Search

Your search keyword '"A. Capra"' showing total 619 results
Start Over Author "A. Capra" Publisher wiley
619 results on '"A. Capra"'

1. P07 BORTEZOMIB-MELPHALAN-PREDNISONE (VMP) VS. LENALIDOMIDE-DEXAMETHASONE (RD) IN REAL-LIFE MULTIPLE MYELOMA PATIENTS INELIGIBLE FOR TRANSPLANT: UPDATED ANALYSIS OF THE RANDOMIZED PHASE IV REAL MM TRIAL

Author

A. Larocca, M. D’Agostino, N. Giuliani, E. Antonioli, R. Zambello, S. Ronconi, I. D. Vincelli, F. Ciceri, A. P. Falcone, M. Michieli, F. Cattel, A. Capra, M. Grasso, A. M. Cafro, F. Bonello, R. Floris, M. Offidani, E. Sciorsi, G. Pietrantuono, P. Curci, F. Patriarca, M. Cavo, S. Mangiacavalli, G. Benevolo, A. Evangelista, G. Ciccone, M. Boccadoro, B. Bruno, and S. Bringhen

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
Full Text
View/download PDF

2. P39 DEDALO: PHASE II STUDY OF DARATUMUMAB PLUS POMALIDOMIDE AND DEXAMETHASONE (DPD) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND 17P DELETION

Author

V. Montefusco, A.M. Cafro, G. Margiotta Casaluci, F. Patriarca, R. Mina, M. D’Agostino, A. Capra, C. Priola, B. Dalla Palma, R. Rizzi, A. Genua, M.T. Petrucci, L. Paris, A. Belotti, M. Cavo, C. Conticello, C. Carlo-Stella, and M Boccadoro

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
Full Text
View/download PDF

3. B02 CARFILZOMIB AND LENALIDOMIDE-BASED THERAPY FOR THE TREATMENT OF PRIMARY PLASMA CELL LEUKEMIA: RESULTS OF THE FINAL ANALYSIS OF THE PROSPECTIVE PHASE 2 EMN12/HOVON-129 STUDY FOR PATIENTS AGED 18-65 YEARS

Author

N. van de Donk, M.C. Minnema, B. van der Holt, F. Schjesvold, K.L. Wu, A. Capra, A. Broyl, W.W.H. Roeloffzen, A.P.A. Gadisseur, G. Pietrantuono, L. Pour, V. van der Velden, T. Lund, M. Offidani, M. Grasso, L. Giaccone, M. Cavo, T. Silkjaer, J. Caers, S. Zweegman, R. Hajek, R. Benjamin, A. Vangsted, M. Boccadoro, F. Gay, P. Sonneveld, and P. Musto

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
Full Text
View/download PDF

4. B03 CARFILZOMIB AND LENALIDOMIDE FOR PRIMARY PLASMA CELL LEUKEMIA: FINAL RESULTS OF THE PROSPECTIVE PHASE 2 EMN12/HOVON-129 STUDY FOR PATIENTS AGED ≥66 YEARS

Author

P. Musto, M.C. Minnema, W.W.H. Roeloffzen, A. Capra, B. van der Holt, A. Juul Vangsted, A. Broyl, F. Schjesvold, T. Lund, T. Silkjaer, R. Benjamin, M. Grasso, K. Lung Wu, J. Caers, M. Cavo, R. Hájek, B. Bruno, A. Gadisseur, G. Pietrantuono, M. Offidani, L. Pour, P. Sonneveld, M. Boccadoro, and N. van de Donk

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
Full Text
View/download PDF

5. S300: HEALTH-RELATED QUALITY OF LIFE IN TRANSPLANT-INELIGIBLE REAL-LIFE MULTIPLE MYELOMA PATIENTS TREATED WITH BORTEZOMIB-MELPHALAN-PREDNISONE (VMP) VS. LENALIDOMIDE-DEXAMETHASONE (RD)

Author

M. D’Agostino, S. Bringhen, R. Ria, F. Ciceri, A. P. Falcone, M. Michieli, M. Grasso, F. Pane, M. Quaresima, F. Cattel, M. Mirabile, F. Fioritoni, M. T. Petrucci, V. Cotugno, A. Capra, S. Pezzatti, M. L. Mosca Siez, M. Cantonetti, G. Margiotta Casaluci, P. Bertazzoni, R. Floris, M. Offidani, G. Pietrantuono, A. Evangelista, M. Boccadoro, and A. Larocca

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

6. P932: ON-DEMAND PLERIXAFOR WITH CYCLOPHOSPHAMIDE AND G-CSF FOR HEMATOPOIETIC STEM-CELL MOBILIZATION IN MULTIPLE MYELOMA PATIENTS: FINAL RESULTS OF THE MOZOBL06877 STUDY

Author

R. Mina, F. Bonello, F. Fazio, R. Saccardi, V. Bongarzoni, F. Marchesi, G. Bertuglia, P. Curci, R. M. Lemoli, S. Ballanti, T. Dentamaro, G. Benevolo, A. Capra, R. Floris, P. Tosi, A. Olivieri, D. Rota-Scalabrini, C. Cangialosi, M. Cavo, P. Corradini, G. Milone, M. Boccadoro, and A. Larocca

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

8. Expanding the phenotype of UPF3B‐related disorder: Case reports and literature review

Author

Romano, Ferruccio, primary, Haanpää, Maria K., additional, Pomianowski, Pawel, additional, Peraino, Amanda Rose, additional, Pollard, John R., additional, Di Feo, Maria Francesca, additional, Traverso, Monica, additional, Severino, Mariasavina, additional, Derchi, Maria, additional, Henzen, Edoardo, additional, Zara, Federico, additional, Faravelli, Francesca, additional, Capra, Valeria, additional, and Scala, Marcello, additional

Published
2024
Full Text
View/download PDF

10. Towards efficient N cycling in intensive maize: role of cover crops and application methods of digestate liquid fraction

Author

Capra, Federico, Abalos, D., Maris, S. C., Ardenti, Federico, Lommi, M., Tabaglio, Vincenzo, Fiorini, Andrea, Capra F., Ardenti F., Tabaglio V. (ORCID:0000-0003-3456-1589), Fiorini A. (ORCID:0000-0002-5601-2954), Capra, Federico, Abalos, D., Maris, S. C., Ardenti, Federico, Lommi, M., Tabaglio, Vincenzo, Fiorini, Andrea, Capra F., Ardenti F., Tabaglio V. (ORCID:0000-0003-3456-1589), and Fiorini A. (ORCID:0000-0002-5601-2954)

Abstract

Digestate, a by-product of biogas production, is widely recognized as a promising renewable nitrogen (N) source with high potential to replace synthetic fertilizers. Yet, inefficient digestate use can lead to pollutant N losses as ammonia (NH3) volatilization, nitrous oxide (N2O) emissions and nitrate (NO - 3) leaching. Cover crops (CCs) may reduce some of these losses and recycle the N back into the soil after incorporation, but the effect on the N balance depends on the CC species. In a one--year field study, we tested two application methods (i.e., surface broadcasting, BDC; and shallow injection, INJ) of the liquid fraction of separated co-digested cattle slurry (digestate liquid fraction [DLF]), combined with different winter cover crop (CC) options (i.e., rye, white mustard or bare fallow), as starter fertilizer for maize. Later, side--dressing with urea was required to fulfil maize N--requirements. We tested treatment effects on yield, N--uptake, N--use efficiency parameters, and N--losses in the form of N2O emissions and NO - 3 leaching. CC development and biomass production were strongly affected by their contrasting frost tolerance, with spring--regrowth for rye, while mustard was winter killed. After the CCs, injection of DLF increased N2O emissions significantly compared with BDC (emission factor of 2.69% vs. 1.66%). Nitrous oxide emissions accounted for a small part (11%-13%) of the overall yield-scaled N losses (0.46-0.97 kg N Mg grain-1). The adoption of CCs reduced fall NO - 3 leaching, being 51% and 64% lower for mustard and rye than under bare soil. In addition, rye reduced NO - 3 leaching during spring and summer after termination by promoting N immobilization, thus leading to -57% lower annual leaching losses compared with mustard. DLF application method modified N-loss pathways, but not the cumulative yield-scaled N losses. Overall, these insights contribute to inform an evidence-based design of cropping systems in which nutrients are recycled m

Published
2023

11. Isatuximab in combination with cemiplimab in patients with relapsed/refractory multiple myeloma: A phase 1/2 study

Author

Alexander Lesokhin, Richard LeBlanc, Meletios A. Dimopoulos, Marcelo Capra, Carmelo Carlo‐Stella, Lionel Karlin, Jean‐Francois Castilloux, Peter Forsberg, Gurdeep Parmar, Axel Tosikyan, Ludek Pour, Vincent Ribrag, Rossella Ribolla, Al‐Ola Abdallah, Nadia Le Roux, Liyan Dong, Helgi van de Velde, Laurent Mayrargue, Lucie Lépine, Sandrine Macé, and Philippe Moreau

Subjects
Cancer Research, Oncology, Radiology, Nuclear Medicine and imaging
Published
2023
Full Text
View/download PDF

13. Refining the electro‐clinical spectrum of NPRL3‐related epilepsy: a novel multiplex family and literature review

Author

Dainelli, Alice, primary, Iacomino, Michele, additional, Rossato, Sara, additional, Bugin, Samuela, additional, Traverso, Monica, additional, Severino, Mariasavina, additional, Gustincich, Stefano, additional, Capra, Valeria, additional, Di Duca, Marco, additional, Zara, Federico, additional, Scala, Marcello, additional, and Striano, Pasquale, additional

Published
2023
Full Text
View/download PDF

14. Clinical and genetic analysis of patients with segmental overgrowth features and somatic mammalian target of rapamycin (mTOR) pathway disruption: Possible novel clinical issues

Author

Ferruccio Romano, Francesca Madia, Patrizia De Marco, Marzia Ognibene, Sara Guerrisi, Marcello Scala, Michele Iacomino, Simona Baldassari, Nadia Vercellino, Francesca Manunza, Ramona Tallone, Marco Pavanello, Gianluca Piatelli, Alberto Garaventa, Federico Zara, and Valeria Capra

Subjects
Embryology, Health, Toxicology and Mutagenesis, Pediatrics, Perinatology and Child Health, Toxicology, Developmental Biology
Published
2022
Full Text
View/download PDF

15. An automated quantification algorithm for evaluating total metabolic tumor volume in patients with FDG‐avid lymphomas using a deep learning model

Author

Xu, T., primary, Jemaa, S., additional, Kumar, M., additional, Balasubramanian, S., additional, Shamas‐Din, A., additional, Lyalina, S., additional, Ounadjela, S., additional, Malik, B., additional, Lee, J., additional, Morales, S. Figueroa, additional, Nielsen, T., additional, Carano, R. A. D., additional, Kostakoglu, L., additional, and Capra, W., additional

Published
2023
Full Text
View/download PDF

17. B02 CARFILZOMIB AND LENALIDOMIDE-BASED THERAPY FOR THE TREATMENT OF PRIMARY PLASMA CELL LEUKEMIA: RESULTS OF THE FINAL ANALYSIS OF THE PROSPECTIVE PHASE 2 EMN12/HOVON-129 STUDY FOR PATIENTS AGED 18-65 YEARS

Author

van de Donk, N., primary, Minnema, M.C., additional, van der Holt, B., additional, Schjesvold, F., additional, Wu, K.L., additional, Capra, A., additional, Broyl, A., additional, Roeloffzen, W.W.H., additional, Gadisseur, A.P.A., additional, Pietrantuono, G., additional, Pour, L., additional, van der Velden, V., additional, Lund, T., additional, Offidani, M., additional, Grasso, M., additional, Giaccone, L., additional, Cavo, M., additional, Silkjaer, T., additional, Caers, J., additional, Zweegman, S., additional, Hajek, R., additional, Benjamin, R., additional, Vangsted, A., additional, Boccadoro, M., additional, Gay, F., additional, Sonneveld, P., additional, and Musto, P., additional

Published
2023
Full Text
View/download PDF

18. P39 DEDALO: PHASE II STUDY OF DARATUMUMAB PLUS POMALIDOMIDE AND DEXAMETHASONE (DPD) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND 17P DELETION

Author

Montefusco, V., primary, Cafro, A.M., additional, Margiotta Casaluci, G., additional, Patriarca, F., additional, Mina, R., additional, D’Agostino, M., additional, Capra, A., additional, Priola, C., additional, Dalla Palma, B., additional, Rizzi, R., additional, Genua, A., additional, Petrucci, M.T., additional, Paris, L., additional, Belotti, A., additional, Cavo, M., additional, Conticello, C., additional, Carlo-Stella, C., additional, and Boccadoro, M, additional

Published
2023
Full Text
View/download PDF

19. Introducing HyPeak: An international network on hydropeaking research, practice, and policy

Author

Alp, M, Batalla, RJ, Dolores Bejarano, M, Boavida, I, Capra, H, Carolli, M, Casas-Mulet, R, Costa, MJ, Halleraker, JH, Hauer, C, Hayes, DS, Harby, A, Noack, M, Palau, A, Schneider, M, Schonfelder, L, Tonolla, D, Vanzo, D, Venus, T, Vericat, D, Zolezzi, G, Bruno, MC, Alp, M, Batalla, RJ, Dolores Bejarano, M, Boavida, I, Capra, H, Carolli, M, Casas-Mulet, R, Costa, MJ, Halleraker, JH, Hauer, C, Hayes, DS, Harby, A, Noack, M, Palau, A, Schneider, M, Schonfelder, L, Tonolla, D, Vanzo, D, Venus, T, Vericat, D, Zolezzi, G, and Bruno, MC

Abstract

An increase in the demand for renewable energy is driving hydropower development and its integration with variable renewable energy sources. When hydropower is produced flexibly from hydropower plants, it causes rapid and frequent artificial flow fluctuations in rivers, a phenomenon known as hydropeaking. Hydropeaking and associated hydrological alterations cause multiple impacts on riverine habitats with cascading effects on ecosystem functioning and structure. Given the significance of its ecological and socio‐economic implications, mitigation of hydropeaking requires an inter‐ and transdisciplinary approach. An interdisciplinary network called HyPeak has been conceived to enrich international research initiatives and support hydropower planning and policy. HyPeak has been founded based on exchange and networking activities linking scientists from several countries where hydropeaking has been widespread for decades and numerous studies dedicated to the topic have been carried out. HyPeak aims to integrate members from other countries and continents in which hydropower production plays a relevant role, and grow to be a reference group that provides expert advice on the topic to policy‐makers, as well as researchers, stakeholders, and practitioners in the field of hydropeaking.

Published
2023

20. Introducing HyPeak : an international network on hydropeaking research, practice, and policy

Author

Alp, Maria, Batalla, Ramon J., Bejarano, Maria Dolores, Boavida, Isabel, Capra, Hervé, Carolli, Mauro, Casas‐Mulet, Roser, Costa, Maria João, Halleraker, Jo Halvard, Hauer, Christoph, Hayes, Daniel S., Harby, Atle, Noack, Markus, Palau, Antoni, Schneider, Matthias, Schönfelder, Lennart, Tonolla, Diego, Vanzo, Davide, Venus, Terese, Vericat, Damià, Zolezzi, Guido, Bruno, Maria Cristina, Alp, Maria, Batalla, Ramon J., Bejarano, Maria Dolores, Boavida, Isabel, Capra, Hervé, Carolli, Mauro, Casas‐Mulet, Roser, Costa, Maria João, Halleraker, Jo Halvard, Hauer, Christoph, Hayes, Daniel S., Harby, Atle, Noack, Markus, Palau, Antoni, Schneider, Matthias, Schönfelder, Lennart, Tonolla, Diego, Vanzo, Davide, Venus, Terese, Vericat, Damià, Zolezzi, Guido, and Bruno, Maria Cristina

Abstract

An increase in the demand for renewable energy is driving hydropower development and its integration with variable renewable energy sources. When hydropower is produced flexibly from hydropower plants, it causes rapid and frequent artificial flow fluctuations in rivers, a phenomenon known as hydropeaking. Hydropeaking and associated hydrological alterations cause multiple impacts on riverine habitats with cascading effects on ecosystem functioning and structure. Given the significance of its ecological and socio-economic implications, mitigation of hydropeaking requires an inter- and transdisciplinary approach. An interdisciplinary network called HyPeak has been conceived to enrich international research initiatives and support hydropower planning and policy. HyPeak has been founded based on exchange and networking activities linking scientists from several countries where hydropeaking has been widespread for decades and numerous studies dedicated to the topic have been carried out. HyPeak aims to integrate members from other countries and continents in which hydropower production plays a relevant role, and grow to be a reference group that provides expert advice on the topic to policy-makers, as well as researchers, stakeholders, and practitioners in the field of hydropeaking.

Published
2023

21. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author

Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Rossi Beatrice Maria Allegri, Anastasia Alteno, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario A Battaglia, Alessandra Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Maria Caniatti, Roberto Cantello, Marco Capobianco, Ruggero Capra, Rocco Capuano, Luca Carmisciano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Giancarlo Comi, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Cinzia Cordioli, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d'Ambrosio, Emanuele D'Amico, Maura Chiara Danni, Alessia d'Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Cava Marco Della, Mario di Napoli, Alessia Di Sapio, Renato Docimo, Anna Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Paolo Immovilli, Daniele Imperiale, Maria Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Maria Rita L'Episcopo, Serena Leva, Giuseppe Liberatore, Re Marianna Lo, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Rosa Mancinelli, Luca Mancinelli, Paolo Manganotti, Giorgia Teresa Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Girolama Alessandra Marfia, Fabiana Marinelli, Alessandro Marti, Boneschi Filippo Martinelli, Zoli Federco Masserano, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita MontiBragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile-Orazio, Agostino Nozzolillo, Marco Onofrj, Riccardo Orlandi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Francesco Patti, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Marta Radaelli, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Calogero Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Marco Salvetti, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Giuditta Ilaria Scarano, Valentina Scarano, Irene Schiavetti, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Maria Pia Sormani, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Emanuela Laura Susani, Giulietta Tabiadon, Francesco Teatini, Gioacchino Tedeschi, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trojano, Maria Trotta, Gabriella Turano, Monica Ulivelli, Manzo Valentino, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani, Bergamaschi, R, Ponzano, M, Schiavetti, I, Carmisciano, L, Cordioli, C, Filippi, M, Radaelli, M, Immovilli, P, Capobianco, M, De Rossi, N, Brichetto, G, Cocco, E, Scandellari, C, Cavalla, P, Pesci, I, Zito, A, Confalonieri, P, Marfia, Ga, Perini, P, Inglese, M, Trojano, M, Brescia Morra, V, Pisoni, E, Tedeschi, G, Comi, G, Battaglia, Ma, Patti, F, Salvetti, M, Sormani, Mp, Abbadessa, Gianmarco, Umberto, Aguglia, Lia, Allegorico, Rossi Beatrice Maria Allegri, Anastasia, Alteno, Maria Pia Amato, Pietro, Annovazzi, Carlo, Antozzi, Lucia, Appendino, Sebastiano, Arena, Viola, Baione, Roberto, Balgera, Valeria, Barcella, Damiano, Baroncini, Caterina, Barrilà, Mario, A Battaglia, Alessandra, Bellacosa, Gianmarco, Bellucci, Roberto, Bergamaschi, Valeria, Bergamaschi, Daiana, Bezzini, Beatrice, Biolzi, Bisecco, Alvino, Bonavita, Simona, Giovanna, Borriello, Chiara, Bosa, Bosco, Antonio, Francesca, Bovi, Marco, Bozzali, Laura, Brambilla, Morra Vincenzo Brescia, Giampaolo, Brichetto, Maria, Buccafusca, Elisabetta, Bucciantini, Sebastiano, Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano, Calabrese, Francesca, Calabria, Francesca, Caleri, Federico, Camilli, Luisa Maria Caniatti, Roberto, Cantello, Marco, Capobianco, Ruggero, Capra, Capuano, Rocco, Luca, Carmisciano, Patrizia, Carta, Paola, Cavalla, Maria Grazia Celani, Maria, Cellerino, Raffaella, Cerqua, Clara, Chisari, Raffaella, Clerici, Marinella, Clerico, Eleonora, Cocco, Gaia, Cola, Giancarlo, Comi, Paolo, Confalonieri, Antonella, Conte, Marta Zaffira Conti, Christian, Cordano, Susanna, Cordera, Cinzia, Cordioli, Corea, Francesco, Claudio, Correale, Salvatore, Cottone, Francesco, Crescenzo, Erica, Curti, Alessandro, D'Ambrosio, Emanuele, D'Amico, Maura Chiara Danni, Alessia, D'Arma, Vincenzo, Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Cava Marco Della, Mario di Napoli, Alessia Di Sapio, Docimo, Renato, Anna, Dutto, Luana, Evangelista, Salvatore, Fanara, Diana, Ferraro, Maria Teresa Ferrò, Massimo, Filippi, Cristina, Fioretti, Fratta, Mario, Jessica, Frau, Marzia, Fronza, Roberto, Furlan, Alberto, Gajofatto, Gallo, Antonio, Paolo, Gallo, Claudio, Gasperini, Anna, Ghazaryan, Bruno, Giometto, Francesca, Gobbin, Flora, Govone, Franco, Granella, Erica, Grange, Maria Grazia Grasso, Angelica, Guareschi, Clara, Guaschino, Simone, Guerrieri, Donata, Guidetti, Pietro, Iaffaldano, Antonio, Ianniello, Luigi, Iasevoli, Paolo, Immovilli, Daniele, Imperiale, Maria Teresa Infante, Matilde, Inglese, Rosa, Iodice, Aniello, Iovino, Giovanna, Konrad, Doriana, Landi, Roberta, Lanzillo, Caterina, Lapucci, Luigi, Lavorgna, Maria Rita L'Episcopo, Serena, Leva, Giuseppe, Liberatore, Re Marianna Lo, Marco, Longoni, Leonardo, Lopiano, Lorena, Lorefice, Matteo, Lucchini, Lus, Giacomo, Davide, Maimone, Maria, Malentacchi, Giulia, Mallucci, Simona, Malucchi, Chiara Rosa Mancinelli, Luca, Mancinelli, Paolo, Manganotti, Giorgia Teresa Maniscalco, Vittorio, Mantero, Sabrina, Marangoni, Damiano, Marastoni, Girolama Alessandra Marfia, Fabiana, Marinelli, Alessandro, Marti, Boneschi Filippo Martinelli, Zoli Federco Masserano, Francesca, Matta, Laura, Mendozzi, Giuseppe, Meucci, Silvia, Miante, Miele, Giuseppina, Eva, Milano, Massimiliano, Mirabella, Missione, Rosanna, Marcello, Moccia, Lucia, Moiola, Sara, Montepietra, Margherita, Montibragadin, Federico, Montini, Roberta, Motta, Raffaele, Nardone, Carolina Gabri Nicoletti, Eduardo, Nobile-Orazio, Agostino, Nozzolillo, Marco, Onofrj, Riccardo, Orlandi, Palmieri, Anna, Damiano, Paolicelli, Livia, Pasquali, Luisa, Pastò, Francesco, Patti, Elisabetta, Pedrazzoli, Paola, Perini, Ilaria, Pesci, Maria, Petracca, Alfredo, Petrone, Carlo, Piantadosi, Anna, M Pietroboni, Federica, Pinardi, Marta, Ponzano, Emilio, Portaccio, Mattia, Pozzato, Carlo, Pozzilli, Luca, Prosperini, Alessandra, Protti, Marta, Radaelli, Paolo, Ragonese, Sarah, Rasia, Sabrina, Realmuto, Anna, Repice, Eleonora, Rigoni, Maria Teresa Rilla, Francesca, Rinaldi, Calogero Marcello Romano, Marco, Ronzoni, Marco, Rovari, Francesca, Ruscica, Loredana, Sabattini, Giuseppe, Salemi, Marco, Salvetti, Lorenzo, Saraceno, Alessia, Sartori, Arianna, Sartori, Elvira, Sbragia, Cinzia, Scandellari, Giuditta Ilaria Scarano, Valentina, Scarano, Irene, Schiavetti, Maria, Sessa, Caterina, Sgarito, Grazia, Sibilia, Gabriele, Siciliano, Alessio, Signori, Signoriello, Elisabetta, Leonardo, Sinisi, Francesca, Sireci, Patrizia, Sola, Claudio, Solaro, Maria Pia Sormani, Stefano, Sotgiu, Sparaco, Maddalena, Maria Laura Stromillo, Silvia, Strumia, Emanuela Laura Susani, Giulietta, Tabiadon, Francesco, Teatini, Tedeschi, Gioacchino, Valentina, Tomassini, Simone, Tonietti, Clerici Valentina Torri, Carla, Tortorella, Simona, Toscano, Rocco, Totaro, Maria, Trojano, Trotta, Maria Consiglia, Gabriella, Turano, Monica, Ulivelli, Manzo, Valentino, Giovanna, Vaula, Domizia, Vecchio, Marco, Vercellino, Elena Pinuccia Verrengia, Marika, Vianello, Eleonora, Virgilio, Francesca, Vitetta, Stefano, Vollaro, Mauro, Zaffaroni, Mauro, Zampolini, Ignazio Roberto Zarbo, Zito, Guido Antonio, Bergamaschi, R., Ponzano, M., Schiavetti, I., Carmisciano, L., Cordioli, C., Filippi, M., Radaelli, M., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Cocco, E., Scandellari, C., Cavalla, P., Pesci, I., Zito, A., Confalonieri, P., Marfia, G. A., Perini, P., Inglese, M., Trojano, M., Brescia Morra, V., Pisoni, E., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Salvetti, M., Sormani, M. P., Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Pisoni, Enrico, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria, Pia, Gianmarco, Abbadessa, Alvino, Bisecco, Simona, Bonavita, Antonio, Bosco, Rocco, Capuano, Francesco, Corea, Renato, Docimo, Mario, Fratta, Antonio, Gallo, Iodice, Rosa, Iovino, Aniello, Lanzillo, Roberta, Giacomo, Lu, Giuseppina, Miele, Rosanna, Missione, Moccia, Marcello, Anna, Palmieri, Elisabetta, Signoriello, Maddalena, Sparaco, Gioacchino, Tedeschi, Maria, Trotta, Antonio, Zito, and Luigi, Zuliani

Subjects
air pollution, coronavirus, multiple sclerosis, medicine.medical_specialty, Multivariate analysis, Coronavirus disease 2019 (COVID-19), Clinical Sciences, Air pollution, Sample (statistics), Neurodegenerative, Settore MED/26, medicine.disease_cause, Autoimmune Disease, law.invention, Sustainable Cities and Communities, Clinical Research, law, Humans, Medicine, Climate-Related Exposures and Conditions, Neurology & Neurosurgery, MuSC-19 study group, SARS-CoV-2, business.industry, Multiple sclerosis, Neurosciences, COVID-19, Retrospective cohort study, Original Articles, medicine.disease, Intensive care unit, Particulate Matter, Air Pollution, Multiple Sclerosis, Brain Disorders, coronaviru, Settore MED/26 - NEUROLOGIA, Good Health and Well Being, Neurology, multiple sclerosi, Emergency medicine, Original Article, Neurology (clinical), Ordered logit, business, Human
Abstract

Background and purpose Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID‐19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID‐19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID‐19 severity amongst PwMS. Methods Data were retrieved from an Italian web‐based platform (MuSC‐19) which includes PwMS with COVID‐19. PM2.5 2016–2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID‐19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID‐19 severity. Results In all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID‐19 course (odds ratio 1.90; p = 0.009). Conclusions Even if several other factors explain the unfavourable course of COVID‐19 in PwMS, the role of air pollutants must be considered and further investigated., Air pollution, often assessed by particulate matter with diameter below 2.5 µg/m3, may contribute to severe COVID‐19 courses. 1087 patients were included, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died. Even if several other factors explain the unfavourable course of COVID‐19 in patients with multiple sclerosis, the role of air pollutants must be considered and further investigated.

Published
2021
Full Text
View/download PDF

22. Towards efficient N cycling in intensive maize: role of cover crops and application methods of digestate liquid fraction

Author

Federico Capra, Diego Abalos, Stefania Codruta Maris, Federico Ardenti, Michela Lommi, Vincenzo Tabaglio, and Andrea Fiorini

Subjects
NO leaching, N O emissions, leaching, NO emissions, Renewable Energy, Sustainability and the Environment, Forestry, digestate broadcasting, digestate injection, cover crop residues, Waste Management and Disposal, Agronomy and Crop Science
Abstract

Digestate, a by-product of biogas production, is widely recognized as a promising renewable nitrogen (N) source with high potential to replace synthetic fertilizers. Yet, inefficient digestate use can lead to pollutant N losses as ammonia (NH 3) volatilization, nitrous oxide (N 2O) emissions and nitrate ((Figure presented.)) leaching. Cover crops (CCs) may reduce some of these losses and recycle the N back into the soil after incorporation, but the effect on the N balance depends on the CC species. In a one-year field study, we tested two application methods (i.e., surface broadcasting, BDC; and shallow injection, INJ) of the liquid fraction of separated co-digested cattle slurry (digestate liquid fraction [DLF]), combined with different winter cover crop (CC) options (i.e., rye, white mustard or bare fallow), as starter fertilizer for maize. Later, side-dressing with urea was required to fulfil maize N-requirements. We tested treatment effects on yield, N-uptake, N-use efficiency parameters, and N-losses in the form of N 2O emissions and (Figure presented.) leaching. CC development and biomass production were strongly affected by their contrasting frost tolerance, with spring-regrowth for rye, while mustard was winter killed. After the CCs, injection of DLF increased N 2O emissions significantly compared with BDC (emission factor of 2.69% vs. 1.66%). Nitrous oxide emissions accounted for a small part (11%–13%) of the overall yield-scaled N losses (0.46–0.97 kg N Mg grain −1). The adoption of CCs reduced fall (Figure presented.) leaching, being 51% and 64% lower for mustard and rye than under bare soil. In addition, rye reduced (Figure presented.) leaching during spring and summer after termination by promoting N immobilization, thus leading to −57% lower annual leaching losses compared with mustard. DLF application method modified N-loss pathways, but not the cumulative yield-scaled N losses. Overall, these insights contribute to inform an evidence-based design of cropping systems in which nutrients are recycled more efficiently.

Published
2023
Full Text
View/download PDF

26. The role of glial cells in Zika virus‐induced neurodegeneration

Author

Quincozes‐Santos, André, primary, Bobermin, Larissa Daniele, additional, Costa, Naithan Ludian Fernandes, additional, Thomaz, Natalie K., additional, Almeida, Rômulo Rodrigo de Souza, additional, Beys‐da‐Silva, Walter O., additional, Santi, Lucélia, additional, Rosa, Rafael L., additional, Capra, Daniela, additional, Coelho‐Aguiar, Juliana M., additional, DosSantos, Marcos Fabio, additional, Heringer, Manoela, additional, Cirne‐Lima, Elizabeth O., additional, Guimarães, Jorge Almeida, additional, Schuler‐Faccini, Lavínia, additional, Gonçalves, Carlos‐Alberto, additional, Moura‐Neto, Vivaldo, additional, and Souza, Diogo Onofre, additional

Published
2023
Full Text
View/download PDF

27. Isatuximab in combination with cemiplimab in patients with relapsed/refractory multiple myeloma: A phase 1/2 study

Author

Lesokhin, Alexander, primary, LeBlanc, Richard, additional, Dimopoulos, Meletios A., additional, Capra, Marcelo, additional, Carlo‐Stella, Carmelo, additional, Karlin, Lionel, additional, Castilloux, Jean‐Francois, additional, Forsberg, Peter, additional, Parmar, Gurdeep, additional, Tosikyan, Axel, additional, Pour, Ludek, additional, Ribrag, Vincent, additional, Ribolla, Rossella, additional, Abdallah, Al‐Ola, additional, Le Roux, Nadia, additional, Dong, Liyan, additional, van de Velde, Helgi, additional, Mayrargue, Laurent, additional, Lépine, Lucie, additional, Macé, Sandrine, additional, and Moreau, Philippe, additional

Published
2023
Full Text
View/download PDF

28. Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it

Author

Brock, Penelope, primary, Meijer, Annelot, additional, Kogner, Per, additional, Ansari, Marc, additional, Capra, Michael, additional, Geller, James, additional, Heuvel‐Eibrink, Marry van den, additional, Knight, Kristin, additional, Kruger, Mariana, additional, Lindemulder, Susan, additional, Maibach, Rudolf, additional, O'Neill, Allison, additional, Papadakis, Vassilios, additional, Rajput, Kaukab, additional, Bleyer, Archie, additional, Bouffet, Eric, additional, and Sullivan, Michael, additional

Published
2023
Full Text
View/download PDF

32. The role of glial cells in Zika virus‐induced neurodegeneration

Author

André Quincozes‐Santos, Larissa Daniele Bobermin, Naithan Ludian Fernandes Costa, Natalie K. Thomaz, Rômulo Rodrigo de Souza Almeida, Walter O. Beys‐da‐Silva, Lucélia Santi, Rafael L. Rosa, Daniela Capra, Juliana M. Coelho‐Aguiar, Marcos Fabio DosSantos, Manoela Heringer, Elizabeth O. Cirne‐Lima, Jorge Almeida Guimarães, Lavínia Schuler‐Faccini, Carlos‐Alberto Gonçalves, Vivaldo Moura‐Neto, and Diogo Onofre Souza

Subjects
Cellular and Molecular Neuroscience, Neurology
Published
2023
Full Text
View/download PDF

34. Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it

Author

Penelope Brock, Annelot Meijer, Per Kogner, Marc Ansari, Michael Capra, James Geller, Marry van den Heuvel‐Eibrink, Kristin Knight, Mariana Kruger, Susan Lindemulder, Rudolf Maibach, Allison O'Neill, Vassilios Papadakis, Kaukab Rajput, Archie Bleyer, Eric Bouffet, and Michael Sullivan

Subjects
Oncology, Pediatrics, Perinatology and Child Health, Hematology
Published
2023
Full Text
View/download PDF

36. Spatial Distribution of Rare Missense Variants Within Protein Structures is Associated with AD Risk

Author

Bowen Jin, John A Capra, Penelope Benchek, Nicholas R. Wheeler, Adam C. Naj, Kara L. Hamilton‐Nelson, John Farrell, Yuk Yee Leung, Brian W. Kunkle, Badri N Vardarajan, Gerard D. Schellenberg, Richard Mayeux, Li‐San Wang, Lindsay A. Farrer, Margaret A. Pericak‐Vance, Eden R. Martin, Jonathan L. Haines, Dana Crawford, and William S. Bush

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
Full Text
View/download PDF

37. Spatial Distribution of Rare Missense Variants Within Protein Structures is Associated with AD Risk

Author

Jin, Bowen, primary, Capra, John A, additional, Benchek, Penelope, additional, Wheeler, Nicholas R., additional, Naj, Adam C., additional, Hamilton‐Nelson, Kara L., additional, Farrell, John, additional, Leung, Yuk Yee, additional, Kunkle, Brian W., additional, Vardarajan, Badri N, additional, Schellenberg, Gerard D., additional, Mayeux, Richard, additional, Wang, Li‐San, additional, Farrer, Lindsay A., additional, Pericak‐Vance, Margaret A., additional, Martin, Eden R., additional, Haines, Jonathan L., additional, Crawford, Dana, additional, and Bush, William S., additional

Published
2022
Full Text
View/download PDF

38. Clinical and genetic analysis of patients with segmental overgrowth features and somatic mammalian target of rapamycin (mTOR) pathway disruption: Possible novel clinical issues

Author

Romano, Ferruccio, primary, Madia, Francesca, additional, De Marco, Patrizia, additional, Ognibene, Marzia, additional, Guerrisi, Sara, additional, Scala, Marcello, additional, Iacomino, Michele, additional, Baldassari, Simona, additional, Vercellino, Nadia, additional, Manunza, Francesca, additional, Tallone, Ramona, additional, Pavanello, Marco, additional, Piatelli, Gianluca, additional, Garaventa, Alberto, additional, Zara, Federico, additional, and Capra, Valeria, additional

Published
2022
Full Text
View/download PDF

41. Congenital posterior cervical spine malformation due to biallelic c.240‐4T>G RIPPLY2 variant: A discrete entity

Author

Christelle Cabrol, Alessandro Consales, Vincenzo Nigro, Lyse Ruaud, Marcello Scala, Gianluca Piatelli, Francesco Musacchia, Valeria Capra, Margaux Serey-Gaut, Nathalie Escande-Beillard, Lionel Van Maldergem, Jean Langlais, Bruno Reversade, Annalaura Torella, Andrea Accogli, Serey-Gaut, M., Scala, M., Reversade, B., Ruaud, L., Cabrol, C., Musacchia, F., Torella, A., Accogli, A., Escande-Beillard, N., Langlais, J., Piatelli, G., Consales, A., Nigro, V., Capra, V., and Van Maldergem, L.

Subjects
0301 basic medicine, cervical spine malformation, supernumerary ribs, 030105 genetics & heredity, 03 medical and health sciences, Exon, Skeletal disorder, spondylocostal dysostosis type 6, Vertebral segmentation defect, Genetics, medicine, Spectrum disorder, Genetics (clinical), Exome sequencing, oculo-auriculo-vertebral spectrum, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, RIPPLY2, Anatomy, medicine.disease, Spinal cord, Spondylocostal dysostosis, 030104 developmental biology, medicine.anatomical_structure, business
Abstract

The clinical and radiological spectrum of spondylocostal dysostosis syndromes encompasses distinctive costo-vertebral anomalies. RIPPLY2 biallelic pathogenic variants were described in two distinct cervical spine malformation syndromes: Klippel–Feil syndrome and posterior cervical spine malformation. RIPPLY2 is involved in the determination of rostro-caudal polarity and somite patterning during development. To date, only four cases have been reported. The current report aims at further delineating the posterior malformation in three new patients. Three patients from two unrelated families underwent clinical and radiological examination through X-ray, 3D computed tomography and brain magnetic resonance imaging. After informed consent was obtained, family-based whole exome sequencing (WES) was performed. Complex vertebral segmentation defects in the cervico-thoracic spine were observed in all patients. WES led to the identification of the homozygous splicing variant c.240-4T>G in all subjects. This variant is predicted to result in aberrant splicing of Exon 4. The current report highlights a subtype of cervical spine malformation with major atlo-axoidal malformation compromising spinal cord integrity. This distinctive mutation-specific pattern of malformation differs from Klippel–Feil syndrome and broadens the current classification, defining a sub-type of RIPPLY2-related skeletal disorder. Of note, the phenotype of one patient overlaps with oculo-auriculo-vertebral spectrum disorder.

Published
2020
Full Text
View/download PDF

42. Meal choice for residential aged care is not yet defined: A scoping review of policies, standards, reports and guidelines

Author

Karen L. Abbey, Sandra Capra, and Mikaela Wheeler

Subjects
Service (systems architecture), Medical education, Nutrition and Dietetics, media_common.quotation_subject, Psychology of self, Ambiguity, Grey literature, Eating, Long-term care, Policy, Homes for the Aged, Humans, Aged care, Psychology, Nursing homes, Meals, Autonomy, Aged, media_common
Abstract

AIM For residents in residential aged care, making choices in relation to food and mealtimes are opportunities to maintain a sense of self and autonomy. It is unknown, however, whether the concept of choice is adequately addressed in texts relating to residential aged care. The purpose of this review is to examine whether residents' right to make choices regarding the meals they eat, is discussed in grey literature including, policies, standards, reports and guidelines, which all impact practice in residential aged care. METHODS Grey literature was located utilising; Google, Google Scholar and hand searching. Texts had to be in reference to residential aged care and were assessed using the Appraisal of Guidelines for Research and Evaluation II and Joanna Briggs Institute tools. RESULTS Twenty-nine texts were included in the final review, consisting of, 12 policies and standards, 12 guidelines and 5 reports. Choice was discussed broadly in the majority of texts, with no definition included for the level of choice that should be provided by residential aged care. The use of alternative meals to provide choice was discussed; however, texts varied in their requirements and recommendations as to what constituted an adequate alternative. CONCLUSIONS The ambiguity surrounding choice affects the practices within residential aged care and ultimately the service provided to residents. With most recommendations being only general in nature, residential aged care homes are not provided with sufficient guidance for meal planning. To ensure residents' right to make choices in their meals is guaranteed, more definitive requirements and recommendations are needed.

Published
2021
Full Text
View/download PDF

43. Emulating Control Arms for Cancer Clinical Trials Using External Cohorts Created From Electronic Health Record‐Derived Real‐World Data

Author

William B. Capra, Brian D. Segal, Lawrence Bellomo, Katherine Tan, Rebecca A. Miksad, Carrie Bennette, Nate Nussbaum, Jonathan Bryan, Aracelis Z. Torres, Melisa Tucker, and Melissa D. Curtis

Subjects
Databases, Factual, Kaplan-Meier Estimate, law.invention, Cohort Studies, Correlation, Randomized controlled trial, law, Electronic health record, Neoplasms, Electronic Health Records, Humans, Medicine, Pharmacology (medical), Correlation of Data, Proportional Hazards Models, Pharmacology, Clinical Trials as Topic, business.industry, Hazard ratio, Random effects model, Progression-Free Survival, Confidence interval, Clinical trial, Cohort, business, Demography
Abstract

Electronic health record (EHR)-derived real-world data (RWD) can be sourced to create external comparator cohorts to oncology clinical trials. This exploratory study assessed whether EHR-derived patient cohorts could emulate select clinical trial control arms across multiple tumor types. The impact of analytic decisions on emulation results was also evaluated. By digitizing Kaplan-Meier curves, we reconstructed published control arm results from 15 trials that supported drug approvals from January 1, 2016, to April 30, 2018. RWD cohorts were constructed using a nationwide EHR-derived de-identified database by aligning eligibility criteria and weighting to trial baseline characteristics. Trial data and RWD cohorts were compared using Kaplan-Meier and Cox proportional hazards regression models for progression-free survival (PFS) and overall survival (OS; individual cohorts) and multitumor random effects models of hazard ratios (HRs) for median endpoint correlations (across cohorts). Post hoc, the impact of specific analytic decisions on endpoints was assessed using a case study. Comparing trial data and weighted RWD cohorts, PFS results were more similar (HR range = 0.63-1.18, pooled HR = 0.84, correlation of median = 0.91) compared to OS (HR range = 0.36-1.09, pooled HR = 0.76, correlation of median = 0.85). OS HRs were more variable and trended toward worse for RWD cohorts. The post hoc case study had OS HR ranging from 0.67 (95% confidence interval (CI): 0.56-0.79) to 0.92 (95% CI: 0.78-1.09) depending on specific analytic decisions. EHR-derived RWD can emulate oncology clinical trial control arm results, although with variability. Visibility into clinical trial cohort characteristics may shape and refine analytic approaches.

Published
2021
Full Text
View/download PDF

44. The first case of mosaic <scp> MNX1 </scp> mutation in an adult female with features of Currarino syndrome

Author

Ferruccio Romano, Marco Di Duca, Federico Zara, Simona Baldassari, Marzia Ognibene, Patrizia De Marco, Marco Pavanello, Gianluca Piatelli, and Valeria Capra

Subjects
0301 basic medicine, Embryology, Mutation, Pathology, medicine.medical_specialty, Genetic heterogeneity, Health, Toxicology and Mutagenesis, Autosomal dominant trait, 030105 genetics & heredity, Biology, Toxicology, medicine.disease_cause, medicine.disease, Penetrance, 03 medical and health sciences, 030104 developmental biology, Pediatrics, Perinatology and Child Health, medicine, Hamartoma, Neurenteric cyst, Imperforate anus, Currarino syndrome, Developmental Biology
Abstract

Background Currarino syndrome (CS) is a rare genetic condition characterized by the association of three major clinical signs: anorectal malformation (ARM), sacro-coccygeal bone defects, and presacral mass. Different kinds of ARM can be present such as anteriorly placed anus, imperforate anus, anorectal stenosis, rectal duplication, and fistulae. The presacral mass can be a benign teratoma, a dermoid or neurenteric cyst, anterior meningocele or hamartoma. Females are more frequently affected and usually present with associated gynecologic and urinary tract problems. CS is considered an autosomal dominant trait, with reduced penetrance and variable expressivity. CS is associated with mutations in the MNX1 gene (motor neuron and pancreas homeobox-1, previously known as HLXB9) mapped to chromosome 7q36. Heterozygous loss-of-function mutations in the coding sequence of MNX1 gene have been reported in nearly all familial CS cases and in approximately 30% of CS sporadic patients. Case Here, we present the case of a woman with features of CS carrying a mosaic mutation in the coding region of MNX1 gene. This is the only reported case of a CS diagnosis in which the mutation is present in less than 50% of cells. Conclusion The lower detection rate of MNX1 mutations in sporadic cases could similarly be explained by somatic mosaicism, mutations occurring outside the coding regions, or genetic heterogeneity.

Published
2021
Full Text
View/download PDF

45. Flying on wood and fabric: The tree species used for the construction of the Ansaldo A.1 'Balilla' biplane (1918)

Author

Lucia Giovannini, Mauro Bernabei, Neva Capra, and Maria Luisa Tomasi

Subjects
Archeology, History, media_common.quotation_subject, Art, Tree species, Biplane, Remote sensing, media_common
Abstract

The Ansaldo A.1 "Balilla" biplane is of great historical interest, because it illustrates the level of development reached by the Italian aircraft industry during the last stages of World War I. To date, the airplane is kept in its original state, and it has never been restored. The aircraft is essentially made of wood and fabric. Wood in particular has been used in a very skilful way, making the airplane lightweight, yet elastic and resistant. In this work, the entire wooden structure of the aircraft was analysed, and the tree species were microscopically identified. Species belonging to six different genera have been identified. We found spruce in the frame, elm in the wing ribs, walnut in the propeller, alder in various plywood layers, rosewood in the outer layer of the decorative plywood, and pine in the tail rudder. The main structure of the aircraft was made of spruce, most likely a Sitka spruce, which was widely used for aircraft construction. The Ansaldo A.1 "Balilla" biplane is an excellent example of the wise use of wood before the revolution upon the boost in synthetic materials and represents an important historical and cultural heritage.

Published
2021
Full Text
View/download PDF

46. Scoring the 10‐year risk of ambulatory disability in multiple sclerosis: the RoAD score

Author

Mar Tintoré, Alex Rovira, Xavier Montalban, Simonetta Galgani, Luca Prosperini, Carla Tortorella, Ruggero Capra, Claudio Gasperini, Shalom Haggiag, Jordi Río, Carlo Pozzilli, and Jaume Sastre-Garriga

Subjects
Treatment response, medicine.medical_specialty, Multiple Sclerosis, Contrast Media, Gadolinium, Disability Evaluation, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Milestone (project management), Humans, Medicine, 030212 general & internal medicine, Glatiramer acetate, Expanded Disability Status Scale, business.industry, Multiple sclerosis, Glatiramer Acetate, medicine.disease, Neurology, Cohort, Ambulatory, Physical therapy, T2 lesions, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug
Abstract

BACKGROUND AND PURPOSE Both baseline prognostic factors and short-term predictors of treatment response can influence the long-term risk of disability accumulation in patients with relapsing-remitting multiple sclerosis (RRMS). The objective was to develop and validate a scoring system combining baseline prognostic factors and 1-year variables of treatment response into a single numeric score predicting the long-term risk of disability. METHODS We analysed two independent datasets of patients with RRMS who started interferon beta or glatiramer acetate, had an Expanded Disability Status Scale (EDSS) score

Published
2021
Full Text
View/download PDF

47. Magnetism: Another Idiosyncrasy of Boron?

Author

Bertrand Vileno, Loic Mager, Gianmarco Bovone, Jean-Louis Gallani, Bertrand Donnio, Marco Capra, Mircea V. Rastei, Maurizio Vignolo, Federico Loria, Cristina Bernini, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
[PHYS]Physics [physics], Idiosyncrasy, Magnetism, Chemistry, Aucun, chemistry.chemical_element, Hardware_PERFORMANCEANDRELIABILITY, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Inorganic Chemistry, Chemical physics, 0103 physical sciences, Hardware_INTEGRATEDCIRCUITS, Particle, 010306 general physics, 0210 nano-technology, Boron
Abstract

International audience; Supporting information for this article is given via a link at the end of the document.

Published
2021
Full Text
View/download PDF

48. The interaction between types of cover crop residue and digestate application methods affects ammonia volatilization during maize cropping season

Author

Vincenzo Tabaglio, Federico Ardenti, Andrea Fiorini, Roberta Boselli, Davide Pochintesta, Stefania Codruta Maris, Gian Maria Beone, and Federico Capra

Subjects
Secale, Environmental Engineering, Nitrogen, 010501 environmental sciences, Management, Monitoring, Policy and Law, Zea mays, 01 natural sciences, Soil, chemistry.chemical_compound, Ammonia, Fertilizers, Cover crop, Waste Management and Disposal, 0105 earth and related environmental sciences, Water Science and Technology, Residue (complex analysis), biology, Sowing, Agriculture, 04 agricultural and veterinary sciences, Ammonia volatilization from urea, biology.organism_classification, Pollution, chemistry, Agronomy, Digestate, 040103 agronomy & agriculture, Urea, 0401 agriculture, forestry, and fisheries, Seasons, Volatilization, Settore AGR/02 - AGRONOMIA E COLTIVAZIONI ERBACEE, White mustard
Abstract

Organic and mineral fertilizers are important sources of ammonia (NH3 ) emissions from agricultural fields. The objectives of this study were (a) to evaluate how different cover crop (CC) residues (i.e., rye [Secale cereale L.], white mustard [Sinapis alba L.], and bare soil as control) in combination with different application methods of digestate (surface broadcast vs. shallow injection) affect NH3 volatilization before planting maize (Zea mays L.) and (b) to assess the residual effect of previous CCs on NH3 volatilization after urea top-dress application at the V5-V6 phonological stage of maize. Ammonia volatilization was measured using semi-static chambers for 14 d (335 h) after planting and for 6 d (150 h) at the V5-V6 stage. Overall, NH3 emissions decreased by 67-77% with digestate injection compared with surface broadcasting. However, the reduction in NH3 volatilization using the injection method was significantly lower with mustard residue (6.72 kg NH3 -N ha-1 ) than with rye residue (14.15 kg NH3 -N ha-1 ), which allowed for more volatilization by increasing the exposure of digestate to the air. Broadcast digestate method did not affect the cumulative NH3 -N losses obtained with different CC types. After urea top-dressing at the V5-V6 stage of maize, the cumulative losses of NH3 (during 150 h) were 2.99 kg NH3 -N ha-1 with rye as previous CC and 2.49 kg NH3 -N ha-1 with mustard. Our study shows that digestate injection before maize planting and urea top-dressing application followed immediately by irrigation (15 mm) could be considered as useful strategies to mitigate NH3 volatilization and increase N use efficiency in maize.

Published
2021
Full Text
View/download PDF

50. ZTTK syndrome: Clinical and molecular findings of 15 cases and a review of the literature

Author

Kushary, S.T., Revah-Politi, A., Barua, S., Ganapathi, M., Accogli, A., Aggarwal, V., Brunetti-Pierri, N., Cappuccio, G., Capra, V., Fagerberg, C.R., Gazdagh, G., Guzman, E., Hadonou, M., Harrison, V., Havelund, K., Iancu, D., Kraus, A., Lippa, N.C., Mansukhani, M., McBrian, D., McEntagart, M., Pacio-Miguez, M., Palomares-Bralo, M., Pottinger, C., Ruivenkamp, C.A.L., Sacco, O., Santen, G.W.E., Santos-Simarro, F., Scala, M., Short, J., Sorensen, K.P., Woods, C.G., Yeboa, K.A., DDD Study, TUDP Consortium, Kushary, S. T., Revah-Politi, A., Barua, S., Ganapathi, M., Accogli, A., Aggarwal, V., Brunetti Pierri, N., Cappuccio, G., Capra, V., Fagerberg, C. R., Gazdagh, G., Guzman, E., Hadonou, M., Harrison, V., Havelund, K., Iancu, D., Kraus, A., Lippa, N. C., Mansukhani, M., Mcbrian, D., Mcentagart, M., Pacio-Miguez, M., Palomares-Bralo, M., Pottinger, C., Ruivenkamp, C. A. L., Sacco, O., Santen, G. W. E., Santos-Simarro, F., Scala, M., Short, J., Sorensen, K. P., Woods, C. G., and Anyane Yeboa, K.

Subjects
Male, Genotype, Mutation, Missense, genotype-phenotype correlation, Article, Congenital Abnormalities, whole exome sequencing, Minor Histocompatibility Antigens, Neuroimaging, Seizures, Intellectual Disability, Intellectual disability, Exome Sequencing, Genetics, Medicine, Missense mutation, Humans, Genetic Predisposition to Disease, Gene, Genetics (clinical), Exome sequencing, Genetic Association Studies, business.industry, Brain, genotype–phenotype correlation, medicine.disease, SON, DNA-Binding Proteins, Phenotype, Variable dysmorphic features, Female, business, multisystemic disorder
Abstract

Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is caused by de novo loss-of-function variants in the SON gene (MIM #617140). This multisystemic disorder is characterized by intellectual disability, seizures, abnormal brain imaging, variable dysmorphic features, and various congenital anomalies. The wide application and increasing accessibility of whole exome sequencing (WES) has helped to identify new cases of ZTTK syndrome over the last few years. To date, there have been approximately 45 cases reported in the literature. Here, we describe 15 additional individuals with variants in the SON gene, including those with missense variants bringing the total number of known cases to 60. We have reviewed the clinical and molecular data of these new cases and all previously reported cases to further delineate the most common as well as emerging clinical findings related to this syndrome. Furthermore, we aim to delineate any genotype–phenotype correlations specifically for a recurring pathogenic four base pair deletion (c.5753_5756del) along with discussing the impact of missense variants seen in the SON gene.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results