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The aim of the present study was to prepare nanostructured lipid carriers (NLCs) and nanoemulsions (NEs) with different lipid compositions for delivery of phenylethyl resorcinol (PR) and investigate the effect of the lipid composition on the performance of lipid-based nanocarriers. The optimized nanocarriers were evaluated by photon correlation spectroscopy (PCS), Laser diffraction (LD), encapsulation efficiency, in vitro release and in vitro penetration studies. The particle sizes of all the freshly prepared nanocarriers were in the range of 70-200 nm. PR-NLCs showed higher encapsulation efficiency than PR-NEs. A controlled-release behavior of PR-NLCs was observed in in vitro release studies. In vitro penetration studies demonstrated nanocarriers with smaller particles possessed higher penetration ability. According to the present study, nanocarriers with small particle sizes can be considered as a potential drug delivery system for typical application.

We report in vitro studies on radiotherapy enhancement of hollow gold nanoparticles (HAuNPs), which feature a 50 nm hollow core and a 30 nm thick polycrystalline shell. A clonogenic cell survival assay was used to assess radiation dose enhancement on breast cancer MDA-MB-231 cells. Cells were cultured in a cell culture solution in which pegylated HAuNPs were added. No cytotoxicity of the HAuNPs was observed at the nanoparticle concentration up to 4.25×109 nanoparticles/ml (350 μM Au concentration). A small animal X-ray irradiator and a clinical linear accelerator were used to irradiate HAuNP-treated and control groups. It shows that the radiation damage to the cells is significantly enhanced when the cells are exposed to HAuNPs. This is the first time that AuNPs with diameter larger than 100 nm has been studied for their radiosensitizing effects. In clinical settings, we envision that HAuNPs could be intratumorally injected into tumors, which is more realistic for practical usage of AuNPs as radiosensitizer than passive accumulation in tumors using the enhanced permeability and retention effect or active targeting. Larger particles are favored for the intratumoral injection approach since larger particles tend to be retained in the injection sites, less likely diffusing into surrounding normal tissues. So, this proof-of-concept evaluation shows a promising potential to use HAuNPs as radiation therapy sensitizer for cancers.

E-commerce enterprises, as a kind of Internet enterprises, data operation model will be their certain choice. They take information as economic factors and use big data as their strategic resources. Management accounting plays a leading role and indispensable role in e-commerce enterprise data operation. Only change processing information methods of management accounting and integrate its processing information tools and establish Balance Scorecard basing operational strategies of data, management accounting will integrate with big data technologies organically. That will promote efficiency of e-commerce enterprise data operation greatly and improve the strategic development of e-commerce enterprises.

The big data era enable us to carry out data operations based on the extremely large data volumes to realize the datamation of manufacturing industrial chain. This provides us a good opportunity to optimize the manufacturing industrial chain and upgrade the development of manufacturing industry. In order to provide beneficial references for the optimization of manufacturing industrial chain and the development of manufacturing industry, in this paper, we explore new paths to realize the datamation of manufacturing industrial chain based on the big data era background. We also analyze the advantages, as well as problems remained to be solved of promoting the datamation of manufacturing industrial chain.

With China's rapid economic development, more and more standardized, and tourism are increasingly mature, there are increasing number of tourism public service needs, strengthening the tourism public service has become an important means to improve the efficiency of tourism industry. However, the current construction of wrong interpretation of tourism services in the tourism destinations in China, resulting in insufficient number of reasonable service delivery, service structure is irrational, and service systems are not perfect, issues such as support and evaluation system is not perfect, which needs to be treated seriously in the development of China's tourism business.

In this paper, neural network and grey fuzzy control technology are applied in Abrasive Flow Machining (AFM) to grind the mico-hole in th nozzle of the twin flapper-nozzle valve. An intelligent control system with fine tuning working pressure is established that can predict the process parameters automatically before machining and forcast the flow to adjust the working pressure in machining.The result of experiment indicates that this system has high level of intelligent and can get very high machining accuracy.

Study on the effect of liquefaction mechanism on the performance of ECC, adding rubber powder mesh size effect on the performance of ECC, respectively, to 40 mesh, 60 mesh, 80 mesh and 100 orders at the same content of rubber powder and 40 mesh in different dosage on ECC compressive strength, flexural toughness was analyzed, results show that: the use of the mechanism of liquefaction of mixing rubber powder in cement based materials, with the increase of ECC number increased ductility, at the same time reduce the compressive strength is larger, rubber powder content in 12%, the comprehensive effect is ideal. The needle for fiber reinforced cement based materials and meticulous research component, has broad prospects in the repair of future building early warning and lane.

Based on the analytical solutions of pore-water pressure and settlement. Problems of the one-dimensional thermal consolidation of saturated soil considering three different permeabilities were analyzed. Aiming at each permeability of thermal consolidation theory, compared with the corresponding Terzaghis consolidation theory, the one-dimensional thermal consolidation behaviour of saturated soil was analyzed in terms of excess pore-water pressure, the settlement. The results show that the permeability plays an important role in the thermal consolidation. The more permeability, the quicker pore-water pressure dissipation and the rate of settlement. Settlement of ground is more sensitive to temperature condition than the excess pore-water pressure. The behaviour of excess pore-water pressure in the process of thermal consolidation is very similar to the corresponding Terzaghis theory.

Through the spatial aggregation, manufacturing industrial cluster gains the excess economic benefits and the notable effect of economy scale, in the process of input flow and output flow. The material flows of manufacturing enterprises cluster have the following characteristics, that is a big effect on environment, the complex and diverse process, and specialism in the supply and distribution. In order to adapt to these new characteristics, basing on the thought of circular economy, it is necessary to adopt the environmental protection use of materials based on manufacturing industrial cluster to curb pollution from manufacturing industrial and promote the manufacturing industrial move forward to the road of sustainable development.

Based on a one-dimensional thermal consolidation formulation with and without thermo-mechanical coupling of saturated porous medium, problems of one-dimensional thermal consolidation of saturated soil were investigated. For the condition with instantaneous constant surface temperature and uniform initial pore-pressure, analytical solutions of excess pore-water pressure and temperature increment were derived respectively by the method of finite Fourier transform and inverse transform. A relevant computer program was developed, and the excess pore-water pressure was compared in detail. The results show that the thermo-mechanical coupling item in the thermal consolidation equation can be ignored.

Abnormally discharged phenols work as toxic pollutants to living environments. In this work, the operation conditions of a newly isolated 2,3-dimethylphenol-degrading Pseudomonas strain including temperature, dissolved oxygen, and pH were investigated. Mixed phenols could be degraded efficiently in diluted mineral-salts medium, avoiding excessive ammonia and phosphate pollution. The results illustrated the potential of bacterial remediation of phenolic pollutants without eutrophication caused by the addition of bacterial growth nutrients.

Monocyclic phenolic compounds (MCPCs) from petroleum and coal sources mainly include phenol, cresols, and xylenols. A newly isolated 2,3-xylenol-degrading strain,Pseudomonassp. XQ23, was found to be capable of degrading up to 10 MCPCs for the first time. Addition of easy-to-degrade MCPCs such as phenol and cresols helped decompose hard-to-degrade xylenols and the sequential digestion of the phenolic substrates was highly dependent on their molecule structures. The action on multiple MCPCs by the new isolate XQ23 from this work revealed useful clues on the co-biodegradation of multiple pollutants.

Wastewaters discharged from oil refineries and coal coking plants often contain large amounts of toxic monocyclic phenolic compounds (MCPCs), mainly including phenol, cresols and xylenols, polluting soils and surface water. In this work, crude phenols or 12 individual MCPCswere used as the enrichment medium and the later strategy was discovered for the first time to be more effective in finding more and competent MCPC-degrading strains. Phylogenetic analysis and multiple MCPC degradation tests revealed that phylogenetically close microbes generally exhibited similar MCPC-degrading spectra.

This paper presents a proposed energy saving system for street lamps based on single-chip microcomputer. In this case, light control timer, smart sensor, wireless transceiver, microcontroller smart regulator and other related techniques are utilized to fullfil a ‘green lighting project’. It can not only automatically turn on or off the master switch according to the local sunrise and sunset, and sooner or later, sunny day, rainy days or the actual brightness of the different lamps, but also control each single lamp intelligently. The system can be widely used in road and tunnel lighting, building lighting, and other fields as well as a variety of energy-saving control dimming voltage based intelligent control areas.

This paper presents a proposed system based on LabVIEW for data acquisition and monitoring of manufacturing process in machine tools with CNC. It was applied to evaluate work piece dimension and failure analysis in real time. The proposed system was developed and tested initially in a CNC milling machine with open architecture. Furthermore, it can be extended to other machines and processes, lines or cells of mass production as well. And it was applied in some factories and workshops now.