1. Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state
- Author
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Eugene Komaroff, Jay Gunawardana, Tara McCoy, Anamika Singh, Stephanie S. Vander Veur, Angara Koneti Rao, Tina Nguyen, and Gary D. Foster
- Subjects
medicine.medical_specialty ,Factor VII ,Endothelium ,business.industry ,medicine.medical_treatment ,Hematology ,medicine.disease ,Article ,chemistry.chemical_compound ,Tissue factor ,Endocrinology ,medicine.anatomical_structure ,Coagulation ,chemistry ,Internal medicine ,Plasminogen activator inhibitor-1 ,Fibrinolysis ,medicine ,Endothelial dysfunction ,business ,Plasminogen activator - Abstract
Childhood obesity is rapidly increasing in prevalence. We compared circulating membrane-bound tissue factor (FIII, F3) procoagulant activity (TF-PCA) and plasma markers of coagulation, fibrinolysis and endothelial dysfunction in 21 obese (10·1 ± 1·5 years, mean ± standard deviation) and 22 healthy weight children (9·9 ± 1·6 years), classified by Body Mass Index (BMI). TF-PCA and factor VII coagulant activity (FVII:C), plasminogen activator inhibitor (PAI-1, SERPINE1) and soluble vascular cell adhesion molecule 1 (sVCAM1) were higher in obese children. BMI correlated positively with TF-PCA, FVII:C, and PAI-1. Childhood obesity is associated with a procoagulant state and endothelial dysfunction. Studies are needed to assess whether weight reduction reverses these abnormalities.
- Published
- 2012