Search

Your search keyword '"Baraldi, E."' showing total 36 results
Start Over Author "Baraldi, E." Publisher wiley
36 results on '"Baraldi, E."'

3. Regular vs prn nebulized treatment in wheeze preschool children

Author

Papi, A., Nicolini, G., Baraldi, E., Boner, A. L., Cutrera, R., Rossi, G. A., Fabbri, Leonardo, and BEclomethasone Study Group, B.

Subjects
Male, Exacerbation, Salbutamol, As needed, Asthma, Beclomethasone, Wheezing, law.invention, administration /&/ dosage/therapeutic use, Randomized controlled trial, law, Bronchodilator, Immunology and Allergy, Medicine, Anti-Asthmatic Agents, Child, Bronchodilator Agents, Treatment Outcome, Inhalation, Child, Preschool, Anesthesia, Administration, Combination, Inhalation, Albuterol, administration /&/ dosage/therapeutic use, Anti-Asthmatic Agents, administration /&/ dosage/therapeutic use, Asthma, drug therapy/physiopathology, Beclomethasone, administration /&/ dosage/therapeutic use, Bronchodilator Agents, administration /&/ dosage/therapeutic use, Child, Preschool, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Glucocorticoids, administration /&/ dosage/therapeutic use, Humans, Infant, Male, Nebulizers and Vaporizers, Respiratory Sounds, drug effects, Treatment Outcome, Drug Therapy, Combination, Female, medicine.symptom, Glucocorticoid, medicine.drug, medicine.medical_specialty, medicine.drug_class, Immunology, Placebo, Drug Administration Schedule, Double-Blind Method, Drug Therapy, Wheeze, Internal medicine, Administration, Inhalation, Humans, Albuterol, Preschool, Glucocorticoids, Respiratory Sounds, business.industry, Nebulizers and Vaporizers, Infant, drug therapy/physiopathology, medicine.disease, drug effects, business
Abstract

Background: International guidelines recommend regular treatment with inhaled glucocorticoids for children with frequent wheezing; however, prn inhaled bronchodilator alone or in combination with glucocorticoid is also often used in practice. We aimed to evaluate whether regular nebulized glucocorticoid plus a prn bronchodilator or a prn nebulized bronchodilator/glucocorticoid combination is more effective than prn bronchodilator alone in preschool children with frequent wheeze. Methods: Double-blind, double-dummy, randomized, parallel-group trial. After a 2-week run-in period, 276 symptomatic children with frequent wheeze, aged 1–4 years, were randomly assigned to three groups for a 3-month nebulized treatment: (1) 400 μg beclomethasone bid plus 2500 μg salbutamol prn; (2) placebo bid plus 800 μg beclomethasone/1600 μg salbutamol combination prn; (3) placebo bid plus 2500 μg salbutamol prn. The percentage of symptom-free days was the primary outcome measure. Secondary outcomes included symptom scores, use of relief medication and exacerbation frequency. Results: As compared with prn salbutamol (61.0 ± 24.83 [SD]), the percentage of symptom-free days was higher with regular beclomethasone (69.6%, SD 20.89; P = 0.034) but not with prn combination (64.9%, SD 24.74). Results were no different in children with or without risk factors for developing persistent asthma. The effect of prn combination was no different from that of regular beclomethasone on the primary and on several important secondary outcomes. Conclusions: Regular inhaled glucocorticoid is the most effective treatment for frequent wheezing in preschool children. However, prn bronchodilator/glucocorticoid combination might be an alternative option, but it requires further study.

Published
2009

6. JAK2 46/1 haplotype is associated with JAK2 V617F - positive myeloproliferative neoplasms in Brazilian patients

Author

Macedo, L. C., primary, Santos, B. C., additional, Pagliarini-e-Silva, S., additional, Pagnano, K. B. B., additional, Rodrigues, C., additional, Quintero, F. C., additional, Ferreira, M. E., additional, Baraldi, E. C., additional, Ambrosio-Albuquerque, E. P., additional, Sell, A. M., additional, and Visentainer, J. E. L., additional

Published
2015
Full Text
View/download PDF

9. International consensus on (ICON) pediatric asthma

Author

Papadopoulos, N. G., primary, Arakawa, H., additional, Carlsen, K.-H., additional, Custovic, A., additional, Gern, J., additional, Lemanske, R., additional, Le Souef, P., additional, Mäkelä, M., additional, Roberts, G., additional, Wong, G., additional, Zar, H., additional, Akdis, C. A., additional, Bacharier, L. B., additional, Baraldi, E., additional, van Bever, H. P., additional, de Blic, J., additional, Boner, A., additional, Burks, W., additional, Casale, T. B., additional, Castro-Rodriguez, J. A., additional, Chen, Y. Z., additional, El-Gamal, Y. M., additional, Everard, M. L., additional, Frischer, T., additional, Geller, M., additional, Gereda, J., additional, Goh, D. Y., additional, Guilbert, T. W., additional, Hedlin, G., additional, Heymann, P. W., additional, Hong, S. J., additional, Hossny, E. M., additional, Huang, J. L., additional, Jackson, D. J., additional, de Jongste, J. C., additional, Kalayci, O., additional, Aït-Khaled, N., additional, Kling, S., additional, Kuna, P., additional, Lau, S., additional, Ledford, D. K., additional, Lee, S. I., additional, Liu, A. H., additional, Lockey, R. F., additional, Lødrup-Carlsen, K., additional, Lötvall, J., additional, Morikawa, A., additional, Nieto, A., additional, Paramesh, H., additional, Pawankar, R., additional, Pohunek, P., additional, Pongracic, J., additional, Price, D., additional, Robertson, C., additional, Rosario, N., additional, Rossenwasser, L. J., additional, Sly, P. D., additional, Stein, R., additional, Stick, S., additional, Szefler, S., additional, Taussig, L. M., additional, Valovirta, E., additional, Vichyanond, P., additional, Wallace, D., additional, Weinberg, E., additional, Wennergren, G., additional, Wildhaber, J., additional, and Zeiger, R. S., additional

Published
2012
Full Text
View/download PDF

34. Induced expression of the Fragaria × ananassa Rapid alkalinization factor‐33‐like gene decreases anthracnose ontogenic resistance of unripe strawberry fruit stages

Author

Francesca Negrini, Elena Baraldi, Maria Cecilia Merino, Annalisa Pession, Dario de Biase, Michela Guidarelli, Merino M.C., Guidarelli M., Negrini F., De Biase D., Pession A., and Baraldi E.

Subjects
0106 biological sciences, 0301 basic medicine, Receptor complex, Colletotrichum acutatum, Hypha, RIPENING, Soil Science, RALF, Plant Science, Biology, Fragaria, 01 natural sciences, COLLETOTRICHUM ACUTATUM, Microbiology, 03 medical and health sciences, Gene expression, Colletotrichum, Molecular Biology, Plant Diseases, Botrytis cinerea, FRAGARIA × ANANASSA, Penicillium, FUNGI, food and beverages, Ripening, Original Articles, purl.org/becyt/ford/4.5 [https], biology.organism_classification, ripening, 030104 developmental biology, Fruit, Original Article, Botrytis, fungi, Penicillium expansum, Fragaria × ananassa, Agronomy and Crop Science, purl.org/becyt/ford/4 [https], 010606 plant biology & botany
Abstract

Rapid alkalinization factor (RALF) genes encode for ubiquitous small peptides that stimulate apoplastic alkalinization through interaction with malectin-like receptor kinase. RALF peptides may act as negative regulators of plant immune response, inhibiting the formation of the signal receptor complex for immune activation. Recently RALF homologues were identified in different fungal pathogen genomes contributing to host infection ability. Here, FaRALF-33-like gene expression was evaluated in strawberry fruits inoculated with Colletotrichum acutatum, Botrytis cinerea, or Penicillium expansum after 24 and 48 h post-infection. To investigate the role of FaRALF-33-like in strawberry susceptibility, transient transformation was used to overexpress it in white unripe fruits and silence it in red ripe fruits. Agroinfiltrated fruits were inoculated with C. acutatum and expression, and histological analysis of infection were performed. Silencing of FaRALF-33-like expression in C. acutatum-inoculated red fruits led to a delay in fruit colonization by the fungal pathogen, and infected tissues showed less penetrated infective hyphae than in wild-type fruits. In contrast, C. acutatum-inoculated white unripe fruits overexpressing the FaRALF-33-like gene decreased the ontogenic resistance of these fruits, leading to the appearance of disease symptoms and penetrated subcuticular hyphae, normally absent in white unripe fruits. The different response of transfected strawberry fruits to C. acutatum supports the hypothesis that the FaRALF-33-like gene plays an important role in the susceptibility of fruits to the fungal pathogen C. acutatum. Fil: Merino, Maria Cecilia. Universidad de Bologna; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Guidarelli, Michela. Universidad de Bologna; Italia Fil: Negrini, Francesca. Universidad de Bologna; Italia Fil: De Biase, Dario. Universidad de Bologna; Italia Fil: Pession, Annalisa. Universidad de Bologna; Italia Fil: Baraldi, Elena. Universidad de Bologna; Italia

Published
2019

35. Metabolomics applied to urine samples in childhood asthma; differentiation between asthma phenotypes and identification of relevant metabolites.

Author

Mattarucchi E, Baraldi E, and Guillou C

Subjects
Asthma classification, Bayes Theorem, Biomarkers urine, Case-Control Studies, Child, Chromatography, Liquid, Dipeptides, Humans, Imidazoles urine, Mass Spectrometry, Metabolomics methods, Multivariate Analysis, Statistics, Nonparametric, Urocanic Acid urine, Asthma urine
Abstract

Asthma is a heterogeneous disorder and one of the most common chronic childhood diseases. An improved characterization of asthma phenotypes would be invaluable for the understanding of the pathogenic mechanisms and the correct treatment of this disease. The aim of this pilot study was to explore the potential of metabolomics applied to urine samples in characterizing asthma, and to identify the most representative metabolites. Urine samples of 41 atopic asthmatic children (further subdivided in sub-groups according to the symptoms) and 12 age-matched controls were analyzed. Untargeted metabolic profiles were collected by LC-MS, and studied by multivariate analysis. The group of the asthmatics was differentiated by a model that proved to be uncorrelated with the chronic assumption of controller drugs on the part of the patients. The distinct sub-groups were also appropriately modeled. Further investigations revealed a reduced excretion of urocanic acid, methyl-imidazoleacetic acid and a metabolite resembling the structure of an Ile-Pro fragment in the asthmatics. The meaning of these findings was discussed and mainly correlated with the modulation of immunity in asthma. Metabolic profiles from urines have revealed the potential to characterize asthma and enabled the identification of metabolites that may have a role in the underlying inflammation., (Copyright © 2011 John Wiley & Sons, Ltd.)

Published
2012
Full Text
View/download PDF

36. Endogenous dopaminergic activity in Child-Pugh A cirrhosis: potential role in renal sodium handling and in the maintenance of clinical compensation.

Author

Sansoè G, Ferrari A, Baraldi E, Grisolia C, De Santis MC, Villa E, and Manenti F

Subjects
Adrenocorticotropic Hormone blood, Adult, Aged, Aldosterone blood, Female, Humans, Liver Cirrhosis blood, Liver Cirrhosis physiopathology, Male, Middle Aged, Renin blood, Renin-Angiotensin System physiology, Dopamine physiology, Kidney metabolism, Liver Cirrhosis metabolism, Sodium metabolism
Abstract

Background: We studied the main determinants of aldosterone secretion in a group of 20 patients with biopsy-proven Child-Pugh A cirrhosis without previous ascites or diuretic consumption., Methods: We evaluated the plasma levels of adrenocorticotrophic hormone (ACTH), active renin and aldosterone (both supine at 07.00 h and after 30 min of upright posture),and active renin and aldosterone responses 30 min and 60 min after the administration of metoclopramide, a dopamine DA2 antagonist (10 mg e.v.). Nine normal subjects were also submitted to the metoclopramide stimulation test., Results: Compared with control subjects, the patients showed significantly greater incremental aldosterone responses both 30 min and 60 min after metoclopramide (+30 min: 157.5+/-73.3 vs. 83.5+/-32.2 pg mL(-1), P< 0003; +60 min: 142.1+/-87.2 vs. 36.8+/-39.0 pg mL(-1), P < 0-001). We found significant positive correlations between amplitude of aldosterone response 30 min after metoclopramide and 24-h urinary fractional excretion of sodium (r=0.61, P < 0.01) and basal morning aldosterone levels (r=0.69, P < 0.001)., Conclusions: The higher incremental aldosterone responses observed after metoclopramide in cirrhotic patients are expressions of increased dopaminergic activity in these patients compared with control subjects. Moreover, the correlation we found between the degree of dopaminergic activity and 24-h urinary fractional excretion of sodium suggests a role for endogenous dopamine as a relevant mediator of natriuresis in cirrhosis, at least in patients with compensated disease.

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results