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878 results on '"Baldi A"'

1. Prevalence and Prognostic Significance of Right Ventricular Dysfunction in Patients With Severe Low‐Flow, Low‐Gradient Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement

Author

Michele Bellino, Germano Junior Ferruzzi, Arturo Giordano, Tiziana Attisano, Francesco Maiellaro, Rodolfo Citro, Cesare Baldi, Nicola Corcione, Alberto Morello, Giovanni Granata, Sara Turino, Marco Di Maio, Angelo Silverio, and Gennaro Galasso

Subjects
clinical outcome, right ventricular function, transcatheter aortic valve implantation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Whether the presence of right ventricular (RV) dysfunction may influence the clinical outcome of patients with low‐flow, low‐gradient aortic stenosis (LFLG‐AS) undergoing transcatheter aortic valve replacement (TAVR) has not yet been established. Methods and Results This study included consecutive patients with LFLG‐AS undergoing TAVR at 2 high‐volume Italian centers. RV dysfunction before TAVR procedure was defined as tricuspid annular plane systolic excursion assessed by transthoracic echocardiography lower than

Published
2024
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2. Transcatheter Mitral Valve Repair With the MitraClip Device for Prior Mitral Valve Repair Failure: Insights From the GIOTTO‐FAILS Study

Author

Arturo Giordano, Paolo Ferraro, Filippo Finizio, Nicola Corcione, Michele Cimmino, Giuseppe Biondi‐Zoccai, Paolo Denti, Antonio Popolo Rubbio, Anna Sonia Petronio, Antonio L. Bartorelli, Annalisa Mongiardo, Salvatore Giordano, Francesco De Felice, Marianna Adamo, Matteo Montorfano, Cesare Baldi, Giuseppe Tarantini, Francesco Giannini, Federico Ronco, Ida Monteforte, Emmanuel Villa, Maurizio Ferrario, Luigi Fiocca, Fausto Castriota, Angelo Squeri, Corrado Tamburino, and Francesco Bedogni

Subjects
MitraClip, mitral regurgitation, mitral valve repair, transcatheter edge‐to‐edge repair, transcatheter mitral valve repair, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Minimally invasive mitral valve repair has a favorable risk–benefit profile in patients with significant de novo mitral regurgitation. Its role in patients with prior mitral valve repair is uncertain. We aimed to appraise the outcome of patients undergoing transcatheter edge‐to‐edge repair (TEER) with prior transcatheter or surgical mitral valve repair (SMVR). Methods and Results We queried the Italian multicenter registry on TEER with MitraClip, distinguishing naïve patients from those with prior TEER or (SMVR). Inhospital and long‐term clinical/echocardiographic outcomes were appraised. The primary outcome was the occurrence of death or rehospitalization for heart failure. A total of 2238 patients were included, with 2169 (96.9%) who were naïve to any mitral intervention, 29 (1.3%) with prior TEER, and 40 (1.8%) with prior SMVR. Several significant differences were found in baseline clinical and imaging features. Respectively, device success was obtained in 2120 (97.7%), 28 (96.6%), and 38 (95.0%, P=0.261) patients; procedural success in 2080 (95.9%), 25 (86.2%), and 38 (95.0%; P=0.047); and inhospital death in 61 (2.8%), 1 (3.5%), and no (P=0.558) patients. Clinical follow‐up after a mean of 14 months showed similar rates of death, cardiac death, rehospitalization, rehospitalization for heart failure, and their composite (all P>0.05). Propensity score–adjusted analysis confirmed unadjusted analysis, with lower procedural success for the prior TEER group (odds ratio, 0.28 [95% CI, 0.09–0.81]; P=0.019) but similar odds ratios and hazard ratios for all other outcomes in the naïve, TEER, and SMVR groups (all P>0.05). Conclusions In carefully selected patients, TEER can be performed using the MitraClip device even after prior TEER or SMVR.

Published
2024
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3. The rare entity of gastrointestinal leiomyosarcomas: An Italian multicenter retrospective study in high‐volume referral centers

Author

Paola Zagami, Alessandro Comandone, Marco Fiore, Giacomo Giulio Baldi, Giovanni Grignani, Bruno Vincenzi, Alessandro Gronchi, Gabriele Antonarelli, Antonella Boglione, Elisabetta Pennacchioli, Giuseppe Curigliano, Fabio Conforti, and Tommaso Martino De Pas

Subjects
gastrointestinal leiomyosarcoma, localized disease, metastatic de novo disease, multidisciplinary, rare tumors, sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background After a huge efficacy of imatinib in treating patients with gastrointestinal stromal tumors (GISTs) was proven, a maximum effort was made to make a differential diagnosis between GISTs and gastrointestinal leiomyosarcomas (GI‐LMS), showing the latter to be an extremely rare tumor entity. Limited data on GI‐LMS biology, clinical behavior and drug‐sensibility are available, and the clinical decision‐making in this subgroup of patients is usually challenging. Methods We conducted a multicenter, retrospective observational study on patients with diagnosed GI‐LMS from 2004 to 2020 within six high‐volume referral centers in Italy. Results Thirty‐three patients had diagnosis of KIT‐negative GI‐LMS confirmed by sarcoma‐expert pathologist. The most common site of origin was the intestine. Twenty‐two patients had localized disease and underwent surgery: with a median follow‐up of 72 months, median disease‐free survival was 42 months. Overall survival (OS)‐rate at 5 years was 73% and median OS was 193 months. Five out of 10 patients with local relapse received a salvage surgery, and 2/5 remained with no evidence of disease. Thirteen patients received neoadjuvant (6) or adjuvant (7) chemotherapy, and 2/13 patients remained free from relapse. The median OS for patients with metastatic LMS was 16.4 months. Conclusion GI‐LMS is very rare and extremely aggressive subgroup of sarcomas with a high tendency to systemic spread. Localized GI‐LMS at diagnosis may be cured if treated with adequate surgery with or without (neo) adjuvant chemotherapy, while de‐novo metastatic disease appeared to have a poor prognosis. Clinical effort to understand GI‐LMS biology and clinical behavior and to develop active treatment strategy, especially for metastatic‐disease, is warranted.

Published
2023
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4. The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament

Author

Fergus M. Payne, Samantha Nie, Gary M. Diffee, Gerard T. Wilkins, David S. Larsen, Joanne C. Harrison, James C. Baldi, and Ivan A. Sammut

Subjects
calcium sensitivity, carbon monoxide, heme, myofilament, Physiology, QP1-981
Abstract

Abstract Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low‐dose carbon monoxide (CO) induces inotropic effects in perfused hearts. Using the CO‐releasing pro‐drug, oCOm‐21, we investigated if this inotropic effect results from an increase in myofilament Ca2+ sensitivity. Male Sprague Dawley rat left ventricular cardiomyocytes were permeabilized, and myofilament force was measured as a function of ‐log [Ca2+] (pCa) in the range of 9.0–4.5 under five conditions: vehicle, oCOm‐21, the oCOm‐21 control BP‐21, and levosimendan, (9 cells/group). Ca2+ sensitivity was assessed by the Ca2+ concentration at which 50% of maximal force is produced (pCa50). oCOm‐21, but not BP‐21 significantly increased pCa50 compared to vehicle, respectively (pCa50 5.52 vs. 5.47 vs. 5.44; p

Published
2024
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7. Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review

Author

Magyar, Christian Tibor Josef, primary, Gretener, Charlene Pierrine, additional, Baldi, Patricia, additional, Storni, Federico, additional, Kim‐Fuchs, Corina, additional, Candinas, Daniel, additional, Berzigotti, Annalisa, additional, Knecht, Matthias, additional, Beldi, Guido, additional, Hirzel, Cédric, additional, Sidler, Daniel, additional, Reineke, David, additional, and Banz, Vanessa, additional

Published
2024
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10. Lung perfusion assessment in children with long-COVID: A pilot study

Author

Pizzuto, D. A., Buonsenso, Danilo, Morello, R., De Rose, Cristina, Valentini, Piero, Fragano, A., Baldi, Fabiana, Di Giuda, Daniela, Buonsenso D., De Rose C., Valentini P. (ORCID:0000-0001-6095-9510), Baldi F., Di Giuda D. (ORCID:0000-0002-5758-3986), Pizzuto, D. A., Buonsenso, Danilo, Morello, R., De Rose, Cristina, Valentini, Piero, Fragano, A., Baldi, Fabiana, Di Giuda, Daniela, Buonsenso D., De Rose C., Valentini P. (ORCID:0000-0001-6095-9510), Baldi F., and Di Giuda D. (ORCID:0000-0002-5758-3986)

Abstract

BackgroundThere is increasing evidence that chronic endotheliopathy can play a role in patients with Post-Covid Condition (PCC, or Long Covid) by affecting peripheral vascularization. This pilot study aimed at assessing lung perfusion in children with Long-COVID with Tc-99m-MAA SPECT/CT. Materials and Methodslung Tc-99m-MAA SPECT/CT was performed in children with Long-COVID and a pathological cardiopulmonary exercise testing (CPET). Intravenous injections were performed on patients in the supine position immediately before the planar scan according to the EANM guidelines for lung scintigraphy in children, followed by lung SPECT/CT acquisition. Reconstructed studies were visually analyzed. ResultsClinical and biochemical data were collected during acute infection and follow-up in 14 children (6 females, mean age: 12.6 years) fulfilling Long-COVID diagnostic criteria and complaining of chronic fatigue and postexertional malaise after mild efforts, documented by CPET. Imaging results were compared with clinical scenarios during acute infection and follow-up. Six out of 14 (42.8%) children showed perfusion defects on Tc-99m-MAA SPECT/CT scan, without morphological alterations on coregistered CT. ConclusionsThis pilot investigation confirmed previous data suggesting that a small subgroup of children can develop lung perfusion defects after severe acute respiratory syndrome coronavirus 2 infection. Larger cohort studies are needed to confirm these preliminary results, providing also a better understanding of which children may deserve this test and how to manage those with lung perfusion defects.

Published
2023

11. Alterations of circulating free fatty acids in patients with pemphigus vulgaris

Author

Maglie, Roberto, primary, Baldi, Simone, additional, Nannini, Giulia, additional, Di Gloria, Leandro, additional, Pallecchi, Marco, additional, Bartolucci, Gianluca, additional, Ramazzotti, Matteo, additional, Niccolai, Elena, additional, Baffa, Maria Efenesia, additional, Camilla, Biagioni, additional, Solimani, Farzan, additional, Antiga, Emiliano, additional, and Amedei, Amedeo, additional

Published
2024
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13. Simulated annealing for balancing covariates

Author

Alessandro Baldi Antognini, Novelli Marco, Maroussa Zagoraiou, Baldi Antognini, Alessandro, Novelli, Marco, and Zagoraiou, Maroussa

Subjects
covariate-adaptive procedures, loss of information, mahalanobis distance, rerandomization, treatment comparisons, Statistics and Probability, Epidemiology
Abstract

Covariate balance is one of the fundamental issues in designing experiments for treatment comparisons, especially in randomized clinical trials. In this article, we introduce a new class of covariate-adaptive procedures based on the Simulated Annealing algorithm aimed at balancing the allocations of two competing treatments across a set of pre-specified covariates. Due to the nature of the simulated annealing, these designs are intrinsically randomized, thus completely unpredictable, and very flexible: they can manage both quantitative and qualitative factors and be implemented in a static version as well as sequentially. The properties of the suggested proposal are described, showing a significant improvement in terms of covariate balance and inferential accuracy with respect to all the other procedures proposed in the literature. An illustrative example based on real data is also discussed.

Published
2023
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14. Health orientation and individual tendencies of a sample of Italian genetic testing consumers

Author

Serena Oliveri, Ilaria Durosini, Ilaria Cutica, Clizia Cincidda, Francesca Spinella, Marina Baldi, Alessandra Gorini, and Gabriella Pravettoni

Subjects
decision‐making, genetic testing, health orientation, public health, risk propensity, Genetics, QH426-470
Abstract

Abstract Background Over the last decade, genetic testing (GT) had markedly spread in European countries and struggled the debate concerning the psychological effects on the population. The aim of this study was to investigate the individual tendencies of GT consumers in a sample of Italian citizens. Methods A total of 152 Italian clients from GenomaLab, a private genetic company, were enrolled from February 2016 to September 2018 and completed an ad hoc survey. Results Results showed that GT consumers were motivated to preserve their well‐being, they felt responsible for their health, they were neither pessimistic nor optimistic toward negative occurrences, and poorly inclined to take high risks in their lives. Participants who had suffered from a disease in the past appear to be less tolerant to the uncertainty for future negative events. Conclusion Our results depict Italian GT consumers as health‐oriented, focused on prevention, who do not have a pessimistic perception of their condition but do not like to “bet” on their health, and probably their intention (and belief) is to acquire genetic information in order to reduce uncertainty and increase their decision‐making “power” related to their health. Taken together, all these results contribute to describe the population of GT users in European countries, to regulate the provision of GT results and to entail the communication of genetic risk information based on a consumers’ personal profile.

Published
2020
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21. An international assessment of the adoption of enhanced recovery after surgery (ERAS®) principles across colorectal units in 2019–2020

Author

Pinkney T., Taylor H., Tong C., Schmitz N. -D., Morton D. G., Pinkney T. D., Bhangu A., Blackwell S., Dardanov D., Dulskas A., Gallo G., Glasbey J., Keatley J., Knowles C., Li Y. E., McCourt V., Minaya-Bravo A., Neary P., Nepogodiev D., Pata F., Pellino G., Sivrikoz E., van Ramshorst G., Zmora O., Perry R., Magill E. L., Abdalkoddus M., Abelevich A., Abraham S., Abraham-Nordling M., Adamina M., Agalar C., Agresta F., Ahallat M., Ahmad N., Aiupov R., Akca O., Aleksic A., Aleotti F., Alias D., Alonso J., Alonso Goncalves S., Alonso Martin J., Alonso Poza A., Alonso-Hernandez N., Alos Company R., Al-Saeedi M., Alvarez-Laso C., Alvarez-Gallego M., Amanatidis T., Americano M., Amorim E., Anandan L., Anania G., Ancans G., Andreev P., Andrejevic P., Antonacci N., Anwer M., Aonzo P., Arencibia B., Argeny S., Arieli H., Arnold S., Ashraf M., Aslam M., Atanasov B., Atif M., Atladottir J., Avital S., Awny S., Aytac B., Azahr N., Aznar-Puig S., Bailey S., Balalis D., Baldi C., Baldonedo R., Balducci G., Balestra F., Balestri R., Balfour A., Baloyiannis I., Banky B., Baral J., Baranyai Z., Barbashinov N., Bargallo J., Barisic G., Barugola G., Batashki I., Battersby N., Belev N., Belli A., Beltran de Heredia J., Bemelman W., Benavides Buleje J., Benckert A., Bernal-Sprekelsen J., Bertocchi E., Beuran M., Bhan C., Bianco F., Bilali S., Bilali V., Bintintan V., Birindelli A., Birsan T., Blanco Antona F., Blas J., Blasco-Segura T., Blom R., Bocchetti T., Boerma E., Bogdan M., Boland M., Bomans B., Borda N., Bowen M., Bradulskis S., Branagan G., Brankovic B., Brenna M., Brewer H., Broadhurst J., Bronder C., Brouwer R., Buccianti P., Buchs N., Buchwald P., Bugatti A., Bui A., Burcos T., Buskens C., Bustamante C., Caceres N., Cagigas Fernandez C., Calero-Lillo A., Camps I., Canda A., Caravaca-Garcia I., Carballo F., Carcoforo P., Carlander J., Carlos S., Caro A., Carpelan A., Carrasco Prats M., Carrillo Lopez M., Carvello M., Casal E., Casoni Pattacini G., Castellvi Valls J., Castillo Diego J., Cavallesco G., Cavenaile V., Cayetano L., Ceccotti A., Cervera-Aldama J., Chabok A., Chafai N., Chandrasinghe P., Chandratreya N., Chaudhri S., Chaudhry Z., Cherdancev D., Chernov A., Chevallay M., Chirletti P., Chouillard E., Chouliaras C., Chowdri N., Cillo M., Cini C., Ciubotaru C., Ciuce C., Claeys D., Cocorullo G., Codina-Cazador A., Colak E., Coletta D., Colombo F., Copaescu C., Corte Real J., Corver M., Cosic J., Costa S., Costa Pereira J., Costa Pereira C., Costa-Navarro D., Cotte E., Cracco N., Cristian D., Cuadrado M., Cuk V., Cunha M., Cunha J., Curinga R., Curletti G., Curtis N., Dabic D., Dainius E., d'Alessandro A., Daniels I., Darvin V., Dauser B., David G., Davidova O., Davies E., de Andres Asenjo B., De franciscis S., de Graaf E., De la Portilla F., De Luca E., De Nisco C., De Toma G., Defoort B., Den Boer F., Di Candido F., Di Saverio S., Diaz Pavon J., Dieguez Fernandez B., Diez-Alonso M., Dimitrijevic I., Dindelegan G., Djuric M., Domingos H., Doornebosch P., Dos Santos M., Drami I., Dudarovaska H., Dusek T., Dzhumabaev H., Eden Y., Egenvall M., Eismiontas V., El Sorogy M., Elgeidie A., Elhemaly M., El-Hussuna A., Ellul S., Elmore U., ElNakeeb A., Elrefai M., Emile S., Enrriquez-Navascues J., Epstein J., Escartin J., Escola D., Escuder J., Espin E., Espina B., Estefania D., Etienne J., Fabbri S., Falato A., Fares R., Farina P., Farkasova M., Farres R., Fasolini F., Fatayer T., Febles G., Feliu F., Feo C., Feoktistov D., Fernandez F., Fernandez Isart M., Fernando J., Ferreira G., Ferrer R., Ferreras Garcia C., Ferri M., Figueiredo N., Finotti E., Fitzgerald J., Flateh Backe I., Flor-Lorente B., Forero-Torres A., Foschi D., Francart D., Francois Y., Frasson M., Freil-Lanter C., Frois Borges M., Fuzun M., Gala T., Galleano R., Galvez P., Galvez Saldana A., Gamundi Cuesta M., Garcia Cabrera A., Garcia Egea J., Garcia Olmo D., Garcia-Gonzalez J., Garcia-Granero A., Garcia-Granero E., Garcia-Septiem J., Gardea A., Garipov M., Gefen R., Geraghty A., Gerkis S., Germanos S., Ghaffari S., Ghilles E., Gianotti L., Gil Santos M., Gilsanz Martin C., Gingert C., Gklavas A., Glehen O., Golda T., Gomez N., Gomez R., Gomez Ruiz M., Gonzalez Santin V., Graham B., Grainger J., Grama F., Gregoir T., Gregori M., Grolich T., Grosek J., Guadalajara H., Guckenheimer S., Guevara J., Gulotta G., Gupta S., Gurevich N., Gurjar S., Haapaniemi S., Hahnloser D., Hamad Y., Hamid M., Hanly A., Harris G., Harsanyi L., Hartig N., Hawkin P., Henriques P., Herbst F., Hermann N., Hernandez Garcia M., Hoch J., Hrora A., Huhtinen H., Iarumov N., Ilkanich A., Insua C., Ioannidis P., Iqbal M., Iqbal A., Isik A., Ismaiel M., Ivlev D., Jadhav V., Jareno S., Jehaes C., Jimenez V., Jimenez-Toscano M., Jimenez-Miramon J., Jimenez-Rodriguez R., Jonsson T., Jotautas V., Julia D., Juloski J., Jung B., Kala Z., Kalayci M., Kara Y., Karachun A., Karagul S., Karvonen J., Katorkin S., Katsoulis I., Katsounis D., Kaubrys M., Kaul N., Kefalou E., Keijzers M., Kelly M., Kenic M., Kennelly R., Khan J., Khan M., Kho H., Kinas V., Knight J., Kocian P., Koeter T., Kokobelyan A., Konsten J., Koolen L., Kosir J., Kostic I., Krdzic I., Kreisler Moreno E., Krivokapic Z., Krstev P., Krsul D., Kumarasinghe N., La Torre F., Labarga F., Ladra M., Lage Laredo A., Lahodzich N., Lai C., Lakkis Z., Lal R., Lamas S., Lang T., Latkauskas T., Lawes D., Lazar G., Lebedev K., Lebedeva M., Lefevre J., Lekic Vitlov V., Lemma M., Leo C., Leon C., Leventoglu S., Levy B., Li L., Licari L., Lizdenis P., Loftas P., Longhi M., Longstaff L., Lopez Dominguez J., Lopez-Lara M., Lora P., Lorenzon L., Lorusso D., Lozev I., Lozoya Trujillo R., Lukic D., Lunins R., Luzan R., Luzzi A., Maderuelo V., Madsboll T., Mahotin D., Majbar M., Makhmudov A., Malik K., Maly O., Mamaloudis I., Mamedli Z., Manatakis D., Mandi D., Mangell P., Marharint T., Mariani N., Maric B., Marimuthu K., Marinello F., Marino F., Markiewicz S., Markovic V., Marom G., Maroni N., Maroulis I., Marsanic P., Marsman H., Martens M., Marti M., Martinek L., Martinez S., Martinez D., Martinez Manzano A., Martins R., Maslyankov S., McArdle K., McDermott F., Mege D., Mehraj A., Mehta A., Mendrila D., Menendez P., Mercantini P., Metwally I., Mikalauskas S., Millan M., Mingoli A., Mirshekar-Syahkal B., Moggia E., Mohan S., Moller P., Mompart Garcia S., Monami B., Moniz Pereira P., Montroni I., Morel P., Moshev B., Mostovoy E., Mothe S., Mukhtar H., Muller P., Munch S., Munoz Camarena J., Munoz-Collado S., Muratore A., Muscara F., Muysoms F., Myrelid P., N. Lah N., Nail S., Narayanan A., Nastos K., Negoi I., Nesbakken A., Nestler G., Nestorovic M., Nesytykh A., Newton K., Ng Y., Ngu J., Nguyen B., Nijs Y., Nikberg M., Nimmersgern T., Nogues E., Norcic G., Nutautiene V., Nygren J., O'Brien J., Ochogavia Segui A., O'Kelly J., Oliveira-Cunha M., Omar W., Omar G., Onishchenko S., Onody P., Opocher E., Orhalmi J., Oshowo A., Otero J., Ozgen U., Pace K., Padin H., Papaconstantinou I., Papadopoulos A., Papadopoulos G., Papandrea M., Paral J., Parc Y., Paredes J., Parmar M., Parra Banos P., Parray F., Pascual Damieta M., Pascual Miguelanez I., Passot G., Pastor C., Paszt A., Patel P., Paterson H., Patron Uriburu J., Paulos A., Pavlov V., Pcolkins A., Pecic V., Pena Ros E., Penkov R., Pera Roman M., Perunicic V., Pery R., Petrovic D., Pezzolla F., Photi E., Pikarsky A., Piramanayagam B., Pisani Ceretti A., Planellas P., Platt E., Pletinckx P., Podda M., Poskus T., Poskus E., Pozdnyakov A., Pravosudov I., Previsic A., Prieto D., Prochazka V., Prodan A., Proud D., Psaila J., Psaras G., Pulighe F., Pullig F., Qureshi M., Rachadell J., Radovanovic Z., Radovanovic D., Raguan B., Rahman M., Raiss M., Ramirez Faraco M., Ramos J., Ramos-Prada J., Rantala A., Rao M., Rasulov A., Ratnatunga K., Raymond T., Refky B., Reggiani L., Regusci L., Reyes Diaz M., Richardson J., Richiteanu G., Rios A., Ris F., Rodriguez Garcia P., Roffi N., Romairone E., Romano G., Romero I., Romero de Diego A., Romero-Simo M., Roque C., Rosati R., Rossi B., Rossi E., Rossini R., Ruano A., Rubbini M., Rubio-Perez I., Ruffo G., Ruiz H., Ruiz Carmona M., Ryska O., Sabia D., Sacchi M., Sacco R., Sakr A., Saladzinskas Z., Salamone G., Salomon M., Salvans Ruiz S., Sammarco G., Sampietro G., Samsonov D., Samsonyuk V., Sanchez J., Sanchez Romero A., Sanchez-Guillen L., Santak G., Santamaria-Olabarrieta M., Santos J., Saraceno F., Saralegui Y., Sarici I., Savino G., Scabini S., Schafli J., Schiltz B., Schofield A., Schon M., Scurtu R., Segalini E., Segelman J., Segura-Sampedro J., Seicean R., Sekulic A., Selniahina L., Seretis F., Serrano Paz P., Shaikh I., Shalaby M., Shams N., Sharma A., Sharma G., Shukla A., Shussman N., Shweejawee Z., Sielezneff I., Sigurdsson H., Sileri P., Silva M., Simcikas D., Simoes J., Simonka Z., Singh B., Sivins A., Skroubis G., Skull A., Slavchev M., Slavin M., Smart N., Smart C., Smart P., Smedh K., Smolarek S., Sokmen S., Sokolov M., Solana Bueno A., Solar L., Sorrentino L., Sotona O., Spacca D., Spinelli A., Stanojevic G., Stearns A., Stefan S., Stift A., Stijns J., Stoyanov V., Straarup D., Strupas K., Stubbs B., Subocius A., Sudlow A., Suero C., Sungurtekin U., Svagzdys S., Syk I., Tamelis A., Tamhane R., Tamini N., Tamosiunas A., Tanis P., Tarasov N., Tate S., Tennakoon A., Teo N., Terzi C., Tezas S., Thabet W., Tham J., Thavanesan N., Theodosopoulos T., Thomas W., Tiret E., Tiselius C., Todorov G., Tomazic A., Tomulescu V., Torkington J., Totis M., Trostchansky I., Truan N., Tulchinsky H., Tutino R., Tzivanakis A., Tzovaras G., Ugolini G., Unger L., Upanishad I., Urbani L., Uth Ovesen A., Vaizey C., Vallribera F., Valsdottir E., Valverde I., Valverde-Sintas J., Van Belle K., Van Cleven S., van Hagen P., van Loon Y., van Ruler O., Van Wijck K., Varabei A., Varcada M., Varpe P., Vartic M., Velchuru V., Vencius J., Venskutonis D., Vercher D., Vermaas M., Vertruyen M., Verza L., Vescio G., Vezakis A., Vieira P., Vignali A., Vigorita V., Vila Tura M., Vinson-Bonnet B., Viso Pons L., Voloshin S., Voronin Y., Vukusic L., Wang X., Wang J., Wani R., Warusavitarne J., Wasserberg N., Weerts J., Weiss D., Weizman A., Westerduin E., Wheat J., White I., Wik T., Wilson J., Winter D., Wolthuis A., Wong M., Yahia S., Yamamoto T., Yanishev A., Yao C., Yildiz A., Yuksel O., Zain Z., Zakaria A., Zakaria Z., Zampitis N., Zarand A., Zarco-Pleguezuelos A., Zattoni D., Zelic M., Zeromskas P., Zhuravlev A., Zimmerman D., Zuhdy M., Zukanovic G., Surgery, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Methodology, APH - Personalized Medicine, Pinkney, T, Taylor, H, Tong, C, Schmitz, N, Morton, D, Bhangu, A, Blackwell, S, Dardanov, D, Dulskas, A, Gallo, G, Glasbey, J, Keatley, J, Knowles, C, Li, Y, Mccourt, V, Minaya-Bravo, A, Neary, P, Nepogodiev, D, Pata, F, Pellino, G, Sivrikoz, E, van Ramshorst, G, Zmora, O, Perry, R, Magill, E, Abdalkoddus, M, Abelevich, A, Abraham, S, Abraham-Nordling, M, Adamina, M, Agalar, C, Agresta, F, Ahallat, M, Ahmad, N, Aiupov, R, Akca, O, Aleksic, A, Aleotti, F, Alias, D, Alonso, J, Alonso Goncalves, S, Alonso Martin, J, Alonso Poza, A, Alonso-Hernandez, N, Alos Company, R, Al-Saeedi, M, Alvarez-Laso, C, Alvarez-Gallego, M, Amanatidis, T, Americano, M, Amorim, E, Anandan, L, Anania, G, Ancans, G, Andreev, P, Andrejevic, P, Antonacci, N, Anwer, M, Aonzo, P, Arencibia, B, 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Subjects
medicine.medical_specialty, Prehabilitation, medicine.medical_treatment, MEDLINE, Colorectal Neoplasm, Perioperative Care, NO, medicine, Humans, 03.02. Klinikai orvostan, Perioperative Optimisation, Enhanced recovery after surgery, Digestive System Surgical Procedures, LS7_4, Enhanced Recovery After Surgery (ERAS), business.industry, Gastroenterology, Digestive System Surgical Procedure, Guideline, Colorectal surgery, Surgery, Family medicine, Perioperative care, Nasogastric intubation, Preoperative fasting, Colorectal Neoplasms, Enhanced Recovery After Surgery, business, Colorectal Surgery, Human
Abstract

Aim The Enhanced Recovery After Surgery (ERAS® ) Society guidelines aim to standardise perioperative care in colorectal surgery via 25 principles. We aimed to assess the variation in uptake of these principles across an international network of colorectal units. Method An online survey was circulated amongst European Society of Coloproctology members in 2019/20. For each ERAS® principle, respondents were asked to score how frequently the principle was implemented in their hospital, from 1 ('rarely') to 4 ('always'). Respondents were also asked to recall whether practice had changed since 2017. Subgroup analyses based on hospital characteristics were conducted. Results Of hospitals approached, 58% responded to the survey (195/335), with 296 individual responses (multiple responses were received from some hospitals). The majority were European (163/195 [83.6%]). Overall, respondents indicated they 'most often' or 'always' adhered to most individual ERAS® principles (18/25 [72%]). Variability in uptake of principles was reported, with universal uptake of some principles (e.g., prophylactic antibiotics; early mobilisation) and inconsistency from 'rarely' to 'always' in others (e.g., no nasogastric intubation; no preoperative fasting and carbohydrate drinks). In alignment with 2018 ERAS® guideline updates, adherence to principles for prehabilitation, managing anaemia, and postoperative nutrition appears to have increased since 2017. Conclusions Uptake of ERAS® principles varied across hospitals, and not all 25 principles were equally adhered to. Whilst some principles exhibited a high level of acceptance, others had a wide variability in uptake indicative of controversy or barriers to uptake. Further research into specific principles is required to improve ERAS® implementation.

Published
2021
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27. The rare entity of gastrointestinal leiomyosarcomas: An Italian multicenter retrospective study in high‐volume referral centers

Author

Zagami, Paola, primary, Comandone, Alessandro, additional, Fiore, Marco, additional, Baldi, Giacomo Giulio, additional, Grignani, Giovanni, additional, Vincenzi, Bruno, additional, Gronchi, Alessandro, additional, Antonarelli, Gabriele, additional, Boglione, Antonella, additional, Pennacchioli, Elisabetta, additional, Curigliano, Giuseppe, additional, Conforti, Fabio, additional, and De Pas, Tommaso Martino, additional

Published
2023
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28. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Prostate‐vesicular transrectal ultrasound reference ranges and associations with clinical, seminal and biochemical characteristics

Author

Francesco Lotti, Francesca Frizza, Giancarlo Balercia, Arcangelo Barbonetti, Hermann M. Behre, Aldo E. Calogero, Jann‐Frederik Cremers, Felice Francavilla, Andrea M. Isidori, Sabine Kliesch, Sandro La Vignera, Andrea Lenzi, Marios Marcou, Adrian Pilatz, Olev Poolamets, Margus Punab, Maria Fernanda Peraza Godoy, Claudia Quintian, Osvaldo Rajmil, Gianmaria Salvio, Osama Shaeer, Wolfgang Weidner, Elisa Maseroli, Sarah Cipriani, Elisabetta Baldi, Selene Degl'Innocenti, Giovanna Danza, Anna Lucia Caldini, Alessandro Terreni, Luca Boni, Csilla Krausz, and Mario Maggi

Subjects
Male, Urology, Endocrinology, Diabetes and Metabolism, Healthy, fertile men, clinical, seminal, hormonal and metabolic parameters, prostate and seminal vesicles reference ranges and normative parameters, transrectal ultrasound, seminal, clinical, Endocrinology, clinical seminal hormonal and metabolic parameters, Pregnancy, Reference Values, Semen, Humans, Andrology, Child, Ultrasonography, Healthy, fertile men, Prostate, Seminal Vesicles, Ejaculatory Ducts, Reproductive Medicine, Healthy fertile men, Female, clinical seminal hormonal and metabolic parameters, Healthy fertile men, prostate and seminal vesicles reference ranges and normative parameters, transrectal ultrasound, hormonal and metabolic parameters
Abstract

Transrectal ultrasound (TRUS) parameters are not standardized, especially in men of reproductive age. Hence, the European Academy of Andrology (EAA) promoted a multicenter study to assess the TRUS characteristics of healthy-fertile men (HFM) to establish normative parameters.To report and discuss the prostate and seminal vesicles (SV) reference ranges and characteristics in HFM and their associations with clinical, seminal, biochemical parameters.188 men (35.6 ± 6.0 years) from a cohort of 248 HFM were studied, evaluating, on the same day, clinical, biochemical, seminal, TRUS parameters following Standard Operating Procedures.TRUS reference ranges and characteristics of the prostate and SV of HFM are reported herein. The mean PV was ∼25 ml. PV lower and upper limits were 15 and 35 ml, defining prostate hypotrophy and enlargement, respectively. PV was positively associated with age, waistline, current smoking (but not with T levels), seminal volume (and negatively with seminal pH), prostate inhomogeneity, macrocalcifications, calcification size and prostate arterial parameters, SV volume before and after ejaculation, deferential and epididymal size. Prostate calcifications and inhomogeneity were frequent, while midline prostatic cysts were rare and small. Ejaculatory duct abnormalities were absent. Periprostatic venous plexus size was positively associated with prostate calcifications, SV volume and arterial peak systolic velocity. Lower and upper limits of SV anterior-posterior diameter after ejaculation were 6 and 16 mm, defining SV hypotrophy or dilation, respectively. SV total volume before ejaculation and delta SV total volume (DSTV) positively correlated with ejaculate volume, and DSTV correlated positively with sperm progressive motility. SV total volume after ejaculation was associated negatively with SV ejection fraction and positively with distal ampullas size. SV US abnormalities were rare. No association between TRUS and time to pregnancy, number of children or history of miscarriage was observed.The present findings will help in better understanding male infertility pathophysiology and the meaning of specific TRUS findings.

Published
2022
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29. Integration analyses of structural variations and differential gene expression associated with beef fatty acid profile in Nellore cattle

Author

Mariana Piatto Berton, Marcos Vinícius Antunes de Lemos, Nedenia Bonvino Stafuzza, Larissa Fernanda Simielli Fonseca, Danielly Beraldo dos Santos Silva, Elisa Peripolli, Angélica S. C. Pereira, Ana Fabricia Braga Magalhães, Lucia G. Albuquerque, and Fernando Baldi

Subjects
Phenotype, Genotype, Fatty Acids, Genetics, Animals, Gene Expression, Reproducibility of Results, Cattle, Animal Science and Zoology, General Medicine, GENÉTICA ANIMAL
Abstract

This study aimed to integrate analyses of structural variations and differentially expressed genes (DEGs) associated with the beef fatty acid (FA) profile in Nellore cattle. Copy numbers variation (CNV) detection was performed using the penncnv algorithm and CNVRuler software in 3794 genotyped animals through the High-Density Bovine BeadChip. In order to perform the genomic wide association study (GWAS), a total of 963 genotyped animals were selected to obtain the intramuscular lipid concentration and quantify the beef FA profile. A total of 48 animals belonging to the same farm and management lot were extracted from the 963 genotyped and phenotyped animals to carry out the transcriptomic and differentially expressed gene analyses. The GWAS with extreme groups of FA profiles was performed using a logistic model. A total of 43, 42, 66 and 35 significant CNV regions (p 0.05) for saturated, monounsaturated, polyunsaturated and omega 3 and 6 fatty acids were identified respectively. The paired-end sequencing of 48 samples was performed using the Illumina HiSeq2500 platform. Real-time quantitative PCR was used to validate the DEGs identified by RNA-seq analysis. The results showed several DEGs associated with the FA profile of Longissimus thoracis, such as BSCL2 and SAMD8. Enriched terms as the cellular response to corticosteroid (GO:0071384) and glucocorticoid stimulus (GO:0071385) could be highlighted. The identification of structural variations harboring candidate genes for beef FA must contribute to the elucidation of the genetic basis that determines the beef FA composition of intramuscular fat in Nellore cattle. Our results will contribute to the identification of potential biomarkers for complex phenotypes, such as the FA profile, to improve the reliability of the genomic predictions including pre-selected variants using differentiated weighting in the genomic models.

Published
2022
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30. Postprocedural trans‐mitral gradient in patients with degenerative mitral regurgitation undergoing mitral valve transcatheter edge‐to‐edge repair

Author

De Felice, Francesco, primary, Paolucci, Luca, additional, Musto, Carmine, additional, Cifarelli, Alberta, additional, Coletta, Silvio, additional, Pennacchi, Mauro, additional, Stio, Rocco, additional, Gabrielli, Domenico, additional, Grasso, Carmelo, additional, Tamburino, Corrado, additional, Adamo, Marianna, additional, Denti, Paolo, additional, Giordano, Arturo, additional, De Marco, Federico, additional, Montorfano, Matteo, additional, Baldi, Cesare, additional, Mongiardo, Annalisa, additional, Monteforte, Ida, additional, Maffeo, Diego, additional, Giannini, Cristina, additional, Crimi, Gabriele, additional, Tarantini, Giuseppe, additional, Popolo Rubbio, Antonio, additional, and Bedogni, Francesco, additional

Published
2023
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37. Characterization of novel lncRNA muscle expression profiles associated with meat quality in beef cattle

Author

Maria Malane Magalhães Muniz, Larissa Fernanda Simielli Fonseca, Daiane Cristina Becker Scalez, Aroa Suarez Vega, Danielly Beraldo dos Santos Silva, Jesus Aparecido Ferro, Artur Loyola Chardulo, Fernando Baldi, Angela Cánovas, Lucia Galvão Albuquerque, Universidade Estadual Paulista (UNESP), University of Guelph, and National Council for Scientific and Technological Development (CNPq)

Subjects
tenderness, lincRNA, Genetics, genic lncRNA, RNA-Seq, General Agricultural and Biological Sciences, marbling, Ecology, Evolution, Behavior and Systematics
Abstract

Made available in DSpace on 2022-05-01T15:46:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The aim of this study was to identify novel lncRNA differentially expressed (DE) between divergent animals for beef tenderness and marbling traits in Nellore cattle. Longissimus thoracis muscle samples from the 20 most extreme bulls (of 80 bulls set) for tenderness, tender (n = 10) and tough (n = 10) groups, and marbling trait, high (n = 10) and low (n = 10) groups were used to perform transcriptomic analysis using RNA-Sequencing. For tenderness, 29 lncRNA were DE (p-value ≤ 0.01) in tough beef animals in relation to tender beef animals. We observed that genic lncRNAs, for example, lncRNA_595.1, were overlapping exonic part of the PICK gene, while lncRNA_3097.2 and lncRNA_3129.5 overlapped intronic part of the genes GADL1 and PSMD6. The lncRNA associated with PICK1, GADL1, and PMD6 genes were enriched in the pathways associated with the ionotropic glutamate receptor, gamma-aminobutyric acid synthesis, and the ubiquitin–proteasome pathway. For marbling, 50 lncRNA were DE (p-value ≤ 0.01) in high marbling group compared with low marbling animals. The genic lncRNAs, such as lncRNA_3191.1, were overlapped exonic part of the ITGAL gene, and the lncRNA_512.1, lncRNA_3721.1, and lncRNA_41.4 overlapped intronic parts of the KRAS and MASP1 genes. The KRAS and ITGAL genes were enriched in pathways associated with integrin signaling, which is involved in intracellular signals in response to the extracellular matrix, including cell form, mobility, and mediates progression through the cell cycle. In addition, the lincRNAs identified to marbling trait were associated with several genes related to calcium binding, muscle hypertrophy, skeletal muscle, lipase, and oxidative stress response pathways that seem to play a role important in the physiological processes related to meat quality. These findings bring new insights to better understand the biology mechanisms involved in the gene regulation of these traits, which will be valuable for a further investigation of the interactions between lncRNA and mRNAs, and of how these interactions may affect meat quality traits. School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), SP Department of Animal Biosciences Centre for Genetic Improvement of Livestock University of Guelph National Council for Scientific and Technological Development (CNPq), SP College of Veterinary and Animal Science São Paulo State University (Unesp), SP School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), SP College of Veterinary and Animal Science São Paulo State University (Unesp), SP

Published
2022
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39. An insight into the patterns and controls of the structure of South America n Chaco woodlands

Author

Antonella Ferraina, Germán Baldi, Diego Abelleyra, Javier Grosfeld, and Santiago Verón

Subjects
Formación Boscosa, Temperature, LIDAR Technology, Soil Science, Precipitation, Dry Forest, Temperatura, Development, Canopy Height, Terrestrial Laser Scanner, Tecnología LIDAR, Escáner Láser Terrestre, Precipitación Atmosférica, Land Use, Región Chaqueña, Environmental Chemistry, Bosque Seco, Woodlands, Altura del Dosel, Utilización de la Tierra, General Environmental Science
Abstract

Logging, grazing, wood extraction, and anthropogenic fires are pervasive throughout the subtropical dry vegetation of South America leading to changes in woodlands structure and ultimately its degradation. The Chac ohaco biome encompasses the second-largest forest in South America and has a long history of intensive use. We sought to characterize the structure and heterogeneity of its woodlands across biogeo graphic subunits and climatic gradients, and evaluate structure controls. We quantified canopy height, cover, vertical complexity, vegetation amount above 3 m and total veg etation amount over 58 woodlands within the Argentinean Chaco by means of terres trial laser scanner. We assessed the relationship between three groups near the maximum, average and minimum values of each structural variable and precipitation, temperature and temperature of the coldest month using quantile regressions. We found large variability in structural attributes within each biogeographical subunit, showing woodland areas with similar structure across broad gradients of climate. This suggests a considerable impact of current and past land use in shaping woodland struc tures across the Chaco. Overall, structural variables were positively associated with precipitation and temperature, albeit more strongly to the former, except for canopy height, which showed a strong association with mean temperature of the coldest month. We hypothesize that land-use impact on woodland structure decreases with increasing precipitation, as the lack of water may limit the recovery of vegetation struc ture. Our results contribute to a better understanding of variation in key structural vari ables of Chaco woodlands in relation to climate and land use. Fil: Ferraina, Antonella. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; Argentina Fil: Baldi, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Matemática Aplicada de San Luis. Grupo de Estudios Ambientales; Argentina. Universidad Nacional de San Luis; Argentina Fil: Abelleyra, D. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; Argentina Fil: Grosfeld, Javier Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico y Tecnológico Patagonia Norte; Argentina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina Fil: Verón, S. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; Argentina

Published
2022
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40. Postprocedural trans-mitral gradient in patients with degenerative mitral regurgitation undergoing mitral valve transcatheter edge-to-edge repair

Author

Francesco De Felice, Luca Paolucci, Carmine Musto, Alberta Cifarelli, Silvio Coletta, Mauro Pennacchi, Rocco Stio, Domenico Gabrielli, Carmelo Grasso, Corrado Tamburino, Marianna Adamo, Paolo Denti, Arturo Giordano, Federico De Marco, Matteo Montorfano, Cesare Baldi, Annalisa Mongiardo, Ida Monteforte, Diego Maffeo, Cristina Giannini, Gabriele Crimi, Giuseppe Tarantini, Antonio Popolo Rubbio, and Francesco Bedogni

Subjects
MV-TEER, Mitraclip, mitral gradient, mitral regurgitation, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2023

46. Estimates of genetic and phenotypic parameters for feeding behaviour and feed efficiency‐related traits in Nelore cattle

Author

Kava, Rafaela, primary, Peripolli, Elisa, additional, Brunes, Ludmilla C., additional, Espigolan, Rafael, additional, Mendes, Egleu D. M., additional, da Silva Neto, João Barbosa, additional, Londoño‐Gil, Marisol, additional, Sainz, Roberto D., additional, Lobo, Raysildo B., additional, and Baldi, Fernando, additional

Published
2023
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48. Male reproductive system inflammation after healing from coronavirus disease 2019

Author

Simone Morselli, Arcangelo Sebastianelli, Andrea Liaci, Claudia Zaccaro, Alessio Pecoraro, Rossella Nicoletti, Alekseja Manera, Claudio Bisegna, Riccardo Campi, Simona Pollini, Alberto Antonelli, Filippo Lagi, Marco Coppi, Elisabetta Baldi, Sara Marchiani, Sabrina Nicolò, Maria Torcia, Francesco Annunziato, Mario Maggi, Linda Vignozzi, Alessandro Bartoloni, Gian Maria Rossolini, Sergio Serni, and Mauro Gacci

Subjects
Inflammation, Male, Tumor Necrosis Factor-alpha, Urology, Endocrinology, Diabetes and Metabolism, Interleukin-1beta, COVID-19, Genitalia, Male, cytokines, inflammation, men, SARS-CoV-2, Semen Analysis, Endocrinology, Reproductive Medicine, Semen, Sperm Motility, Cytokines, Humans, Prospective Studies, Azoospermia, Retrospective Studies
Abstract

There is evidence that, after severe acute respiratory syndrome coronavirus 2 infection, male reproductive function and semen quality may be damaged OBJECTIVES: To evaluate a panel of inflammatory mediators in semen in patients recovered from coronavirus disease 2019.Sexually active men with previous severe acute respiratory syndrome coronavirus 2 infection and proven recovery from coronavirus disease 2019 were enrolled in a prospective cohort study. Clinical, uro-andrological data and semen specimens were prospectively collected. For previously hospitalized coronavirus disease 2019 patients, data on serum inflammatory markers were retrospectively collected.A total of 43 men were enrolled in the study. Of these, 32 men were normozoospermic, three were oligozoospermic, and eight were crypto-azoospermic. Serum inflammatory markers (procalcitonin and C-reactive protein) were analyzed in previously hospitalized patients both at admission and at peak of infection. Levels at admission were statistically significantly higher in patients resulting in crypto-azoospermic with respect to those resulting in normozoospermic (p = 0.05; p = 0.03 and p = 0.02, respectively) after healing. Seminal cytokine levels were similar among all groups. Interleukin-1β and tumor necrosis factor-α levels were significantly negatively related to sperm total number and concentration, whereas interleukin-4 was correlated with sperm motility.Negative correlations between interleukin-1β and tumor necrosis factor-α and sperm number and the overall high levels of semen cytokines indicate a potential detrimental role of severe acute respiratory syndrome coronavirus 2 driven inflammation on spermatogenesis. Overall, our results indicate that male patients recovering from coronavirus disease 2019 deserve accurate follow-up for their fertility status.

Published
2021
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49. Large‐scale analysis reveals spatiotemporal circadian patterns of cilia transcriptomes in the primate brain

Author

Wedad Alhassen, Siwei Chen, Pierre Baldi, Amal Alachkar, Mohammad Khoudari, and Henry Nguyen

Subjects
Primates, Cilium, Brain, Biology, Circadian Rhythm, Transcriptome, Cellular and Molecular Neuroscience, Basal (phylogenetics), Spatiotemporal gene expression, Databases, Genetic, Basal ganglia, Animals, Humans, Basal body, Cilia, Circadian rhythm, Nerve Net, Prefrontal cortex, Neuroscience
Abstract

Cilia are dynamic subcellular systems, with core structural and functional components operating in a highly coordinated manner. Since many environmental stimuli sensed by cilia are circadian in nature, it is reasonable to speculate that genes encoding cilia structural and functional components follow rhythmic circadian patterns of expression. Using computational methods and the largest spatiotemporal gene expression atlas of primates, we identified and analyzed the circadian rhythmic expression of cilia genes across 22 primate brain areas. We found that around 73% of cilia transcripts exhibited circadian rhythmicity across at least one of 22 brain regions. In 12 brain regions, cilia transcriptomes were significantly enriched with circadian oscillating transcripts, as compared to the rest of the transcriptome. The phase of the cilia circadian transcripts deviated from the phase of the majority of the background circadian transcripts, and transcripts coding for cilia basal body components accounted for the majority of cilia circadian transcripts. In addition, adjacent or functionally connected brain nuclei had large overlapping complements of circadian cilia genes. Most remarkably, cilia circadian transcripts shared across the basal ganglia nuclei and the prefrontal cortex peaked in these structures in sequential fashion that is similar to the sequential order of activation of the basal ganglia-cortical circuitry in connection with movement coordination, albeit on completely different timescales. These findings support a role for the circadian spatiotemporal orchestration of cilia gene expression in the normal physiology of the basal ganglia-cortical circuit and motor control. Studying orchestrated cilia rhythmicity in the basal ganglia-cortical circuits and other brain circuits may help develop better functional models, and shed light on the causal effects cilia functions have on these circuits and on the regulation of movement and other behaviors.

Published
2021
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50. Effect of randomizers on the power spectrum excess of space telemetry signals

Author

Marco Baldi, Gian Paolo Calzolari, Franco Chiaraluce, E. Vassallo, Roberto Garello, and Massimo Battaglioni

Subjects
randomizer, Computer science, business.industry, telemetry, Electrical engineering, Spectral density, power spectrum, Space (mathematics), space links, Telemetry, Media Technology, Electrical and Electronic Engineering, business
Published
2021
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