1. CYTOMEGALOVIRUS ROLE IN INDUCING REJECTION REACTIONS IN HEART TRANSPLANTATION PATIENTS.
- Author
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HABOR, A., SIN, A., VARTOLOMEI, M. D., CIUCA, I., SUCIU, H., and TILINCA, M.
- Subjects
CYTOMEGALOVIRUSES ,HEART transplant recipients ,ATHEROSCLEROSIS ,CELLULAR immunity ,T cells - Abstract
The study was performed on 45 patients with heart transplantation out of which 30 presented serologic cytomegalovirus infection. For histological study we used: hematoxylin eosin, van Gieson, Masson's trichrome, green methyl pironin stains. Immunohistochemistry was performed using ABC technique (avidin - biotin complexes or avidin - biotin) with the following monoclonal antibodies: CD8, CD4, CD20, CD68, CD31, CD45 RO, HLA-DR, and E13. In many of our cases cytomegalovirus infection was commonly associated with acute rejection. The presence of endothelial cells expressing HLA-DR antigens and subendothelial accumulation of activated T lymphocytes and macrophages, often in contact with endothelial cells, highlights the role of cellular immunity in the production of accelerated atherosclerosis lesions. [ABSTRACT FROM AUTHOR]
- Published
- 2016