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Your search keyword '"BANCROFT, A. J."' showing total 42 results
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42 results on '"BANCROFT, A. J."'

2. Where is my hand? Proprioceptive disturbances in posterior cortical atrophy and typical Alzheimer’s disease

Author

Yong, Keir X X, primary, Bancroft, Matthew J, additional, Bai, Yuhan, additional, Hayes, Oliver S, additional, Mahendran, Sharveena, additional, Ocal, Dilek, additional, Brotherhood, Emilie V, additional, Hoe, Juanita, additional, Kaski, Diego, additional, Pisella, Laure, additional, Crutch, Sebastian J, additional, and Day, Brian L, additional

Published
2023
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6. Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins

Author

Nithichanon, Arnone, Gourlay, Louise J, Bancroft, Gregory J, Ato, Manabu, Takahashi, Yoshimasa, and Lertmemongkolchai, Ganjana

Subjects
bacteria
Abstract

Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been exposed to the bacteria and have developed some immunity, which may have helped to prevent disease. Here, we used a humanized mouse model (hu-PBL-SCID), reconstituted with human peripheral blood mononuclear cells from seropositive donors, to illustrate the potential of three known antigens (FliC, OmpA and N-PilO2) for boosting both T-cell and B-cell immune responses. All three antigens boosted the production of specific antibodies in vivo, and increased the number of antibody and interferon-γ-secreting cells, and induced antibody affinity maturation. Moreover, antigen-specific antibodies isolated from either seropositive individuals or boosted mice, were found to enhance phagocytosis and oxidative burst activities from human polymorphonuclear cells. Our study demonstrates that FliC, OmpA and N-PilO2 can stimulate human memory T and B cells and highlight the potential of the hu-PBL-SCID system for screening and evaluation of novel protein antigens for inclusion in future vaccine trials against melioidosis.

Published
2017

9. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection

Author

Rinchai, Darawan, Khaenam, Prasong, Kewcharoenwong, Chidchamai, Buddhisa, Surachat, Pankla, Rungnapa, Chaussabel, Damien, Bancroft, Gregory J, and Lertmemongkolchai, Ganjana

Abstract

Septicemia is the most severe form of melioidosis caused by the Gram-negative bacterium, Burkholderia pseudomallei. Here, we show that levels of IL-27p28 transcript and protein were both significantly elevated in patients with sepsis, particularly melioidosis and in patients with unfavorable disease outcome. Moreover, human monocytes/macrophages and neutrophils were the major source of IL-27 during infection. The addition of exogenous IL-27 in vitro resulted in significantly increased bacterial survival, reduced B. pseudomallei-induced oxidative burst, and enhanced IL-1β and TNF-α production by purified neutrophils from healthy subjects. Finally, blockade of endogenous IL-27 in neutrophils using soluble IL-27 receptor antagonist prior to infection led to significantly reduced survival of bacteria and decreased IL-1β, but not TNF-α production. These results indicate a potential role for IL-27 in the suppression of anti-bacterial defense mechanisms that might contribute to disease severity in sepsis. The targeting of this cytokine may be beneficial in the management of human sepsis.

Published
2012

18. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence

Author

Movahedzadeh, Farahnaz, primary, Smith, Debbie A., additional, Norman, Richard A., additional, Dinadayala, Premkumar, additional, Murray-Rust, Judith, additional, Russell, David G., additional, Kendall, Sharon L., additional, Rison, Stuart C. G., additional, McAlister, Mark S. B., additional, Bancroft, Gregory J., additional, McDonald, Neil Q., additional, Daffe, Mamadou, additional, Av-Gay, Yossef, additional, and Stoker, Neil G., additional

Published
2003
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40. Extracellular vesicles induce protective immunity against Trichuris muris.

Author

Shears RK, Bancroft AJ, Hughes GW, Grencis RK, and Thornton DJ

Subjects
Animals, Extracellular Vesicles ultrastructure, Humans, Male, Mice, Mice, Inbred C57BL, Mice, SCID, Trichuriasis parasitology, Vaccination, Antibodies, Helminth immunology, Extracellular Vesicles immunology, Trichuriasis immunology, Trichuris immunology, Vaccines immunology
Abstract

Gastrointestinal nematodes, such as Trichuris trichiura (human whipworm), are a major source of morbidity in humans and their livestock. There is a paucity of commercially available vaccines against these parasites, and vaccine development for T. trichiura has been impeded by a lack of known host protective antigens. Experimental vaccinations with T. muris (murine whipworm) soluble Excretory/Secretory (ES) material have demonstrated that it is possible to induce protective immunity in mice; however, the potential for extracellular vesicles (EVs) as a source of antigenic material has remained relatively unexplored. Here, we demonstrate that EVs isolated from T. muris ES can induce protective immunity in mice when administered as a vaccine without adjuvant and show that the protective properties of these EVs are dependent on intact vesicles. We also identified several proteins within EV preparations that are targeted by the host antibodies following vaccination and subsequent infection with T. muris. Many of these proteins, including VWD and vitellogenin N and DUF1943-domain-containing protein, vacuolar protein sorting-associated protein 52 and TSP-1 domain-containing protein, were detected in both soluble ES and EV samples and have homologues in other parasites of medical and veterinary importance, and as such are possible protective antigens., (© 2018 The Authors. Parasite Immunology Published by John Wiley & Sons Ltd.)

Published
2018
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41. The role of TNF-alpha in Trichuris muris infection II: global enhancement of ongoing Th1 or Th2 responses.

Author

Hayes KS, Bancroft AJ, and Grencis RK

Subjects
Animals, Female, Goblet Cells immunology, Goblet Cells metabolism, Hormones, Ectopic metabolism, Intercellular Signaling Peptides and Proteins, Interleukin-13 immunology, Lymph Nodes immunology, Male, Mesentery immunology, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C57BL, Mucin-2, Mucins immunology, Mucins metabolism, Th1 Cells parasitology, Th2 Cells parasitology, Th1 Cells immunology, Th2 Cells immunology, Trichuriasis immunology, Trichuris immunology, Tumor Necrosis Factor-alpha immunology
Abstract

Host resistance to Trichuris muris is driven by Th2 responses. However, TNF-alpha has also been shown to play a role in protection. As TNF-alpha has a variety of actions, the exact role of TNF-alpha in immunity to T. muris is yet to be established. Here we demonstrate that although blocking TNF-alpha has been shown to abrogate resistance, rTNF-alpha treatment does not promote resistance. Further, we show that TNF-alpha functions to enhance the ongoing immune response. AKR animals that typically respond to infection with a polarized Th1 response produce greater levels of Th1 cytokines when treated with TNF-alpha and BALB/c animals that normally respond with a polarized Th2 response produce higher levels of Th2 cytokines. Crucially, blocking TNF-alpha in the strong Th2 responder strain BALB/c does not prevent expulsion of T. muris, thus supporting its role as a biological enhancer. TNF-alpha does increase transcription of both IFN-gamma and IL-13 in vitro but can also act synergistically with IL-13 in vitro to promote production of RELMbeta, which has also been shown to play a role in resistance to T. muris. Thus, this data demonstrates that TNF-alpha acts to enhance an ongoing immune response but is not necessary for a strong protective Th2 response.

Published
2007
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42. The role of TNF-alpha in Trichuris muris infection I: influence of TNF-alpha receptor usage, gender and IL-13.

Author

Hayes KS, Bancroft AJ, and Grencis RK

Subjects
Animals, Female, Male, Mice, Mice, Inbred C57BL, Receptors, Tumor Necrosis Factor, Type I immunology, Sex Factors, Th1 Cells immunology, Th2 Cells immunology, Tumor Necrosis Factor Decoy Receptors immunology, Interleukin-13 immunology, Receptors, Tumor Necrosis Factor immunology, Trichuriasis immunology, Trichuris immunology, Tumor Necrosis Factor-alpha immunology
Abstract

Th1 and Th2 responses to the gut-dwelling nematode Trichuris muris have been well established in mouse models of infection, with Th2 responses clearly playing an important role in resistance. TNF-alpha has previously been shown to play an undefined role in resistance, although it is not a typical Th2 cytokine. However, the relative importance of the two TNF-alpha receptors, p55 and p75, has not previously been investigated. We demonstrate that p55 is the dominant TNF-alpha receptor during T. muris infection as p55-/- mice are more susceptible to infection than p75-/- mice. Moreover, p75 clearly plays a role in negatively regulating TNF-alpha. We also demonstrate that a gender difference influences the immune response of p55-/- and p75-/- mice in response to T. muris infection, with female mice fully expelling by day 35 post-infection (p.i.) and male mice harbouring chronic infections. Further, this gender difference can be reversed with recombinant IL-13 (rIL-13) in male gene-deficient mice or IL-13R2.Fc treatment in female gene-deficient mice.

Published
2007
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