Search

Your search keyword '"Chai, Renjie"' showing total 35 results
Start Over Author "Chai, Renjie" Publisher wiley
35 results on '"Chai, Renjie"'

3. Pcolce2 overexpression promotes supporting cell reprogramming in the neonatal mouse cochlea

Author

Xu, Changling, primary, Zhang, Liyan, additional, Zhou, Yinyi, additional, Du, Haoliang, additional, Qi, Jieyu, additional, Tan, Fangzhi, additional, Peng, Li, additional, Gu, Xingliang, additional, Li, Nianci, additional, Sun, Qiuhan, additional, Zhang, Ziyu, additional, Lu, Yicheng, additional, Qian, Xiaoyun, additional, Tong, Busheng, additional, Sun, Jiaqiang, additional, Chai, Renjie, additional, and Shi, Yi, additional

Published
2024
Full Text
View/download PDF

4. Electroacoustic Responsive Cochlea‐on‐a‐Chip

Author

Hu, Yangnan, primary, Xing, Jiayue, additional, Zhang, Hui, additional, Pang, Xinyi, additional, Zhai, Yabo, additional, Cheng, Hong, additional, Xu, Dongyu, additional, Liao, Menghui, additional, Qi, Yanru, additional, Wu, Danqi, additional, Zhang, Bin, additional, Cheng, Lin, additional, Chu, Bo, additional, Zhang, Chen, additional, Zhao, Yuanjin, additional, and Chai, Renjie, additional

Published
2024
Full Text
View/download PDF

5. Clinical practice guidelines for gene therapy to treat hereditary hearing loss

Author

Qi, Jieyu, primary, Tan, Fangzhi, additional, Zhang, Liyan, additional, Lu, Ling, additional, Wang, Hongyang, additional, Li, Wenyan, additional, Liu, Wenwen, additional, Fu, Xiaolong, additional, He, Zuhong, additional, Ding, Xiaoqiong, additional, Sun, Shan, additional, Fang, Qiaojun, additional, Dong, Yaodong, additional, Zhu, Xuewei, additional, Tong, Busheng, additional, Cao, Xianbao, additional, Guo, Min, additional, Fan, Xinmiao, additional, Wang, Qin, additional, Ma, Lu, additional, Zhang, Tianhong, additional, Yu, Yafeng, additional, Li, Yongxin, additional, Fan, Jiangang, additional, Cui, Yong, additional, Wu, Peina, additional, Zhang, Hongzheng, additional, Tang, Jie, additional, Guo, Weiwei, additional, Zha, Dingjun, additional, Ye, Fanglei, additional, He, Shuangba, additional, Cao, Wei, additional, Yang, Jianming, additional, Qian, Xiaoyun, additional, Zhao, Yu, additional, Sun, Jingwu, additional, Chen, Xiaowei, additional, Sun, Yu, additional, Xia, Ming, additional, Wang, Qiuju, additional, Yuan, Huijun, additional, Feng, Yong, additional, Kong, Weijia, additional, Yang, Shiming, additional, Wang, Haibo, additional, Duan, Maoli, additional, Gao, Xia, additional, Li, Huawei, additional, Xu, Lei, additional, and Chai, Renjie, additional

Published
2024
Full Text
View/download PDF

8. AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness

Author

Qi, Jieyu, primary, Tan, Fangzhi, additional, Zhang, Liyan, additional, Lu, Ling, additional, Zhang, Shanzhong, additional, Zhai, Yabo, additional, Lu, Yicheng, additional, Qian, Xiaoyun, additional, Dong, WenXiu, additional, Zhou, Yinyi, additional, Zhang, Ziyu, additional, Yang, Xuehan, additional, Jiang, Lulu, additional, Yu, Chaorong, additional, Liu, Jiancheng, additional, Chen, Tian, additional, Wu, Lianqiu, additional, Tan, Chang, additional, Sun, Sijie, additional, Song, Huaien, additional, Shu, Yilai, additional, Xu, Lei, additional, Gao, Xia, additional, Li, Huawei, additional, and Chai, Renjie, additional

Published
2024
Full Text
View/download PDF

9. Preclinical Efficacy And Safety Evaluation of AAV‐OTOF in DFNB9 Mouse Model And Nonhuman Primate

Author

Qi, Jieyu, primary, Zhang, Liyan, additional, Tan, Fangzhi, additional, Zhang, Yang, additional, Zhou, Yinyi, additional, Zhang, Ziyu, additional, Wang, Hongyang, additional, Yu, Chaorong, additional, Jiang, Lulu, additional, Liu, Jiancheng, additional, Chen, Tian, additional, Wu, Lianqiu, additional, Zhang, Shanzhong, additional, Sun, Sijie, additional, Sun, Shan, additional, Lu, Ling, additional, Wang, Qiuju, additional, and Chai, Renjie, additional

Published
2023
Full Text
View/download PDF

12. Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels

Author

Fu, Xiaolong, primary, Wan, Peifeng, additional, Lu, Ling, additional, Wan, Yingcui, additional, Liu, Ziyi, additional, Hong, Guodong, additional, Cao, Shengda, additional, Bi, Xiuli, additional, Zhou, Jing, additional, Qiao, Ruifeng, additional, Guo, Siwei, additional, Xiao, Yu, additional, Wang, Bingzheng, additional, Chang, Miao, additional, Li, Wen, additional, Li, Peipei, additional, Zhang, Aizhen, additional, Sun, Jin, additional, Chai, Renjie, additional, and Gao, Jiangang, additional

Published
2023
Full Text
View/download PDF

15. Dyslexia‐Related Hearing Loss Occurs Mainly through the Abnormal Spontaneous Electrical Activity of Spiral Ganglion Neurons

Author

Hong, Guodong, primary, Fu, Xiaolong, additional, Chen, Xin, additional, Zhang, Liyan, additional, Han, Xuan, additional, Ding, Shuqin, additional, Liu, Ziyi, additional, Bi, Xiuli, additional, Li, Wen, additional, Chang, Miao, additional, Qiao, Ruifeng, additional, Guo, Siwei, additional, Tu, Hailong, additional, and Chai, Renjie, additional

Published
2023
Full Text
View/download PDF

18. Endothelial Arid1a deletion disrupts the balance among angiogenesis, neurogenesis and gliogenesis in the developing brain

Author

Wang, Yuanyuan, primary, Su, Libo, additional, Wang, Wenwen, additional, Zhao, Jinyue, additional, Wang, Yanyan, additional, Li, Sihan, additional, Liu, Yan, additional, Chai, Renjie, additional, Li, Xin, additional, Teng, Zhaoqian, additional, Liu, Changmei, additional, Hu, Baoyang, additional, Ji, Fen, additional, and Jiao, Jianwei, additional

Published
2023
Full Text
View/download PDF

19. Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Author

Liu, Dong, primary, Liang, Chun‐hui, additional, Huang, Bin, additional, Zhuang, Xiao, additional, Cui, Weiwei, additional, Yang, Li, additional, Yang, Yinghong, additional, Zhang, Yudan, additional, Fu, Xiaolong, additional, Zhang, Xiaoju, additional, Du, Lutao, additional, Gu, Wei, additional, Wang, Xiangdong, additional, Yin, Chengqian, additional, Chai, Renjie, additional, and Chu, Bo, additional

Published
2023
Full Text
View/download PDF

23. Compact SchCas9 Recognizes the Simple NNGR PAM

Author

Wang, Shuai, primary, Mao, Huilin, additional, Hou, Linghui, additional, Hu, Ziying, additional, Wang, Yao, additional, Qi, Tao, additional, Tao, Chen, additional, Yang, Yuan, additional, Zhang, Chengdong, additional, Li, Miaomiao, additional, Liu, Huihui, additional, Hu, Shijun, additional, Chai, Renjie, additional, and Wang, Yongming, additional

Published
2021
Full Text
View/download PDF

26. Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth (Small 38/2021)

Author

Yangnan Hu, Xiaoyun Qian, Xiaofeng Ma, Hao Wei, Xia Gao, Yuanjin Zhao, Chen Zhang, Wei Cao, Chai Renjie, and Zhuoyue Chen

Subjects
Materials science, Butterfly wing, General Chemistry, Carbon nanotube, law.invention, Biomaterials, medicine.anatomical_structure, law, medicine, Biophysics, General Materials Science, Neuron, Electrical conductor, Spiral ganglion, Biotechnology
Published
2021

28. Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth

Author

Hao Wei, Xia Gao, Xiaoyun Qian, Zhuoyue Chen, Wei Cao, Yangnan Hu, Xiaofeng Ma, Chai Renjie, Yuanjin Zhao, and Chen Zhang

Subjects
Materials science, Neurite, Butterfly wing, Biomaterials, Neurites, otorhinolaryngologic diseases, medicine, Animals, Wings, Animal, General Materials Science, Electrical conductor, Spiral ganglion, Neurons, biology, Morpho menelaus, Regeneration (biology), Electric Conductivity, General Chemistry, Adhesion, biology.organism_classification, medicine.anatomical_structure, Biophysics, Neuron, Spiral Ganglion, Butterflies, Biotechnology
Abstract

Spiral ganglion neuron (SGN) degeneration can lead to severe hearing loss, and the directional regeneration of SGNs has shown great potential for improving the efficacy of auditory therapy. Here, a novel 3D conductive microstructure with surface topologies is presented by integrating superaligned carbon-nanotube sheets (SA-CNTs) onto Morpho Menelaus butterfly wings for SGN culture. The parallel groove-like topological structures of M. Menelaus wings induce the cultured cells to grow along the direction of its ridges. The excellent conductivity of SA-CNTs significantly improves the efficiency of cellular information conduction. When integrating the SA-CNTs with M. Menelaus wings, the SA-CNTs are aligned in parallel with the M. Menelaus ridges, which further strengthens the consistency of the surface topography in the composite substrate. The SA-CNTs integrated onto butterfly wings provide powerful physical signals and regulate the behavior of SGNs, including cell survival, adhesion, neurite outgrowth, and synapse formation. These features indicate the possibility of directed regeneration after auditory nerve injury.

Published
2021

34. Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction.

Author

Hu Y, Fang L, Zhang H, Zheng S, Liao M, Cui Q, Wei H, Wu D, Cheng H, Qi Y, Wang H, Xin T, Wang T, and Chai R

Abstract

Hearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field., Competing Interests: The authors declare that there are no competing interests., (© 2023 The Authors. Smart Medicine published by Wiley‐VCH GmbH on behalf of Wenzhou Institute, University of Chinese Academy of Sciences.)

Published
2023
Full Text
View/download PDF

35. Basic fibroblast growth factor-loaded methacrylate gelatin hydrogel microspheres for spinal nerve regeneration.

Author

Chen X, Ren L, Zhang H, Hu Y, Liao M, Shen Y, Wang K, Cai J, Cheng H, Guo J, Qi Y, Wei H, Li X, Shang L, Xiao J, Sun J, and Chai R

Abstract

Spinal cord injury is a severe central nervous system injury, and developing appropriate drug delivery platforms for spinal nerve regeneration is highly anticipated. Here, we propose a basic fibroblast growth factor (bFGF)-loaded methacrylate gelatin (GelMA) hydrogel microsphere with ideal performances for spinal cord injury repair. Benefitting from the precise droplet manipulation capability of the microfluidic technology, the GelMA microspheres possess uniform and satisfactory size and good stability. More importantly, by taking advantage of the porous structures and facile chemical modification of the GelMA microspheres, bFGF could be easily loaded and gradually released. By co-culturing with neural stem cells, it is validated that the bFGF-loaded GelMA microspheres could effectively promote the proliferation and differentiation of neural stem cells. We also confirm the effective role of the bFGF-loaded GelMA microspheres in nerve repair of spinal cord injury in rats. Our results demonstrate the potential value of the microspheres for applications in repairing central nervous system injuries., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Luoran Shang is a member of the Smart Medicine editorial board., (© 2023 The Authors. Smart Medicine published by Wiley‐VCH GmbH on behalf of Wenzhou Institute, University of Chinese Academy of Sciences.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results