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Your search keyword '"Cannet, Catherine"' showing total 15 results
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15 results on '"Cannet, Catherine"'

6. In vivo assessments of mucus dynamics in the rat lung using a Gd-Cy5.5-bilabeled contrast agent for magnetic resonance and optical imaging

Author

Blé, François-Xavier, primary, Schmidt, Philipp, additional, Cannet, Catherine, additional, Kneuer, Rainer, additional, Karmouty-Quintana, Harry, additional, Bergmann, Reinhard, additional, Coote, Kevin, additional, Danahay, Henry, additional, Zurbruegg, Stefan, additional, Gremlich, Hans-Ulrich, additional, and Beckmann, Nicolau, additional

Published
2009
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14. Long-term distribution of biodegradable microparticles in rat muscle quantified noninvasively by MRI.

Author

Kameni Tcheudji J, Cannet C, Gérard C, Curdy C, and Beckmann N

Subjects
Animals, Delayed-Action Preparations chemistry, Drug Carriers chemistry, Lactic Acid chemistry, Lactic Acid pharmacokinetics, Male, Models, Chemical, Muscles metabolism, Polyglycolic Acid chemistry, Polyglycolic Acid pharmacokinetics, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Rats, Wistar, Somatostatin analogs & derivatives, Somatostatin chemistry, Somatostatin pharmacokinetics, Delayed-Action Preparations pharmacokinetics, Drug Carriers pharmacokinetics, Magnetic Resonance Imaging methods, Microspheres, Muscles chemistry
Abstract

Purpose: To demonstrate the feasibility of MRI to monitor longitudinally the fate of PLGA microparticles in muscle tissue after intramuscular injection in rats using standard equipment., Methods: MRI was performed at different time points and until day 28 after intramuscular administration of microparticles. Image segmentation was used to quantify the MRI signals. Histology was performed at selected time points to validate the in vivo observations. The SOM230-long acting release formulation was used as test compound., Results: Microparticles were detected in vivo until 28 days following their administration. Imaging and histology data indicated that the MRI signals followed three phases: in an early phase (≤ 48 h after injection), vehicle, edema and hydration of microparticles contributed to the signals. In the second (days 3-17) and third phases (day 17 onward), microparticle hydration was the main contributor. SOM230 in blood displayed peaks at days 2 and 17., Conclusion: MRI was suitable to follow longitudinally the presence of PLGA microparticles in the rat muscle without labeling them. This is advantageous, because labeling could potentially alter the properties and pharmacokinetics of the microparticles. Data were consistent with an initial compound release followed by diffusion and microparticle erosion as main mechanisms of SOM230 release., (© 2015 Wiley Periodicals, Inc.)

Published
2016
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15. Bleomycin-induced lung injury in mice investigated by MRI: model assessment for target analysis.

Author

Babin AL, Cannet C, Gérard C, Saint-Mezard P, Page CP, Sparrer H, Matsuguchi T, and Beckmann N

Subjects
Administration, Intranasal, Alleles, Animals, Cadherins genetics, Dose-Response Relationship, Drug, Female, Genetic Carrier Screening, Genetic Predisposition to Disease, Lung pathology, MAP Kinase Kinase Kinases genetics, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Proto-Oncogene Proteins genetics, Pulmonary Fibrosis genetics, Pulmonary Fibrosis pathology, Sex Factors, Antibiotics, Antineoplastic toxicity, Bleomycin toxicity, Image Enhancement, Image Processing, Computer-Assisted, Lung drug effects, Magnetic Resonance Imaging, Pulmonary Fibrosis chemically induced
Abstract

Magnetic resonance imaging (MRI) has been used to follow the course of bleomycin-induced lung injury in mice and to investigate two knockout mouse lines with the aim of providing potential therapeutic targets. Bleomycin (0.25 mg/kg) was administered intranasally six times, once a day. MRI was carried out on spontaneously breathing animals up to day 70 after bleomycin. Neither cardiac nor respiratory gating was applied during image acquisition. A long lasting response following bleomycin has been detected by MRI in the lungs of male C57BL/6 mice. Histology showed that, from day 14-70 after bleomycin, fibrosis was the predominant component of the injury. Female C57BL/6 mice displayed a smaller response than males. Bleomycin-induced injury was significantly more pronounced in C57BL/6 than in Balb/C mice. MRI and histology demonstrated a protection against bleomycin insult in female heterozygous and male homozygous cancer Osaka thyroid kinase knockout animals. In contrast, no protection was seen in cadherin-11 knockout animals. In summary, MRI can quantify, in spontaneously breathing mice, bleomycin-induced lung injury. With the ability for repetitive measurements in the same animal, the technique is attractive for in vivo target analysis and compound profiling in this murine model., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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