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14 results on '"Chahud, Fernando"'

1. LAMP3 induces ectopic TLR7 expression in salivary gland epithelial cells and amplifies type I IFN production in Sjögren's disease

Author

Nakamura, Hiroyuki, primary, Tanaka, Tsutomu, additional, Zheng, Changyu, additional, Afione, Sandra A., additional, Atsumi, Tatsuya, additional, Noguchi, Masayuki, additional, Oliveira, Fabiola Reis, additional, Motta, Ana Carolina F., additional, Chahud, Fernando, additional, Rocha, Eduardo M., additional, Warner, Blake M., additional, and Chiorini, John A., additional

Published
2024
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3. Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia

Author

de Castro, Fabíola Attié, primary, Mehdipour, Parinaz, additional, Chakravarthy, Ankur, additional, Ettayebi, Ilias, additional, Loo Yau, Helen, additional, Medina, Tiago Silva, additional, Marhon, Sajid A., additional, de Almeida, Felipe Campos, additional, Bianco, Thiago Mantello, additional, Arruda, Andrea G. F., additional, Devlin, Rebecca, additional, de Figueiredo‐Pontes, Lorena Lobo, additional, Chahud, Fernando, additional, da Costa Cacemiro, Maira, additional, Minden, Mark D., additional, Gupta, Vikas, additional, and De Carvalho, Daniel D., additional

Published
2023
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5. Exuberant nodular lesion in the parotid gland

Author

Teixeira, Lucas Ribeiro, primary, Cavalcanti, Graziela Vieira, additional, Saggioro, Fabiano Pinto, additional, Motta, Tatiane Cardoso, additional, de Freitas, Luiz Carlos Conti, additional, Chahud, Fernando, additional, and Motta, Ana Carolina Fragoso, additional

Published
2023
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6. COVID‐19 bimodal clinical and pathological phenotypes

Author

Batah, Sabrina S., primary, Benatti, Maíra N., additional, Siyuan, Li, additional, Telini, Wagner M., additional, Barboza, Jamile O., additional, Menezes, Marcelo B., additional, Nadai, Tales R., additional, Sá, Keyla S. G., additional, Vaswani, Chirag M., additional, Gupta, Sahil, additional, Zamboni, Dario S., additional, Wada, Danilo T., additional, Calado, Rodrigo T., additional, Oliveira, Renê D. R., additional, Louzada‐Junior, Paulo, additional, Auxiliadora‐Martins, Maria, additional, Veras, Flávio P., additional, Cunha, Larissa D., additional, Cunha, Thiago M., additional, Luppino‐Assad, Rodrigo, additional, Balancin, Marcelo L., additional, Morais, Sirlei S., additional, Martins, Ronaldo B., additional, Arruda, Eurico, additional, Chahud, Fernando, additional, Santos, Marcel Koenigkam, additional, Cetlin, Andrea A., additional, Cunha, Fernando Q., additional, dos Santos, Claudia, additional, Capelozzi, Vera L., additional, Fukuoka, Junya, additional, Achcar, Rosane Duarte, additional, and Fabro, Alexandre T., additional

Published
2022
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7. Detection of respiratory viruses in primary cholesteatoma tissues

Author

Viana, Rosa M. M., primary, Souza, Juliano P., additional, Jorge, Daniel M. M., additional, Martins, Ronaldo B., additional, Castro, Italo A., additional, Cardoso, Ricardo S., additional, Volpini, Lays P. B., additional, Souza Luna, Luciano K., additional, Spano, Liliana C., additional, Bellei, Nancy C. J., additional, Chahud, Fernando, additional, Arruda, Eurico, additional, and Hyppolito, Miguel, additional

Published
2021
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8. Immunohistochemical characterization of immune cell infiltration in paediatric and adult Langerhans cell histiocytosis

Author

Paredes, Silvia Elena Yacarini, primary, Almeida, Luciana Yamamoto, additional, Trevisan, Glauce Lunardelli, additional, Polanco, Xiomara Beatriz Jimenez, additional, Silveira, Heitor Albergoni, additional, Vilela Silva, Evânio, additional, Segato, Raquel Assed Bezerra, additional, Silva, Léa Assed Bezerra, additional, Chahud, Fernando, additional, and León, Jorge Esquiche, additional

Published
2020
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13. Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll-Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome-Associated Membrane Protein 3.

Author

Nakamura H, Tanaka T, Zheng C, Afione SA, Atsumi T, Noguchi M, Oliveira FR, Motta ACF, Chahud F, Rocha EM, Warner BM, and Chiorini JA

Subjects
Animals, Mice, Humans, Signal Transduction, Female, Interferon-gamma metabolism, Cell Line, Salivary Glands, Minor immunology, Salivary Glands, Minor metabolism, Neoplasm Proteins, Lysosomal-Associated Membrane Protein 3, Sjogren's Syndrome immunology, Sjogren's Syndrome genetics, Sjogren's Syndrome metabolism, Interferon Type I metabolism, Epithelial Cells metabolism, Toll-Like Receptor 7 genetics, Toll-Like Receptor 7 metabolism, Salivary Glands metabolism, Salivary Glands immunology, Lysosomal Membrane Proteins genetics, Lysosomal Membrane Proteins metabolism
Abstract

Objective: Lysosome-associated membrane protein 3 (LAMP3) misexpression in salivary gland epithelial cells plays a causal role in the development of salivary gland dysfunction and autoimmunity associated with Sjögren's disease (SjD). This study aimed to clarify how epithelial LAMP3 misexpression is induced in SjD., Methods: To explore upstream signaling pathways associated with LAMP3 expression, we conducted multiple RNA sequencing analyses of minor salivary glands from patients with SjD, submandibular glands from a mouse model of SjD, and salivary gland epithelial cell lines. A hypothesis generated by the RNA sequencing analyses was further tested by in vitro and in vivo assays with gene manipulation., Results: Transcriptome analysis suggested LAMP3 expression was associated with enhanced type I interferon (IFN) and IFNγ signaling pathways in patients with SjD. In vitro studies showed that type I IFN but not IFNγ stimulation could induce LAMP3 expression in salivary gland epithelial cells. Moreover, we discovered that LAMP3 overexpression could induce ectopic Toll-like receptor 7 (TLR-7) expression and type I IFN production in salivary gland epithelial cells both in vitro and in vivo. TLR-7 knockout mice did not develop any SjD-related symptoms following LAMP3 induction., Conclusion: Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR-7 expression in salivary gland epithelial cells. This positive feedback loop can contribute to maintaining LAMP3 misexpression and amplifying type I IFN production in salivary glands, which plays an essential role in the pathophysiology of SjD., (© 2024 The Author(s). Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)

Published
2024
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14. Intraoral primary syphilis mimicking lymphoproliferative disorder.

Author

E Silva LDA, Silva EV, Silveira HA, Silva HC, Chahud F, León JE, and Mesquita ATM

Subjects
Humans, Lymphocytes pathology, Diagnosis, Differential, Syphilis diagnosis, Syphilis pathology, Lymphoproliferative Disorders diagnosis, Lymphoproliferative Disorders pathology, Lymphoma, B-Cell, Marginal Zone pathology
Abstract

Syphilis can mimic, clinically and microscopically, many other diseases. By microscopy, typically syphilis presents with plasma cell infiltration, admixed with lymphocytes and macrophages, in lichenoid and/or perivascular/perineural distribution pattern. When exuberant, this inflammatory infiltrate can mimic a lymphoproliferative disorder (LPD), notably plasma cell neoplasia or lymphoma. To date, about 12 cases of secondary syphilis, all but one in extraoral location, suggesting initially a LPD, have been published. Here, to our knowledge, we report an unusual case of intraoral primary syphilis initially suggesting LPD, notably lymphoid hyperplasia (pseudolymphoma); however, mucosa-associated lymphoid tissue (MALT) lymphoma and follicular lymphoma could not be disregarded. Polyclonality of plasma cells on immunohistochemistry, in strict clinical correlation, was essential to arrive at the correct diagnosis., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2024
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