6 results on '"Chrelias C"'
Search Results
2. Prenatal diagnosis of fetal left ventricular non‐compaction cardiomyopathy
- Author
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Tsapakis, E. G., primary, Eleftheriades, M., additional, Daskalakis, G., additional, Chrelias, C., additional, and Hassiakos, D., additional
- Published
- 2012
- Full Text
- View/download PDF
3. Placental volume at 11 to 14 gestational weeks in pregnancies complicated with fetal growth restriction and preeclampsia.
- Author
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Papastefanou I, Chrelias C, Siristatidis C, Kappou D, Eleftheriades M, and Kassanos D
- Subjects
- Adult, Case-Control Studies, Female, Fetal Growth Retardation etiology, Humans, Imaging, Three-Dimensional, Organ Size, Placenta diagnostic imaging, Placenta Diseases pathology, Pre-Eclampsia etiology, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Registries, Ultrasonography, Prenatal, Uterine Artery diagnostic imaging, Fetal Growth Retardation pathology, Placenta pathology, Placental Insufficiency pathology, Pre-Eclampsia pathology
- Abstract
Objective: The study aims to evaluate the predictive value of first trimester placental volume in pregnancies destined to develop fetal growth restriction (FGR) and preeclampsia (PE)., Methods: Prospective observational study including placentas from 34 FGR, 12 PE, 15 GH (gestational hypertension) pregnancies, and 265 controls. Placental volume (PV) was obtained using VOCAL technique, and a z score was calculated (z-PV). The association of PV with other first trimester variables and maternal characteristics was assessed with Spearman's correlation., Results: PV increased exponentially with crown-rump length (CRL) and was unrelated to maternal factors (weight, age, parity, and smoking status) as well as first trimester uterine artery Doppler, free β-hCG, nuchal translucency, or fetal heart rate. However, PV was positively associated with maternal height, CRL, PAPP-A, and birth weight. z-PV was a strong predictor for FGR with abnormal fetal Dopplers (AUC = 0.9472, P < 0.001). z-PV provided moderate prediction of FGR with normal fetal Dopplers (AUC = 0.8396, P < 0.001), PE (AUC = 0.8312, P < 0.001), and GH (AUC = 0.7640, P < 0.001). The addition of maternal weight, PAPP-A, β-hCG, and uterine artery Doppler improved our models., Conclusion: At 11 to 14 weeks, PV is an independent predictor of pregnancy complications related to placental insufficiency, and the predictive ability is greater for FGR pregnancies with abnormal fetal Dopplers., (© 2018 John Wiley & Sons, Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
4. Screening for birth weight deviations by second and third trimester ultrasound scan.
- Author
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Papastefanou I, Pilalis A, Chrelias C, Kassanos D, and Souka AP
- Subjects
- Female, Humans, Infant, Newborn, Pregnancy, Retrospective Studies, Birth Weight, Infant, Small for Gestational Age, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Ultrasonography, Prenatal
- Abstract
Objective: The aim of this article was to predict small for gestational age (SGA, at or less than the fifth birth weight percentile) and large for gestational age (LGA, at or greater than the 95th birth weight percentile) fetuses by using maternal and fetal parameters from the second and third trimester ultrasound examinations., Method: This article is a retrospective cohort study on 1979 singleton pregnancies that had a routine 20 to 24 weeks anomaly and a 30 to 34 weeks growth ultrasound scans. SGA delivered before 30 gestational weeks were excluded., Results: Second trimester estimated fetal weight (EFW2 ), uterine arteries pulsatility index (PI), and maternal pregnancy characteristics were predictive for SGA (SGA second trimester model: R(2) = 0.225, area under the curve [AUC] = 0.815) and LGA (LGA second trimester model: R(2) = 0.203, AUC = 0.793). Third trimester EFW (EFW3 ), EFW2 , uterine arteries PI2 , umbilical PI, and maternal pregnancy characteristics improved the prediction of SGA (SGA combined model: R(2) = 0.423, AUC = 0.896) and LGA (LGA combined model: R(2) = 0.383, AUC = 0.882). Contingent screening with risk stratification by the second trimester model performed equally well for SGA (AUC = 0.882) and LGA (AUC = 0.861) as the combined models., Conclusion: Second trimester model performs well in the prediction of SGA and LGA. The addition of third trimester scan offers substantial improvement. Contingency screening is feasible with similar effectiveness., (© 2014 John Wiley & Sons, Ltd.)
- Published
- 2014
- Full Text
- View/download PDF
5. Third trimester ultrasound for the prediction of the large for gestational age fetus in low-risk population and evaluation of contingency strategies.
- Author
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Pilalis A, Souka AP, Papastefanou I, Michalitsi V, Panagopoulos P, Chrelias C, and Kassanos D
- Subjects
- Adolescent, Adult, Cross-Sectional Studies, Female, Fetal Macrosomia diagnosis, Fetus anatomy & histology, Fetus physiology, Gestational Age, Humans, Infant, Newborn, Infant, Newborn, Diseases diagnosis, Infant, Newborn, Diseases diagnostic imaging, Infant, Newborn, Diseases etiology, Middle Aged, Obstetric Labor Complications diagnosis, Obstetric Labor Complications etiology, Population, Pregnancy, Pregnancy Complications diagnosis, Pregnancy Complications diagnostic imaging, Pregnancy Complications etiology, Prognosis, Risk, Young Adult, Fetal Macrosomia diagnostic imaging, Fetal Weight physiology, Obstetric Labor Complications diagnostic imaging, Pregnancy Trimester, Third physiology, Ultrasonography, Prenatal methods
- Abstract
Objective: Evaluation of the effectiveness of third trimester fetal biometry and Doppler studies in predicting the birth of a large for gestational age neonate (LGA ≥ 95(th) centile). Assessment of the value of integrated models (combining maternal characteristics, first trimester parameters, third trimester fetal biometry) and the usefulness of contingency strategies., Method: Observational cross-sectional study on 2308 uncomplicated singleton pregnancies examined at 11 to 14 weeks and at 30 to 34 weeks., Results: Ultrasound estimated fetal weight (EFW, area under the curve (AUC) = 0.83) was the best single predictor of LGA. Maternal weight, delta nuchal translucency and EFW were independent predictors for the integrated model, but the latter was not statistically better (AUC = 0.84) than using EFW alone. The detection rates for LGA were 72.5% and 73.7% for a 25% screen positive rate, by EFW and the third trimester integrated model respectively. A contingency strategy of rescanning 50% of the population in the third trimester according to the risk estimation by a first trimester prediction model results in detection rate of 64.7% for LGA for the same 25% screen positive rate (AUC = 0.78)., Conclusions: Third trimester ultrasound is an effective screening modality for identifying fetal macrosomia. A contingency strategy utilizing first trimester parameters can reduce the need for unnecessary examinations., (© 2012 John Wiley & Sons, Ltd.)
- Published
- 2012
- Full Text
- View/download PDF
6. The diagnostic accuracy of two methods for E6&7 mRNA detection in women with minor cytological abnormalities.
- Author
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Koliopoulos G, Chrelias C, Pappas A, Makridima S, Kountouris E, Alepaki M, Spathis A, Stathopoulou V, Panayiotides I, Panagopoulos P, Karakitsos P, and Kassanos D
- Subjects
- Adult, Diagnosis, Differential, Female, Flow Cytometry, Humans, Prospective Studies, Sensitivity and Specificity, Triage, Uterine Cervical Dysplasia virology, Oncogene Proteins, Viral genetics, Papillomavirus E7 Proteins genetics, Papillomavirus Infections diagnosis, RNA, Messenger analysis, Repressor Proteins genetics, Self-Sustained Sequence Replication methods, Uterine Cervical Neoplasms virology
- Abstract
Objective: To examine the diagnostic accuracy of nucleic acid sequence based amplification (NASBA) and flow cytometry for E6&7 human papillomavirus (HPV) mRNA detection in the triage of minor cytological abnormalities., Design: Prospective diagnostic accuracy study., Setting: Gynecology outpatient clinics of a university hospital., Population: 472 women with low-grade squamous intraepithelial lesion (LSIL) or atypical squamous cells of undetermined significance (ASCUS)., Methods: Residual material of the liquid-based smears was tested by NASBA and by flow cytometry for E6&E7 mRNA expression. Histological diagnosis was used as reference standard., Main Outcome Measures: Accuracy indices of the two techniques and of type 16-specific NASBA for the detection of cervical intraepithelial neoplasia (CIN) 2+ and CIN3+, accuracy indices at age >35 years, correlation between NASBA and flow, comparison between integrated and episomal high-risk HPV infection for risk of CIN2+., Results: Both tests showed increased positivity rates with increasing severity of the lesion (p < 0.05, chi-squared test for trend). There was a positive correlation between NASBA and flow results (phi coefficient = 0.325). NASBA-positive cases were more likely to have CIN2+ than were NASBA-negative/DNA-positive for types 16, 18, 31, 33, 45 (25/73 vs. 4/52, p= 0.0004; Fisher's exact test). In the LSIL group the NASBA accuracy indices for CIN3+ were: sensitivity 75%, specificity 78.7% and positivity rate 20.8%, and for flow 77.8%, 64.5% and 35.9%, respectively., Conclusions: NASBA has favorable specificity and positivity rates for triaging LSIL prior to colposcopy. A relatively low sensitivity warrants cytological surveillance of the NASBA-negative LSILs. Flow cytometry does not perform as well overall., (© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.)
- Published
- 2012
- Full Text
- View/download PDF
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