9 results on '"Balzer, Laura B."'
Search Results
2. Uptake of a patient‐centred dynamic choice model for HIV prevention in rural Kenya and Uganda: SEARCH SAPPHIRE study
- Author
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Kabami, Jane, primary, Kakande, Elijah, additional, Chamie, Gabriel, additional, Balzer, Laura B., additional, Petersen, Maya L., additional, Camlin, Carol S., additional, Nyabuti, Marilyn, additional, Koss, Catherine A., additional, Bukusi, Elizabeth A., additional, Kamya, Moses R., additional, Havlir, Diane V., additional, and Ayieko, James, additional
- Published
- 2023
- Full Text
- View/download PDF
3. Causal inference methods for vaccine sieve analysis with effect modification
- Author
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Yang, Guandong, primary, Balzer, Laura B., additional, and Benkeser, David, additional
- Published
- 2022
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- View/download PDF
4. Uptake and outcomes of a novel community‐based HIV post‐exposure prophylaxis (PEP) programme in rural Kenya and Uganda
- Author
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Ayieko, James, primary, Petersen, Maya L, additional, Kabami, Jane, additional, Mwangwa, Florence, additional, Opel, Fred, additional, Nyabuti, Marilyn, additional, Charlebois, Edwin D, additional, Peng, James, additional, Koss, Catherine A, additional, Balzer, Laura B, additional, Chamie, Gabriel, additional, Bukusi, Elizabeth A, additional, Kamya, Moses R, additional, and Havlir, Diane V, additional
- Published
- 2021
- Full Text
- View/download PDF
5. Defining and estimating effects in cluster randomized trials: A methods comparison.
- Author
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Benitez A, Petersen ML, van der Laan MJ, Santos N, Butrick E, Walker D, Ghosh R, Otieno P, Waiswa P, and Balzer LB
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- Infant, Newborn, Female, Humans, Computer Simulation, Randomized Controlled Trials as Topic, Sample Size, Causality, Cluster Analysis, Premature Birth
- Abstract
Across research disciplines, cluster randomized trials (CRTs) are commonly implemented to evaluate interventions delivered to groups of participants, such as communities and clinics. Despite advances in the design and analysis of CRTs, several challenges remain. First, there are many possible ways to specify the causal effect of interest (eg, at the individual-level or at the cluster-level). Second, the theoretical and practical performance of common methods for CRT analysis remain poorly understood. Here, we present a general framework to formally define an array of causal effects in terms of summary measures of counterfactual outcomes. Next, we provide a comprehensive overview of CRT estimators, including the t-test, generalized estimating equations (GEE), augmented-GEE, and targeted maximum likelihood estimation (TMLE). Using finite sample simulations, we illustrate the practical performance of these estimators for different causal effects and when, as commonly occurs, there are limited numbers of clusters of different sizes. Finally, our application to data from the Preterm Birth Initiative (PTBi) study demonstrates the real-world impact of varying cluster sizes and targeting effects at the cluster-level or at the individual-level. Specifically, the relative effect of the PTBi intervention was 0.81 at the cluster-level, corresponding to a 19% reduction in outcome incidence, and was 0.66 at the individual-level, corresponding to a 34% reduction in outcome risk. Given its flexibility to estimate a variety of user-specified effects and ability to adaptively adjust for covariates for precision gains while maintaining Type-I error control, we conclude TMLE is a promising tool for CRT analysis., (© 2023 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
6. SpiderLearner: An ensemble approach to Gaussian graphical model estimation.
- Author
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Shutta KH, Balzer LB, Scholtens DM, and Balasubramanian R
- Subjects
- Humans, Likelihood Functions, Software, Gene Expression, Ovarian Neoplasms genetics, Algorithms, Normal Distribution
- Abstract
Gaussian graphical models (GGMs) are a popular form of network model in which nodes represent features in multivariate normal data and edges reflect conditional dependencies between these features. GGM estimation is an active area of research. Currently available tools for GGM estimation require investigators to make several choices regarding algorithms, scoring criteria, and tuning parameters. An estimated GGM may be highly sensitive to these choices, and the accuracy of each method can vary based on structural characteristics of the network such as topology, degree distribution, and density. Because these characteristics are a priori unknown, it is not straightforward to establish universal guidelines for choosing a GGM estimation method. We address this problem by introducing SpiderLearner, an ensemble method that constructs a consensus network from multiple estimated GGMs. Given a set of candidate methods, SpiderLearner estimates the optimal convex combination of results from each method using a likelihood-based loss function. K $$ K $$ -fold cross-validation is applied in this process, reducing the risk of overfitting. In simulations, SpiderLearner performs better than or comparably to the best candidate methods according to a variety of metrics, including relative Frobenius norm and out-of-sample likelihood. We apply SpiderLearner to publicly available ovarian cancer gene expression data including 2013 participants from 13 diverse studies, demonstrating our tool's potential to identify biomarkers of complex disease. SpiderLearner is implemented as flexible, extensible, open-source code in the R package ensembleGGM at https://github.com/katehoffshutta/ensembleGGM., (© 2023 John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
7. Adaptive pre-specification in randomized trials with and without pair-matching.
- Author
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Balzer LB, van der Laan MJ, and Petersen ML
- Subjects
- HIV Infections prevention & control, Humans, Male, Probability, Randomized Controlled Trials as Topic, Research Design
- Abstract
In randomized trials, adjustment for measured covariates during the analysis can reduce variance and increase power. To avoid misleading inference, the analysis plan must be pre-specified. However, it is often unclear a priori which baseline covariates (if any) should be adjusted for in the analysis. Consider, for example, the Sustainable East Africa Research in Community Health (SEARCH) trial for HIV prevention and treatment. There are 16 matched pairs of communities and many potential adjustment variables, including region, HIV prevalence, male circumcision coverage, and measures of community-level viral load. In this paper, we propose a rigorous procedure to data-adaptively select the adjustment set, which maximizes the efficiency of the analysis. Specifically, we use cross-validation to select from a pre-specified library the candidate targeted maximum likelihood estimator (TMLE) that minimizes the estimated variance. For further gains in precision, we also propose a collaborative procedure for estimating the known exposure mechanism. Our small sample simulations demonstrate the promise of the methodology to maximize study power, while maintaining nominal confidence interval coverage. We show how our procedure can be tailored to the scientific question (intervention effect for the study sample vs. for the target population) and study design (pair-matched or not). Copyright © 2016 John Wiley & Sons, Ltd., (Copyright © 2016 John Wiley & Sons, Ltd.)
- Published
- 2016
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8. Targeted estimation and inference for the sample average treatment effect in trials with and without pair-matching.
- Author
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Balzer LB, Petersen ML, and van der Laan MJ
- Subjects
- HIV Infections diagnosis, HIV Infections epidemiology, Humans, Likelihood Functions, Randomized Controlled Trials as Topic, Research Design
- Abstract
In cluster randomized trials, the study units usually are not a simple random sample from some clearly defined target population. Instead, the target population tends to be hypothetical or ill-defined, and the selection of study units tends to be systematic, driven by logistical and practical considerations. As a result, the population average treatment effect (PATE) may be neither well defined nor easily interpretable. In contrast, the sample average treatment effect (SATE) is the mean difference in the counterfactual outcomes for the study units. The sample parameter is easily interpretable and arguably the most relevant when the study units are not sampled from some specific super-population of interest. Furthermore, in most settings, the sample parameter will be estimated more efficiently than the population parameter. To the best of our knowledge, this is the first paper to propose using targeted maximum likelihood estimation (TMLE) for estimation and inference of the sample effect in trials with and without pair-matching. We study the asymptotic and finite sample properties of the TMLE for the sample effect and provide a conservative variance estimator. Finite sample simulations illustrate the potential gains in precision and power from selecting the sample effect as the target of inference. This work is motivated by the Sustainable East Africa Research in Community Health (SEARCH) study, a pair-matched, community randomized trial to estimate the effect of population-based HIV testing and streamlined ART on the 5-year cumulative HIV incidence (NCT01864603). The proposed methodology will be used in the primary analysis for the SEARCH trial. Copyright © 2016 John Wiley & Sons, Ltd., (Copyright © 2016 John Wiley & Sons, Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
9. Adaptive pair-matching in randomized trials with unbiased and efficient effect estimation.
- Author
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Balzer LB, Petersen ML, and van der Laan MJ
- Subjects
- Africa, Anti-Retroviral Agents therapeutic use, Computer Simulation, Data Interpretation, Statistical, HIV Infections drug therapy, Humans, Linear Models, Logistic Models, Cluster Analysis, Randomized Controlled Trials as Topic methods, Research Design
- Abstract
In randomized trials, pair-matching is an intuitive design strategy to protect study validity and to potentially increase study power. In a common design, candidate units are identified, and their baseline characteristics used to create the best n/2 matched pairs. Within the resulting pairs, the intervention is randomized, and the outcomes measured at the end of follow-up. We consider this design to be adaptive, because the construction of the matched pairs depends on the baseline covariates of all candidate units. As a consequence, the observed data cannot be considered as n/2 independent, identically distributed pairs of units, as common practice assumes. Instead, the observed data consist of n dependent units. This paper explores the consequences of adaptive pair-matching in randomized trials for estimation of the average treatment effect, conditional the baseline covariates of the n study units. By avoiding estimation of the covariate distribution, estimators of this conditional effect will often be more precise than estimators of the marginal effect. We contrast the unadjusted estimator with targeted minimum loss based estimation and show substantial efficiency gains from matching and further gains with adjustment. This work is motivated by the Sustainable East Africa Research in Community Health study, an ongoing community randomized trial to evaluate the impact of immediate and streamlined antiretroviral therapy on HIV incidence in rural East Africa., (Copyright © 2014 John Wiley & Sons, Ltd.)
- Published
- 2015
- Full Text
- View/download PDF
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