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Your search keyword '"Chen, Chuan-Mu"' showing total 32 results
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32 results on '"Chen, Chuan-Mu"'

3. Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO‐1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (ARPE‐19) cells

Author

Chiang, Yun‐Wei, primary, Su, Chun‐Hung, additional, Sun, Han‐Yin, additional, Chen, Shih‐Pin, additional, Chen, Chun‐Jung, additional, Chen, Wen‐Ying, additional, Chang, Chia‐Che, additional, Chen, Chuan‐Mu, additional, and Kuan, Yu‐Hsiang, additional

Published
2021
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7. Cigarette smoke enhances oncogene addiction to c‐ MET and desensitizes EGFR ‐expressing non‐small cell lung cancer to EGFR TKI s

Author

Tu, Chih‐Yen, primary, Cheng, Fang‐Ju, additional, Chen, Chuan‐Mu, additional, Wang, Shu‐Ling, additional, Hsiao, Yu‐Chun, additional, Chen, Chia‐Hung, additional, Hsia, Te‐Chun, additional, He, Yu‐Hao, additional, Wang, Bo‐Wei, additional, Hsieh, I‐Shan, additional, Yeh, Yi‐Lun, additional, Tang, Chih‐Hsin, additional, Chen, Yun‐Ju, additional, and Huang, Wei‐Chien, additional

Published
2018
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17. Anti‐Inflammatory Effects of Antrodia camphorata and its Active Compound, Ergostatrien‐3β‐ol, in a Mouse Skin Ischemia Model

Author

Liao Jiunn-Wang, Tung Yu-Tang, kuo Yueh-Hsiung, Chong Kowit-Yu, Tsai Hsin-Chung, Tsai Tung-Chou, Chen Chuan-Mu, and Chen Hsiao-Ling

Subjects
biology, medicine.drug_class, Chemistry, Ischemia, Pharmacology, medicine.disease, biology.organism_classification, Biochemistry, Anti-inflammatory, Active compound, Mouse skin, Genetics, medicine, Antrodia, Molecular Biology, Biotechnology
Published
2015

31. Treadmill running upregulates the expression of acetylcholine receptor in rat gastrocnemius following botulinum toxin A injection.

Author

Tsai SW, Tung YT, Chen HL, Shen CJ, Chuang CH, Tang TY, and Chen CM

Subjects
Animals, Exercise Test, Gene Expression drug effects, Gene Expression physiology, Male, Muscle Contraction drug effects, Muscle Contraction physiology, Muscle Proteins genetics, Muscle, Skeletal innervation, Neuromuscular Agents pharmacology, Neuromuscular Junction drug effects, Neuromuscular Junction physiology, Protein Subunits genetics, Rats, Rats, Sprague-Dawley, Up-Regulation drug effects, Up-Regulation physiology, Botulinum Toxins, Type A pharmacology, Muscle, Skeletal drug effects, Muscle, Skeletal physiology, Receptors, Nicotinic genetics, Running physiology
Abstract

Treadmill running is a commonly used training method for patients with spasticity to improve functional performance. Botulinum toxin has been widely used therapeutically to reduce contraction force of spastic muscle. However, the effects of treadmill running in neuromuscular junction expression and motor unit physiology on muscle following botulinum toxin injection are not well established. To assess the effects of treadmill running on neuromuscular recovery of gastrocnemius following botulinum toxin A (BoNT-A) injection, we observed changes in gene expression. We hypothesized that the expression of acetylcholine receptor (AChR), myogenesis, and nerve plasticity could be enhanced. Twenty-four Sprague-Dawley rats received botulinum toxin injection in right gastrocnemius and were then randomly assigned into untrained control and treadmill running groups. The rats assigned to the treadmill running group were trained on a treadmill 3 times/week with a running speed of 15 m/min for 8 weeks. The duration of training was 20 min per session. Muscle strength and gene expression of AChR subunit (α, β, δ, γ, and ε), MyoD, Myf-5, MRF4, myogenin, p21, IGF-1, GAP43, were analyzed. Treadmill running had no influence on gastrocnemius mass, but improved the maximal contraction force of the gastrocnemius in the treadmill running group (p < 0.05). Upregulation of GAP-43, IGF-1, Myo-D, Myf-5, myogenin, and AChR subunits α and β were found following treadmill running. The expression of genes associated with neurite and AChR regeneration following treadmill exercise was upregulated, which may have contributed to enhanced recovery of gastrocnemius strength., (Copyright © 2012 Orthopaedic Research Society.)

Published
2013
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32. Effects of treadmill running on rat gastrocnemius function following botulinum toxin A injection.

Author

Tsai SW, Chen CJ, Chen HL, Chen CM, and Chang YY

Subjects
Action Potentials drug effects, Animals, Male, Muscle Contraction drug effects, Muscle, Skeletal physiology, Random Allocation, Rats, Rats, Sprague-Dawley, Botulinum Toxins, Type A pharmacology, Muscle, Skeletal drug effects, Physical Conditioning, Animal
Abstract

Exercise can improve and maintain neural or muscular function, but the effects of exercise in physiological adaptation to paralysis caused by botulinum toxin A has not been well studied. Twenty-four rats were randomly assigned into control and treadmill groups. The rats assigned to the treadmill group were trained on a treadmill three times per week with the running speed set at 15 m/min. The duration of training was 20 min/session. Muscle strength, nerve conduction study and sciatic functional index (SFI) were used for functional analysis. Treadmill training improved the SFI at 2, 3, and 4 weeks (p = 0.01, 0.004, and 0.01, respectively). The maximal contraction force of the gastrocnemius muscle in the treadmill group was greater than in the control group (p < 0.05). The percentage of activated fibers was higher in the treadmill botox group than the percentage for the control botox group, which was demonstrated by differences in amplitude and area of compound muscle action potential (CMAP) under the curve between the groups (p < 0.05). After BoNT-A injection, treadmill improved the physiological properties of muscle contraction strength, CMAP amplitude, and the recovery of SFI., (Copyright © 2011 Orthopaedic Research Society.)

Published
2012
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