1. Genetic risk variants associated with in situ breast cancer
- Author
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Ruth C. Travis, Sara Lindström, Christopher A. Haiman, Peter Kraft, Loic Le Marchand, Rudolf Kaaks, Federico Canzian, Petra H.M. Peeters, Stephen J. Chanock, Elisabete Weiderpass, Aditi Hazra, Dimitrios Trichopoulos, Mia M. Gaudet, Walter C. Willett, Salvatore Panico, Robert N. Hoover, Afshan Siddiq, Susan M. Gapstur, Brian E. Henderson, Amit Joshi, Susan E. Hankinson, Malin Sund, David J. Hunter, Myrto Barrdahl, Amanda Black, W. Ryan Diver, Pilar Amiano, Anne Tjønneland, Laure Dossus, Daniele Campa, Regina G. Ziegler, Campa, Daniele, Barrdahl, Myrto, Gaudet, Mia M, Black, Amanda, Chanock, Stephen J, Diver, W. Ryan, Gapstur, Susan M, Haiman, Christopher, Hankinson, Susan, Hazra, Aditi, Henderson, Brian, Hoover, Robert N, Hunter, David J, Joshi, Amit D, Kraft, Peter, Le Marchand, Loic, Lindström, Sara, Willett, Walter, Travis, Ruth C, Amiano, Pilar, Siddiq, Afshan, Trichopoulos, Dimitrio, Sund, Malin, Tjønneland, Anne, Weiderpass, Elisabete, Peeters, Petra H, Panico, Salvatore, Dossus, Laure, Ziegler, Regina G, Canzian, Federico, and Kaaks, Rudolf
- Subjects
Oncology ,Cancer Research ,IDENTIFIES 2 ,Genome-wide association study ,Bioinformatics ,GENOME-WIDE ASSOCIATION ,SUSCEPTIBILITY LOCI ,PROSTATE-CANCER ,COMMON VARIANTS ,CONFER SUSCEPTIBILITY ,CLINICAL-SIGNIFICANCE ,COHORT CONSORTIUM ,CARCINOMA ,WOMEN ,Prostate cancer ,Non-U.S. Gov't ,Medicine(all) ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,Research Support, Non-U.S. Gov't ,Population Surveillance ,Female ,Case-Control Studie ,Medical Genetics ,Breast Neoplasm ,Carcinoma in Situ ,Research Article ,Human ,Risk ,medicine.medical_specialty ,Breast Neoplasms ,Single-nucleotide polymorphism ,Research Support ,Polymorphism, Single Nucleotide ,Breast cancer ,Internal medicine ,medicine ,Journal Article ,Humans ,Genetic Predisposition to Disease ,Medicinsk genetik ,Cancer och onkologi ,business.industry ,Carcinoma in situ ,CDKN2BAS ,Case-control study ,Cancer ,Genetic Variation ,medicine.disease ,Case-Control Studies ,Cancer and Oncology ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,business - Abstract
Introduction Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered one of the strongest risk factors for BCIS. Methods To evaluate the association of BC susceptibility loci with BCIS risk, we genotyped 39 single nucleotide polymorphisms (SNPs), associated with risk of invasive BC, in 1317 BCIS cases, 10,645 invasive BC cases, and 14,006 healthy controls in the National Cancer Institute’s Breast and Prostate Cancer Cohort Consortium (BPC3). Using unconditional logistic regression models adjusted for age and study, we estimated the association of SNPs with BCIS using two different comparison groups: healthy controls and invasive BC subjects to investigate whether BCIS and BC share a common genetic profile. Results We found that five SNPs (CDKN2BAS-rs1011970, FGFR2-rs3750817, FGFR2-rs2981582, TNRC9-rs3803662, 5p12-rs10941679) were significantly associated with BCIS risk (P value adjusted for multiple comparisons
- Published
- 2015