1. Effects of different frequencies of physical training on electron transport chain and oxidative damage in healthy mice
- Author
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Luciano A. Silva, Camila B. Tromm, Ramiro Doyenart, Anand Thirupathi, Paulo Cesar Loock Silveira, and Ricardo Aurinho Pinho
- Subjects
frequency of exercise ,training ,respiratory chain ,oxidative damage ,adaptation ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Abstract Aims: The present study investigated the effect of different frequencies (three and five times a week) on electron transport chain and oxidative stress after 8 weeks of run training. Methods: Eighteen male mice (CF1, 30-35g) were distributed into the following groups (n=6): untrained (UT); trained three-time per week (T3) and trained five- time per week (T5). All training sessions were at the same intensity and duration (45min/day) in a treadmill for small animals. Forty-eight hours after the last training session, the animals were killed by decapitation and quadriceps (red portion) was removed and stored at -70ºC. Succinate dehydrogenase (SDH), complexes I, II, II-III, IV and hydroperoxides were measured. Results: Training sessions for five times per week were more effective in increasing the mitochondrial respiratory chain enzyme activities (SDH, complexes I, II, II-III, IV) as well as in decreasing the formation hydroperoxides than sessions performed for three times training per week (p
- Published
- 2018
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