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We reported a cace of a 61-year-old man with squamous cell carcinoma (SCC) on the external ear, which metastasized to the parotid lymph node, although the tumor was 2cm in diameter at an elrly stage. During past 10 years, we have experienced 13 patients with SCC on the external ear. All patients were male with a mean age of 76.8 years. The tumor were located mostly on the helix. Two patients developed lymph nodes metastasis, but no distal metastasis. SCC of the external ear is an aggressive cancer with higher metasiatic rates than cutaneous SCC as seen in other parts of the body. Poor prognotic facters included specific growth pattern and perineural invasion.

We reported a case of a 68 year-old man with Merkel cell carcinoma. He noticed a tumor on his left leg about seven months previously. As the tumor expanded gradually, he visited Mie University Hospital. At his first visit, the lesion composed of a smooth, easily bleeding tumor in the center and a violet plaque around the tumor. Light microscopy showed two diffirent parts in the lesion, which are Merkel cell carcinoma and squamous cell carcinoma. Immunohistochemical examination showed positive reaction of CEA on the part of Merkel cell carcinoma.

Sixty-six year old house wife developped a large ulcerative mass on her left tigh and left groin. Histopathologically differentiated squamous cells with atypical nuclei proliferated and invaded into surrounding muscles.Immunohistochemically, tumor cells were CAM5.2, MA903 and thrombomodulin positive, but HMB45 and vimentin negative.Considering with no indication for curative surgical treatment and poor general condition, we choosed the continuous intra-arterial 5FU infusion with irradiation. She complaind no symtom by side effect of chemotherapy. Biopsy of tumor lesion after treatment could not detect any alive tumor cells. Eight month following up showed no organ metastasis and lesional recurrence.

We reported a case of an 80-year-old woman with angiosarcoma on the abdomen. She had received a subwide-range total hysterectomy and postoperative irradiation at age of 72 for the uterin cancer. She noticed a subcutaneus induration on the abdomen since then. She was referred to us for a red black tumor on the induration of three months duration. Total resection of the tumor, irradiation and immunochemotherapy with IL-2 were performed under the diagnosis of angiosarcoma. Nine months later, two tumors as same as the first one recurred near by the primary lesion. Irradiation and immunotherapy had some good effect to reducing the size of the tumors. We speculated that the healing process of endthelial cells after irradiation damages might be related to the occurrence of angiosarcoma.

77歳女性の下肢に出現した血管肉腫を経験した。右膝窩部に鶏卵大暗赤色結節を3個認め, Moh's療法を中心に治療を試みたが腫瘍出現から1年で死亡。腫瘍細胞は, 未分化な蜂巣状増殖を示すものから血管腔を形成するものまで多種多様の形態が見られた。電顕的にも血管肉腫と診断したが死亡時諸臓器への遠隔転移は認められなかった。