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1. Thirteen‐gene DNA methylation analysis of oral brushing samples: A potential surveillance tool for periodic monitoring of treated patients with oral cancer

Author

Gissi, Davide B., primary, Rossi, Roberto, additional, Lenzi, Jacopo, additional, Tarsitano, Achille, additional, Gabusi, Andrea, additional, Balbi, Tiziana, additional, Montebugnoli, Lucio, additional, Marchetti, Claudio, additional, Foschini, Maria Pia, additional, and Morandi, Luca, additional

Published
2024
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4. Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study

Author

Cristine Naomi Ohara, Maria Irma Suarez, Koody Hassemi Kitawara, Welder Zamoner, André Luis Balbi, and Daniela Ponce

Subjects
Renal Replacement Therapy, Biomaterials, Cardiovascular Diseases, Risk Factors, Hypertension, Biomedical Engineering, Humans, Medicine (miscellaneous), Bioengineering, General Medicine, Acute Kidney Injury, Retrospective Studies
Abstract

Treatment for severe acute kidney injury (AKI) typically involves the use of acute kidney replacement therapy (AKRT) to prevent or reverse complications.We aimed to determine the prevalence of successful discontinuation of AKRT and its predictive factors. A retrospective cohort study was performed with 316 patients hospitalized at a public Brazilian university hospital between January 2011 and June 2020.Success and hospital discharge were achieved for most patients (85% and 74%, respectively). Multivariable logistic regression analysis showed that C-reactive protein (CRP), urine output, and need mechanical ventilation at the time of interruption were variable associated with discontinuation success (OR 0.969, CI 0.918-0.998, p = 0.031; OR 1.008, CI 1.001-1.012, p = 0.041 and OR 0.919, CI 0.901-0.991, p = 0.030; respectively), while the absence of comorbidities such as chronic kidney disease (OR 0.234, CI 0.08-0.683, p = 0.008), cardiovascular disease (OR 0.353, CI 0.134-0.929, p = 0.035) and hypertension (OR 0.278, CI 0.003-0.882, p = 0.009), as well as pH values at the time of AKRT indication (OR 1.273, CI 1.003-1.882, p = 0.041), mechanical ventilation at the time of interruption (OR 0.19, CI 0.19-0.954, p = 0.038) and successful discontinuation (OR 8.657, CI 3.135-23.906, p 0.001) were identified as variables associated with hospital discharge.These results show that clinical conditions such as comorbidities, urine output, and mechanical ventilation, and laboratory variables such as pH and CRP are factors associated with hospital discharge and AKRT discontinuation success, requiring larger studies for confirmation.

Published
2022

5. Looking for the Elusive Imine Tautomer of Creatinine: Different States of Aggregation Studied by Quantum Chemistry and Molecular Spectroscopy

Author

José L. Alonso, Cristina Puzzarini, Elena R. Alonso, Alice Balbi, Vincenzo Barone, Santiago Mata, Iker León, Lorenzo Spada, Nicola Tasinato, Leon I., Tasinato N., Spada L., Alonso E.R., Mata S., Balbi A., Puzzarini C., Alonso J.L., Barone V., Leon, I., Tasinato, N., Spada, L., Alonso, E. R., Mata, S., Balbi, A., Puzzarini, C., Alonso, J. L., and Barone, V.

Subjects
Imine, Infrared spectroscopy, Quantum chemistry, quantum chemistry, chemistry.chemical_compound, Isomerism, rotational spectroscopy, Computational chemistry, Hyperfine structure, Settore CHIM/12 - Chimica dell'Ambiente e dei Beni Culturali, Spectrum Analysi, Aqueous solution, Full Paper, Spectrum Analysis, Water, General Chemistry, Full Papers, Tautomer, vibrational spectroscopy, tautomerism, chemistry, Creatinine, laser ablation, Amine gas treating, Imines, Rotational spectroscopy
Abstract

New spectroscopic experiments and state‐of‐the‐art quantum‐chemical computations of creatinine in different aggregation states unequivocally unveiled a significant tuning of tautomeric equilibrium by the environment: from the exclusive presence of the amine tautomer in the solid state and aqueous solution to a mixture of amine and imine tautomers in the gas phase. Quantum‐chemical calculations predict the amine species as the most stable tautomer by about 30 kJ mol−1 in condensed phases. On the contrary, moving to the isolated forms, both Z and E imine isomers become more stable by about 7 kJ mol−1. Since the imine isomers and one amine tautomer are separated by significant energy barriers, all of them should be present in the gas phase. This prediction has indeed been confirmed by high‐resolution rotational spectroscopy, which provides the first experimental characterization of the elusive imine tautomer. The interpretation of the complicated hyperfine structure of the rotational spectrum, originated by three 14N nuclei, makes it possible to use the spectral signatures as a sort of fingerprint for each individual tautomer in the complex sample., A journey among the aggregation states of a key biomolecule, creatinine, is reported, guided by state‐of‐the‐art quantum‐chemical computations and spectroscopic techniques. The fine tuning of the creatinine tautomeric equilibrium by different environments is unveiled and fully understood by vis‐à‐vis comparison between simulated and experimental signatures.

Published
2021

6. Extracorporeal Shock Waves Increase Markers of Cellular Proliferation in Bronchial Epithelium and in Primary Bronchial Fibroblasts of COPD Patients

Author

Antonino Di Stefano, Roberto Frairia, Fabio L. M. Ricciardolo, Isabella Gnemmi, Antonella Marino Gammazza, Alessio Piraino, Francesco Cappello, Bruno Balbi, and Maria Graziella Catalano

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Chronic obstructive pulmonary disease (COPD) is due to structural changes and narrowing of small airways and parenchymal destruction (loss of the alveolar attachment as a result of pulmonary emphysema), which all lead to airflow limitation. Extracorporeal shock waves (ESW) increase cell proliferation and differentiation of connective tissue fibroblasts. To date no studies are available on ESW treatment of human bronchial fibroblasts and epithelial cells from COPD and control subjects. We obtained primary bronchial fibroblasts from bronchial biopsies of 3 patients with mild/moderate COPD and 3 control smokers with normal lung function. 16HBE cells were also studied. Cells were treated with a piezoelectric shock wave generator at low energy (0.3 mJ/mm2, 500 pulses). After treatment, viability was evaluated and cells were recultured and followed up for 4, 24, 48, and 72 h. Cell growth (WST-1 test) was assessed, and proliferation markers were analyzed by qRT-PCR in cell lysates and by ELISA tests in cell supernatants and cell lysates. After ESW treatment, we observed a significant increase of cell proliferation in all cell types. C-Kit (CD117) mRNA was significantly increased in 16HBE cells at 4 h. Protein levels were significantly increased for c-Kit (CD117) at 4 h in 16HBE (p

Published
2020
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7. Milestones and Timescale of Poststroke Recovery: A Cohort Study

Author

Marianna Loi, Alberto Zaliani, Marta Abbamonte, Elena P. Ferrari, Roberto Maestri, Luigi Trojano, and Pietro Balbi

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background. Progressive increase of an aging population in Western countries will result in a growth of stroke prevalence. As many stroke survivors chronically show severe disability, increase in economic, social, and medical burden could be expected in the future. Objective and subjective measures of poststroke recovery are necessary to obtain predictive information, to improve the treatments, and to better allocate resources. Aim. To explore a measure of the temporal dimension of poststroke recovery, to search for predictive association with multiple clinical variables, and to improve tailoring of poststroke treatments. Method. In this observational monocentric cohort study, 176 poststroke inpatients at their first cerebrovascular event were consecutively enrolled. A novel measure based on the time needed to reach the main milestones of motor recovery was proposed. Moreover, two commonly used outcome measures, a measure of global functioning (Functional Independence Measure (FIM™)) and a measure of neurological poststroke deficit (Fugl-Meyer scale), were collected for the investigations of possible predictors. Results. The patients showed a substantial increase in Fugl-Meyer and FIM scores during the rehabilitative treatment. The acquisition of three milestones was significantly associated with female sex (autonomous standing), length of stay and Fugl-Meyer initial score (autonomous walking), and Fugl-Meyer initial score (functional arm). These findings provided quantitative data on motor milestone reacquisition in a sample of poststroke patients. It also demonstrated the value of the Fugl-Meyer score in predicting the acquisition of two motor milestones, relevant for daily life activities. Conclusion. Systematic recording of the timescale of poststroke recovery showed that motor milestone reacquisition happens, on average and when attainable, in less than 30 days in our sample of patients. The present study underscores the importance of the Fugl-Meyer score as a possible predictor for better improvement in reacquisition times of milestone functional recovery.

Published
2020
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8. Genome‐wide scan for signatures of selection in the Brangus cattle genome

Author

Paulo Álvarez Cecco, Andrés Rogberg Muñoz, Marianela Balbi, Martín Bonamy, Sebastián Munilla, Natalia Soledad Forneris, Pilar Peral García, Rodolfo Juan Carlos Cantet, Guillermo Giovambattista, and María Elena Fernández

Subjects
Genome, Gene Frequency, Food Animals, Reproduction, Animals, Cattle, Animal Science and Zoology, Genomics, General Medicine, Polymorphism, Single Nucleotide, Linkage Disequilibrium
Abstract

Brangus is a composite cattle breed developed with the objective of combining the advantages of Angus and Zebuine breeds (Brahman, mainly) in tropical climates. The aim of this work was to estimate breed composition both genome-wide and locally, at the chromosome level, and to uncover genomic regions evidencing positive selection in the Argentinean Brangus population/nucleus. To do so, we analysed marker data from 478 animals, including Brangus, Angus and Brahman. Average breed composition was 35.0% ± 9.6% of Brahman, lower than expected according to the theoretical fractions deduced by the usual cross-breeding practice in this breed. Local ancestry analysis evidenced that breed composition varies between chromosomes, ranging from 19.6% for BTA26 to 56.1% for BTA5. Using approaches based on allelic frequencies and linkage disequilibrium, genomic regions with putative selection signatures were identified in several chromosomes (BTA1, BTA5, BTA6 and BTA14). These regions harbour genes involved in horn development, growth, lipid metabolism, reproduction and immune response. We argue that the overlapping of a chromosome segment originated in one of the parental breeds and over-represented in the sample with the location of a signature of selection constitutes evidence of a selection process that has occurred in the breed since its take off in the 1950s. In this regard, our results could contribute to the understanding of the genetic mechanisms involved in cross-bred cattle adaptation and productivity in tropical environments.

Published
2022

9. Cryptocurrencies trading algorithms: A review

Author

Eli Hadad Junior, Pedro Paulo Balbi de Oliveira, and Isabela Ruiz Roque da Silva

Subjects
Strategy and Management, Modeling and Simulation, Management Science and Operations Research, Statistics, Probability and Uncertainty, Computer Science Applications
Published
2022

13. Resistance ofCorynespora cassiicolafrom soybean to QoI and MBC fungicides in Brazil

Author

Cláudia Vieira Godoy, Helen Prudente da Silva, Valéria S. Lopes-Caitar, Sheila A. Xavier-Valencio, Maria Isabel Balbi-Peña, Flávia Elis de Mello, Sören Franzenburg, Francismar Corrêa Marcelino-Guimarães, Joseph-Alexander Verreet, and Andreas Mehl

Subjects
Fungicide, Horticulture, biology, Resistance (ecology), Genetics, Plant Science, Corynespora cassiicola, biology.organism_classification, Agronomy and Crop Science, Cross-resistance
Published
2021

15. Mortality and Recovery of Renal Function in Acute Kidney Injury Patients Treated with Prolonged Intermittent Hemodialysis Sessions Lasting 10 versus 6 Hours: Results of a Randomized Clinical Trial

Author

Bianca Ballarin Albino, Mariele Gobo-Oliveira, André Luís Balbi, and Daniela Ponce

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Purpose. This trial aimed to compare mortality and recovery of renal function in acute kidney injury (AKI) patients treated with different durations of prolonged hemodialysis (PHD) sessions (6 h versus 10 h). Methodology. We included patients with sepsis-associated AKI, >18 years, who are in use of a norepinephrine (lower than 0.7 ucg/kg/min). Results. One hundred and ninety-four patients were treated with 531 sessions of PHD (G1=104 and G2=90 patients). The two groups were similar in age and SOFA. There was no significant difference in hypotension, hypokalemia, and anticoagulation during PHD sessions. The two groups showed differences in filter clotting, hypophosphatemia, and treatment discontinuation (12.3 versus 23.1%, p=0.002; 15.5 versus 25.8%, p=0.005; and 7.9 versus 15.6%, p=0.008, respectively). There was no difference in fluid balance (FB) before and after PHD sessions. Death and complete recovery of renal function were similar (81.3 versus 82.2%, p=0.87 and 21 versus 31.2%, p=0.7, respectively). At logistic regression, the positive FB before and after dialysis was identified as risk factor for death, while volume overload after three PHD sessions and predialysis creatinine were negatively associated with recovery of renal function in 28 days. Conclusion. There was no difference in the mortality and recovery of renal function of AKI patients submitted to different durations of PHD and sessions lasting 10 h presented higher filter clotting, hypophosphatemia, and treatment discontinuation. ISRCTN Registry number is ISRCTN33774458.

Published
2018
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16. The human amniotic fluid stem cell secretome triggers intracellular Ca 2+ oscillations, NF‐κB nuclear translocation and tube formation in human endothelial colony‐forming cells

Author

Sharon Negri, Carolina Balbi, Pawan Faris, Sveva Bollini, Valentina Balducci, Vittorio Rosti, Ambra Costa, and Francesco Moccia

Subjects
human amniotic fluid stem cell secretome, Ca, Angiogenesis, NAADP, 2+, paracrine therapy, NF-κB, InsP3Rs, endothelial colony-forming cells, angiogenesis, chemistry.chemical_compound, Paracrine signalling, Ca2+ signalling, Extracellular, signalling, TRPV4, tubulogenesis, Humans, endothelial colony‐forming cells, Cells, Cultured, Secretome, Tube formation, Chemistry, Stem Cells, NF‐κB, NF-kappa B, Endothelial Cells, Original Articles, Cell Biology, Amniotic Fluid, In vitro, Cell biology, Protein Transport, Culture Media, Conditioned, Molecular Medicine, Original Article, Calcium, Stem cell, Intracellular, Signal Transduction
Abstract

Second trimester foetal human amniotic fluid‐derived stem cells (hAFS) have been shown to possess remarkable cardioprotective paracrine potential in different preclinical models of myocardial injury and drug‐induced cardiotoxicity. The hAFS secretome, namely the total soluble factors released by cells in their conditioned medium (hAFS‐CM), can also strongly sustain in vivo angiogenesis in a murine model of acute myocardial infarction (MI) and stimulates human endothelial colony‐forming cells (ECFCs), the only truly recognized endothelial progenitor, to form capillary‐like structures in vitro. Preliminary work demonstrated that the hypoxic hAFS secretome (hAFS‐CMHypo) triggers intracellular Ca2+ oscillations in human ECFCs, but the underlying mechanisms and the downstream Ca2+‐dependent effectors remain elusive. Herein, we found that the secretome obtained by hAFS undergoing hypoxic preconditioning induced intracellular Ca2+ oscillations by promoting extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 4 (TRPV4). TRPV4‐mediated Ca2+ entry, in turn, promoted the concerted interplay between inositol‐1,4,5‐trisphosphate‐ and nicotinic acid adenine dinucleotide phosphate‐induced endogenous Ca2+ release and store‐operated Ca2+ entry (SOCE). hAFS‐CMHypo‐induced intracellular Ca2+ oscillations resulted in the nuclear translocation of the Ca2+‐sensitive transcription factor p65 NF‐κB. Finally, inhibition of either intracellular Ca2+ oscillations or NF‐κB activity prevented hAFS‐CMHypo‐induced ECFC tube formation. These data shed novel light on the molecular mechanisms whereby hAFS‐CMHypo induces angiogenesis, thus providing useful insights for future therapeutic strategies against ischaemic‐related myocardial injury.

Published
2021

17. Genome‐wide scan for signatures of selection in the Brangus cattle genome

Author

Álvarez Cecco, Paulo, primary, Rogberg Muñoz, Andrés, additional, Balbi, Marianela, additional, Bonamy, Martín, additional, Munilla, Sebastián, additional, Forneris, Natalia Soledad, additional, Peral García, Pilar, additional, Cantet, Rodolfo Juan Carlos, additional, Giovambattista, Guillermo, additional, and Fernández, María Elena, additional

Published
2022
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20. Blocking glutamate mGlu 5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1 G93A mouse model of amyotrophic lateral sclerosis

Author

Giambattista Bonanno, Nadia Bertola, Giulia Frumento, Mandeep Kumar, T P Nhung Nguyen, Tiziana Bonifacino, Arianna Roberta Zerbo, Carola Torazza, Matilde Balbi, Maurizio Viale, Aldo Profumo, Sara Ferrando, Francesca Provenzano, Marco Milanese, and Silvia Ravera

Subjects
Male, amyotrophic lateral sclerosis (ALS), Allosteric modulator, 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (CTEP), Receptor, Metabotropic Glutamate 5, SOD1, Glutamic Acid, Mice, Transgenic, Pharmacology, Mice, Superoxide Dismutase-1, medicine, Animals, ddc:610, Amyotrophic lateral sclerosis, Receptor, 2‐chloro‐4‐((2,5‐dimethyl‐1‐(4‐(trifluoromethoxy)phenyl)‐1H‐imidazol‐4‐yl)ethynyl)pyridine (CTEP), metabotropic glutamate receptor 5 (mGlu5 receptor), drug therapy [Amyotrophic Lateral Sclerosis], Superoxide Dismutase, business.industry, Amyotrophic Lateral Sclerosis, 5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (CTEP), Glutamate receptor, in vivo pharmacological treatment, Motor neuron, medicine.disease, Research Papers, genetics [Superoxide Dismutase-1], Disease Models, Animal, 2-chloro-4-((2, medicine.anatomical_structure, Spinal Cord, Metabotropic glutamate receptor, Disease Progression, Female, SOD1G93A mice, business, Research Paper, 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (CTEP), amyotrophic lateral sclerosis (ALS), in vivo pharmacological treatment, metabotropic glutamate receptor 5 (mGlu5 receptor), SOD1G93A mice, Astrocyte
Abstract

Background and Purpose The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic glutamate receptors (mGlu1 and mGlu5) are overexpressed in ALS and regulate cellular disease processes. Expression and function of mGlu5 receptors are altered at early symptomatic stages in the SOD1G93A mouse model of ALS and knockdown of mGlu5 receptors in SOD1G93A mice improved disease progression. Experimental Approach We treated male and female SOD1G93A mice with 2‐chloro‐4‐((2,5‐dimethyl‐1‐(4‐(trifluoromethoxy)phenyl)‐1H‐imidazol‐4‐yl)ethynyl)pyridine (CTEP), an orally available mGlu5 receptor negative allosteric modulator (NAM), using doses of 2 mg·kg−1 per 48 h or 4 mg·kg−1 per 24 h from Day 90, an early symptomatic disease stage. Disease progression was studied by behavioural and histological approaches. Key Results CTEP dose‐dependently ameliorated clinical features in SOD1G93A mice. The lower dose increased survival and improved motor skills in female mice, with barely positive effects in male mice. Higher doses significantly ameliorated disease symptoms and survival in both males and females, females being more responsive. CTEP also reduced motor neuron death, astrocyte and microglia activation, and abnormal glutamate release in the spinal cord, with equal effects in male and female mice. No differences were also observed in CTEP access to the brain. Conclusion and Implications Our results suggest that mGlu5 receptors are promising targets for the treatment of ALS and highlight mGlu5 receptor NAMs as effective pharmacological tools with translational potential.

Published
2021

22. NEOTROPICAL FRESHWATER FISHES : A dataset of occurrence and abundance of freshwater fishes in the Neotropics

Author

Tonella, Lívia Helena, primary, Ruaro, Renata, additional, Daga, Vanessa Salete, additional, Garcia, Diego Azevedo Zoccal, additional, Vitorino, Oscar Barroso, additional, Lobato‐de Magalhães, Tatiana, additional, Reis, Roberto Esser, additional, Di Dario, Fabio, additional, Petry, Ana Cristina, additional, Mincarone, Michael Maia, additional, Assis Montag, Luciano Fogaça, additional, Pompeu, Paulo Santos, additional, Teixeira, Adonias Aphoena Martins, additional, Carmassi, Alberto Luciano, additional, Sánchez, Alberto J., additional, Giraldo Pérez, Alejandro, additional, Bono, Alessandra, additional, Datovo, Aléssio, additional, Flecker, Alexander S., additional, Sanches, Alexandra, additional, Godinho, Alexandre Lima, additional, Matthiensen, Alexandre, additional, Peressin, Alexandre, additional, Hilsdorf, Alexandre Wagner Silva, additional, Barufatti, Alexéia, additional, Hirschmann, Alice, additional, Jung, Aline, additional, Cruz‐Ramírez, Allan K., additional, Braga Silva, Alline, additional, Cunico, Almir Manoel, additional, Saldanha Barbosa, Amanda, additional, Barradas, Amauri de Castro, additional, Rêgo, Ana Carolina Lacerda, additional, Franco, Ana Clara Sampaio, additional, Costa, Ana Paula Lula, additional, Vidotto‐Magnoni, Ana Paula, additional, Ferreira, Anderson, additional, Kassner Filho, Anderson, additional, Nobile, André Batista, additional, Magalhães, André Lincoln Barroso, additional, Teixeira da Silva, André, additional, Bialetzki, Andréa, additional, Gomes, Andréa Cristina dos Santos Maroclo, additional, Nobre, Andrezza Bellotto, additional, Casimiro, Armando Cesar Rodrigues, additional, Angulo Sibaja, Arturo, additional, Capelli dos Santos, Arthur Alexandre, additional, Araújo, Átila Rodrigues, additional, Frota, Augusto, additional, Quirino, Bárbara Angélio, additional, Ferreira, Beatriz Moreira, additional, Albuquerque, Bianca Weiss, additional, Meneses, Bruna Arbo, additional, Oliveira, Brunno Tolentino, additional, Torres Parahyba Campos, Bruno Augusto, additional, Gonçalves, Bruno Bastos, additional, Kubiak, Bruno Busnello, additional, Silveira Prudente, Bruno, additional, Gorini de Araujo Passos Pacheco, Bruno, additional, Nakagawa, Bruno Kazuo, additional, Nascimento, Bruno Tayar Marinho, additional, Maia, Calebe, additional, Cantagallo Devids, Camila, additional, Rezende, Carla Ferreira, additional, Muñoz‐Mendoza, Carla, additional, Peres, Carlos A., additional, Sousa Rodrigues Filho, Carlos Alberto, additional, Lucena, Carlos Alberto Santos, additional, Fernandes, Carlos Alexandre, additional, Kasper, Carlos Benhur, additional, DoNascimiento, Carlos, additional, Emidio, Carmino, additional, Carrillo‐Moreno, Carolina, additional, Machado, Carolina, additional, Pera, Carolina, additional, Hartmann, Caroline, additional, Pringle, Catherine M., additional, Leal, Cecília Gontijo, additional, Jézéquel, Céline, additional, Harrod, Chris, additional, Rosa, Clarissa Alves, additional, Quezada‐Romegialli, Claudio, additional, Pott, Crisla Maciel, additional, Larentis, Crislei, additional, Nascimento, Cristiane A. S., additional, Silva Gonçalves, Cristina, additional, Cunha, Cristina Jaques, additional, Pisicchio, Cristina Moreira, additional, Carvalho, Daniel Cardoso, additional, Galiano, Daniel, additional, Gomez‐Uchida, Daniel, additional, Santana, Daniel Oliveira, additional, Salas Johnson, Daniel, additional, Petsch, Danielle Katharine, additional, Freitas, Danielly Torres Hashiguti, additional, Bailly, Dayani, additional, Machado, Débora Ferreira, additional, Carvalho, Débora Reis, additional, Topan, Dhyego Hamilton, additional, Cañas‐Rojas, Diego, additional, Silva, Diego, additional, Freitas‐Souza, Diogo, additional, Lima‐Júnior, Dilermando Pereira, additional, Piscor, Diovani, additional, Moraes, Djalma Pereira, additional, Viana, Douglas, additional, Caetano, Dyego Leonardo Ferraz, additional, Gubiani, Éder André, additional, Okada, Edson K., additional, Amaral, Eduardo Cazuni, additional, Brambilla, Eduardo Meneguzzi, additional, Cunha, Eduardo Ribeiro, additional, Kashiwaqui, Elaine Antoniassi Luiz, additional, Rocha, Elise Amador, additional, Barp, Elisete Ana, additional, Costa Fraga, Elmary, additional, D'Bastiani, Elvira, additional, Zandonà, Eugenia, additional, Dary, Eurizângela Pereira, additional, Benedito, Evanilde, additional, Barba‐Macías, Everardo, additional, Calvache Uvidia, Evelyn Vanessa, additional, Fonseca, Fabiana Luques, additional, Ferreira, Fabiane Silva, additional, Lima, Fábio, additional, Maffei, Fábio, additional, Porto‐Foresti, Fábio, additional, Teresa, Fabrício Barreto, additional, Andrade Frehse, Fabrício, additional, Oliveira, Fagner Júnior M., additional, Silva, Felipe Pessoa, additional, Lima, Felipe Pontieri, additional, Prado, Fernanda Dotti, additional, Jerep, Fernando Camargo, additional, Vieira, Fernando Emmanuel Gonçalves, additional, Gertum Becker, Fernando, additional, Carvalho, Fernando Rogério, additional, Ubaid, Flávio Kulaif, additional, Teixeira, Francisco Keilo, additional, Provenzano Rizzi, Francisco, additional, Severo‐Neto, Francisco, additional, Villamarín, Francisco, additional, Mello, Franco Teixeira, additional, Keppeler, Friedrich Wolfgang, additional, Avila Batista, Gabriel, additional, Menezes Yazbeck, Gabriel, additional, Tesitore, Giancarlo, additional, Salvador, Gilberto Nepomuceno, additional, Soteroruda Brito, Gita Juan, additional, Carmassi, Giulianna Rondineli, additional, Kurchevski, Gregório, additional, Goyenola, Guillermo, additional, Pereira, Hasley Rodrigo, additional, Alvez, Helen Jamille Fernandes Silva, additional, Prado, Helena Alves, additional, Pinho, Henrique Ledo Lopes, additional, Sousa, Híngara Leão, additional, Bornatowski, Hugo, additional, Oliveira Barbosa, Hugo, additional, Tobes, Ibon, additional, Paiva Affonso, Igor, additional, Queiroz, Igor Raposo, additional, Vila, Irma, additional, Negrete, Iván Vinicio Jácome, additional, Prado, Ivo Gavião, additional, Vitule, Jean Ricardo Simões, additional, Figueiredo‐Filho, Jessé, additional, Gonzalez, Jessica Antúnez, additional, Faria Falcão, Jéssica Caroline, additional, Teixeira, Jéssica Vieira, additional, Pincheira‐Ulbrich, Jimmy, additional, Silva, Jislaine Cristina, additional, Araujo Filho, João Antonio, additional, Silva, João Fernando Marques, additional, Genova, João Gabriel, additional, Giovanelli, João Gabriel Ribeiro, additional, Andriola, João Vitor Perin, additional, Alves, Jonatas, additional, Valdiviezo‐Rivera, Jonathan, additional, Brito, Jorge, additional, Botero, Jorge Iván Sánchez, additional, Liotta, Jorge, additional, Ramirez, Jorge Luis, additional, Marinho, Jorge Reppold, additional, Birindelli, José Luís Olivan, additional, Novaes, Jorge, additional, Hawes, Joseph E., additional, Ribolli, Josiane, additional, Rivadeneira, Juan Francisco, additional, Schmitter‐Soto, Juan Jacobo, additional, Assis, Juliana Camara, additional, Silva, Juliana Paulo, additional, Santos, Juliana Silveira, additional, Wingert, Juliana, additional, Wojciechowski, Juliana, additional, Bogoni, Juliano André, additional, Ferrer, Juliano, additional, Solórzano, Julio César Jut, additional, Sá‐Oliveira, Júlio César, additional, Vaini, Jussara Oliveira, additional, Silva Ingenito, Leonardo Ferreira, additional, Contreras Palma, Kamila, additional, Orlandi Bonato, Karine, additional, Lima Pereira, Karla Dayane, additional, Santos Sousa, Kassiano, additional, Borja‐Acosta, Kevin Giancarlo, additional, Carneiro, Laís, additional, Faria, Larissa, additional, Oliveira, Leonardo Brito, additional, Resende, Leonardo Cardoso, additional, Oliveira Silva, Leonardo, additional, Rodrigues, Leydiane Nunes, additional, Guarderas Flores, Lida, additional, Martins, Lidiane, additional, Tonini, Lorena, additional, Braga, Lorrana Thaís Máximo Durville, additional, Gomes, Louise Cristina, additional, Fries, Lucas, additional, Silva, Lucas Gonçalves, additional, Jarduli, Lucas Ribeiro, additional, Lima, Luciano Benedito, additional, Gomes Fischer, Luciano, additional, Wolff, Luciano Lazzarini, additional, Santos, Luciano Neves, additional, Bezerra, Luis Artur Valões, additional, Sarmento Soares, Luisa Maria, additional, Manna, Luisa Resende, additional, Duboc, Luiz Fernando, additional, Santos Ribas, Luiz Guilherme, additional, Malabarba, Luiz Roberto, additional, Brito, Marcelo Fulgêncio Guedes, additional, Braga, Marcelo Rennó, additional, Almeida, Marcelo Silva, additional, Sily, Maria Cecília, additional, Barros, Maria Claudene, additional, Nascimento, Maria Histelle Sousa, additional, Souza Delapieve, Maria Laura, additional, Piedade, Maria Teresa Fernandez, additional, Tagliaferro, Marina, additional, Pinna, Mário Cesar Cardoso, additional, Yánez‐Muñoz, Mario H., additional, Orsi, Mário Luís, additional, Rosa, Marlon Ferraz, additional, Bastiani, Marlos, additional, Stefani, Marta Severino, additional, Moreno, Martha Elena Valdez, additional, Carvalho, Mateus Moreira, additional, Kütter, Mateus Tavares, additional, Freitas, Matheus Oliveira, additional, Cañas‐Merino, Mauricio, additional, Cetra, Mauricio, additional, Herrera‐Madrid, Mauricio, additional, Petrucio, Mauricio Mello, additional, Galetti, Mauro, additional, Salcedo, Miguel Ángel, additional, Pascual, Miguel, additional, Ribeiro, Milton Cesar, additional, Abelha, Milza Celi Fedatto, additional, Silva, Mônica Andrade, additional, Araujo, Mônica Pacheco, additional, Dias, Murilo Sversut, additional, Guimaraes Sales, Naiara, additional, Benone, Naraiana Loureiro, additional, Sartor, Natane, additional, Fontoura, Nelson Ferreira, additional, Souza Trigueiro, Nicholas Silvestre, additional, Álvarez‐Pliego, Nicolás, additional, Shibatta, Oscar Akio, additional, Tedesco, Pablo A., additional, Lehmann Albornoz, Pablo Cesar, additional, Santos, Pablo Henrique Fernandes, additional, Freitas, Pâmela Virgolino, additional, Fagundes, Patricia Calegari, additional, Freitas, Patrícia Domingues, additional, Mena‐Valenzuela, Patricio, additional, Tufiño, Paul, additional, Catelani, Paula Araujo, additional, Peixoto, Paula, additional, Ilha, Paulo, additional, Aquino, Pedro De Podestà Uchôa, additional, Gerhard, Pedro, additional, Carvalho, Pedro Hollanda, additional, Jiménez‐Prado, Pedro, additional, Galetti, Pedro Manoel, additional, Borges, Pedro Paulino, additional, Nitschke, Pedro Peixoto, additional, Manoel, Pedro Sartori, additional, Bernardes Perônico, Phamela, additional, Soares, Philip Teles, additional, Piana, Pitágoras Augusto, additional, Oliveira Cunha, Priscila, additional, Plesley, Priscila, additional, Souza, Rafael Couto Rosa, additional, Rosa, Rafael Rogério, additional, El‐Sabaawi, Rana W., additional, Rodrigues, Raoni Rosa, additional, Covain, Raphael, additional, Loures, Raquel Coelho, additional, Braga, Raul Rennó, additional, Ré, Reginaldo, additional, Bigorne, Rémy, additional, Cassemiro Biagioni, Renata, additional, Silvano, Renato Azevedo Matias, additional, Dala‐Corte, Renato Bolson, additional, Martins, Renato Tavares, additional, Rosa, Ricardo, additional, Sartorello, Ricardo, additional, Almeida Nobre, Rodrigo, additional, Bassar, Ronald D., additional, Gurgel‐Lourenço, Ronaldo César, additional, Pinheiro, Ronaldo Fernando Martins, additional, Carneiro, Ronaldo Leal, additional, Florido, Rosa, additional, Mazzoni, Rosana, additional, Silva‐Santos, Rosane, additional, Paula Santos, Rosiane, additional, Delariva, Rosilene Luciana, additional, Hartz, Sandra Maria, additional, Brosse, Sebastien, additional, Althoff, Sérgio Luiz, additional, Nóbrega Marinho Furtado, Shaka, additional, Lima‐Junior, Sidnei Eduardo, additional, Lustosa Costa, Silvia Yasmin, additional, Arrolho, Solange, additional, Auer, Sonya K., additional, Bellay, Sybelle, additional, Fátima Ramos Guimarães, Taís, additional, Francisco, Talitha Mayumi, additional, Mantovano, Tatiane, additional, Gomes, Tatyana, additional, Ramos, Telton Pedro Anselmo, additional, Assis Volpi, Thaís, additional, Emiliano, Thais Moura, additional, Barbosa, Thiago Augusto Pedrosa, additional, Balbi, Thiago José, additional, Silva Campos, Thiago Nascimento, additional, Silva, Thiago Teixeira, additional, Occhi, Thiago Vinícius Trento, additional, Garcia, Thiely Oliveira, additional, Silva Freitas, Tiago Magalhães, additional, Begot, Tiago Octavio, additional, Silveira, Tony Leandro Rezende, additional, Lopes, Ueslei, additional, Schulz, Uwe Horst, additional, Fagundes, Valéria, additional, Batista da Silva, Valéria Flávia, additional, Azevedo‐Santos, Valter M., additional, Ribeiro, Vanessa, additional, Tibúrcio, Vanessa Graciele, additional, Almeida, Vera Lúcia Lescano, additional, Isaac‐Nahum, Victoria J., additional, Abilhoa, Vinicius, additional, Campos, Vinicius Farias, additional, Kütter, Vinicius Tavares, additional, Cionek, Vivian de Mello, additional, Prodocimo, Viviane, additional, Vicentin, Wagner, additional, Martins, Waldney Pereira, additional, Moraes Pires, Walna Micaelle, additional, da Graça, Weferson Júnio, additional, Smith, Welber Senteio, additional, Dáttilo, Wesley, additional, Aguirre Maldonado, Windsor Efren, additional, Gomes Ponce de Carvalho Rocha, Yuri, additional, Súarez, Yzel Rondon, additional, and de Lucena, Zilda Margarete Seixas, additional

Published
2022
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25. Microvesicles released from activated CD4+T cells alter microvascular endothelial cell function

Author

Vdovenko, Daria, primary, Balbi, Carolina, additional, Di Silvestre, Dario, additional, Passignani, Giulia, additional, Puspitasari, Yustina M., additional, Zarak‐Crnkovic, Martina, additional, Mauri, Pierluigi, additional, Camici, Giovanni G., additional, Lüscher, Thomas F., additional, Eriksson, Urs, additional, and Vassalli, Giuseppe, additional

Published
2022
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26. Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self‐assembly Chemical Library

Author

Katrina H. Andrews, Marco Catalano, Federica Mazzieri, Dario Neri, Jörg Scheuermann, James Clayton, Mustafa Moroglu, Martina Bigatti, Stuart J. Conway, and Petra Balbi

Subjects
Models, Molecular, CREBBP bromodomain, DNA-encoded chemical library, Encoded self-assembly chemical library, Inhibitors, Medicinal chemistry, Stereochemistry, Response element, Cell Cycle Proteins, Enzyme-Linked Immunosorbent Assay, 01 natural sciences, Biochemistry, Chemical library, Small Molecule Libraries, Affinity maturation, chemistry.chemical_compound, Complementary DNA, Drug Discovery, Humans, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Benzodiazepinones, Molecular Structure, 010405 organic chemistry, Chemistry, Binding protein, Organic Chemistry, CREB-Binding Protein, 0104 chemical sciences, Bromodomain, 010404 medicinal & biomolecular chemistry, Molecular Medicine, DNA, Transcription Factors
Abstract

DNA‐encoded chemical libraries (DECLs) are collections of chemical moieties individually coupled to distinctive DNA barcodes. Compounds can be displayed either at the end of a single DNA strand (i. e., single‐pharmacophore libraries) or at the extremities of two complementary DNA strands (i. e., dual‐pharmacophore libraries). In this work, we describe the use of a dual‐pharmacophore encoded self‐assembly chemical (ESAC) library for the affinity maturation of a known 4,5‐dihydrobenzodiazepinone ring (THBD) acetyl‐lysine (KAc) mimic for the cyclic‐AMP response element binding protein (CREB) binding protein (CREBBP or CBP) bromodomain. The new pair of fragments discovered from library selection showed a sub‐micromolar affinity for the CREBBP bromodomain in fluorescence polarization and ELISA assays, and selectivity against BRD4(1). © 2020 Wiley-VCH GmbH. ISSN:1860-7179 ISSN:1860-7187

Published
2020

28. Differential Proteomic Analysis of Nuclear Matrix in Muscle-Invasive Bladder Cancer: Potential to Improve Diagnosis and Prognosis

Author

Paola Barboro, Alessandra Rubagotti, Paola Orecchia, Bruno Spina, Mauro Truini, Erica Repaci, Giorgio Carmignani, Andrea Romagnoli, Carlo Introini, Francesco Boccardo, Barbara Carnemolla, and Cecilia Balbi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
Abstract

Introduction: Although several molecular markers for bladder cancer have been identified, at present little information on prognostic biomarkers is available in the literature. Prognostication of this tumor is largely based on clinicopathological characteristics. Our aim was to identify nuclear matrix (NM) proteins that might serve to better characterize the phenotype of the invasive bladder cancer and to investigate their diagnostic and prognostic roles.

Published
2008
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29. Resistance ofCorynespora cassiicolafrom soybean to QoI and MBC fungicides in Brazil

Author

Mello, Flávia E. de, primary, Lopes‐Caitar, Valéria S., additional, Xavier‐Valencio, Sheila A., additional, Silva, Helen P., additional, Franzenburg, Sören, additional, Mehl, Andreas, additional, Verreet, Joseph‐Alexander, additional, Balbi‐Peña, Maria I., additional, Marcelino‐Guimaraes, Francismar C., additional, and Godoy, Cláudia V., additional

Published
2021
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31. Pisa Syndrome in Parkinson’s Disease: Electromyographic Aspects and Implications for Rehabilitation

Author

Giuseppe Frazzitta, Pietro Balbi, Francesco Gotti, Roberto Maestri, Annarita Sabetta, Luca Caremani, Laura Gobbi, Marina Capobianco, Rossana Bera, Nir Giladi, and Davide Ferrazzoli

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Pisa Syndrome (PS) is a real clinical enigma, and its management remains a challenge. In order to improve the knowledge about resting state and during maximal voluntary muscle contraction (MVMC) of the axial muscles, we described the electromyography results of paraspinal muscles, rectus abdominis, external oblique, and quadratus lumborum of both sides of 60 patients. Electromyography was assessed at rest, during MVMC while bending in the opposite direction of the PS and during MVMC while bending in the direction of the PS. The MVMC gave information about the interferential pattern (INT) or subinterferential pattern (sub-INT). We defined asymmetrical activation (AA) when a sub-INT was detected on the muscle on the side opposite to the PS bending and an INT of same muscle in the direction of PS bending. We observed significant AA during MVMC only in the external oblique muscles in 78% of the subjects. Our results of asymmetric ability to generate maximal voluntary force of the external oblique muscles support a central dissynchronisation of axial muscles as a significant contributor for the bending of the spine in erect position. These results could have important implication to physiotherapy and the use of botulinum toxin in the treatment of PS.

Published
2015
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32. Differential diagnosis between a granuloma and radicular cyst: effectiveness of magnetic resonance imaging

Author

Sofia Asioli, T. Balbi, M. R. Gatto, Manuela Coe, Giuseppe Lizio, Gian Andrea Pelliccioni, Eugenio Salizzoni, and Lizio G, Salizzoni E, Coe M, Gatto MR, Asioli S, Balbi T, Pelliccioni GA.

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Diagnosis, Differential, histology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, periapical diseases, Humans, magnetic resonance imaging, Medicine, Periapical Diseases, Medical diagnosis, General Dentistry, apicoectomy, Aged, Observer Variation, Radicular Cyst, Receiver operating characteristic, medicine.diagnostic_test, business.industry, Reproducibility of Results, Magnetic resonance imaging, 030206 dentistry, Middle Aged, ROC Curve, 030220 oncology & carcinogenesis, Apicoectomy, Female, Radiology, Differential diagnosis, business, Periapical Granuloma, Kappa
Abstract

AIM: To investigate the diagnostic reliability and accuracy of magnetic resonance imaging (MRI) to differentiate periapical lesions of endodontic origin and to compare the results with histopathological information. METHODOLOGY: The radiolucent periapical jaw lesions of 34 patients, which were surgically enucleated, were investigated by two radiologists using MRI, based on the same six criteria, to categorize the lesions as granulomas, radicular cysts or others. After apicoectomies, two oral pathologists (blinded to the radiologist's diagnoses) analysed all specimens by referring to seven specific parameters and diagnosed the specimens as granulomas, radicular cysts or other conditions. The inter-rater agreements between the radiologists and pathologists in terms of MRI and histological diagnoses, respectively, along with the discriminant power of the adopted criteria and the accuracy of the MRI assessments compared with the histopathological results, were calculated. Cohen's kappa test was adopted to examine inter-rater agreement between the two radiologists and two pathologists. Guttman's lambda coefficient (λ6 ) was used to evaluate the internal consistency of the items used for the differential diagnosis by radiologists. The accuracy resulted from a receiver operator characteristic (ROC) analysis. RESULTS: A strong inter-rater reliability was observed between the two radiologists (k-statistic = 0.86, P = 0.0001) and the two pathologists (k-statistic = 0.88, P = 0.0001). The internal consistency of the diagnostic items was 0.605 for cysts and 0.771 for granulomas. The accuracy (true positives plus true negatives) of the radiologists was greater than that of the pathologists based on analysis (area under the curve = 0.87 and 0.91, respectively). CONCLUSIONS: The reliability and accuracy of MRI were high and comparable to histopathological reliability, highlighting the usefulness of this noninvasive technique as a pre-treatment diagnostic method for periapical endodontic lesions.

Published
2018

36. Estimates for Genetic Variance Components in Reciprocal Recurrent Selection in Populations Derived from Maize Single-Cross Hybrids

Author

Matheus Costa dos Reis, José Maria Villela Pádua, Guilherme Barbosa Abreu, Fernando Lisboa Guedes, Rodrigo Vieira Balbi, and João Cândido de Souza

Subjects
Technology, Medicine, Science
Abstract

This study was carried out to obtain the estimates of genetic variance and covariance components related to intra- and interpopulation in the original populations (C0) and in the third cycle (C3) of reciprocal recurrent selection (RRS) which allows breeders to define the best breeding strategy. For that purpose, the half-sib progenies of intrapopulation (P11 and P22) and interpopulation (P12 and P21) from populations 1 and 2 derived from single-cross hybrids in the 0 and 3 cycles of the reciprocal recurrent selection program were used. The intra- and interpopulation progenies were evaluated in a 10×10 triple lattice design in two separate locations. The data for unhusked ear weight (ear weight without husk) and plant height were collected. All genetic variance and covariance components were estimated from the expected mean squares. The breakdown of additive variance into intrapopulation and interpopulation additive deviations (στ2) and the covariance between these and their intrapopulation additive effects (CovAτ) found predominance of the dominance effect for unhusked ear weight. Plant height for these components shows that the intrapopulation additive effect explains most of the variation. Estimates for intrapopulation and interpopulation additive genetic variances confirm that populations derived from single-cross hybrids have potential for recurrent selection programs.

Published
2014
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38. Blocking glutamate mGlu 5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1 G93A mouse model of amyotrophic lateral sclerosis

Author

Milanese, Marco, primary, Bonifacino, Tiziana, additional, Torazza, Carola, additional, Provenzano, Francesca, additional, Kumar, Mandeep, additional, Ravera, Silvia, additional, Zerbo, Arianna Roberta, additional, Frumento, Giulia, additional, Balbi, Matilde, additional, Nguyen, T. P. Nhung, additional, Bertola, Nadia, additional, Ferrando, Sara, additional, Viale, Maurizio, additional, Profumo, Aldo, additional, and Bonanno, Giambattista, additional

Published
2021
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39. A deep‐sea bacterium related to coastal marine pathogens

Author

Lasa, Aide, primary, Auguste, Manon, additional, Lema, Alberto, additional, Oliveri, Caterina, additional, Borello, Alessio, additional, Taviani, Elisa, additional, Bonello, Guido, additional, Doni, Lapo, additional, Millard, Andrew D., additional, Bruto, Maxime, additional, Romalde, Jesus L., additional, Yakimov, Michail, additional, Balbi, Teresa, additional, Pruzzo, Carla, additional, Canesi, Laura, additional, and Vezzulli, Luigi, additional

Published
2021
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40. What Type of Technosignatures Can We Detect?

Author

Amedeo Balbi

Subjects
business.industry, Computer science, Pattern recognition, Artificial intelligence, Type (model theory), business, Selection (genetic algorithm)
Abstract

The existence of causal constraints introduces a temporal selection effect in the type of technosignatures that we can detect. I discuss the implications of this fact on the characteristic of detec...

Published
2020

41. Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation

Author

Terezila M. Coimbra, Heloísa D. C. Francescato, Ana Paula C. Balbi, Evelyn C. S. Marin, and Roberto S. Costa

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Exposure to an adverse environment in utero appears to programme physiology and metabolism permanently, with long-term consequences for health of the fetus or offspring. It was observed that the offspring from dams submitted to high-sodium intake during pregnancy present disturbances in renal development and in blood pressure. These alterations were associated with lower plasma levels of angiotensin II (AII) and changes in renal AII receptor I (AT1) and mitogen-activated protein kinase (MAPK) expressions during post natal kidney development. Clinical and experimental evidence show that the renin-angiotensin system (RAS) participates in renal development. Many effects of AII are mediated through MAPK pathways. Extracellular signal-regulated protein kinases (ERKs) play a pivotal role in cellular proliferation and differentiation. In conclusion, high-sodium intake during pregnancy and lactation can provoke disturbances in renal development in offspring leading to functional and structural alterations that persist in adult life. These changes can be related at least in part with the decrease in RAS activity considering that this system has an important role in renal development.

Published
2012
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42. Long-Term Outcome of Patients Followed by Nephrologists after an Acute Tubular Necrosis Episode

Author

G. A. Brito, A. L. Balbi, J. M. G. Abrão, and D. Ponce

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Aims of our study were to describe the long-term survival in patients surviving an acute tubular necrosis (ATN) episode and determine factors associated with late mortality. We performed a prospective cohort study that evaluated the long-term outcome of 212 patients surviving an ATN episode. Mortality at the end of followup was 24.5%, and the probability of these patients being alive 5 years after discharge was 55%. During the followup, 4.7% of patients needed chronic dialysis. Univariate analysis showed that previous CKD (), cardiovascular disease (), age greater than 60 years (), and higher SCr baseline (), after 12 months () and 36 months (), were predictors of long-term mortality. In multivariate analysis, older age (HR = 6.4, CI 95% = 1.2–34.5, ) and higher SCr after 12 months (HR = 2.1, 95% CI 95% = 1.14–4.1, ) were identified as risk factors associated with late mortality. In conclusion, 55% of patients surviving an ATN episode were still alive, and less than 5% required chronic dialysis 60 months later; older age and increased Scr after 12 months were identified as risk factors associated with late death.

Published
2012
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43. General Characteristics and Risk Factors of Cardiovascular Disease among Interstate Bus Drivers

Author

Raquel Pastréllo Hirata, Luciana Maria Malosa Sampaio, Fernando Sergio Studart Leitão Filho, Alberto Braghiroli, Bruno Balbi, Salvatore Romano, Giuseppe Insalaco, and Luis Vicente Franco de Oliveira

Subjects
Technology, Medicine, Science
Abstract

Workers in the transportation industry are at greater risk of an incorrect diet and sedentary behavior. The aim of our study was to characterize a population of professional bus drivers with regard to clinical and demographic variables, lipid profile, and the presence of cardiovascular risk factors. Data from 659 interstate bus drivers collected retrospectively, including anthropometric characteristics, systolic and diastolic blood pressure, lipid profile, fasting blood glucose, meatoscopy, and audiometry. All participants were male, with a mean age of 41.7±6.9 years, weight of 81.4±3.3 kg, and BMI 27.2±3.3 Kg/m2; the mean abdominal and neck circumferences were 94.4±8.6 cm and 38.9±2.2 cm; 38.2% of the sample was considered hypertensive; mean HDL cholesterol was 47.9±9.5 mg/dL, mean triglyceride level was 146.3±87.9 mg/dL, and fasting glucose was above 100 mg/dL in 249 subjects (39.1%). Drivers exhibited reduced audiometric hearing at 4–8 kHz, being all sensorineural hearing loss. The clinical characterization of a young male population of interstate bus drivers revealed a high frequency of cardiovascular risk factors, as obesity, hypertension, hyperlipidemia, and hyperglycemia, as well as contributing functional characteristics, such as a low-intensity activity, sedentary behavior, long duration in a sitting position, and high-calorie diet, which lead to excessive weight gain and associated comorbidities.

Published
2012
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44. Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with mammary tumours and histopathological analyses

Author

Aline dos Santos Moreira, Kênia Balbi El-Jaick, Maria de Lourdes Gonçalves Ferreira, M V G Soares, Ana Maria Reis Ferreira, F.B. Costa, G E F Araujo, and Tábata Maués

Subjects
0301 basic medicine, Genotype, 040301 veterinary sciences, Genes, BRCA2, Mammary Neoplasms, Animal, Single-nucleotide polymorphism, Biology, medicine.disease_cause, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Germline, 0403 veterinary science, 03 medical and health sciences, Exon, Dogs, medicine, Animals, Dog Diseases, Gene, General Veterinary, Haplotype, Exons, Sequence Analysis, DNA, 04 agricultural and veterinary sciences, BRCA2 Protein, Molecular biology, 030104 developmental biology, Haplotypes, Female, Carcinogenesis
Abstract

The canine BRCA2 is a tumor supressor gene which encodes the BRCA2 protein, involved in DNA repair through interaction with the RAD51 recombinase. This process is mediated by eigth BRC repeats that are encoded by BRCA2 exon 11. Two variants corresponding to human mutations in human BRC3 repeat have been reported in canine BRC3 repeat. In addition, other variants have also been described in canine BRCA2 exon 11. Considering the importance of polymorphisms in human BRCA2 to breast cancer development, this study aimed to investigate the frequency of variants in BRCA2 exon 11 in 48 blood and tissue DNA samples from bitches with canine mammary tumors (CMT), as well as, to analyze tumor stage and histopathological features. Seven Single Nucleotide Polymorphisms (SNPs) were identified, three of which were evaluated as possibily or probably deleterious variant. Interestingly, almost all the 22 mammary tumors (except one) which presented a clinical staging equal to or greater than III carried at least one mutant allele of these three variants. Besides that, no statistically significant correlation was observed between any of the reported SNPs in heterozygosis or homozygosis and either dogs data (such as breed, age or disease stage) or mammary tumors histopathological characteristics. A total of 97.9% of bitches had one to three polymorphisms of the seven identified in this study, which suggests a possibly correlation between the canine BRCA2 exon 11 polymorphisms and mammary carcinogenesis.

Published
2018

45. Wildland Fire Behaviour Case Studies and Fuel Models for Landscape-Scale Fire Modeling

Author

Paul-Antoine Santoni, Jean-Baptiste Filippi, Jacques-Henri Balbi, and Frédéric Bosseur

Subjects
Heat, QC251-338.5
Abstract

This work presents the extension of a physical model for the spreading of surface fire at landscape scale. In previous work, the model was validated at laboratory scale for fire spreading across litters. The model was then modified to consider the structure of actual vegetation and was included in the wildland fire calculation system Forefire that allows converting the two-dimensional model of fire spread to three dimensions, taking into account spatial information. Two wildland fire behavior case studies were elaborated and used as a basis to test the simulator. Both fires were reconstructed, paying attention to the vegetation mapping, fire history, and meteorological data. The local calibration of the simulator required the development of appropriate fuel models for shrubland vegetation (maquis) for use with the model of fire spread. This study showed the capabilities of the simulator during the typical drought season characterizing the Mediterranean climate when most wildfires occur.

Published
2011
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46. CAREM Project Status

Author

H. Boado Magan, D. F. Delmastro, M. Markiewicz, E. Lopasso, F. Diez, M. Giménez, A. Rauschert, S. Halpert, M. Chocrón, J. C. Dezzutti, H. Pirani, C. Balbi, A. Fittipaldi, M. Schlamp, G. M. Murmis, and H. Lis

Subjects
Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

CAREM is a CNEA (Comisión Nacional de Energía Atómica) project. This project consists of the development, design, and construction of a small nuclear power plant. First, a prototype of an electrical output of about 27 MW, CAREM 25, will be built in order to validate the innovation of the CAREM concept and then developed to commercial version. After several years of development, the CAREM Project reached such a maturity level that the Argentine government decided on the construction of CAREM prototype. Several activities are ongoing with the purpose of obtaining the construction permit for the CAREM prototype.

Published
2011
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47. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus

Author

Ernesto Fedele, Claudia Rebosio, Roberta Ricciarelli, Matilde Balbi, and Mario Passalacqua

Subjects
0301 basic medicine, Agonist, Gs alpha subunit, medicine.drug_class, Clinical Biochemistry, Glutamate receptor, General Medicine, Neurotransmission, Biochemistry, gamma-Aminobutyric acid, Cell biology, Adenylyl cyclase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, medicine, Molecular Medicine, GABAergic, Receptor, 030217 neurology & neurosurgery, medicine.drug
Abstract

Glucagon-like peptide-1 receptors (GLP-1Rs) have been shown to mediate cognitive-enhancing and neuroprotective effects in the central nervous system. However, little is known about their physiological roles on central neurotransmission, especially at the presynaptic level. Using purified synaptosomal preparations and immunofluorescence techniques, here we show for the first time that GLP-1Rs are localized on mouse cortical and hippocampal synaptic boutons, in particular on glutamatergic and GABAergic nerve terminals. Their activation by the selective agonist exendin-4 (1-100 nM) was able to increase the release of either [3 H]d-aspartate or [3 H]GABA. These effects were abolished by 10 nM of the selective GLP1-R antagonist exendin-3 (9-39) and were prevented by the selective adenylyl cyclase inhibitor 2',5'-dideoxyadenosine (10 µM), indicating the involvement of classic GLP-1Rs coupled to Gs protein stimulating cAMP synthesis. Our data demonstrate the existence and activity of presynaptic receptors for GLP-1 that could represent additional mechanisms by which this neurohormone exerts its effects in the CNS. © 2017 BioFactors, 44(2):148-157, 2018.

Published
2017

49. Validation of novel 3‐dimensional quantitative coronary angiography based software to calculate fractional flow reserve post stenting

Author

Masdjedi, Kaneshka, primary, Zandvoort, Laurens JC, additional, Balbi, Matthew M, additional, Nuis, Rutger‐Jan, additional, Wilschut, Jeroen, additional, Diletti, Roberto, additional, Jaegere, Peter P.T., additional, Zijlstra, Felix, additional, Van Mieghem, Nicolas M, additional, and Daemen, Joost, additional

Published
2020
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