1. Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
- Author
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Bharti Garg, Emily K. Clennon, Aaron B. Caughey, and Brian Duty
- Subjects
Adult ,Gestational hypertension ,medicine.medical_specialty ,030232 urology & nephrology ,Context (language use) ,Chorioamnionitis ,California ,Preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Urolithiasis ,Pregnancy ,medicine ,Humans ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Retrospective cohort study ,medicine.disease ,Pregnancy Complications ,Gestational diabetes ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,business - Abstract
Objectives Evaluate the association between urolithiasis during pregnancy and obstetric outcomes outside the context of urological intervention. Methods We conducted a retrospective cohort study of singleton, non-anomalous gestations delivered at 23–42 weeks in California from 2007 to 2011. Maternal outcomes (preterm delivery [early (χ 2-tests and multivariable logistic regression. Results A total of 2,013,767 pregnancies met inclusion criteria, of which 5,734 (0.28%) were complicated by urolithiasis. Stone disease during pregnancy was associated with 30% greater odds of each early (aOR 1.30; 95% CI 1.19–1.43) and late (aOR 1.29; 95% CI 1.18–1.41) preterm delivery. Cesarean delivery, UTI at delivery, gestational hypertension, gestational diabetes, preeclampsia, and sepsis were all significantly positively associated with urolithiasis. Odds of NAS (aOR 2.11; 95% CI 1.27–3.51) and jaundice were significantly greater in the neonates of stone-forming patients (aOR 1.08; 95% CI 1.01–1.16). Conclusions Urolithiasis during pregnancy was associated with 30% greater odds of preterm delivery and increased risk of myriad metabolic, hypertensive, and infectious disorders of gestation. Neonates born to stone-forming patients were more than twice as likely to develop neonatal abstinence syndrome but did not have significantly greater odds of complications of prematurity.
- Published
- 2020