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Your search keyword '"Andrade, Silvia P."' showing total 10 results
Start Over Author "Andrade, Silvia P." Publisher wiley
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10. The intensity of the foreign body response to polyether-polyurethane implant in diabetic mice is strain-dependent.

Author

de Almeida SA, Orellano LAA, Pereira LX, Viana CTR, Andrade SP, Campos PP, and Ferreira MAND

Subjects
Animals, Biocompatible Materials, Disease Models, Animal, Fibrosis, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Polyurethanes, Diabetes Mellitus, Experimental chemically induced, Foreign-Body Reaction, Genetic Background, Prostheses and Implants
Abstract

A number of genetic factors have been linked to the development of diabetes, a condition that often requires implantable devices such as glucose sensors. In normoglycaemic individuals, this procedure induces a foreign body reaction (FBR) that is detrimental to bioimplant functionality. However, the influence of the genetic background on this reaction in diabetes has not been investigated. We examined the components of FBR (capsule thickness, collagen deposition, mast cell and foreign body giant cell number) in subcutaneous implants of polyether polyurethane (SIPP) in streptozotocin (STZ)-induced diabetes in Swiss, C57BL/6 and Balb/c mice. The fasting blood glucose levels before STZ injections were 133.5 ± 5.1 mg/dL, after the treatment increased 68.4% in Swiss mice, 62.4% in C57BL/6 and 30.9% in Balb/c mice. All FBR features were higher in implants of Swiss and C57BL/6 mice compared with those in implants of Balb/c. Likewise, the apoptotic index was higher in implants of diabetic Swiss and C57BL/6 mice whose glycaemic levels were the highest. Our findings show an association between the severity of hyperglycaemic levels and the intensity of the FBR to SIPP. These important strain-related differences in susceptibility to diabetes and the intensity of the FBR must be considered in management using implantable devices in diabetic individuals., (© 2021 Company of the International Journal of Experimental Pathology (CIJEP).)

Published
2021
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