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Uvod/Cilj. Incidencija vanplućne tuberkuloze (VPTB) je u porastu širom sveta. Srbija, koja se nalazi u periodu socioekonomske tranzicije je zemlja niske-srednje prevalencije infekcije HIV i srednje-niske stope incidencije tuberkuloze (TB) sa 100% primenjenom strategijom neposredno nadzirane terapije (DOT) i obaveznom BCG vakcinacijom po rođenju. Cilj našeg rada bio je da se ispita incidencija i klinički oblici VPTB u Srbiji tokom 15 godina. Metode. Retrospektivna opservaciona studija obuhvatila je sve slučajeve VPTB dijagnostikovane u periodu od 1. januara 1993. do 31. decembra 2007. godine, prema Godišnjim izveštajima Instituta za plućne bolesti i tuberkulozu u Beogradu (nacionalna referentna ustanova) i Centralnog registra za tuberkulozu. Procena broja stanovnika izvršena je na osnovu popisa stanovništva od 1991. i 2002. godine. Rezultati. Dok je ukupna stopa incidencije TB pokazala blagu neznatnu tendenciju opadanja (p = 0,535), našli smo značajan porast stope incidencije VPTB (y = 1,7996 + 0,089x; R2 = 0,4141; p = 0.01). Ukupno 2 858 bolesnika sa VPTB (novodijagnostikovani i 10% recidiva) dalo je prosečnu starosno specifičnu stopu incidencije od 2,51/100 000 stanovnika (interval poverenja 95%, SD = 0,6182) sa godišnjim porastom od 8,9%. Odnos broja obolelih osoba muškog i ženskog pola bilo je 0,54. Najčešće su bile zahvaćene limfne žlezde (48,5%), potom urogenitalni organi (20,5%), pleura (12%) i koštanozglobni sistem (10,3%). Kod 88,29% bolesnika lečenje je uspešno završeno, 3,64% bolesnika je umrlo, 5,18% prekinulo lečenje, 0,57% premešteno, dok je za 2,3% ishod leče nja bio nepoznat. Zaključak. Tendencija porasta incidencije VPTB u Srbiji može da bude rezultat porasta morbiditeta usled još uvek prisutnih faktora rizika, moguće veće stope otkrivanja slučajeva i boljeg prijavljivanja. Visoki obuhvat novorođenčadi BCG vakcinacijom može da objasni što je VPTB u Srbiji kod dece retka., Background/Aim. Increased incidence of extrapulmonary tuberculosis (XPTB) is reported worldwide. Serbia is a country in socio-economic transition period with lowmiddle HIV prevalence and intermediate-to-low tuberculosis (TB) incidence rate, 100% directly observed treatment (DOT) coverage, and mandatory BCG vaccination at birth. The aim of the study was to examine the incidence trend and clinical features of XPTB in Serbia during a 15-year period. Methods. This retrospective observational study included XPTB cases diagnosed in the period between 1st January 1993 and 31st Decembre 2007, according to the reports of the National Referral Institute of Lung Diseases and Tuberculosis in Belgrade and Central Tuberculosis Register. Population estimates with extrapolations were based on 1991 and 2002 census data. Results. While the overall TB incidence rate showed a slight, not significant decreasing trend (p = 0.535), a significant increase was found for XPTB (y = 1.7996 + 0.089x; R2 = 0.4141; p = 0.01). A total of 2,858 XPTB cases (newly diagnosed and 10% relapses) gave an average age specific incidence rate of 2.51/100,000 population (95% confidence interval, SD = 0.6182) with 8.9% annual increase. The male-to-female ratio was 0.54. Lymph nodes were most frequently affected site (48.5%) followed by genitourinary (20.5%), pleural (12%), and osseo-arthicular (10.3%) TB. Treatment outcome was successful in 88.29% of patients (cured and completed), 3.64% died, 5.18% interrupted, 0.57% displaced, and 2.3% unknown. Conclusion. Increasing trend of XPTB incidence rate may be a result of increased morbidity due to still present risk factors, possible higher detection rate in Serbia and better notification. A high coverage of newborns with BCG vaccination at birth might contribute to a decreased number and rare XPTB cases in children.