1. The Relationship between Hepatic Steatosis, inflammation and insulin Resistance in type 2 Diabetes with Metabolic Imbalance
- Author
-
Alina Onofriescu, Victoriţa Șorodoc, Bogdan Mircea-Mihai, Mariana Floria, Cristina Mihaela Lăcătușu, Elena-Daniela Grigorescu, Alina Delia Popa, A. Ceasovschih, Ioana Creţu, Laurenţiu Șorodoc, and Irina M. Jaba
- Subjects
medicine.medical_specialty ,business.industry ,nutritional and metabolic diseases ,030209 endocrinology & metabolism ,Inflammation ,General Medicine ,Type 2 diabetes ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Endocrinology ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,Steatosis ,medicine.symptom ,business - Abstract
Aim. Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are in a bidirectional relationship. This prospective study focused on associations between parameters common to the pathogenesis of insulin resistance, inflammation and hepatic steatosis in T2DM patients with metabolic imbalance. Methods. We used clinical data, insulin resistance and inflammation indices, and hepatic steatosis markers from 120 patients. Results. The patients (44% men, mean age 58) had a mean body mass index (BMI) of 32 kg/m2 and mean T2DM history of 6 years. With exceptions, significant correlations were found between metabolic, inflammatory and hepatic parameters. Conclusions. In T2DM patients with poor glycemic control, hepatic steatosis correlates significantly with insulin resistance and inflammation. Increased prevalence and poor prognosis of these diseases together justify the need for NAFLD screening of diabetic patients.
- Published
- 2019