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Cyclophosphamide (4000 mg intravenously, in daily doses of 400 mg) in combination with moderate dose of prednisone (1075 mg during 30 days) was given to 39 patients with the chronically progressing form of multiple sclerosis. The results of this treatment were evaluated immediately after the treatment and one and two years later, using a numerical scale of neurological examination in the scales of motor efficiency A. I. (ambulation index) and the DDS (disability status scale of Kurtzke). In the first year after this treatment stabilization of the disease (60% of cases) or even clinical improvement (10-20%) were noted. However, in the second year after the treatment an evident progression of symptoms occurred in 50-60% of cases. In view of moderately positive results of this treatment it is necessary to carry out observations extended over many years, to repeat cyclophosphamide cycles, and to compare the results with those after other immunosuppressants.

The aim of the reported study was an assessment of the effectiveness of high doses of methylprednisolone in the treatment of active exacerbation and its effect on the natural course of multiple sclerosis. The study was carried out on 24 patients with clinically certain disease, who were divided, according to the treatment given to them, into two subgroups: treated with methylprednisolone and treated with prednisone. The treatment was conducted by the double blind method. The statistical analysis of the results obtained in this material showed that in patients with acute and severe exacerbation of the disease methylprednisolone administration in high doses caused a rapid regression of paralysis and paresis and improved motor efficiency. However, an evaluation of the results after a year from treatment termination showed in both subgroups a progression of clinical changes and increased motor deficiency. This suggests that treatment with corticosteroids has no significant effect on the course of multiple sclerosis.

Flaccid tetraparesis was observed in a young woman which was caused by embolism of the anterior medullary artery. Topographic investigations of the spinal arteries were carried out, and pathological examination was done confirming the presence of embolic material which was the cause of medullary ischaemia.