1. Ligand-Controlled Regiodivergent and Enantioselective Copper-Catalyzed Hydroallylation of Alkynes
- Author
-
Guoxing Xu, Haiyan Zhao, Bin Fu, Aijie Cang, Ge Zhang, Qian Zhang, and Tao Xiong
- Subjects
Allylic rearrangement ,Denticity ,Chemistry ,Ligand ,010405 organic chemistry ,Enantioselective synthesis ,chemistry.chemical_element ,General Chemistry ,General Medicine ,010402 general chemistry ,Combinatorial chemistry ,Copper ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Copper catalyzed ,Organic chemistry ,Carbene - Abstract
A ligand-controlled regiodivergent and enantioselective copper-catalyzed intermolecular hydroallylation of alkynes with allylic phosphates and hydrosilanes has been achieved for the first time. The chiral bidentate sulfonate-containing N-heterocyclic carbene ligated CuCl complex leads to enantioenriched SN2′-type products, whereas the use of the IMesCuCl catalyst affords SN2-type products. Thus a range of chiral branched and achiral linear 1,4-dienes could be facilely synthesized from readily available alkynes in a regiodivergent manner.
- Published
- 2017
- Full Text
- View/download PDF