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To identify how patient journey mapping is being undertaken and reported.A scoping review of the literature was undertaken using JBI guidance.Databases were searched in July 2021 (16th-21st), including Ovid's Medline, Embase, Emcare and PsycINFO; Scopus; Web of Science Core Collection, the Directory of Open Access Journals; Informit and; ProQuest Dissertations and Theses Global.Eligible articles included peer-reviewed literature documenting journey mapping methodologies and studies conducted in healthcare services. Reviewers used Covidence to screen titles and abstracts of located sources, and to screen full-text articles. A table was used to extract data and synthesize results.Eighty-one articles were included. An acceleration of patient journey mapping research was observed, with 76.5% (n = 62) of articles published since 2015. Diverse mapping approaches were identified. Reporting of studies was inconsistent and largely non-adherent with relevant, established reporting guidelines.Patient journey mapping is a relatively novel approach for understanding patient experiences and is increasingly being adopted. There is variation in process details reported. Considerations for improving reporting standards are provided.Patient journey mapping is a rapidly growing approach for better understanding how people enter, experience and exit health services. This type of methodology has significant potential to inform new, patient centred models of care and facilitate clinicians, patients and health professionals to better understand gaps and strategies in health services. The synthesised results of this review alert researchers to options available for journey mapping research and provide preliminary guidance for elevating reporting quality.

Literature examining the effects of mothers' work status on infant language development is mixed, with little focus on varying work-schedules and early vocabulary. We use naturalistic data to analyze the productive vocabulary of 44 17-month-olds in relation to mothers' work status (Full-time, Part-time, Stay-at-home) at 6 and 18 months. Infants who experienced a combination of care from mothers and other caretakers had larger productive vocabularies than infants in solely full-time maternal or solely other-caretaker care. Our results draw from naturalistic data to suggest that this care combination may be particularly beneficial for early lexical development.

1. Wildlife managers often require estimates of abundance. Direct methods of estimation are often impractical, especially in closed-forest environments, so indirect methods such as dung or nest surveys are increasingly popular. 2. Dung and nest surveys typically have three elements: surveys to estimate abundance of the dung or nests; experiments to estimate the production (defecation or nest construction) rate; and experiments to estimate the decay or disappearance rate. The last of these is usually the most problematic, and was the subject of this study. 3. The design of experiments to allow robust estimation of mean time to decay was addressed. In most studies to date, dung or nests have been monitored until they disappear. Instead, we advocate that fresh dung or nests are located, with a single follow-up visit to establish whether the dung or nest is still present or has decayed. 4. Logistic regression was used to estimate probability of decay as a function of time, and possibly of other covariates. Mean time to decay was estimated from this function. 5. Synthesis and applications. Effective management of mammal populations usually requires reliable abundance estimates. The difficulty in estimating abundance of mammals in forest environments has increasingly led to the use of indirect survey methods, in which abundance of sign, usually dung (e.g. deer, antelope and elephants) or nests (e.g. apes), is estimated. Given estimated rates of sign production and decay, sign abundance estimates can be converted to estimates of animal abundance. Decay rates typically vary according to season, weather, habitat, diet and many other factors, making reliable estimation of mean time to decay of signs present at the time of the survey problematic. We emphasize the need for retrospective rather than prospective rates, propose a strategy for survey design, and provide analysis methods for estimating retrospective rates.

Incidence of breast cancer (BC) varies among ethnic groups, with higher rates in white than in African-American women. Until now, most epidemiological and genetic studies have been carried out in white women. To investigate whether interactions between genetic and reproductive risk factors may explain part of the ethnic disparity in BC incidence, a genetic epidemiology study was conducted, between 1989 and 1994, at the Howard University Cancer Center (Washington, DC), which led to the recruitment of 245 African-American families. Segregation analysis of BC was performed by use of the class D regressive logistic model that allows for censored data to account for a variable age of onset of disease, as implemented in the REGRESS program. Segregation analysis of BC was consistent with a putative dominant gene effect (P < 0.000001) and residual sister-dependence (P < 0.0001). This putative gene was found to interact significantly with age at menarche (P = 0.048), and an interaction with a history of spontaneous abortions was suggested (P = 0.08). A late age at menarche increased BC risk in gene carriers but had a protective effect in non-gene carriers. A history of spontaneous abortions had a protective effect in gene carriers and increased BC risk in non-gene carriers. Our findings agree partially with a similar analysis of French families showing a significant gene x parity interaction and a suggestive gene x age at menarche interaction. Investigating gene x risk factor interactions in different populations may have important implications for further biological investigations and for BC risk assessment.

Diatom assemblages and limnological data were analyzed from 74 lakes spanning arctic treeline in three geographical regions of northern Russia: near the mouth of the Pechora River, on the Taimyr Peninsula, and near the mouth of the Lena River. Analysis of similarities indicated that diatom assemblages in tundra and forest lakes were significantly different from each other in all regions, with tundra lakes generally associated with higher abundances of small benthic Fragilaria Lyngbye taxa. Canonical correspondence analysis identified variables related to ion concentrations (e.g. Na+, dissolved inorganic carbon), lake depth, silica concentrations, and surface water temperatures as factors that explained significant amounts of variation in the diatom assemblages. Across treeline, the generally higher surface water temperatures of the forested lakes consistently accounted for a significant proportion of the diatom distribution patterns. Major ion concentrations also explained significant amounts of variation in the diatom assemblages across treeline for all three regions; however, regional trends were most likely influenced by local factors (i.e. ocean proximity or anthropogenic activities). The importance of climatic gradients across treeline (e.g. temperature) diatom distributions provides additional evidence that diatoms may be useful as paleoclimatic indicators. However, combination of the three calibration sets revealed that local water chemistry determinants (e.g. lithology, marine influence) overrode the influence of climatic gradients in explaining diatom distributions, suggesting that regional differences must be minimized for successful combination of geographically separate calibration sets.

Most mated, honey-fed, female Trichogramma minutum, provided with host eggs of Ephestia kuehniella from eclosion, were shown to produce broods of exclusively male offspring as they aged. Females produced an average of 218.5 ± 69.9 offspring during a reproductive period of > 20 days. Of these offspring, 96.7 ± 59.5 were males that were produced after the mother had ceased to produce female offspring. Females that had shifted to all-male production were capable of re-mating and resuming production of female progeny, indicating that either sperm depletion or loss of sperm viability played a role in the shift to all-male production. However, honey-fed, mated females that were held without access to hosts for up to 16 days at 25° C or 28 days at 16° C were able to produce female offspring when allowed to parasitize. This indicates that sperm would remain viable in the females' spermatheca for extended periods of time and that sperm depletion was, at least partially, the cause of the shift to all-male progeny production. Honey-fed females held without host eggs for up to 8 days at 25° C or 28 days at 16°C had reductions in their initial, 2-day offspring production of only 10% and 20%, respectively. This could allow for the build-up of large numbers of effective parasitoids for mass culture or field release.

Maximum likelihood linkage analyses were performed to test for linkage between serum apoB levels and several candidate gene markers including apolipoprotein B, lipoprotein lipase, hepatic lipase, cholesterol ester transfer protein, and apolipoprotein AI in a large pedigree. Parameters of general Mendelian inheritance derived from maximum likelihood segregation analysis of the serum apoB levels were used in the linkage analysis. The highest two-point lod score between the quantitative trait and a marker defined by a single restriction digest was 1.86 at recombination fraction (theta) = 0. This was observed for linkage between serum apoB levels and the presence or absence of a PvuII digestion site in the apoB gene. Linkage between serum apoB levels and polymorphisms of the apoB gene defined by the two restriction digests EcoR1 and PvuII was supported by a lod score of 3.30, while inclusion of VNTR typings led to a lod score of 2.33. None of the other candidate genes gave positive evidence of linkage.

A variety of robust and model-dependent genetic linkage methods were applied to log transformed lipid levels from a large pedigree in which the LDL receptor defect has been shown to segregate by molecular biologic techniques. Applicationof the Haseman-Elston and avariance-components based test for linkage identified LDL and cholesterol as cosegregating with the marker C3, which is genetically linked to the LDL receptor defect. Consideration of lipid fractions as a multivariate response identified (0.723×cholesterol)-(0.55 1×triglycerides) as most strongly supporting evidence for linkage with C3. Subsequent segregation and linkage analyses provided support for an autosomal dominant major gene influencing either LDL or the function of cholesterol and triglycerides

Segregation analysis of discrete traits can be conducted by the classical mixed model and the recently introduced regressive models. The mixed model assumes an underlying liability to the disease, to which a major gene, a multifactorial component, and random environment contribute independently. Affected persons have a liability exceeding a threshold. The regressive logistic models assume that the logarithm of the odds of being affected is a linear function of major genotype effects, the phenotypes of older relatives, and other covariates. A formulation of the regressive models, based on an underlying liability model, has been recently proposed. The regression coefficients on antecedents are expressed in terms of the relevant familial correlations and a one-to-one correspondence with the parameters of the mixed model can thus be established. Computer simulations are conducted to evaluate the fit of the two formulations of the regressive models to the mixed model on nuclear families. The two forms of the class D regressive model provide a good fit to a generated mixed model, in terms of both hypothesis testing and parameter estimation. The simpler class A regressive model, which assumes that the outcomes of children depend solely on the outcomes of parents, is not robust against a sib–sib correlation exceeding that specified by the model, emphasizing testing class A against class D. The studies reported here show that if the true state of nature is that described by the mixed model, then a regressive model will do just as well. Moreover, the regressive models, allowing for more patterns of family dependence, provide a flexible framework to understand gene–environment interactions in complex diseases. © 1992 Wiley-Liss, Inc.

We have identified 2 sisters with probable dementia of the Alzheimer type who have an unusual 22-derived marker chromosome with a greatly elongated short arm containing 2 well-separated nucleolus organizer regions. A marker chromosome similar in appearance is uncommon in the general population. Eleven of 24 of their biological relatives were also found to have the marker. The known pedigree of this family encompasses 6 generations in 2 of which there is evidence of 10 cases of dementia of the Alzheimer type. The average age-at-onset of dementia is 65.8 +/- 5.5 years; the average age-at-death among those apparently affected is 74.9 +/- 8.3 years. A new model for the estimation of risk was applied to the family data. Persons in this family with the marker were found to be 4 times more likely to develop dementia than those without the marker, the 95% confidence interval for this risk being 1-50. The probability that the association of dementia and the marker is due to chance alone is .05 (1 in 20).

NUMEROUS STUDIES have been made on the respiration of land plants and some on water plants, but very few such studies have been made on semi-submerged water plants (Samantarai, 1938). Yet, from the standpoint of the environment, semi-submerged plants offer very interesting material because of the belief that they were once terrestrial and have subsequently invaded the water, and because it is difficult to understand how the rhizomes of plants with terrestrial form are able to endure the condition of low aeration that exists in the mud at the bottom of a pond (Cole, 1932).2 That this ability is not due to particular structural features may be deduced from the fact that rhizomes of very diverse structures are found imbedded in the submerged mud. For example, Furthermore, the ability to endure the nearly anaerobic conditions of the submerged mud is not associated with a particular habit of growth and fruiting, because all of the species of thick spongy rhizomes mentioned above as well as one of the toughest and firmest of rhizomes to be found anywhere, namely, that of Scirpus validus, grow progressively through the mud, branching only occasionally, sending up fruiting culms at irregular intervals, and always dying and becoming decayed at the rear; while the hard young rhizomes of Typha latifolia and Sparganiurn eurycarpum and the corms of Sagittaria latifolia are formed one at the terminal end of each of the slender spongy stolons that radiate from a parent plant which dies at the end of its fruiting season.