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Your search keyword '"Casswall, Thomas"' showing total 21 results
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21 results on '"Casswall, Thomas"'

5. Diagnostic disagreement between clinical standard histopathological- and retrospective assessment of histopathology-based gastrointestinal graft-versus-host disease in children

Author

Mårtensson, Thomas, Szakos, Attila, Mellgren, Karin, Toporski, Jacek, Arvidson, Johan, Mattsson, Jonas, Gustafsson, Britt, Casswall, Thomas H., Mårtensson, Thomas, Szakos, Attila, Mellgren, Karin, Toporski, Jacek, Arvidson, Johan, Mattsson, Jonas, Gustafsson, Britt, and Casswall, Thomas H.

Abstract

Background: No previous paediatric study has evaluated the frequency of diagnostic disagreement between clinical standard histopathological assessment (CSHA) and retrospective, independent, histopathological assessment (RIHA) of gastrointestinal Graft-Versus-Host Disease (GI-GVHD). Methods: In a retrospective cohort study, based on gastrointestinal biopsies collected from allogeneic HSCT-treated children (<18 years) with symptom-based GI-GVHD, we evaluated; disagreement of histopathology-based GI-GVHD diagnosis in CSHA vs RIHA, and potential clinical consequences of differences between the assessments. The CSHA-based diagnoses were retrieved from histopathology reports. The RIHA was performed by one pathologist, blinded to the CSHA outcomes and based on the minimal criteria for histopathology-based GI-GVHD diagnosis by theNIH 2014. Results: Seventy children with 92 endoscopic occasions (including 22 re-endoscopies) were enrolled. GI-GVHD was observed in 73% (67/92) of the endoscopies in the RIHA and in 54% (50/92) in the CSHA (P = .014). The RIHA confirmed 94% (47/50) with GI-GVHD and 52% (22/42) with non-GI-GVHD diagnoses, established in the CSHA. Disagreement, that is endoscopic occasions with GI-GVHD solely detected in RIHA or detection of GI-GVHD in CSHA but not in RIHA, was observed in 20/42 (48%) and 3/50 (6%), respectively (McNemar's test, P = .0008). The risk of a subsequent re-endoscopy was higher in endoscopic occasions with GI-GVHD detected in RIHA but not in CSHA vs if non-GI-GVHD were detected in both readings (P = .005). Conclusion: Our results suggest that in children with symptom-based GI-GVHD without histopathological confirmation in CSHA, a second,NIH 2014based histopathological assessment should be considered before performing a re-endoscopy.

Published
2020
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6. Clinical relevance of endoscopy with histopathological assessment in children with suspected gastrointestinal graft-versus-host disease

Author

Mårtensson, Thomas, Mellgren, Karin, Toporski, Jacek, Arvidson, Johan, Szakos, Attila, Casswall, Thomas H., Gustafsson, Britt, Mårtensson, Thomas, Mellgren, Karin, Toporski, Jacek, Arvidson, Johan, Szakos, Attila, Casswall, Thomas H., and Gustafsson, Britt

Abstract

Endoscopy with histopathological assessment is an established practice to confirm gastrointestinal graft-versus-host disease (GI-GVHD). However, the clinical relevance of this approach in children is incompletely evaluated. In a retrospective cohort study, we investigated the frequency of treatment changes in response to histopathological findings in all children (<18 years) in Sweden who underwent endoscopy for suspected GI-GVHD (2000-2013) after receiving hematopoietic stem cell transplantation. Sixty-eight children with ninety-one endoscopic occasions were enrolled. At the time of endoscopy, anti-GI-GVHD treatment was ongoing in 71% (65/91). In 18% (12/65) with ongoing treatment, no histopathological evidence of GI-GVHD or another cause to justify anti-GI-GVHD treatment was found. In 48% (44/91), endoscopy with histopathological assessment led to changes in the treatment regimen. Re-endoscopy was more frequent among those with treatment changes, versus unchanged treatment, 39% (17/44) and 13% (6/47), respectively (P = .007). Histopathological findings generating treatment changes were as follows: GI-GVHD in 68% (30/44), normal histology in 25% (11/44), and an alternative diagnosis in 7% (3/44). In conclusion, this study supports that endoscopy with histopathological assessment should be considered in all children with suspected GI-GVHD.

Published
2020
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8. Helicobacter pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016

Author

Kori, Michal, primary, Le Thi, Thu Giang, additional, Werkstetter, Katharina, additional, Sustmann, Andrea, additional, Bontems, Patrick, additional, Lopes, Ana Isabel, additional, Oleastro, Monica, additional, Iwanczak, Barbara, additional, Kalach, Nicolas, additional, Misak, Zrinjka, additional, Cabral, José, additional, Homan, Matjaž, additional, Cilleruelo Pascual, Maria Luz, additional, Pehlivanoglu, Ender, additional, Casswall, Thomas, additional, Urruzuno, Pedro, additional, Martinez Gomez, Maria José, additional, Papadopoulou, Alexandra, additional, Roma, Eleftheria, additional, Dolinsek, Jernej, additional, Rogalidou, Maria, additional, Urbonas, Vaidotas, additional, Chong, Sonny, additional, Kindermann, Angelika, additional, Miele, Erasmo, additional, Rea, Francesca, additional, Cseh, Áron, additional, and Koletzko, Sibylle, additional

Published
2020
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10. Research priorities for liver glycogen storage disease: An international priority setting partnership with the James Lind Alliance

Author

Peeks, Fabian, primary, Boonstra, Willemijn F., additional, de Baere, Lut, additional, Carøe, Camilla, additional, Casswall, Thomas, additional, Cohen, Damián, additional, Cowan, Katherine, additional, Ferrecchia, Iris, additional, Ferriani, Alberto, additional, Gimbert, Caroline, additional, Landgren, Marcus, additional, Maldonado, Nerea L., additional, McMillan, Jason, additional, Nemeth, Antal, additional, Seidita, Niccolò, additional, Stachelhaus‐Theimer, Ute, additional, Weinstein, David A., additional, and Derks, Terry G. J., additional

Published
2019
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21. Research priorities for liver glycogen storage disease: An international priority setting partnership with the James Lind Alliance.

Author

Peeks F, Boonstra WF, de Baere L, Carøe C, Casswall T, Cohen D, Cowan K, Ferrecchia I, Ferriani A, Gimbert C, Landgren M, Maldonado NL, McMillan J, Nemeth A, Seidita N, Stachelhaus-Theimer U, Weinstein DA, and Derks TGJ

Subjects
Biomedical Research, Caregivers, Consensus, Cooperative Behavior, Health Personnel, Humans, Liver metabolism, United Kingdom, Glycogen Storage Disease, Health Priorities, Health Surveys, Patient Participation
Abstract

The international liver glycogen storage disease (GSD) priority setting partnership (IGSDPSP) was established to identify the top research priorities in this area. The multiphase methodology followed the principles of the James Lind Alliance (JLA) guidebook. An international scoping survey in seven languages was distributed to patients, carers, and healthcare professionals to gather uncertainties, which were consolidated into summary questions. The existing literature was reviewed to ensure that the summary questions had not yet been answered. A second survey asked responders to prioritize these summary questions. A final shortlist of 22 questions was discussed during an international multi-stakeholder workshop, and a consensus was reached on the top 11 priorities using an adapted nominal group technique.In the first survey, a total of 1388 questions were identified from 763 responders from 58 countries. These original uncertainties were refined into 72 summary questions for a second prioritization survey. In total 562 responders from 58 countries answered the second survey. From the second survey, the top 10 for patients, carers and healthcare professionals was identified and this shortlist of 22 questions was taken to the final workshop. During the final workshop, participants identified the worldwide top 11 research priorities for liver GSD. In addition, a top three research priorities per liver GSD subtype was identified.This unique priority setting partnership is the first international, multilingual priority setting partnership focusing on ultra-rare diseases. This process provides a valuable resource for researchers and funding agencies to foster interdisciplinary and transnational research projects with a clear benefit for patients., (© 2019 The Authors. Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM.)

Published
2020
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