1. Drug-Induced Hypoglycemia: A Systematic Review
- Author
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Mohamed B. Elamin, Patricia J. Erwin, Rebecca J. Mullan, M. Hassan Murad, Fernando Coto-Yglesias, Amy T. Wang, Nasim Sheidaee, and Victor M. Montori
- Subjects
Drug ,medicine.medical_specialty ,Side effect ,business.industry ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Biochemistry (medical) ,Clinical Biochemistry ,MEDLINE ,Scopus ,Context (language use) ,Hypoglycemia ,medicine.disease ,Biochemistry ,Endocrinology ,Data extraction ,Internal medicine ,Medicine ,business ,Adverse effect ,media_common - Abstract
Context: Drug-induced hypoglycemia is a significant adverse effect that may cause important morbidity. Objective: The aim of the study was to systematically review the literature for drugs reported to cause hypoglycemia and assess the quality of evidence and strength of association supporting this causal link. Data Sources: We searched electronic databases (MEDLINE, EMBASE, Web of Science, and SCOPUS) and the drug information system Micromedex through November 2007 and sought additional references from experts. Study Selection: Studies were eligible if they reported hypoglycemia as a side effect of a drug not used to treat hyperglycemia, regardless of their design, language, size, or follow-up duration. We excluded hypoglycemia caused by industrial exposures, nonpharmacological chemical exposures, alcohol, herbs, nutritional supplements, and in vitro and animal studies. Data Extraction: Reviewers extracted study characteristics and methodological quality and, when possible, data to estimate the odds of de...
- Published
- 2009
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