1. Numerical zero-dimensional hepatic artery hemodynamics model for balloon-occluded transarterial chemoembolization.
- Author
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Aramburu J, Antón R, Rivas A, Ramos JC, Larraona GS, Sangro B, and Bilbao JI
- Subjects
- Blood Flow Velocity, Computer Simulation, Humans, Models, Biological, Pressure, Reproducibility of Results, Vascular Resistance, Balloon Occlusion, Chemoembolization, Therapeutic, Hemodynamics physiology, Hepatic Artery physiology, Numerical Analysis, Computer-Assisted
- Abstract
Balloon-occluded transarterial chemoembolization (B-TACE) is a valuable treatment option for patients with inoperable malignant tumors in the liver. Balloon-occluded transarterial chemoembolization consists of the transcatheter infusion of an anticancer drug mixture and embolic agents. Contrary to conventional TACE, B-TACE is performed via an artery-occluding microballoon catheter, which makes the blood flow to redistribute due to the intra- and extrahepatic arterial collateral circulation. Several recent studies have stressed the importance of the redistribution of blood flow in enhancing the treatment outcome. In the present study, the geometries of a representative hepatic artery and the communicating arcades (CAs) are modeled. An in silico zero-dimensional hemodynamic model is created by characterizing the geometry and the boundary conditions and then is validated in vitro. The role of CAs is assessed by combining 2 cancer scenarios and 2 catheter locations. The importance of the diameter of the CAs is also studied. Results show that occluding a main artery leads to collateral circulation and CAs start to play a role in blood-flow redistribution. In summary, numerical zero-dimensional simulations permit a fast and reliable approach for exploring the blood-flow redistribution caused by the occlusion of a main artery, and this approach could be used during B-TACE planning., (Copyright © 2018 John Wiley & Sons, Ltd.)
- Published
- 2018
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