1. Hepatic arterial infusion chemotherapy in combination with pegylated interferon-α-2b for advanced hepatocellular carcinoma.
- Author
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Okita K, Yamasaki T, Hamabe S, Saeki I, Harima Y, Terai S, and Sakaida I
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Carcinoma, Hepatocellular mortality, Carcinoma, Hepatocellular pathology, Female, Fluorouracil administration & dosage, Humans, Infusions, Intra-Arterial, Interferon alpha-2, Interferon-alpha administration & dosage, Kaplan-Meier Estimate, Leucovorin administration & dosage, Liver Neoplasms mortality, Liver Neoplasms pathology, Male, Middle Aged, Polyethylene Glycols administration & dosage, Recombinant Proteins administration & dosage, Retrospective Studies, Survival Rate, Time Factors, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Carcinoma, Hepatocellular drug therapy, Liver Neoplasms drug therapy
- Abstract
Background/aims: We previously reported that combination therapy comprising hepatic arterial infusion chemotherapy (HAIC) with 3 drugs, namely, cisplatin (CDDP), 5-fluorouracil (5-FU) (low-dose FP) and isovorin and interferon (IFN)-α-2b was not beneficial for patients with advanced hepatocellular carcinoma (HCC). In this study, we investigated the efficacy of combination therapy comprising HAIC and pegylated interferon (PEG-IFN)-α-2b in advanced HCC patients by comparing our results with previous data., Methodology: From a total of 29 patients, 12 received HAIC and PEGIFN- α-2b (PEG-IFN group) and 17 received HAIC and IFN-α-2b (IFN group). There were no significant differences in clinical characteristics between the 2 groups., Results: The response rate was 33.3% (complete response (CR)=1; partial response (PR)=3) in the PEGIFN group and 47.1% (PR=8) in the IFN group. The 1-, 2- and 3-year cumulative survival rates were 50%, 25% and 8%, respectively, in the PEG-IFN group, whereas they were 53%, 18% and 12%, respectively, in the IFN group. There were no significant differences in the response rate (p=0.251) and survival (p=0.938) between the two groups., Conclusions: We found that combination therapy comprising HAIC using low-dose FP with isovorin and PEG-IFN-α-2b was not beneficial for advanced HCC.
- Published
- 2012
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