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Start Over Author "Hirokazu Kodama" Publisher the japan institute of heterocyclic chemistry
1 results on '"Hirokazu Kodama"'

1. A Facile Synthesis of 1,1-Disubstituted 1,2,3,4-Tetrahydro-b-carbolines via Trifluoroacetic Acid Catalyzed Pictet- Spengler Reaction Using Titanium(IV) Isopropoxide as an Imination Reagent

Author

Toshiaki Saitoh, Akiko Kida, Takehiro Sano, Masayoshi Nakamura, Yoshie Horiguchi, and Hirokazu Kodama

Subjects
Pharmacology, Tryptamine, Pictet–Spengler reaction, General method, Organic Chemistry, chemistry.chemical_element, Analytical Chemistry, Catalysis, chemistry.chemical_compound, chemistry, Reagent, Trifluoroacetic acid, Organic chemistry, Titanium
Abstract

A synthesis of 1,1-disubstitued 1,2,3,4-tetrahydro-β-carbolines (13) was achieved in a highly effective manner via the trifluoroacetic acid catalyzed Pictet-Spengler reaction of the keto imines (9) prepared from tryptamine (8) with acyclic and cyclic ketones using titanium(IV) isopropoxide as the imination reagent under one pot procedure. This reaction provides a convenient and general method for preparing various 1,2,3,4-tetrahydro-β-carbolines derivatives.

Published
2003
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