1. Preparation of Biocompatible Composites based on Poly-L-Lactide/Hydroxyapatite and Investigation of their Anti-Inflammatory Activity
- Author
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Irina Kurzina, D.N. Lytkina, L. A. Rasskazova, N. M. Korotchenko, I. V. Zhuk, Julia Kzhyshkowska, A. G. Filimoshkin, Yelena Shapovalova, and Alexandru Gudima
- Subjects
Materials science ,Biocompatibility ,medicine.drug_class ,020502 materials ,Mechanical Engineering ,Composite number ,New materials ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Biocompatible material ,Anti-inflammatory ,In vitro ,chemistry.chemical_compound ,0205 materials engineering ,Polylactic acid ,chemistry ,Mechanics of Materials ,Poly-L-lactide ,medicine ,General Materials Science ,Composite material ,0210 nano-technology ,Biomedical engineering - Abstract
Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of anti-inflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites
- Published
- 2016