1. Rheumatoid arthritis and the risk of preterm birth
- Author
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Robbi Miguel G. Falcon, Renne Margaret U. Alcazar, Alric V. Mondragon, Ester G. Penserga, and Ourlad Alzeus G. Tantengco
- Subjects
Reproductive Medicine ,Immunology ,Obstetrics and Gynecology ,Immunology and Allergy - Abstract
During pregnancy, many diseases are correlated with different adverse outcomes. In turn, pregnancy affects the body, leading to increased disease susceptibility. This interplay between diseased states and pregnancy outcomes is illustrated in the effect of the chronic autoimmune disorder, rheumatoid arthritis (RA), and the adverse outcome, preterm birth (PTB). RA is a systemic disorder characterized by inflammation of the joints and other body organs. Joint pain and swelling are the most prominent manifestations of RA during pregnancy. However, the exact role of RA on PTB among pregnant women has yet to be established. This review highlighted the immunologic mechanisms involved in PTB in pregnant patients with RA. The immune cell population in pregnant women with RA exhibited higher activity of macrophages, dendritic cells, neutrophils, helper T (Th) 1 cells, and Vδ1 cells, but lower activity of CD4 + CD25
- Published
- 2022
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