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1. Association of nutrition status and hospital‐acquired infections in older adult orthopedic trauma patients

Author

Oluwaseun Akeju, Marilyn Heng, Esteban Franco-Garcia, Carmen Zhou, Ruben J. Azocar, Sadeq A. Quraishi, and Anni Rong

Subjects
medicine.medical_specialty, 030309 nutrition & dietetics, Nutritional Status, Medicine (miscellaneous), Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Humans, Medicine, General hospital, Elective surgery, Geriatric Assessment, Aged, Retrospective Studies, 0303 health sciences, Hip fracture, Nutrition and Dietetics, business.industry, Malnutrition, Perioperative, medicine.disease, Hospitals, Orthopedic trauma, Nutrition Assessment, Cohort, Emergency medicine, 030211 gastroenterology & hepatology, business
Abstract

Background Poor nutritional status is linked to suboptimal outcomes following elective surgery. Trauma patients do not typically have an opportunity for preoperative nutritional optimization and may be at risk for malnutrition with its related complications. Our goal was to investigate whether nutritional status is associated with development of hospital-acquired infections (HAIs) in elderly, orthopedic trauma patients. Methods We performed a retrospective analysis of data between 01/01/2017 to 08/30/2018 from the Massachusetts General Hospital Geriatric Inpatient Fracture Trauma Service (GIFTS). Admission nutritional status was assessed using the Mini Nutritional Assessment (MNA) and HAIs were validated through the American College of Surgeons National Surgical Quality Improvement Project database. To investigate whether nutritional status is associated with HAIs, we performed a multiple variable logistic regression analysis, controlling for age, sex, Charlson Comorbidity Index, glomerular filtration rate, and type of anesthesia. Results 461 patients comprised the analytic cohort. Multiple variable regression analysis demonstrated that each unit increment in MNA score was associated with a 13% reduction in risk of HAI (OR 0.87; 95%CI 0.79-0.97). Furthermore, adjusting for timing of perioperative antibiotics, perioperative transfusions, or development of pressure injury during hospitalization results did not materially change these results. Conclusion Our results demonstrate that malnutrition is highly prevalent in elderly orthopedic trauma patients and that nutritional status may influence the risk of developing HAIs in this cohort of patients. Further studies are needed to determine whether optimizing perioperative nutritional status in elderly orthopedic trauma patients can reduce infectious complications and improve overall health outcomes. This article is protected by copyright. All rights reserved.

Published
2021
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2. How reproducible are surface areas calculated from the BET equation?

Author

Avcı, Seda Keskin (ORCID 0000-0001-5968-0336 & YÖK ID 40548), Osterrieth, J.W.M., Rampersad, J., Madden, D., Rampal, N., Skoric, L., Connolly, B., Allendorf, M.D., Stavila, V., Snider, J.L., Ameloot, R., Marreiros, J., Ania, C., Azevedo, D., Vilarrasa-Garcia, E., Santos, B.F., Bu, X.H., Chang, Z., Bunzen, H., Champness, N.R., Griffin, S.L., Chen, B., Lin, R.B., Coasne, B., Cohen, S., Moreton, J.C., Colón, Y.J., Chen, L., Clowes, R., Coudert, F.X., Cui, Y., Hou, B., D'Alessandro, D.M., Doheny, P.W., Dinc?, M., Sun, C., Doonan, C., Huxley, M.T., Evans, J.D., Falcaro, P., Ricco, R., Farha, O., Idrees, K.B., Islamoglu, T., Feng, P., Yang, H., Forgan, R.S., Bara, D., Furukawa, S., Sanchez, E., Gascon, J., Telalovi?, S., Ghosh, S.K., Mukherjee, S., Hill, M.R., Sadiq, M.M., Horcajada, P., Salcedo-Abraira, P., Kaneko, K., Kukobat, R., Kenvin, J., Kitagawa, S., Otake, K.I., Lively, R.P., DeWitt, S.J.A., Llewellyn, P., Lotsch, B.V., Emmerling, S.T., Pütz, A.M., Martí-Gastaldo, C., Padial, N.M., García-Martínez, J., Linares, N., Maspoch, D., Suárez Del Pino, J.A., Moghadam, P., Oktavian, R.; Morris, R.E.; Wheatley, P.S.; Navarro, J.; Petit, C.; Danacı, D.; Rosseinsky, M.J.; Katsoulidis, A.P.; Schröder, M.; Han, X.; Yan, S.; Serre, C.; Mouchaham, G.; Sholl, D.S.; Thyagarajan, R.; Siderius, D.; Snurr, R.Q.; Goncalves, R.B.; Telfer, S.; Lee, S.J.; Ting, V.P.; Rowlandson, J.L.; Uemura T, Iiyuka, T.; van derVeen, Monique A.; Rega, Davide; Van Speybroeck, Veronique; Rogge, Sven M. J.; Lamaire, Aran; Walton, Krista S.; Bingel, Lukas W.; Wuttke, Stefan; Andreo, Jacopo; Yaghi, Omar; Zhang, Bing; Yavuz, Cafer T.; Nguyen, Thien S.; Zamora, Felix; Montoro, Carmen; Zhou, Hongcai; Kirchon, Angelo; Fairen-Jimenez, David, College of Engineering, Department of Chemical and Biological Engineering, Avcı, Seda Keskin (ORCID 0000-0001-5968-0336 & YÖK ID 40548), Osterrieth, J.W.M., Rampersad, J., Madden, D., Rampal, N., Skoric, L., Connolly, B., Allendorf, M.D., Stavila, V., Snider, J.L., Ameloot, R., Marreiros, J., Ania, C., Azevedo, D., Vilarrasa-Garcia, E., Santos, B.F., Bu, X.H., Chang, Z., Bunzen, H., Champness, N.R., Griffin, S.L., Chen, B., Lin, R.B., Coasne, B., Cohen, S., Moreton, J.C., Colón, Y.J., Chen, L., Clowes, R., Coudert, F.X., Cui, Y., Hou, B., D'Alessandro, D.M., Doheny, P.W., Dinc?, M., Sun, C., Doonan, C., Huxley, M.T., Evans, J.D., Falcaro, P., Ricco, R., Farha, O., Idrees, K.B., Islamoglu, T., Feng, P., Yang, H., Forgan, R.S., Bara, D., Furukawa, S., Sanchez, E., Gascon, J., Telalovi?, S., Ghosh, S.K., Mukherjee, S., Hill, M.R., Sadiq, M.M., Horcajada, P., Salcedo-Abraira, P., Kaneko, K., Kukobat, R., Kenvin, J., Kitagawa, S., Otake, K.I., Lively, R.P., DeWitt, S.J.A., Llewellyn, P., Lotsch, B.V., Emmerling, S.T., Pütz, A.M., Martí-Gastaldo, C., Padial, N.M., García-Martínez, J., Linares, N., Maspoch, D., Suárez Del Pino, J.A., Moghadam, P., Oktavian, R.; Morris, R.E.; Wheatley, P.S.; Navarro, J.; Petit, C.; Danacı, D.; Rosseinsky, M.J.; Katsoulidis, A.P.; Schröder, M.; Han, X.; Yan, S.; Serre, C.; Mouchaham, G.; Sholl, D.S.; Thyagarajan, R.; Siderius, D.; Snurr, R.Q.; Goncalves, R.B.; Telfer, S.; Lee, S.J.; Ting, V.P.; Rowlandson, J.L.; Uemura T, Iiyuka, T.; van derVeen, Monique A.; Rega, Davide; Van Speybroeck, Veronique; Rogge, Sven M. J.; Lamaire, Aran; Walton, Krista S.; Bingel, Lukas W.; Wuttke, Stefan; Andreo, Jacopo; Yaghi, Omar; Zhang, Bing; Yavuz, Cafer T.; Nguyen, Thien S.; Zamora, Felix; Montoro, Carmen; Zhou, Hongcai; Kirchon, Angelo; Fairen-Jimenez, David, College of Engineering, and Department of Chemical and Biological Engineering

Abstract

Porosity and surface area analysis play a prominent role in modern materials science. At the heart of this sits the Brunauer-Emmett-Teller (BET) theory, which has been a remarkably successful contribution to the field of materials science. The BET method was developed in the 1930s for open surfaces but is now the most widely used metric for the estimation of surface areas of micro- and mesoporous materials. Despite its widespread use, the calculation of BET surface areas causes a spread in reported areas, resulting in reproducibility problems in both academia and industry. To prove this, for this analysis, 18 already-measured raw adsorption isotherms were provided to sixty-one labs, who were asked to calculate the corresponding BET areas. This round-robin exercise resulted in a wide range of values. Here, the reproducibility of BET area determination from identical isotherms is demonstrated to be a largely ignored issue, raising critical concerns over the reliability of reported BET areas. To solve this major issue, a new computational approach to accurately and systematically determine the BET area of nanoporous materials is developed. The software, called ""BET surface identification"" (BETSI), expands on the well-known Rouquerol criteria and makes an unambiguous BET area assignment possible., European Union (EU); Horizon 2020; European Research Council (ERC); Research and Innovation Programme; NanoMOFdeli; COFLeaf; ERC-2016-COG; SCoTMOF; ERC-2015-StG; COSMOS; 2017-StG; European Commission (EC); H2020-MSCA-RISE-2019 Program; ZEOBIOCHEM; Innovate UK; EPSRC IAA; U.S. Department of Energy; Office of Basic Energy Sciences, Materials Sciences and Engineering Division; SERB; Spanish MICINN; AEI/FEDER; University of Alicante; Severo Ochoa Program; Spanish MINECO; Fund for Scientific Research Flanders (FWO); EPSRC Cambridge NanoDTC; National Research Foundation of Korea; Indonesian Endowment Fund for Education-LPDP;Cambridge International Scholarship; Trinity-Henry Barlow Scholarship (Honorary); U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy; Hydrogen and Fuel Cell Technologies Office; Hydrogen Storage Materials Advanced Research Consortium (HyMARC); Alexander von Humboldt Foundation; Center for Information Services and High Performance Computing (ZIH); Sandia National Laboratories; Official contribution of the National Institute of Standards and Technology (NIST)

Published
2022

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