1. The role of enterovirus infections in type 1 diabetes in Tunisia
- Author
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Imen Boussaid, Ramzi Zemni, Ines Slim, Foued Slama, Elyes Chabchoub, Asma Boumiza, and Latifa Gueddah
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Tunisia ,Adolescent ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Disease ,medicine.disease_cause ,Gastroenterology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Enterovirus Infections ,Humans ,Medicine ,Young adult ,Child ,Enterovirus ,Type 1 diabetes ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Case-control study ,Autoantibody ,Middle Aged ,medicine.disease ,Diabetes Mellitus, Type 1 ,030104 developmental biology ,Case-Control Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,biology.protein ,RNA, Viral ,Female ,Antibody ,business - Abstract
Background:Enteroviral infections have long been suspected in having a role in β cell destruction and therefore leading to the onset of clinical type 1 diabetes (T1D). The frequency of enterovirus (EV)-related T1D in North Africa is still unknown. The aim of the present study was to investigate the relationship between infection with EV and T1D in Tunisia.Methods:A total of 95 T1D patients (41 children and 54 adults) and 141 healthy control subjects (57 children and 84 adults) were tested for the presence of EV-RNA by a highly sensitive nested reverse transcription-polymerase chain reaction (RT-PCR) method.Results:EV-RNA was detected more frequently in plasma from diabetic patients than in plasma of controls (31.6% vs. 7.8%, pConclusions:EV-RNA is associated with T1D mellitus in the Tunisian population especially in children. These results support the hypothesis that EV act as environmental risk factors for T1D.
- Published
- 2017
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