1. Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
- Author
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Marie Lou Camara, Harris A. Eyre, Bernhard T. Baune, Catharine Jawahar, Helen Anscomb, and Heinrich Körner
- Subjects
Necrosis ,General Neuroscience ,medicine.medical_treatment ,Multiple sclerosis ,Alpha (ethology) ,medicine.disease ,Cytokine ,Downregulation and upregulation ,Schizophrenia ,Immunology ,medicine ,Tumor necrosis factor alpha ,medicine.symptom ,Psychology ,Neuroinflammation - Abstract
Background Tumour necrosis factor - alpha (TNF-α) is a pro-inflammatory cytokine that combines a plethora of activities in the early stages of an immune response. TNF-α has gained increasing importance given TNF-α upregulation in multiple brain pathologies like neuropsychiatric conditions such as depression, schizophrenia, as well as neuroinflammatory disorder like multiple sclerosis (MS).
- Published
- 2012
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