139 results on '"Zembala, M."'
Search Results
2. Arrhythmia in the transplanted heart: What problems does it generate? Further considerations. Authors' reply.
- Author
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Myrda K, Nowowiejska-Wiewióra A, Zembala M, and Gąsior M
- Subjects
- Heart, Humans, Anti-Arrhythmia Agents, Arrhythmias, Cardiac etiology
- Published
- 2022
- Full Text
- View/download PDF
3. More for less - long-term survival modeling for surgical aortic valve replacement follow-up: The division between a ministernotomy and a full sternotomy approach.
- Author
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Kaczmarczyk M, Zembala M, Kaczmarczyk A, Filipiak K, Hrapkowicz T, Pacholewicz J, and Zembala M
- Abstract
Background: This study aimed to assess long-term results after surgical AVR (sAVR) depending on the used surgical technique (ministernotomy vs. full sternotomy) and to determine which patient- and treatment-related attributes were most associated with shorter time to the main endpoint., Methods: Out of 2147 patients, who underwent sAVR from January 2006 to December 2017, 615 patients were treated minimally invasively (MIAVR) and 1532 patients received conventional full sternotomy aortic valve replacement (FSAVR). Multiple Cox regressive models corresponding to the four major endpoints were developed. Long-term survival and a time to re-hospitalization for acute coronary syndrome, stroke, and heart failure (HF) were analyzed independently. Kaplan-Meier actuarial analysis was performed for univariate comparison., Results: The median follow-up time was 71.9 months. No significant difference in terms of long-term survival was found between MIAVR and FSAVR (hazard ratio [HR], 0.99; P = 0.91). Novel advantages of MIAVR in preventing re-hospitalization for late cerebrovascular events and the progression of HF were observed (HR, 0.53; P = 0.03; HR, 0.64, P = 0.005; respectively). Importantly, for the late mortality risk, early in-hospital complications dominated. However, the baseline atrial fibrillation (AF), diabetes, pulmonary disease, and impaired mobility showed the strongest patient-specific prediction for the other three long-run models., Conclusions: MIAVR through ministernotomy provides at least as good long-term survival as FSAVR. Nevertheless, it should be recommended for diabetic, poor-mobility patients with pre-existing AF to reduce their high cerebrovascular risk and to limit the progression of HF. MIAVR also needs to be considered in patients with chronic lung diseases to improve their extremely poor survival prognosis.
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- 2022
- Full Text
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4. COVID-19 mortality in patients after orthotopic heart transplantation: A single-center one-year observational study.
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Kuczaj A, Zakliczyński M, Przybyłowski P, Zembala M, and Hrapkowicz T
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- Humans, Retrospective Studies, SARS-CoV-2, COVID-19, Heart Transplantation adverse effects
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- 2022
- Full Text
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5. Comparison of clinical characteristics, in-hospital course, and 12-month prognosis in women and men with chronic coronary syndromes.
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Duda-Pyszny D, Trzeciak P, Desperak P, Zembala M, and Gąsior M
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- Aged, Female, Hospitals, Humans, Male, Prognosis, Sex Factors, Treatment Outcome, Diabetes Mellitus, Type 2, Percutaneous Coronary Intervention
- Abstract
Background: The prognosis of men and women with chronic coronary syndromes (CCS) remains ambiguous., Aims: This study aimed to compare the clinical characteristics and 12‑month prognosis of women and men with CCS included in the prospective single‑center registry., Methods: The study was based on the Prospective Registry of Stable Angina Management and Treatment (PRESAGE) including 11 021 patients with CCS hospitalized between 2006 and 2016 and subjected to coronary angiography. The composite endpoint included all‑cause death, nonfatal myocardial infarction, acute coronary syndrome with revascularization, unstable coronary artery disease, or stroke., Results: Women were older than men (mean [SD] age, 66.6 [9] vs 63.5 [9.6] years; P <0.001). Arterial hypertension (85.8% vs 79%; P <0.001) and type 2 diabetes (38.2% vs 33.7%; P <0.001) were more often diagnosed in women compared with men. Multivessel disease or left main disease were more frequent in men. Percutaneous coronary intervention and coronary artery bypass grafting were more often performed in men than in women (47.1% vs 36%, P <0.001 and 10.6% vs 6.1%, P <0.001, respectively). At 12‑month follow‑up, the composite endpoint was more frequently reached in men (7.4% vs 10.2%; P <0.001), including death (3.3% vs 4.5%; P = 0.002). In multivariable analysis, sex was not an independent predictor of the composite endpoint (hazard ratio, 1.08; 95% CI, 0.89-1.31, P = 0.45)., Conclusions: Women and men with CCS differ in terms of the incidence of risk factors and revascularization treatments received. In men, a higher frequency of death and the composite endpoint was noted at 12‑month follow‑up. However, sex was not an independent predictor of patient outcomes at 12 months.
- Published
- 2021
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6. Mechanical circulatory support. An expert opinion of the Association of Intensive Cardiac Care and the Association of Cardiovascular Interventions of the Polish Cardiac Society.
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Tycińska A, Grygier M, Biegus J, Czarnik T, Dąbrowski M, Depukat R, Gierlotka M, Gil M, Hawranek M, Hirnle T, Jemielity M, Kapelak B, Kralisz P, Kuliczkowski W, Kuśmierczyk M, Ligowski M, Łopatowska P, Puślecki M, Świątkowski A, Trzeciak P, Zawiślak B, Zembala M, and Zymliński R
- Subjects
- Expert Testimony, Humans, Intra-Aortic Balloon Pumping adverse effects, Intra-Aortic Balloon Pumping methods, Poland, Shock, Cardiogenic therapy, Heart-Assist Devices adverse effects, Percutaneous Coronary Intervention adverse effects
- Abstract
Mechanical circulatory support (MCS) methods are used in patients with both acute and chronic heart failure, who have exhausted other options for pharmacological or surgical treatments. The purpose of their use is to support, partially or completely, the failed ventricles and ensure adequate organ perfusion, which allows patients to restore full cardiovascular capacity, prolonging their life and effectively improving its quality. The three most popular devices include an intra-aortic balloon pump (IABP), percutaneous assist devices (including Impella, TandemHeart), and venoarterial extracorporeal membrane oxygenation (VA-ECMO). A multidisciplinary approach with the special participation of the Heart Team is required to determine the proper MCS strategy, the choice of the supporting method, and the time of its use. The studies published so far do not allow us to determine which MCS method is the safest and the most effective. Thus, the site experience and accessibility of the method seem to matter most today. MCS finds particular application in patients with acute coronary syndromes complicated by refractory cardiogenic shock, as well as in patients with acute heart failure of the high potential for reversibility. It can also serve as a backup for percutaneous coronary interventions of high risk (complex and high-risk indicated percutaneous coronary intervention [PCI], complex and high-risk indicated PCI [CHIP]). The use of appropriate supportive drugs, precise hemodynamic and echocardiographic monitoring, as well as optimal non-invasive or mechanical ventilation, are extremely important in the management of a patient with MCS. The most serious complications of MCS include bleeding, thromboembolic events, as well as infections, and hemolysis.
- Published
- 2021
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7. Heart Failure Heart Team - time to act… now.
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Zembala M, Hryniewiecki T, Wita K, Kalarus Z, Gąsior M, and Zembala M
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- Humans, Patient Care Team, Heart Failure diagnosis, Heart Failure therapy
- Published
- 2021
- Full Text
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8. Is anthracycline-induced heart failure reversible?
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Klotzka A, Kufel-Grabowska J, Zembala M, Mitkowski P, and Lesiak M
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- Anthracyclines adverse effects, Antibiotics, Antineoplastic adverse effects, Heart, Humans, Heart Failure chemically induced, Heart Failure drug therapy, Neoplasms drug therapy
- Published
- 2020
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9. Mechanical circulatory support restores eligibility for heart transplant in patients with significant pulmonary hypertension.
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Biełka A, Kalinowski M, Hawranek M, Małyszek-Tumidajewicz J, Pacholewicz J, Kowalczuk-Wieteska A, Ratman K, Kubiak G, Król B, Przybyłowski P, Zembala M, and Zembala MO
- Subjects
- Female, Heart Failure complications, Heart Failure surgery, Heart-Assist Devices, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Heart Transplantation, Hypertension, Pulmonary
- Abstract
Background: An increasing number of patients with end‑stage heart failure implies a wider use of left ventricular assist devices (LVADs). Irreversible pulmonary hypertension (PH) is a predictor of unfavorable prognosis and a contraindication to orthotopic heart transplant (OHT)., Aims: The aim of this study was to evaluate the effect of continuous‑flow LVAD (CF‑LVAD) support on pulmonary pressure and pulmonary vascular resistance (PVR) as well as the impact of pre‑LVAD hemodynamic parameters on survival during LVAD support., Methods: Data collected from 106 patients who underwent CF‑LVAD implantation in the years 2009 to 2018 (men, 95.3%; mean [SD] age, 51.8 [12] years; mean [SD] INTERMACS profile, 2.9 [1.6]; mean [SD] LVAD support time, 661 [520] days; follow‑up until May 2019) were retrospectively analyzed., Results: Right heart catheterization was performed before LVAD implantation in 94 patients (88.7%), after implantation-in 31 (29.2%), and before and after implantation-in 28 (26.4%). We observed mean pulmonary artery pressure (mPAP) >25 mm Hg in 65 patients (61.3%) and PVR >2.5 Wood units in 33 patients (31.1%) before LVAD implantation. A significant improvement after CF‑LVAD implantation was noted in mPAP, pulmonary capillary wedge pressure, transpulmonary gradient, PVR, cardiac output (P <0.001 for all parameters), and cardiac index (P = 0.003). All patients with initially irreversible PH became eligible for OHT during LVAD support. Survival during LVAD support did not depend on initial mPAP and PVR., Conclusions: In patients with end‑stage heart failure, CF‑LVAD support leads to a significant reduction of pre‑ and postcapillary PH. Survival on CF‑LVAD support is independent of elevated mPAP and PVR before implantation, which suggests that LVADs decrease the risk associated with PH.
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- 2020
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10. An 18-year follow-up after the first successful heart-lung transplant in Poland. Authors' tribute to the pioneers of heart and lung transplantation.
- Author
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Zembala M, Religa Z, Large S, Perdeus J, Wojarski J, Nowalany-Kozielska E, Małyszek-Tumidajewicz J, Zawadzki F, Wajda-Pokrontka M, and Ochman M
- Subjects
- Follow-Up Studies, Heart, Humans, Poland, Heart Transplantation, Heart-Lung Transplantation, Lung Transplantation
- Published
- 2020
- Full Text
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11. Long-term echocardiographic evaluation of asymptomatic patients undergoing minimally invasive valve repair for severe primary mitral regurgitation.
- Author
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Gerber W, Sanetra K, Drzewiecka-Gerber A, Jankowska-Sanetra J, Bochenek A, Zembala M, and Cisowski M
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- Echocardiography, Heart Atria diagnostic imaging, Humans, Stroke Volume, Treatment Outcome, Ventricular Function, Left, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency surgery
- Abstract
Background: Asymptomatic patients with newly diagnosed severe primary mitral regurgitation (MR) may not be candidates for surgery according to clinical guidelines., Aims: We aimed to determine whether asymptomatic patients with severe primary MR benefit from minimally invasive mitral valve repair., Methods: This prospective registry study assessed consecutive asymptomatic patients who underwent mitral valve repair using right minithoracotomy. Left ventricular ejection fraction, end‑diastolic and end‑‑systolic volumes, end‑diastolic and end‑systolic diameters, as well as left atrial (LA) area and volume were measured. Major adverse cardiovascular and cerebrovascular events (MACCEs) were assessed at 6, 12, and 24 months after surgery., Results: The study included 114 patients, of whom 16 (14%) were lost to follow‑up (except the endpoint of death). No deaths were reported during follow‑up. A comparison of median echocardiographic parameters at baseline and 24 months revealed significant reverse remodeling: left ventricular ejection fraction, 68% vs 60% (P <0.001); end‑diastolic volume, 165 cm3 vs 107.5 cm3 (P <0.001); end‑systolic volume, 51 cm3 vs 43.5 cm3 (P = 0.02), end‑diastolic diameter, 58 mm vs 49 mm (P <0.001); end‑systolic diameter, 35 mm vs 30 mm (P <0.001); LA area, 26 cm2 vs 18 cm2 (P <0.001); and LA volume, 96 cm3 vs 49.5 cm3(P <0.001). There were 9 MACCEs (9.2%): 2 reoperations (2%), 1 hospitalization for heart failure (1%), and 6 cases of new‑onset atrial fibrillation (6.1%)., Conclusions: Minimally invasive mitral valve repair is safe and effective in asymptomatic patients with severe primary MR. It should be recommended regardless of ventricular and atrial dimensions.
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- 2020
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12. How to effectively analyze scientific evidence in clinical practice? Rationale behind and design of an observational analytical model.
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Gąsior M, Desperak P, Cieśla D, Niedziela J, Pyka Ł, Skrzypek M, Zembala M, and Wojakowski W
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- Humans, Observational Studies as Topic, Evidence-Based Medicine
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- 2020
- Full Text
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13. Heart failure in Poland: Left ventricular assist device destination therapy and other challenges of interventional cardiology and cardiac surgery.
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Kuśmierczyk M, Różański J, Zembala M, Dudek D, Braksator W, Grodzicki T, Hoffman P, Sadowski J, Gruchała M, Legutko J, Siondalski P, Wierzbicki K, Kapelak B, Opolski G, Juraszek A, Bondaryk K, Walczak J, Pieniążek I, Grys M, and Przygodzki P
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- Humans, Poland, Cardiology, Heart Failure diagnosis, Heart Failure therapy, Heart Transplantation, Heart-Assist Devices
- Abstract
Patients with severe heart failure (HF), who are not eligible for cardiac transplantation and receive optimal medical management, based mainly on the use of pharmacological treatment and devices such as resynchronization therapy (implantable cardioverter-defibrillator), achieve poor clinical outcomes and constitute a group with extremely poor prognosis. Currently, the technology used in the latest generation left ventricular assist devices (LVADs), such as the HeartMate 3, makes it possible to achieve patient survival at the level obtained by patients after heart transplantation, and they can be used not only in patients eligible for heart transplantation as a bridge to transplant, but also in those with significantly worse prognosis, who are ineligible for heart transplantation as destination therapy. The objective of this publication is to present recommendations from experts in cardiology and cardiac surgery, supported by clinical trial results, on the use of LVADs as a destination therapy in HF patients who are not eligible for cardiac transplantation. The paper also presents the issue of cardiac transplantation and extracorporeal membrane oxygenation therapy in Poland, as well as current challenges faced by interventional cardiology and cardiac surgery in Poland.
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- 2020
- Full Text
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14. Echocardiographic evaluation of the results of minimally invasive repair of asymptomatic mitral regurgitation.
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Gerber W, Sanetra K, Drzewiecka-Gerber A, Jankowska-Sanetra J, Bochenek A, Zembala M, and Cisowski M
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- Adult, Aged, Female, Humans, Male, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve surgery, Mitral Valve Insufficiency diagnostic imaging, Treatment Outcome, Echocardiography, Minimally Invasive Surgical Procedures, Mitral Valve Insufficiency surgery
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- 2019
- Full Text
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15. A novel survey examining the level of knowledge about anticoagulant and anti-infectious prophylaxis in patients after mechanical cardiac valve implantation.
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Parys M, Kowalczuk-Wieteska A, Kulik H, Majchrzyk I, and Zembala M
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- Aged, Anticoagulants therapeutic use, Coronary Thrombosis etiology, Female, Humans, Infections etiology, Male, Middle Aged, Surveys and Questionnaires, Coronary Thrombosis prevention & control, Heart Valve Prosthesis Implantation adverse effects, Heart Valves surgery, Infection Control
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- 2019
- Full Text
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16. The role of long-term mechanical circulatory support in the treatment of end-stage heart failure.
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Paluszkiewicz L, Kukulski T, Zembala M, Gummert J, and Morshuis M
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- Aged, Disease Progression, Female, Heart Failure physiopathology, Humans, Male, Quality of Life, Stroke Volume, Assisted Circulation methods, Heart Failure therapy, Heart-Assist Devices, Palliative Care methods
- Abstract
Heart failure is a clinical syndrome of multifactorial aetiology with typical symptoms and diverse prevalence depending on the world region, reaching more than 10% in the population over 70 years of age. The prognosis, in spite of a dynamic improve- ment in medical therapy, remains poor. The only treatment for these patients is heart transplantation, however, its availability is highly limited because of the shortage of donor organs. Mechanical circulatory support can offer an alternative treatment for this patient cohort. In this review the authors discuss the present indications for, as well as results and complications of different types of long-term mechanical circulatory support. The long-term survival in patients receiving this therapy, in spite of many complication, is much better than in those receiving medical treatment. The use of mechanical circulatory support is an established treatment option for many patients with end-stage heart failure. The most important issue for the cardiologist is to identify patients eligible for this therapy in order to give them a chance for a longer life and better quality of life.
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- 2019
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17. First Polish analysis of the treatment of advanced heart failure in children with the use of BerlinHeart EXCOR mechanical circulatory support.
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Pawlak S, Przybylski R, Skalski J, Śliwka J, Kansy A, Grzybowski A, Wierzyk A, Białkowski J, Maruszewski B, and Zembala M
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- Adolescent, Child, Child, Preschool, Female, Heart Transplantation, Humans, Infant, Male, Poland, Treatment Outcome, Heart Failure therapy, Heart-Assist Devices adverse effects
- Abstract
Background: The treatment of advanced heart failure (HF) in children and infants poses a serious management problem. Heart failure in that patient group is usually of congenital aetiology. The treatment schedules for paediatric patients are in most cases adapted from the guidelines for treatment of adults. Up to 2009, the treatment of that extremely difficult group of patients was limited to pharmacological therapy and occasional heart transplantations. Constantly increasing problems with recruiting donors, especially for the paediatric group, contribute to the fact that mechanical support with the use of ventricular assist devices is for many children the only chance of surviving the period of waiting for a heart donor., Aim: The aim of the study was to analyse the outcomes of circulatory support in Poland and to assess the advisability of this method for treatment of children with severe HF., Methods: This treatment of paediatric patients is currently used in three Polish centres. From December 28, 2009 to August 1, 2015, 27 implantations of BerlinHeart EXCOR® mechanical circulatory support system were performed in children aged from one month to 16 years (10 patients below one year of age; 37%). Left ventricular assist devices were implanted to 21 patients, whereas the remaining children received biventricular support. The most common reason for using this method was HF developed in the course of cardiomyopathy. In one case, HF after Fontan operation was the indication., Results: The duration of the circulatory support period ranged from six to 1215 days. It was followed by successful heart transplantations in 10 (37%) patients, in five (18.1%) it resulted in regeneration of the heart, enabling explantation of the device, whereas three children are still waiting for transplantations. Nine (33%) children died during the therapy because of thromboembolic complications., Conclusions: As follows from our data, circulatory support utilising the BerlinHeart EXCOR® system is an effective and promising method used as a bridge to cardiac transplantation, or for regeneration of the myocardium in paediatric patients. In the group of the youngest and the most difficult patients, the method requires close cooperation of the medical and nursing personnel.
- Published
- 2018
- Full Text
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18. The Columbus of cardiovascular surgery. A tribute to Francis Fontan (1929-2018).
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Mazurak M, Kusa J, Orantek S, and Zembala M
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- Cardiac Surgical Procedures history, France, History, 20th Century, History, 21st Century, Cardiology history, Fontan Procedure history
- Published
- 2018
- Full Text
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19. The first successful bridging with an Impella CP® to minimally invasive HeartMate 3 LVAD implantation in Poland.
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Antończyk K, Antończyk R, Zembala M, Zakliczyński M, and Zembala MO
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- Adult, Cardiomyopathies complications, Female, Heart Failure complications, Humans, Treatment Outcome, Cardiomyopathies surgery, Heart Failure surgery, Heart-Assist Devices
- Published
- 2018
- Full Text
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20. Hybrid ablation in a patient with persistent, long-standing atrial fibrillation after left-sided pneumonectomy.
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Buchta P, Zembala M, Myrda K, Wojtaszczyk AJ, Witek M, and Gąsior M
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- Aged, Atrial Fibrillation etiology, Humans, Male, Atrial Fibrillation surgery, Catheter Ablation, Pneumonectomy adverse effects
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- 2018
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21. Prognostic value of selected risk scales in patients with end-stage heart failure.
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Szczurek W, Szyguła-Jurkiewicz B, Zakliczyński MW, Król B, Gąsior M, and Zembala M
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- Female, Heart Transplantation, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Sensitivity and Specificity, Heart Failure diagnosis, Severity of Illness Index
- Abstract
Background: Due to the increasing number of patients placed on waiting lists for orthotopic heart transplantation (OHT), the selection of patients with the highest risk of death has become paramount., Aim: This study aimed to evaluate the predictive value of the Model for End-stage Liver Disease eXcluding INR (MELD-XI) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) scales in ambulatory patients awaiting OHT and compare them to the Heart Failure Survival Score (HFSS)., Methods: The study was a retrospective review of 370 adult ambulatory patients with end-stage heart failure, who were added to the OHT waiting list at our institution between 2012 and 2016., Results: The median age of the patients was 54.0 (46.0-60.0) years, and 324 (87.6%) of them were male. The overall one-year mortality was 27.6%. The areas under the curve (AUCs) for the MAGGIC and HFSS scales were comparable: 0.771 (95% confidence interval [CI] 0.720-0.823); sensitivity 77%, specificity 68% vs. 0.781 (95% CI 0.732-0.829); sensitivity 90%, specificity 58%, respectively. The AUC for the MELD-XI scale was higher than that for the HFSS scale: 0.812 (95% CI 0.769-0.856); sensitivity 91%, specificity 63% vs. 0.781 (95% CI 0.732-0.829) sensitivity 90%, specificity 58%, respectively., Conclusions: Our study demonstrated that elevated MELD-XI and MAGGIC scores and lowered HFSS scores were associated with an increased risk of death during one-year follow-up. The prognostic utility of the MELD-XI scoring system was better than that of the HFSS scale, while the MAGGIC scale was comparable to the HFSS.
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- 2018
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22. Impact of CoreValve size selection based on multi-slice computed tomography on paravalvular leak after transcatheter aortic valve implantation.
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Chodór P, Wilczek K, Przybylski R, Głowacki J, Kukulski T, Streb W, Niklewski T, Honisz G, Trzeciak P, Podolecki T, Włoch Ł, Zembala M, and Kalarus Z
- Subjects
- Aged, Aged, 80 and over, Aortic Valve diagnostic imaging, Aortic Valve physiopathology, Aortic Valve Insufficiency diagnostic imaging, Aortic Valve Insufficiency etiology, Aortic Valve Insufficiency physiopathology, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis physiopathology, Aortography, Clinical Decision-Making, Echocardiography, Transesophageal, Female, Humans, Male, Predictive Value of Tests, Prosthesis Design, Retrospective Studies, Risk Factors, Time Factors, Transcatheter Aortic Valve Replacement adverse effects, Treatment Outcome, Aortic Valve surgery, Aortic Valve Insufficiency prevention & control, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Multidetector Computed Tomography, Transcatheter Aortic Valve Replacement instrumentation
- Abstract
Background: Paravalvular leak (PVL) has significant impact on long-term outcomes in patients after transcatheter aortic valve implantation (TAVI). This study sought to determine whether multi-slice computed tomography (MSCT)-guided valve selection reduces PVL after CoreValve implantation., Methods: The analysis encompassed 69 patients implanted with CoreValve and were divided into two groups. In Group I (30 patients), valve selection was based on standard procedures, in Group II (39 patients), on MSCT measurements. Paravalvular leak was assessed with angiography and echocardiography., Results: Multi-slice computed tomography results influenced a change of decision as to the size of the implanted valve in 12 (30.9%) patients in Group II and would have caused the decision to change in 9 (37.5%) patients in Group I. The degree of oversizing in Group I and II was 12.8% ± ± 7.6% vs. 18.6% ± 5.1% (p = 0.0006), respectively. The oversizing among the patients with leak degree of 0-1 and ≥ 2 was 18.1% ± 6.0% and 12.8% ± 7.4% (p = 0.0036). Angiographic assessment indicated post-procedural PVL ≥ 2 in 50% of patients in Group I and 20.5% in Group II (p = 0.01), while echocardiographic assessment indicated the same in 73.3% of patients in Group I and 45.6% in Group II (p = 0.0136). The composite endpoint occurred in 26.6% (8/30) patients in Group I vs. 5.1% (2/39) patients in Group II (p = 0.0118)., Conclusions: Selecting the CoreValve device based on MSCT resulted in smaller rates of PVL and less frequent composite endpoint. In 1/3 of patients MSCT led to a change of the valve size. The degree of oversizing had a significant impact on PVL.
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- 2017
- Full Text
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23. In-hospital and long-term outcomes of coronary artery bypass graft surgery in patients ≤ 45 years of age and older (from the KROK registry).
- Author
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Trzeciak P, Karolak W, Gąsior M, and Zembala M
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- Adult, Aged, Coronary Artery Bypass mortality, Female, Follow-Up Studies, Hospital Mortality, Humans, Male, Middle Aged, Poland, Treatment Outcome, Coronary Artery Bypass statistics & numerical data, Registries
- Abstract
Background: There is a paucity of data concerning the clinical characteristics, management, and outcomes of coronary artery bypass graft surgery (CABG) in patients ≤ 45 years old., Aim: We aimed to compare the clinical characteristics, and in-hospital and long-term outcomes of patients ≤ 45 years and > 45 years old, who underwent isolated CABG., Methods: We identified consecutive patients who had isolated CABG in the Department of Cardiac Surgery and Transplantology in the Silesian Centre for Heart Diseases in Zabrze between January 2006 and December 2011 and were enrolled in the Polish National Registry of Cardiac Surgery Procedures (KROK registry). A total of 8196 patients were identified and split into two groups, age ≤ 45 years old (young group; n = 130) and > 45 years old (old group; n = 8066)., Results: Patients ≤ 45 years old were less often females (18.5% vs. 27.6%, p < 0.027), more often smokers (84.6% vs. 66.9%, p < 0.0001), and had a higher incidence of previous myocardial infarction (MI) (40.8% vs. 29.6%, p = 0.008). Patients ≤ 45 years old more often received only one graft (27.7% vs. 15.0%, p < 0.0001), were operated on with minimally invasive direct coronary artery bypass (MIDCAB) technique (12.3% vs. 3.9%, p < 0.0001), and had complete arterial revascularisation (55.4% vs. 18.1%, p < 0.0001). There were no significant differences between the groups regarding in-hospital mortality (0.8% vs. 1.4%, p = 0.808). Long-term outcomes revealed that young patients, compared with the older patients, showed no significant differences in the number of MI (4.6% vs. 5.6%), unstable angina (8.5% vs. 9.9%), coronary angioplasty (12.3% vs. 15.1%), reCABG (0.8% vs. 0.1%), and strokes (2.3% vs. 4.3%) during the follow-up period; long-term mortality occurred less often in the young patients (4.6% vs. 15.0%, p = 0.002)., Conclusions: We conclude that patients ≤ 45 years old requiring CABG differ from their older counterparts in clinical and surgical characteristics. We noted no significant differences in the in-hospital mortality; however, patients ≤ 45 years old had a lower mortality rate in the long-term follow-up.
- Published
- 2017
- Full Text
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24. Assessment of cardiovascular function following transcatheter aortic valve implantation based on six-minute walk test.
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Chodór P, Wilczek K, Zielińska T, Przybylski R, Głowacki J, Włoch Ł, Zembala M, and Kalarus Z
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- Adult, Aged, Aged, 80 and over, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis physiopathology, Female, Follow-Up Studies, Heart Ventricles diagnostic imaging, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Severity of Illness Index, Time Factors, Aortic Valve Stenosis surgery, Exercise Tolerance physiology, Heart Ventricles physiopathology, Risk Assessment methods, Transcatheter Aortic Valve Replacement, Ventricular Function, Left physiology, Walk Test methods
- Abstract
Background: Transcatheter aortic valve implantation (TAVI) is presently a recognized treatment mo-dality for patients with severe aortic stenosis ineligible for surgery. It reduces mortality as compared to the conservative treatment. It is further expected from this therapy to improve quality of life by improving of the cardiovascular function performance. The aim of this study is to compare patients' cardiovascular system efficiency in the 6-minute walk test (6MWT) made before and after TAVI and at the 6-12-month follow-up., Methods: From January 2009 until February 2012, in the Silesian Center for Heart Diseases in Zabrze, TAVI was performed in 104 patients. Eighty-two patients who underwent 6MWT before surgery were qualified for the analysis. The average age of the patients was 76.0 ± 9.17 years, women made 45.1%. The risk of surgical treatment according to the Logistic Euroscore averaged 22.76 ± 12.63%, and by the Society of Thoracic Surgeons - 5.55 ± 3.34%. The 6MWT was performed within 1 month before the TAVI procedure, up to a month after the procedure and during the 6-12-month follow-up., Results: The 6-minute walk test after TAVI was performed by 64 patients, and after 6-12 month follow-up by 46 patients. The average distance in 6MWT increased from 268.4 ± 89.0 m before treat-ment to 290.0 ± 98.2 m after the procedure (p = 0.008) and 276.1 ± 93.5 m to 343.1 ± 96.7 m after 6-12 months (p < 0.0001)., Conclusions: Transcatheter aortic valve implantation procedures significantly improve function of the cardiovascular system evaluated by the 6MWT in 1- and 6-12-month observations. (Cardiol J 2017; 24, 2: 167-175).
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- 2017
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25. Transcatheter aortic valve implantation. Expert Consensus of the Association of Cardiovascular Interventions of the Polish Cardiac Society and the Polish Society of Cardio-Thoracic Surgeons, approved by the Board of the Polish Cardiac Society….
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Parma R, Zembala MO, Dąbrowski M, Jagielak D, Witkowski A, Suwalski P, Dudek D, Olszówka P, Wojakowski W, Przybylski R, Gil R, Kuśmierczyk M, Lesiak M, Sadowski J, Dobrzycki S, Ochała A, Hoffman P, Kapelak B, Kaźmierczak J, Jasiński M, Stępińska J, Szymański P, Hryniewiecki T, Kochman J, Grygier M, Zembala M, Legutko J, and Różański J
- Subjects
- Female, Humans, Male, Poland, Cardiology, Societies, Scientific, Transcatheter Aortic Valve Replacement
- Abstract
Patients with severe symptomatic aortic stenosis have a poor prognosis with medical management alone, and surgical aortic valve replacement can improve symptoms and survival. In recent years, transcatheter aortic valve implantation (TAVI) has been demonstrated to improve survival in inoperable patients and to be an alternative treatment in patients in whom the risk of surgical morbidity or mortality is high or intermediate. A representative expert committee, summoned by the Association of Cardiovascular Interventions of the Polish Cardiac Society (ACVI) and the Polish Society of Cardio-Thoracic Surgeons, devel-oped this Consensus Statement in transcatheter aortic valve implantation. It endorses the important role of a multi-disciplinary "TAVI team" in selecting patients for TAVI and defines operator and institutional requirements fundamental to the establish-ment of a successful TAVI programme. The article summarises current evidence and provides specific recommendations on organisation and conduct of transcatheter treatment of patients with aortic valve disease in Poland.
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- 2017
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26. Improvement of quality of life following transcatheter aortic valve implantation in the elderly: a multi-centre study based on the Polish national TAVI registry.
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Stańska A, Jagielak D, Brzeziński M, Zembala M, Wojakowski W, Kochman J, Huczek Z, Witkowski A, and Zembala M
- Subjects
- Aged, 80 and over, Aortic Valve Stenosis epidemiology, Aortic Valve Stenosis surgery, Depression, Female, Follow-Up Studies, Humans, Male, Pain, Poland, Registries, Risk, Surveys and Questionnaires, Treatment Outcome, Aortic Valve Stenosis prevention & control, Quality of Life, Transcatheter Aortic Valve Replacement
- Abstract
Background: Transcatheter aortic valve implantation (TAVI) is an effective therapeutic method for elderly high-risk patients with symptomatic severe aortic stenosis, not eligible for surgical treatment., Aim: The aim of the study was to evaluate short-term changes in elderly people's quality of life following TAVI, based on the POL-TAVI registry., Methods: One hundred and eighty-four octogenarians' and nonagenarians' samples from the POL-TAVI database were included in the study. The quality of life status was assessed with EQ-5D-3L questionnaire at baseline and after one-month follow-up., Results: The mean of patients' age was 84 (80-93) years. Logistic EuroSCORE mean was 19.83% (3.48-83.94%), and transaortic mean gradient was 54.99 (19.0-149.0) mm Hg. At baseline, up to 24.50% of patients declared severe problems in performing usual activities. 13.60% felt extreme pain or discomfort; 9.80% were unable to wash and dress by themselves; 8.20% were extremely anxious or depressed; and 7.10% of the patients in the study were confined to bed. After 30 days the percentage of patients declaring severe problems in each dimension did not exceed 4.00%. The comparison between quality of life data at baseline and after one-month follow-up showed a significant improvement in each of five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression (p < 0.001). Patients' quality of life was increasing regardless of gender (female vs. male), the type of anaesthesia (general vs. local), and the type of procedure (TA vs. TF)., Conclusions: Short-term quality of life in the elderly subjects was significantly improved after one-month follow-up following TAVI.
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- 2017
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27. Hybrid ablation of haemodynamically unstable ventricular tachycardia using a transabdominal minimally-invasive approach and percutaneous left ventricular assist device.
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Buchta P, Zembala M, Hawranek M, Zembala M, and Gąsior M
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- Aged, Heart-Assist Devices, Humans, Male, Ablation Techniques, Tachycardia, Ventricular surgery
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- 2017
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28. State-of-the-art of transcatheter treatment of aortic valve stenosis and the overview of the InFlow project aiming at developing the first Polish TAVI system.
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Kachel M, Milewski K, Buszman P, Michalak M, Domaradzki W, Gerber W, Śliwka J, Nożyński J, Sobota M, Hirnle P, Białek-Brodocz M, Zembala M, Pawlak M, Płowiecki E, Kasperczyk J, Mężyk A, Bochenek A, and Buszman P
- Subjects
- Aortic Valve surgery, Equipment Design, Humans, Poland, Prosthesis Design, Aortic Valve Stenosis surgery, Biomedical Research, Transcatheter Aortic Valve Replacement instrumentation
- Abstract
Initial experience of transcatheter aortic valve implantation (TAVI) or replacement (TAVR) has ap-peared as a promising minimally invasive technology for patients disqualified from surgical treatment (SAVR). Safety and efficacy of TAVI has been analyzed and assessed through numerous registries and trials. Furthermore, results obtained from comparative TAVI vs. SAVR trials proved that both treat¬ments can be considered equal in terms of post-procedural mortality and morbidity in high-risk, as well as lower risk patients. However, there are still some issues that have to be addressed, such as higher chance of paravalvular leakage, vascular injuries, conduction disturbances, malpositioning and the yet unmet problem of insufficient biological valves durability. Recent technological developments along with the learning curve of operators prove a great potential for improvement of TAVI and a chance of surpassing SAVR in various groups of patients in the near future. In pursuit of finding new solutions, the CardValve Consortium consisting of leading scientific and research institutions in Poland has been created. Under the name of InFlow and financial support from the National Center for Research and Development, they have started a project with the aim to design, create and implement into clinical practice the first, Polish, low-profile TAVI valve system, utilizing not only biological but also artificial, polymeric-based prosthesis. This review focuses on current developments in TAVI technologies including the InFlow project.
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- 2017
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29. Successful use of Impella CP® in cardiogenic shock after cardiac arrest: a first in Poland.
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Nadziakiewicz P, Zembala M, Słonka G, and Balak W
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- Female, Heart Arrest complications, Heart-Assist Devices, Humans, Poland, Shock, Cardiogenic complications, Young Adult, Assisted Circulation, Heart Arrest surgery, Minimally Invasive Surgical Procedures, Shock, Cardiogenic surgery
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- 2017
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30. Symetis Acurate Neo transfemoral aortic bioprosthesis - initial Polish experience.
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Zembala M, Hawranek M, Wacławski J, Niklewski T, Nadziakiewicz P, Koba R, Przybylski R, Walas R, Głowacki J, Jazwiec T, Garbacz M, Gąsior M, and Zembala M
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- Aged, Aged, 80 and over, Aortic Valve surgery, Female, Humans, Male, Poland, Treatment Outcome, Aortic Valve Stenosis surgery, Bioprosthesis, Heart Valve Prosthesis
- Abstract
Background and Aim: Transcatheter aortic valve implantation (TAVI) has proven to be a valuable alternative to conventional surgical aortic valve replacement in high-risk and surgically inoperable patients who suffer from severe symptomatic aortic stenosis. With the second generation of TAVI devices improvements in both handling and performance are highly demanded. This brief clinical communication reports the first Polish experience with the second generation of transfemoral TAVI device--Symetis Acurate Neo., Methods: From November 19th 2014 until February 18th 2015 nine (n = 9) patients with severe symptomatic aortic stenosis have been operated on using the Symetis Acurate Neo. Patients were subject to seven-day evaluation and 30-day phone follow-up., Results: The procedure was safely and successfully performed in all patients. A SMALL (S) valve (21-23 mm equivalent) was used in two patients, MEDIUM valve (M; 23-25 mm equivalent) in five patients, and a LARGE valve (L; 25-26 mm equivalent) in two patients. In three cases post-release balloon dilatation was required. There were no intraoperative complications and no major adverse events (as per VARC classification) during initial hospitalisation, including conduction or rhythm disturbances. In all cases, the mean gradient on the prosthetic valves was 7.8 mm Hg (10.2 mm Hg on the "S" valves). Rapid improvement in patients' functional class was noted. Perivalvular leak was evaluated as "mild" in three cases, "trace" in one, and "not existing" in five., Conclusions: This initial experience with the Symetis Acurate Neo demonstrates its good safety profile and excellent haemodynamics. Low radial stress of the valve results in minimal incidence of atrioventricular rhythm disturbances, and a sealing crown for nearly non-existent paravalvular leak.
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- 2016
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31. COnteMporary Modalities In Treatment of Heart Failure: a report from the COMMIT-HF registry.
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Gąsior M, Pyka Ł, Gorol J, Hawranek M, Tajstra M, Słonka G, Kurek A, Krajewski A, Rozentryt P, Gierlotka M, Lekston A, Zembala M, and Poloński L
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- Aged, Female, Humans, Male, Middle Aged, Poland, Prognosis, Prospective Studies, Heart Failure therapy, Registries
- Abstract
Background and Aim: Heart failure (HF) has become a global health problem and is a significant burden for health-care systems worldwide. It is reported as the reason for 1-4% of all hospital admissions in developed countries. The prognosis in HF remains unfavourable. Having at our disposal a large group of patients with systolic HF at a high-volume reference cardiovascular centre with the possibility to implement complete diagnostics and therapy we decided to analyse the clinical data, administered therapies, and prognosis in HF patients., Methods: The COMMIT-HF is a single-centre observational study that is underway in the Third Chair and Department of Cardiology of the Silesian Centre for Heart Diseases in Zabrze. The study population is a cohort of adult HF patients with left ventricular ejection fraction (LVEF) ≤ 35%. Patients with acute coronary syndromes are excluded from the analysis. Complete patient demographics: medical history, hospitalisation data (diagnostic and therapeutic), and in-hospital results are collected. Twelve-month follow-up is based on the information acquired from the national health-care provider., Results: As of 31 December 2013 a group of 1798 patients have been enrolled (mean age 60.9 ± 12.8 years, 20.3% of subjects female, mean LVEF 26.06 ± 6.09, ischaemic aetiology 64.5%, atrial fibrillation 33.2%, diabetes mellitus 41.2%, chronic kidney disease stage ≥ III 29%). A significant proportion of patients underwent invasive procedures (ICD/CRT-D implantation 61.1%, coronary angiography 56.2%, PCI 19.6%, CABG 5.1%, heart transplantation qualification 5.5%, IABP 2.5%). All-cause 12-month morality was 12.5%. HF-related rehospitalisation rate was 28.9%., Conclusions: The COMMIT-HF study will provide valuable information on the HF patient population. Initial analyses show that in this difficult patient population satisfactory long-term results can be achieved.
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- 2016
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32. Paravalvular leak after transcatheter aortic valve implantation (TAVI): Short-term results. Data from Polish national POL-TAVI registry.
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Kleczyński P, Zasada W, Bagieński M, Rzeszutko Ł, Sorysz D, Sobczyński R, Trębacz J, Kapelak B, Zembala M, and Dudek D
- Subjects
- Aged, Aged, 80 and over, Aortic Valve diagnostic imaging, Aortic Valve Insufficiency diagnosis, Aortic Valve Insufficiency epidemiology, Echocardiography, Transesophageal, Female, Follow-Up Studies, Humans, Incidence, Male, Poland epidemiology, Retrospective Studies, Survival Rate trends, Time Factors, Aortic Valve surgery, Aortic Valve Insufficiency etiology, Aortic Valve Stenosis surgery, Heart Valve Prosthesis adverse effects, Postoperative Complications epidemiology, Registries, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Background: The authors analyzed data from Polish national POL-TAVI registry in terms of paravalvular leak (PVL) occurrence after transcatheter aortic valve implantation (TAVI) and its impact on clinical outcomes., Methods: A total of 331 patients with severe aortic stenosis underwent TAVI (Edwards Sapien, n = 141; CoreValve, n = 190). The grade of PVL and survival rate were assessed at6-month follow-up., Results: One hundred and eighty-one (54.7%) patients developed mild PVL, and 22 (6.6%) - moderate PVL after TAVI. No severe PVLs were observed. Occurrence of moderate PVL was device dependent and more frequent in the CoreValve group (p = 0.02). Larger CoreValve device used correlated with the grade of PVL (Spearman: r = 0.19; p = 0.01), but for Edwards Sapien devices this correlation was inverted (Spearman: r = -0.62; p = 0.01). Six-month mortality rate was not significant between patients with no or mild PVL compared to those with moderate PVL (p = 0.12)., Conclusions: The PVL occurrence remains a frequent problem after TAVI and is device de-pendent, more common with Edwards 23 mm valve and 31 mm CoreValve prosthesis.
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- 2016
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33. Coronary artery bypass graft surgery in a 103-year-old female patient.
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Kowalczuk-Wieteska A, Jaworska I, Filipiak K, Grzebieniak T, and Zembala M
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- Aged, 80 and over, Echocardiography, Female, Humans, Non-ST Elevated Myocardial Infarction diagnostic imaging, Coronary Artery Bypass, Non-ST Elevated Myocardial Infarction surgery
- Published
- 2015
34. Incidence, treatment, in-hospital mortality and one-year outcomes of acute myocardial infarction in Poland in 2009-2012--nationwide AMI-PL database.
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Gierlotka M, Zdrojewski T, Wojtyniak B, Poloński L, Stokwiszewski J, Gąsior M, Kozierkiewicz A, Kalarus Z, Wierucki Ł, Chlebus K, Zembala M, Wysocki M, and Opolski G
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- Adult, Aged, Aged, 80 and over, Female, Hospital Mortality, Humans, Incidence, Male, Middle Aged, Myocardial Infarction therapy, Poland epidemiology, Treatment Outcome, Myocardial Infarction epidemiology
- Abstract
Background and Aim: Nationwide data on acute myocardial infarction (AMI) are available for some Western but not for Central and Eastern European countries. We performed a study on nationwide data of all Polish AMI patients in 2009-2012 to assess incidence, quality of care, and cardiovascular events during 1 year following AMI., Methods: The database of the only public, obligatory health insurer in Poland (National Health Fund) together with data from the Central Statistical Office were used. AMI cases were selected based on primary diagnosis ICD-10 codes I21-I22. For years 2009-2012, index hospitalisations (n = 311,813) in a given year and death records were analysed. Additionally, data on hospitalisations, procedures and deaths during 1 year follow-up were obtained for 2009., Results: Age-adjusted incidence of AMI in Poland in 2009 was 196 cases per 100,000 population (176 per 100,000 were hospitalised), with a decreasing trend over time. The incidence was 2.5 times higher in men than in women. The median age was 63 years in men and 74 years in women. The proportion of ST elevation myocardial infarction (STEMI) decreased from 59% to 48% in 2012, and the proportion of patients receiving invasive treatment increased from 72% to 81%. Age-adjusted case fatality rate was equal in women and men. In 2009, the number of patients with AMI was 75,054 (61% men, 39% women) and 83% of them were treated in cardiology units. Invasive strategy was used in 77% of patients with STEMI and 66% of those with non-STEMI, thrombolysis in 1% and coronary artery bypass grafting in 1.9% of patients. Invasive treatment was used less frequently in women and the elderly patients. When all hospitals where a patient was treated until the final discharge were taken into account, in-hospital mortality was 10.5%. The lowest in-hospital mortality was noted among patients treated invasively (6.3%). The total number of readmissions within 1 year following AMI was 84,718, of which 61.9% were due to cardiovascular causes. The most common causes were stable coronary artery disease (27%), heart failure (7.9%), recurrent infarction (7.0%), and unstable angina (6.8%). Within 1 year after AMI, only 22% of patients participated in a cardiac rehabilitation programme. Total 1-year mortality was 19.4% (invasive treatment 12.3%, non-invasive treatment 38.0%)., Conclusions: Standards of care and early outcomes in AMI in Poland are similar to Western countries. The major cause of higher mortality due to AMI in the Polish population is a high incidence of AMI, indicating a need for intensification of primary prevention programmes. Secondary prevention is also underused, especially in the field of cardiac rehabilitation.
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- 2015
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35. Left ventricular assist as a key factor for heart self-restoration in a 20-year-old patient with severe left ventricular dysfunction: five-year echocardiographic observation.
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Kowalczuk-Wieteska A, Pacholewicz J, Zakliczyński M, Barańska-Kosakowska A, and Zembala M
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- Adult, Cardiomyopathy, Dilated diagnostic imaging, Cardiomyopathy, Dilated drug therapy, Cardiomyopathy, Dilated rehabilitation, Humans, Male, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left drug therapy, Ventricular Dysfunction, Left rehabilitation, Young Adult, Cardiac Valve Annuloplasty, Cardiomyopathy, Dilated surgery, Echocardiography, Heart-Assist Devices, Ventricular Dysfunction, Left surgery
- Published
- 2015
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36. Summary of recommendations for the haemodynamic and angiographic assessment of the pulmonary circulation. Joint statement of the Polish Cardiac Society's Working Group on Pulmonary Circulation and Association of Cardiovascular Interventions.
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Kurzyna M, Araszkiewicz A, Błaszczak P, Grabka M, Hawranek M, Kopeć G, Mroczek E, Zembala M, Torbicki A, and Ochała A
- Subjects
- Dilatation, Pathologic diagnosis, Hemodynamics, Humans, Poland, Angiography, Cardiac Catheterization, Cardiology, Hypertension, Pulmonary diagnosis, Pulmonary Circulation, Societies, Medical
- Abstract
Right heart catheterisation (RHC) is the 'gold standard' for haemodynamic assessment of the pulmonary circulation. For the diagnosis of pulmonary hypertension (PH), the guidelines of the European Society of Cardiology require a mean pulmonary arterial pressure ≥ 25 mm Hg to be confirmed by direct haemodynamic measurement. Additionally, RHC provides a lot of valuable information about the differential diagnosis and severity of PH, and also helps determine the patient's prognosis. Acute vasoreactivity testing performed in patients with pulmonary arterial hypertension is intended to identify the group of patients who should be treated with calcium channel blockers. Patients referred for heart transplantation require advanced pulmonary vascular disease to be ruled out either on resting examination or during vasoreactivity testing. RHC is a component of such interventional procedures as balloon atrial septostomy, closure of intracardiac shunts in congenital heart and great vessel defects, valvuloplasty for pulmonary valve stenosis, and pulmonary angioplasty. Pulmonary angiography is an examination recommended when selecting patients for pulmonary endarterectomy or balloon pulmonary angioplasty in thromboembolic PH. Due to the dynamic growth in the number of patients diagnosed with and treated for PH in Poland, the Boards of the Polish Cardiac Society's Working Group on Pulmonary Circulation and Association of Cardiovascular Interventions have undertaken a joint project to develop recommendations to standardise guidelines for RHC procedure, acute vasoreactivity testing and pulmonary angiography at cardiac wards and haemodynamic laboratories in Poland. This document has been prepared by experts delegated by the Working Group on Pulmonary Circulation and the Association of Cardiovascular Interventions, and subsequently approved by the Boards of both organs of the Polish Cardiac Society.
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- 2015
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37. Symetis Acurate Transapical Aortic Valve: the initial experience with a second generation of transcatheter aortic valve replacement device.
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Zembala MO, Piegza J, Wacławski J, Hawranek M, Hilker M, Niklewski T, Głowacki J, Parys M, Nadziakiewicz P, Chodór P, Wilczek K, Przybylski R, Gąsior M, and Zembala M
- Subjects
- Adult, Aged, Aged, 80 and over, Animals, Female, Humans, Male, Middle Aged, Poland, Swine, Aortic Valve surgery, Aortic Valve Stenosis surgery, Bioprosthesis, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Heart Valve Prosthesis Implantation methods
- Abstract
Background: Transcatheter aortic valve replacement (TAVR) has proven to be a valuable alternative to conventional surgical aortic valve replacement in high risk and surgically in operable patients who suffer from severe symptomatic aortic stenosis. However, a significant number of complications, associated with both the learning curve and device specificity, have required attention and subsequent improvement. The Symetis transapical TAVR system is a self-positioning bioprosthesis composed of a non-coronary leaflet of surgical quality porcine tissue valve sewn into a self-expanding nitinol stent that iscovered with a PET-skirt., Methods: From June to September 2013 six patients have been operated on severe aortic stenosis using the new TAVR device. All patients have undergone critical assessment of a local Heart Team and have been disqualified from conventional AVR. Five were woman. Mean age was 82.3 ± 2.0 (mean LogEuroScore 23.9 ± 14.3). Four patients suffered from coronary artery disease - two had history of previous percutaneous coronary intervention with intracoronary stents, while the next two had history of coronary artery bypass grafting. Diabetes was frequent (n = 3) as well as chronic obstructive pulmonary disease (n = 4). Carotid artery disease was encountered in three patients similarly to atrial fibrillation. Mean left ventricular ejection fraction (LVEF) was 51.5 ± 11.8%, but one patient had suffered from low-flow-low-gradient aortic stenosis with LVEF of 29%., Results: The procedure was carried out successfully in all six cases. Two patients have received the valve sized L, three - M and one - S. Mean procedure time was 180 ± 19 min, mean cine 7.2 ± 1.2 min. Mean X-ray dose 930 ± 439 mGy, while mean volume of contrast given was 135 ± 61 mL. In all patients but one perivalvular leak (PVL) was not present. One patient had trace of PVL. Also, good LVEF was noted in all patients. Similar findings were obtained 30 days post procedure. No strokes, transient ischaemic attack or other cerebrovascular incidents were observed., Conclusions: This brief clinical communication reports the first Polish experience with the second generation of TAVR device - the Symetis Acurate Transapical Aortic Valve. While it lacks large patient population and longer follow-up, it reveals that TAVR procedure can be performed safely, with minimal X-ray exposure time and contrast given and successfully - with almost nonexistent PVL and no cerebrovascular incidents or heart rhythm disturbances. Heart Team approach is vital, and transapical access should not be treated inferiorly, but rather as an equally appealing TAVR option.
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- 2014
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38. [Primary pulmonary artery sarcoma in 36-year-old women: 3-years follow-up after partial resection and radiotherapy].
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Drożdż J, Warchoł E, Fijuth J, Filipiak K, Spych M, Maciejewski M, Piestrzeniewicz K, Ludomir S, Janaszek-Sitkowska H, Januszewicz A, and Zembala M
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Pulmonary Artery surgery, Radiotherapy, Adjuvant, Sarcoma radiotherapy, Ultrasonography, Vascular Neoplasms radiotherapy, Pulmonary Artery diagnostic imaging, Sarcoma diagnosis, Sarcoma surgery, Vascular Neoplasms diagnosis, Vascular Neoplasms surgery
- Abstract
Intimal sarcoma of the heart and pulmonary artery is a very rare, malignant, primary tumour. The prognosis in patients with primary sarcoma of the pulmonary artery, including intimal sarcoma, is poor. We present the case and 3-years follow-up of 36-year-old woman who was successfully treated with surgical, partial resection of the tumour followed by radiotherapy.
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- 2013
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39. Matrix metalloproteinases and the activity of their tissue inhibitors in patients with ST-elevation myocardial infarction treated with primary angioplasty.
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Kuliczkowski W, Urbaniak J, Hallén J, Woźniak M, Poloński L, Mysiak A, Atar D, Zembala M, and Serebruany V
- Subjects
- Female, Humans, Male, Middle Aged, Ventricular Remodeling physiology, Angioplasty, Balloon, Coronary, Matrix Metalloproteinase 2 blood, Matrix Metalloproteinase 9 blood, Matrix Metalloproteinase Inhibitors blood, Myocardial Infarction enzymology, Myocardial Infarction therapy
- Abstract
Background: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a role in heart remodelling after acutemyocardial infarction (MI). Their activity is connected with outcome and heart failure development. There is little data on MMP and TIMP activity changes in the setting of ST elevation MI (STEMI) treated with primary percutaneous coronary intervention (pPCI)., Aim: To assess the dynamics of activity of MMP-2 and MMP-9 and their endogenous inhibitors TIMP-1 and TIMP-2 in the course of invasive treatment of STEMI., Methods: The study included 95 patients (age 61.8 ± 12.4 years; 35 women) treated with pPCI with stent implantation due to 100% closure of the target vessel in a setting of STEMI. We measured the activity of MMP-2 and MMP-9 (by zymography,expressed with arbitrary units, AU), CK-MB (U/L), troponin I (ng/mL), TIMP-1, TIMP-2 (ng/mL) concentrations in a peripheral blood before the pPCI, immediately after and 3, 6, 12, 24 and 48 h after the procedure. Left ventricular ejection fraction(LVEF) was estimated at the hospital discharge using the Simpson method. There were two control groups: 15 healthy persons and 15 patients with stable coronary artery disease matched for age and sex with the studied group., Results: The abrupt opening of the target vessel did not produce an early increase in the activity of the MMPs. Their activity was high at the beginning and slowly lowered with time after pPCI so that at 12, 24 and 48 h after pPCI their activity was significantly lower than before and immediately after the pPCI (p < 0.05 for all comparisons). The abrupt opening of the target vessel did not produce significant changes in the TIMP concentration. Only the TIMP-1 showed a slow increase in concentration and achieved a significantly higher level 48 h after the procedure compared to its concentration before and immediately after pPCI (p < 0.05). In 14 patients (15% of the studied group), the post procedure TIMI flow was estimated as lower than 3 (TIMI 1 or 2). There was significantly higher MMP-9 activity in this group before, immediately after and up to 3 h after PCI compared to the group with good angiographic effect (TIMI = 3 after procedure). Patients with lowered LVEF(< 50%) at hospital discharge had higher MMP-9 activity immediately after and 3 h after pPCI compared to patients with preserved LVEF. The same relation was observed for TIMP-2 level, where patients with a higher level before and immediately after pPCI had lowered LVEF at discharge., Conclusions: 1. The activity level of MMP-2 and MMP-9 is elevated during the STEMI acute phase and falls 12 h after successful pPCI, while TIMP-1 concentration only rises 48 h after the procedure. 2. The abrupt opening of the target vessel in STEMI does not produce acute changes in MMP-2, MMP-9 activity or TIMP-1 and TIMP-2 concentration. 3. The 'no-reflow'phenomenon in STEMI patients occurs more often in those with higher MMP-9 activity before pPCI. 4. Lowered LVEF at hospital discharge is observed in patients with higher periprocedural MMP-9 activity and TIMP-2 level.
- Published
- 2013
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40. Outcomes of invasive treatment in very elderly Polish patients with non-ST-segment-elevation myocardial infarction from 2003-2009 (from the PL-ACS registry).
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Gierlotka M, Gąsior M, Tajstra M, Hawranek M, Osadnik T, Wilczek K, Kalarus Z, Lekston A, Zembala M, and Poloński L
- Subjects
- Acute Coronary Syndrome drug therapy, Adrenergic beta-Antagonists therapeutic use, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Calcium Channel Blockers therapeutic use, Electrocardiography, Female, Hemorrhage mortality, Humans, Incidence, Male, Myocardial Infarction drug therapy, Percutaneous Coronary Intervention adverse effects, Platelet Aggregation Inhibitors therapeutic use, Poland epidemiology, Recurrence, Registries statistics & numerical data, Risk Factors, Stroke mortality, Treatment Outcome, Acute Coronary Syndrome mortality, Acute Coronary Syndrome therapy, Myocardial Infarction mortality, Myocardial Infarction therapy, Percutaneous Coronary Intervention mortality
- Abstract
Background: Elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI) are rarely included in randomized trials due to concomitant diseases. As a result, invasive treatment and aggressive pharmacotherapy are used less frequently in this group. The aim of the study was to analyze the impact of invasive treatment used for elderly patients (≥ 80 years) with NSTEMI from 2003-2009 and its impact on 24-month outcomes., Methods: We performed analysis of 13,707 elderly patients, out of 78,422 total NSTEMI patients, enrolled in the prospective, nationwide, Polish Registry of Acute Coronary Syndromes (PL-ACS) from 2003 to 2009., Results: The percentage of elderly NSTEMI population was 17.5%. Invasive treatment received 24% of them. In-hospital complications (stroke, reinfarction and death) were significantly less frequent in the invasive group, with the exception of major bleeding, which occurred almost three times more frequently (2.9% vs. 1.1%, p < 0.0001) in the invasive group. The 24-month mortality was lower (29.4% vs. 50.4%, p < 0.0001) in the invasive group and remained so after matching patients by the propensity score method (31.1% vs. 40.9%, p < 0.0001). From 2003 to 2009 the use of thienopyridines, beta-blockers and statins rose significantly. The frequency of invasive strategy increased significantly, from 10% in to over 50% in 2009. The frequency of major bleeding increased twofold, however a significant reduction in the 24-month mortality was observed over the years., Conclusions: Elderly patients with NSTEMI benefit significantly from invasive strategies and modern pharmacotherapy recommended by treatment guidelines. Nevertheless, this approach is associated with an increased incidence of major bleeding.
- Published
- 2013
- Full Text
- View/download PDF
41. [Epicardial approach during ablation of ventricular tachycardia in patients with ischaemic cardiomyopathy - utility and safety of the method].
- Author
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Buchta P, Arya A, Hindricks G, Piorkowski C, Poloński L, Gąsior M, and Zembala M
- Subjects
- Catheter Ablation adverse effects, Electrocardiography methods, Endocardium surgery, Humans, Catheter Ablation methods, Epicardial Mapping methods, Myocardial Ischemia surgery, Tachycardia, Ventricular surgery
- Published
- 2012
42. The influence of diabetes on in-hospital and long-term mortality in patients with myocardial infarction complicated by cardiogenic shock: results from the PL-ACS registry.
- Author
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Gąsior M, Pres D, Gierlotka M, Hawranek M, Słonka G, Lekston A, Buszman P, Kalarus Z, Zembala M, and Poloński L
- Subjects
- Aged, Comorbidity, Coronary Disease epidemiology, Female, Humans, Hypercholesterolemia epidemiology, Hypertension epidemiology, Male, Multivariate Analysis, Obesity epidemiology, Prognosis, Registries, Sex Distribution, Sex Factors, Shock, Cardiogenic therapy, Survival Rate, Diabetes Mellitus epidemiology, Hospital Mortality trends, Myocardial Infarction mortality, Shock, Cardiogenic mortality
- Abstract
Background: Cardiogenic shock (CS) affects the prognosis in patients with myocardial infarction (MI). An additional factor affecting the prognosis is diabetes mellitus (DM)., Aim: To evaluate the impact of DM on in-hospital and long-term mortality in patients with MI complicated by CS, who were included in the Polish Registry of Acute Coronary Syndromes (PL-ACS). We also sought to demonstrate a relationship between treatment method and mortality in this group., Methods: 71,290 consecutive patients with non-ST elevation MI (NSTEMI; 33,392) and ST elevation MI (STEMI; 37,898) were included in the PL-ACS register. CS was diagnosed on admission in 4,144 patients. This group included 1,159 patients with DM., Results: The patients with DM were older, more frequently female and more frequently presented with hypertension, hypercholesterolaemia, obesity, suffered from multivessel coronary disease significantly more frequently (76.4% vs. 64.6%; p = 0.00003) and had lower coronary angioplasty efficacy (TIMI 3 flow) (67% vs. 75.8%; p = 0.001) compared to patients without DM. The mortality rate comparisons for patients with DM vs. those without DM, respectively, were as follows: inhospital mortality, 61.4% vs. 55.9%; p = 0.001 (revascularisation treatment: 45.7% vs. 39.5%; p = 0.03, conservative treatment: 69.3% vs. 64.6%; p = 0.02) and 3-year mortality 78.6% vs. 70.7%; p 〈 0.0001 (revascularisation treatment: 64.7% vs. 55.0%; p = 0.001, conservative treatment: 85.5% vs. 79.2%; p = 0.0001). In the multivariate analysis, DM was, with borderline statistical significance, an independent predictor of higher in-hospital mortality (OR = 1.16; 95% CI 1.00-1.35; p = 0.054] and 3-year mortality (HR = 1.11; 95% CI 1.02-1.20; p = 0.01). Interestingly, after excluding patients who died in the hospital, DM was still associated with significantly higher 3-year mortality (50.1% vs. 40.0%; p 〈 0.0001). Multivariate analysis revealed that DM was still an independent risk factor for higher 3-year mortality (HR = 1.21; 95% CI 1.04-1.41; p = 0.02)., Conclusions: Diabetes is associated with higher in-hospital and long-term mortality in patients with MI complicated by CS. Revascularisation treatment, compared to conservative treatment, reduces mortality in this group of patients.
- Published
- 2012
43. Minimally invasive hybrid ablation procedure for the treatment of persistent atrial fibrillation: one year results.
- Author
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Zembala M, Filipiak K, Kowalski O, Boidol J, Sokal A, Lenarczyk R, Niklewski T, Garbacz M, Nadziakiewicz P, Kalarus Z, and Zembala M
- Subjects
- Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Cardiac Tamponade diagnosis, Cardiac Tamponade etiology, Cardiac Tamponade surgery, Catheter Ablation methods, Echocardiography, Electrocardiography, Ambulatory, Esophageal Perforation diagnosis, Esophageal Perforation etiology, Female, Follow-Up Studies, Hemorrhage etiology, Humans, Lacerations etiology, Lacerations surgery, Male, Middle Aged, Postoperative Care, Prospective Studies, Treatment Outcome, Vena Cava, Inferior injuries, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Minimally Invasive Surgical Procedures adverse effects, Minimally Invasive Surgical Procedures methods
- Abstract
Background: The concept of a hybrid approach, combining the most effective techniques of surgical and endocardial catheter ablation has resulted in the creation of the convergent ablation procedure. This novel, pericardioscopic, hybrid approach can be an effective option for highly symptomatic patients with persistent atrial fibrillation (PSAF) and longstanding persistent atrial fibrillation (LSPAF) for whom standalone surgical or endocardial ablation procedures offer sometimes unsatisfactory outcomes., Aim: To assess the safety, efficacy and effectiveness of a hybrid epicardial and endocardial radiofrequency ablation for the treatment of PSAF and LSPAF., Methods: Single-centre, prospective, non-randomised clinical study. Between August 2009 and December 2011, 27 patients with PSAF (n = 5) and LSPAF (n = 22) underwent hybrid ablation (HABL). Mean age was 52.52 ± 11.27 years, and the mean EHRA class was 2.5; 14 (51.8%) patients had a history of electrical cardioversion (n = 6) or catheter ablation (n = 8). Five patients had left ventricular ejection fraction (LVEF) of less than 35%. Mean AF duration for all patients was 3.46 ± 2.5 years. All patients were on antiarrhythmic drugs (AAD) and oral anticoagulation. Patients were scheduled for three, six and 12 month follow-up with seven day Holters, REVEAL® XT and ECHO measurements., Results: The HABL procedure was feasible in all patients. At six months post procedure, 72.2% (13/18) of patients were in SR, and 66.5% (12/18) were off class I/III AADs. Four patients were in AF and one patient developed right atrial flutter. At one year post procedure, 80% (8/10) of patients were in SR and off class I/III AADs. At two year post procedure, 100% (6/6) of patients were in SR and off class I/III AADs. Rapid change in left ventricular function was noted in patients with low LVEF (≤ 35%) prior to the procedure. Patients with LVEF +40% had less apparent improvement., Conclusions: Hybrid, epicardial and endocardial, radiofrequency ablation is feasible and safe, effectively restoring sinus rhythm in the vast majority of patients with PSAF and LSPAF.
- Published
- 2012
44. Professor Zbigniew Religa (1938-2009). An outstanding cardiac surgeon. Director, Chancellor, member of Parliament, Senator, and Minister.
- Author
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Zembala M
- Subjects
- History, 20th Century, History, 21st Century, Humans, Poland, Cardiac Surgical Procedures history, Education, Medical history, Faculty, Medical history, Politics
- Published
- 2012
- Full Text
- View/download PDF
45. [Hybrid room - the new standard for cooperation of cardiosurgeon, anaesthesiologist and invasive cardiologist in treating difficult, complex cardiovascular patients].
- Author
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Hawranek M, Gąsior M, Tajstra M, Zembala M, Filipiak KJ, Hrapkowicz T, Poloński L, and Zembala M
- Subjects
- Anesthesiology, Cardiology, Cardiovascular Surgical Procedures standards, Hospital Design and Construction methods, Hospital Design and Construction standards, Humans, Operating Rooms organization & administration, Patient Satisfaction, Patients psychology, Physicians psychology, Surgery, Computer-Assisted standards, Cardiovascular Surgical Procedures methods, Interprofessional Relations, Operating Rooms standards, Physicians organization & administration
- Abstract
The concept of hybrid room is to combine capabilities of cardiosurgery operating room and fully equipped cathlab. Since May 2011, an ultramodern hybrid room has been working, in our center. The cases reported in this article show the possibilities of cooperation of cardiosurgeons, anaesthesiologists and invasive cardiologists in performing difficult, complex cardiovascular interventions. In near future the capabilities of hybrid room will allow to perform simultaneously a number of complex cardiovascular procedures. It should not only shorten the time of hospitalisation but also substantially improve the patients comfort.
- Published
- 2012
46. Does the method of heart transplantation affect left ventricular filling?
- Author
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Markowicz Pawlus E, Duszańska A, Przybylski R, Szulik M, Streb W, Zembala M, Kalarus Z, and Kukulski T
- Subjects
- Anastomosis, Surgical methods, Echocardiography, Graft Rejection, Heart Transplantation pathology, Humans, Pulmonary Artery physiopathology, Pulmonary Circulation, Systole physiology, Venae Cavae surgery, Heart Atria diagnostic imaging, Heart Transplantation methods, Heart Transplantation physiology, Heart Ventricles diagnostic imaging, Myocardium pathology, Ventricular Function, Left physiology
- Abstract
Background: For over 40 years now orthotopic heart transplantation (OHT) has been the treatment of choice in patients with advanced heart failure. For many years patients undergoing OHT have been treated with the classical approach involving anastomosis of the donor atria with the recipient atria resulting in a heart in which the atria are enlarged. An alternative method for OHT is the bicaval anastomosis technique, which involves connecting both of the donor's venae cavae with the recipient's venae cavae., Aim: To assess left ventricular (LV) filling in patients undergoing OHT using the classical (biatrial) versus bicaval approach., Methods: We analysed 60 patients who had undergone OHT between 1 and 36 months before. Myocardial biopsy at echocardiography revealed grade 0 or 1A rejection in all the patients. All the patients were also in NYHA functional class I. The patients were divided in two groups: patients who had undergone biatrial anastomosis (Group 1, n = 40) and patients who had undergone bicaval OHT (Group 2, n = 20). In order to render the results independent of pre-OHT blood pressure values in the pulmonary circulation we assessed the values of right ventricular systolic pressure (RVSP), mean pulmonary artery pressure (PAP) and transpulmonary gradient (TPG) in all the patients before OHT. We assessed the following echocardiographic parameters: peak early filling velocity (E-wave), peak atrial filling velocity (A-wave), E-wave deceleration time, early diastolic mitral valve ring motion velocity (E'), E/E', isovolumetric relaxation time of the LV, duration of the A-wave, right atrial area and left atrial area, LV mass, LV mass index, LV end-diastolic and end-systolic dimension, and the severity of tricuspid regurgitation (TR)., Results: The values of RVSP, PAP and TPG in the study groups before OHT did not differ significantly. The values of E (86.5 ± 12.5 vs. 67.3 ± 8.5; p < 0.001), E' (11.9 ± 1.1 vs. 10.9 ± 0.9; p = 0.003) and E/E' (7.4 ± 1.5 vs. 6.1 ± 0.85; p = 0.006) differed between the groups and were significantly higher in the group undergoing surgery using the biatrial approach. The duration of the A-wave was significantly longer in the group undergoing surgery using the bicaval approach (129.0 ± 5.1 vs. 136.7 ± 10.0; p = 0.001). There were no significant differences in the other parameters of LV filling. Right atrial area was significantly lower in the group undergoing surgery using the bicaval approach (19.2 ± 3.0 vs. 14.0 ± 2.0; p < 0.001). LV size, LV mass and LV mass index did not differ significantly between the groups. The lack of TR was more commonly observed in the group undergoing surgery using the bicaval approach at the limit of p = 0.05. Pacemaker implantation was required in 12 (30%) patients from the group undergoing surgery using the classical method and 2 (10%) patients from the group undergoing OHT using the bicaval approach (p = 0.04)., Conclusions: Certain echocardiographic parameters suggest a better LV filling in patients undergoing OHT using the bicaval approach. Preservation of the right atrial geometry in patients undergoing OHT using the bicaval approach plays an important role in LV filling.
- Published
- 2012
47. [Statement on the diagnosis and treatment of tobacco dependence in patients with cardiovascular diseases].
- Author
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Zatoński W, Jankowski P, Banasiak W, Kawecka-Jaszcz K, Musiał J, Narkiewicz K, Opolski G, Podolec P, Torbicki A, and Zembala M
- Subjects
- Humans, Patient Acceptance of Health Care, Poland, Smoking adverse effects, Tobacco Use Disorder complications, Bupropion therapeutic use, Cardiovascular Diseases complications, Dopamine Uptake Inhibitors therapeutic use, Smoking Cessation methods, Tobacco Use Disorder diagnosis, Tobacco Use Disorder drug therapy
- Published
- 2011
48. Presidential letter: from Turin (1951) to Moscow (2011). The past, present and future of cardiovascular surgery--reflections at the time of the Diamond Jubilee of the ESCVS.
- Author
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Zembala M
- Subjects
- History, 20th Century, History, 21st Century, Humans, Cardiovascular Diseases history, Cardiovascular Diseases surgery, Societies, Medical
- Published
- 2011
49. Implantation of an Andrastent XL in an adult with advanced chronic heart failure due to coarctation of the aorta.
- Author
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Białkowski J, Szkutnik M, Fiszer R, Wolny T, Knapik T, Nowalany-Kozielska E, and Zembala M
- Subjects
- Aortic Coarctation surgery, Heart Failure surgery, Humans, Intensive Care Units, Male, Middle Aged, Time Factors, Tomography, X-Ray Computed methods, Treatment Outcome, Aortic Coarctation complications, Heart Failure etiology, Stents
- Abstract
We report the case of a 49 year-old-man with congenital coarctation of the aorta (CoA), admitted in a critical clinical condition due to advanced secondary cardiomyopathy and chronic heart failure. An Andrastent XL was implanted successfully in the CoA. The procedure resulted in an almost completely resolved CoA and prompt clinical improvement in the patient.
- Published
- 2011
50. [The use of extracorporeal membrane oxygenation (ECMO) in the treatment of acute respiratory distress syndrome due to pandemic influenza].
- Author
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Knapik P, Przybylski R, Nadziakiewicz P, Koba R, Maciejewski T, Borowicz M, Włoczka G, Pawlak S, and Zembala M
- Subjects
- Adult, Female, Humans, Influenza, Human complications, Respiratory Distress Syndrome etiology, Respiratory Distress Syndrome virology, Treatment Outcome, Extracorporeal Membrane Oxygenation, Influenza A Virus, H1N1 Subtype, Influenza, Human epidemiology, Pandemics, Respiratory Distress Syndrome therapy
- Abstract
Pandemic influenza particularly often is associated with symptoms of acute respiratory failure, and in case of refractory hypoxemia patients may have indications for the extracorporeal membrane oxygenation (ECMO). The paper presents a case of a pandemic influenza virus infection, where classical indications for veno-venous ECMO occured. Practical aspects of this kind of treatment in the intensive care unit are discussed.
- Published
- 2011
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