Search

Your search keyword '"Miguelhete Lisboa"' showing total 2 results
Start Over Author "Miguelhete Lisboa" Publisher universidade de sao paulo
2 results on '"Miguelhete Lisboa"'

1. Characterization of resistance profile of Mycobacterium tuberculosis isolates from patients with tuberculosis in Beira, Sofala - Mozambique

Author

Evangelina Inácio Namburete, Miguelhete Lisboa, Inês Tivane, Lee Harrison, and Valdes Roberto Bollela

Subjects
Mycobacterium tuberculosis. Drug Resistance. Isoniazid, Medicine
Abstract

Objective: To analyze the resistance profile of Mycobacterium tuberculosis isolates from patients with tuberculosis in Beira, Sofala, Mozambique. Method: Descriptive cross-sectional study that analyzed secondary data from patients who had positive culture for M. tuberculosis on MGIT960-BACTECTM. For each patient, demographic data, information of Human Immunodeficiency Virus (HIV) serology, rapid molecular test - GeneXpertα-Cepheid result and first line drug susceptibility test (DST) were reviewed . All tests were performed in the Referral Laboratory of Tuberculosis in Beira, from January 2014 to March 2015. Findings: Totally of 87 isolates from Sofala province, Mozambique were analyzed. Of these, 33/87 (37.9%) isolates had any anti-TB drug resistance detected while in 54/87 (62.1%) the drug resistance was not detected. Among the 33 isolates with drug resistance: 18/33 (54,7%) were multidrug-resistant (MDR), 11/33 (33,3%) were Isoniazid (INH) mono-resistant, 2/33 (6%) Rifampicin (RIF) mono-resistant and 2/33 (6%) were Etambutol mono-resistant. Of the total isolates with resistance to INH, 5/11 (42%) were additionally resistance to streptomycin (Sm). Of the 49 patients with HIV serology known, 30 (61,2%) were confirmed HIV positive. The HIV infection was two times more frequent among patients with drug resistant compared to those without drug resistance. All isolates resistant to INH and RIF (MDR) had previous history of tuberculosis treatment. Conclusion: There is high proportion of co-infection TB/HIV among patients with any drug resistant TB MDR or monoresistance . We also observed high frequency of monoresistance to isoniazid and association of drug resistance between isoniazid and streptomycin

Published
2016
Full Text
View/download PDF

2. Characterization of resistance profile of Mycobacterium tuberculosis isolates from patients with tuberculosis in Beira, Sofala - Mozambique

Author

Miguelhete Lisboa, Valdes Roberto Bollela, Inês Tivane, Evangelina Inácio Namburete, and Lee H. Harrison

Subjects
Mycobacterium tuberculosis, Tuberculosis, biology, business.industry, lcsh:R, Medicine, lcsh:Medicine, General Medicine, biology.organism_classification, business, medicine.disease, Molecular biology, Mycobacterium tuberculosis. Drug Resistance. Isoniazid
Abstract

Objetivo: Avaliar o perfil de resistencia do Mycobacterium tuberculosis isolado de pacientes da cidade de Beira, Sofala, Mocambique. Metodo: Estudo descritivo transversal, que analisou dados secundarios de pacientes que tiveram cultura positiva para M. tuberculosis MGIT960-BACTEC™. Para cada isolado foram revistos dados demogra- ficos do respetivo paciente, a sorologia para o virus da imunodeficiencia humana (HIV), o resultado do teste rapido molecular (TRM) - GeneXpertα-Cepheid e o teste de fenotipico de sensibilidade aos farmacos (TS) de primeira linha. Os testes foram realizados no Laboratorio de Referencia para tuberculose na cidade de Beira, Mocambique no periodo de Janeiro de 2014 a Marco de 2015. Resultados: Foram analisadas 87 isolados de M. tuberculosis de pacientes da provincia de Sofala, Mocambique. Desses, 33/87 (37,9%) apresentaram algum tipo de resistencia do bacilo aos farmacos anti-TB, enquanto que em 54/87 (62,1%) a resistencia nao foi detectada. Dos 33 isolados com resistencia: 18/33 (54,7%) foram classificados como multidrogarresistentes (TB-MDR), 11/33 (33,3%) monorresistentes a isoniazida(INH), e 2/33 (6%) monorresistentes a rifampicina (RMP) e 2/33 (6%) resistentes ao Etambutol. Do total de isolados com resistencia a INH, 5/11 (42%) tambem apresentavam resistencia a estreptomicina (Sm). De 49 pacientes que fizeram sorologia para HIV, 30/49 (61,2%) tinham infeccao confirmada pelo HIV, sendo esta duas vezes mais frequente entre os pacientes portadores do Mycobacterium tuberculosis resistente do que naqueles com bacilo sensivel. Todos isolados resistentes a RIF e INH eram pacientes com historia previa de tratamento para TB . Conclusao: Observa-se uma alta proporcao de coinfeccao HIV/TB entre pacientes portador de cepas do M. tuberculosis monorresistente ou MDR. Alem de alta taxa de monorresistencia a isoniazida, e a associacao entre resistencia concomitante a INH e Sm

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results