1. Myocardial Scar and Mortality in Chronic Aortic Regurgitation
- Author
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Maan Malahfji, Alpana Senapati, Bhupendar Tayal, Duc T. Nguyen, Edward A. Graviss, Sherif F. Nagueh, Michael J. Reardon, Miguel Quinones, William A. Zoghbi, and Dipan J. Shah
- Subjects
aortic regurgitation ,aortic valve replacement ,cardiac magnetic resonance ,myocardial scar ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Chronic aortic regurgitation (AR) can be associated with myocardial scarring. It is unknown if scarring in AR is linked to poor outcomes and whether aortic valve replacement impacts this association. We investigated the relationship of myocardial scarring to mortality in chronic AR using cardiac magnetic resonance. Methods and Results We enrolled patients with moderate or greater AR between 2009 and 2019 and performed a blinded assessment of left ventricle remodeling, AR severity, and presence and extent of myocardial scarring by late gadolinium enhancement. The primary outcome was all‐cause mortality. We followed 392 patients (median age 62 [interquartile range, 51–71] years), and 78.1% were men, and 25.8% had bicuspid valves. Median aortic valve regurgitant volume was 39 mL (interquartile range, 30–60). Myocardial scar was present in 131 (33.4%) patients. Aortic valve replacement was performed in 165 (49.1%) patients. During follow‐up, up to 10.8 years (median 32.3 months [interquartile range, 9.8–69.5]), 51 patients (13%) died. Presence of myocardial scar (hazard ratio [HR], 3.62; 95% CI, 2.06–6.36; P
- Published
- 2020
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