi, Earnshaw, William C., Pagano, Michele, Kudo, Yasusei, Tsunematsu, Takaaki, Arakaki, Rieko, Kawai, Hidehiko, Ruppert, Jan, Tsuneyama, Koichi, Ishimaru, Naozumi, Earnshaw, William C., Pagano, Michele, and Kudo, Yasusei

Abstract

During mitosis, the chromosomal passenger complex (CPC) ensures the faithful transmission of the genome. The CPC is composed of the enzymatic component Aurora B (AURKB) and the three regulatory and targeting components borealin, INCENP, and survivin (also known as BIRC5). Although the CPC is known to be involved in diverse mitotic events, it is still unclear how CPC function terminates after mitosis. Here we show that borealin is ubiquitylated by the anaphase promoting complex/cyclosome (APC/C) and its cofactor Cdh1 (also known as FZR1) and is subsequently degraded in G1 phase. Cdh1 binds to regions within the N terminus of borealin that act as a non-canonical degron. Aurora B has also been shown previously to be degraded by the APC/CCdh1 from late mitosis to G1. Indeed, Cdh1 depletion sustains an Aurora B activity with stable levels of borealin and Aurora B throughout the cell cycle, and causes reduced efficiency of DNA replication after release from serum starvation. Notably, inhibition of Aurora B kinase activity improves the efficiency of DNA replication in Cdh1-depleted cells. We thus propose that APC/CCdh1 terminates CPC activity upon mitotic exit and thereby contributes to proper control of DNA replication.

Published
2020

6. CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

Author

Otake, Koichiro, primary, Ohzeki, Jun-ichirou, additional, Shono, Nobuaki, additional, Kugou, Kazuto, additional, Okazaki, Koei, additional, Nagase, Takahiro, additional, Yamakawa, Hisashi, additional, Kouprina, Natalay, additional, Larionov, Vladimir, additional, Kimura, Hiroshi, additional, Earnshaw, William C., additional, and Masumoto, Hiroshi, additional

Published
2020
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7. H3K9me3 maintenance on a Human Artificial Chromosome is required for segregation but not centromere epigenetic memory

Author

Martins, Nuno M. C., primary, Cisneros-Soberanis, Fernanda, additional, Pesenti, Elisa, additional, Kochanova, Natalia Y., additional, Shang, Wei-Hao, additional, Hori, Tetsuya, additional, Nagase, Takahiro, additional, Kimura, Hiroshi, additional, Larionov, Vladimir, additional, Masumoto, Hiroshi, additional, Fukagawa, Tatsuo, additional, and Earnshaw, William C., additional

Published
2020
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12. Contrasting roles of condensin I and II in mitotic chromosome formation

Author

Green, Lydia C., primary, Kalitsis, Paul, additional, Chang, Tsz M., additional, Cipetic, Miri, additional, Kim, Ji Hun, additional, Marshall, Owen, additional, Turnbull, Lynne, additional, Whitchurch, Cynthia B., additional, Vagnarelli, Paola, additional, Samejima, Kumiko, additional, Earnshaw, William C., additional, Choo, K. H. Andy, additional, and Hudson, Damien F., additional

Published
2012
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13. SUMOylation modulates the function of Aurora-B kinase

Author

Fernández-Miranda, Gonzalo, primary, de Castro, Ignacio Pérez, additional, Carmena, Mar, additional, Aguirre-Portolés, Cristina, additional, Ruchaud, Sandrine, additional, Fant, Xavier, additional, Montoya, Guillermo, additional, Earnshaw, William C., additional, and Malumbres, Marcos, additional

Published
2010
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23. A dynamic connection between centromeres and ND10 proteins

Author

Everett, Roger D., primary, Earnshaw, William C., additional, Pluta, Ann F., additional, Sternsdorf, Thomas, additional, Ainsztein, Alexandra M., additional, Carmena, Mar, additional, Ruchaud, Sandrine, additional, Hsu, Wei-Li, additional, and Orr, Anne, additional

Published
1999
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