1. Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas
- Author
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Sidney, John, Diehl, Sean A., Satchidanandam, Vijaya, Grifoni, Alba, Costa, Priscilla R., Sette, Alessandro, Macary, Paul A., Nchinda, Godwin, de Silva, Aravinda M., Desai, Anita, Turtle, Lance, Cerpas, Cristhiam, Rivino, Laura, Harris, Eva, Ravi, Vasanthapram, Peters, Bjoern, Phillips, Elizabeth, Solomon, Tom, de Silva, Aruna D., Tatullo, Filippo, Nkenfou, Celine, Durbin, Anna P., Coloma, Josefina, Lim, Mei Qiu, O'Rourke, Patrick H., Weiskopf, Daniela, Collins, Matthew H., Kallas, Esper G., Lopez, Benjamin, Angelo, Michael A., Maestri, Alvino, Balmaseda, Angel, Silveira, Cassia G.T., and Mallal, Simon
- Subjects
viruses ,virus diseases ,biochemical phenomena, metabolism, and nutrition ,3. Good health - Abstract
Dengue is a major public health problem worldwide. Assessment of adaptive immunity is important to understanding immunopathology and to define correlates of protection against dengue virus (DENV). To enable global assessment of CD4+ T cell responses, we mapped HLA-DRB1-restricted DENV-specific CD4+ T cell epitopes in individuals previously exposed to DENV in the general population of the dengue-endemic region of Managua, Nicaragua.