Author: "Chung, K F." / Publisher: wiley - Searchworks@Jio Institute Digital Library Search Results

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62 results on '"Chung, K F."'

1. Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study

Author: Menditto, Enrica, Costa, Elisio, Midao, Luis, Bosnic-Anticevich, Sinthia, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Mair, Alpana, Rajabian-Soderlund, Rojin, Arnavielhe, Sylvie, Bedbrook, Anna, Czarlewski, Wienczyslawa, Annesi-Maesano, Isabella, Anto, Josep M., Devillier, Philippe, De Vries, Govert, Keil, Thomas, Sheikh, Aziz, Orlando, Valentina, Larenas-Linnemann, Desiree, Cecchi, Lorenzo, De Feo, Giulia, Illario, M., Stellato, Cristiana, Fonseca, Joao, Malva, Joao, Morais-Almeida, Mario, Pereira, Ana Maria, Todo-Bom, Ana Maria, Kvedariene, Violeta, Valiulis, Arunas, Bergmann, Karl Christian, Klimek, Ludger, Moesges, Ralph, Pfaar, Oliver, Zuberbier, Torsten, Cardona, Vicky, Mullol, Joaquim, Papadopoulos, Nikos G., Prokopakis, Emmanuel P., Bewick, Mike, Ryan, Dermot, Roller-Wirnsberger, Regina E., Tomazic, Peter Valentin, Cruz, Alvaro A., Kuna, Piotr, Samolinski, Boleslaw, Fokkens, Wytske J., Reitsma, Sietze, Bosse, Isabelle, Fontaine, Jean-Francois, Laune, Daniel, Haahtela, Tari, Toppila-Salmi, Sanna, Bachert, Claus, Hellings, Peter W., Melen, Erik, Wickman, Magnus, Bindslev-Jensen, Carsten, Eller, Esben, O'Hehir, Robyn E., Cingi, Cemal, Gemicioglu, Bilun, Kalayci, Omer, Ivancevich, Juan Carlos, Bousquet, Jean, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiar-Dini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghe, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Bialoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Marciniak, M. Bochenska, Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, Pj, Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Cabanas, M. T. Burguete, Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Coehlo, A. C. Carvalho, Colas, L., Colgan, E., Coll, J., Conforti, D., De Sousa, J. Correia, Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, Mc, Al Courbis, F., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., Emerson, M. De Fatima, De Feo, G., De Vries, G., De Martino, B., Rubina, N. P. Motta, Deleanu, D., Demoly, P., Denburg, Ja, Devillier, P., Ercolano, S. Di Capua, Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, Patrik, Eller, E., Emuzyte, R., Farrell, J., Farsi, A., De Mello, J. Ferreira, Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fok-Kens, W. J., Fonseca, Ja, Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Van Wijk, R. Gerth, Gomez, R. M., Gomez-Vera, J., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Guidacci, M., Guldemond, Na, Gutter, Z., Guzman, Ma, Haahtela, T., Hajjam, J., Hernandez, L., Houri-Hane, J O ' B, Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Ispayeva, Z., Ivancevich, J. C., Jares, Ej, Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Falta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Liplec, A., Lipworth, B., Carlsen, K. C. Lodrup, Louis, R., Lourenco, O., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., Keenoy, E. De Manuel, Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Campos, J. J. Matta, Matos, Al, Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melen, E., Melo-Gomes, E., Meltzer, Eo, Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Monte-Fort, S., Monti, R., Bogado, D. Mora, Morais-Almeida, M., Morato-Castro, Mosges, R., Mota-Pinto, A., Santo, P. Moura, Mullol, J., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, Td, O'Hehir, Re, Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Cisneros, M. Ortega, Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Ross, R. E. Pulido, Przemecka, M., Rabe, K. F., Raciborski, F., Raja-Bian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Riv-Ero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Gonzalez, M. Rodriguez, Rodriguez-Manas, L., Rolland, C., Valle, S. Rodrigues, Rodriguez, M. Roman, Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimaki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Sir-Oux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sonder-Mann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, Jn, Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Ulrik, C. Suppli, Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., Menditto, Enrica, Costa, Elisio, Midao, Luis, Bosnic-Anticevich, Sinthia, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Mair, Alpana, Rajabian-Soderlund, Rojin, Arnavielhe, Sylvie, Bedbrook, Anna, Czarlewski, Wienczyslawa, Annesi-Maesano, Isabella, Anto, Josep M., Devillier, Philippe, De Vries, Govert, Keil, Thomas, Sheikh, Aziz, Orlando, Valentina, Larenas-Linnemann, Desiree, Cecchi, Lorenzo, De Feo, Giulia, Illario, M., Stellato, Cristiana, Fonseca, Joao, Malva, Joao, Morais-Almeida, Mario, Pereira, Ana Maria, Todo-Bom, Ana Maria, Kvedariene, Violeta, Valiulis, Arunas, Bergmann, Karl Christian, Klimek, Ludger, Moesges, Ralph, Pfaar, Oliver, Zuberbier, Torsten, Cardona, Vicky, Mullol, Joaquim, Papadopoulos, Nikos G., Prokopakis, Emmanuel P., Bewick, Mike, Ryan, Dermot, Roller-Wirnsberger, Regina E., Tomazic, Peter Valentin, Cruz, Alvaro A., Kuna, Piotr, Samolinski, Boleslaw, Fokkens, Wytske J., Reitsma, Sietze, Bosse, Isabelle, Fontaine, Jean-Francois, Laune, Daniel, Haahtela, Tari, Toppila-Salmi, Sanna, Bachert, Claus, Hellings, Peter W., Melen, Erik, Wickman, Magnus, Bindslev-Jensen, Carsten, Eller, Esben, O'Hehir, Robyn E., Cingi, Cemal, Gemicioglu, Bilun, Kalayci, Omer, Ivancevich, Juan Carlos, Bousquet, Jean, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiar-Dini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghe, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Bialoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Marciniak, M. Bochenska, Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, Pj, Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Cabanas, M. T. Burguete, Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Coehlo, A. C. Carvalho, Colas, L., Colgan, E., Coll, J., Conforti, D., De Sousa, J. Correia, Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, Mc, Al Courbis, F., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., Emerson, M. De Fatima, De Feo, G., De Vries, G., De Martino, B., Rubina, N. P. Motta, Deleanu, D., Demoly, P., Denburg, Ja, Devillier, P., Ercolano, S. Di Capua, Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, Patrik, Eller, E., Emuzyte, R., Farrell, J., Farsi, A., De Mello, J. Ferreira, Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fok-Kens, W. J., Fonseca, Ja, Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Van Wijk, R. Gerth, Gomez, R. M., Gomez-Vera, J., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Guidacci, M., Guldemond, Na, Gutter, Z., Guzman, Ma, Haahtela, T., Hajjam, J., Hernandez, L., Houri-Hane, J O ' B, Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Ispayeva, Z., Ivancevich, J. C., Jares, Ej, Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Falta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Liplec, A., Lipworth, B., Carlsen, K. C. Lodrup, Louis, R., Lourenco, O., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., Keenoy, E. De Manuel, Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Campos, J. J. Matta, Matos, Al, Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melen, E., Melo-Gomes, E., Meltzer, Eo, Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Monte-Fort, S., Monti, R., Bogado, D. Mora, Morais-Almeida, M., Morato-Castro, Mosges, R., Mota-Pinto, A., Santo, P. Moura, Mullol, J., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, Td, O'Hehir, Re, Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Cisneros, M. Ortega, Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Ross, R. E. Pulido, Przemecka, M., Rabe, K. F., Raciborski, F., Raja-Bian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Riv-Ero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Gonzalez, M. Rodriguez, Rodriguez-Manas, L., Rolland, C., Valle, S. Rodrigues, Rodriguez, M. Roman, Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimaki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Sir-Oux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sonder-Mann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, Jn, Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Ulrik, C. Suppli, Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., and Zurkuhlen, A.
Abstract: Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
Published: 2019
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2. Effect of couple‐based cognitive behavioural intervention on prevention of postnatal depression: multisite randomised controlled trial

Author: Ngai, F‐W, primary, Wong, PW‐C, additional, Chung, K‐F, additional, Chau, P‐H, additional, and Hui, P‐W, additional
Published: 2019
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3. Integrative body-mind-spirit intervention for concurrent sleep and mood disturbances: sleep-specific daytime functioning mediates sleep and mood improvements

Author: Ji, X-W, Ng, S-M, Chan, CLW, Chan, JSM, Chan, CHY, Chung, K-F, Ji, X-W, Ng, S-M, Chan, CLW, Chan, JSM, Chan, CHY, and Chung, K-F
Abstract: Sleep disturbances and depressive symptoms are associated closely with daytime dysfunctions, yet few studies have investigated their temporal relationship in a randomized controlled trial. We investigated the inter-relationships among sleep, depressive symptoms and daytime functioning following an integrative body-mind-spirit (I-BMS) intervention. One hundred and eighty-five participants (mean age 55.28 years, 75.1% female) with co-existing sleep and depressive symptoms were randomized to I-BMS or waiting-list. Daytime functioning variables included the daytime dysfunction items of the Pittsburg Sleep Quality Index (PSQI-day), Somatic Symptom Inventory, Hospital Anxiety Depression Scale and Short Form Health Survey collected at baseline, post-treatment and 3-month follow-up. Sleep and depressive symptoms were measured by the sleep items of the PSQI (PSQI-night) and Center for Epidemiological Studies Depression Scale (excluding the sleep item) (CESD-M). Regression and path analyses were used to understand the role of daytime functioning in sleep and depressive symptoms. We found significant group and time effects on almost all daytime variables and significant group × time interactions on PSQI-day and somatic symptoms. The adjusted regression model showed that CESD-M was associated with all daytime variables. However, PSQI-night was associated only with PSQI-day. Path analyses indicated that PSQI-day bridged PSQI-night and CESD-M in a two-way direction after the I-BMS intervention. The conclusion was that, following I-BMS intervention, improvement in daytime functioning was related predominantly to improvement in depressive symptoms. Night-time sleep related only to daytime dysfunction that was specific to sleep disturbances. Therefore, 'sleep-specific daytime impairment' could be regarded as a major link from night-time sleep to depressive symptoms. More studies are required to understand the concept of 'sleep-specific daytime impairment'.
Published: 2018

4. Aryl hydrocarbon receptor activation by diesel exhaust particles mediates epithelium‐derived cytokines expression in severe allergic asthma

Author: Weng, C.‐M., primary, Wang, C.‐H., additional, Lee, M.‐J., additional, He, J.‐R., additional, Huang, H.‐Y., additional, Chao, M.‐W., additional, Chung, K. F., additional, and Kuo, H.‐P., additional
Published: 2018
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5. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Bousquet, J., primary, Farrell, J., additional, Crooks, G., additional, Hellings, P., additional, Bel, E. H., additional, Bewick, M., additional, Chavannes, N. H., additional, de Sousa, J. Correia, additional, Cruz, A. A., additional, Haahtela, T., additional, Joos, G., additional, Khaltaev, N., additional, Malva, J., additional, Muraro, A., additional, Nogues, M., additional, Palkonen, S., additional, Pedersen, S., additional, Robalo-Cordeiro, C., additional, Samolinski, B., additional, Strandberg, T., additional, Valiulis, A., additional, Yorgancioglu, A., additional, Zuberbier, T., additional, Bedbrook, A., additional, Aberer, W., additional, Adachi, M., additional, Agusti, A., additional, Akdis, C. A., additional, Akdis, M., additional, Ankri, J., additional, Alonso, A., additional, Annesi-Maesano, I., additional, Ansotegui, I. J., additional, Anto, J. M., additional, Arnavielhe, S., additional, Arshad, H., additional, Bai, C., additional, Baiardini, I., additional, Bachert, C., additional, Baigenzhin, A. K., additional, Barbara, C., additional, Bateman, E. D., additional, Beghé, B., additional, Kheder, A. Ben, additional, Bennoor, K. S., additional, Benson, M., additional, Bergmann, K. C., additional, Bieber, T., additional, Bindslev-Jensen, C., additional, Bjermer, L., additional, Blain, H., additional, Blasi, F., additional, Boner, A. L., additional, Bonini, M., additional, Bonini, S., additional, Bosnic-Anticevitch, S., additional, Boulet, L. P., additional, Bourret, R., additional, Bousquet, P. J., additional, Braido, F., additional, Briggs, A. H., additional, Brightling, C. E., additional, Brozek, J., additional, Buhl, R., additional, Burney, P. G., additional, Bush, A., additional, Caballero-Fonseca, F., additional, Caimmi, D., additional, Calderon, M. A., additional, Calverley, P. M., additional, Camargos, P. A. M., additional, Canonica, G. W., additional, Camuzat, T., additional, Carlsen, K. H., additional, Carr, W., additional, Carriazo, A., additional, Casale, T., additional, Cepeda Sarabia, A. M., additional, Chatzi, L., additional, Chen, Y. Z., additional, Chiron, R., additional, Chkhartishvili, E., additional, Chuchalin, A. G., additional, Chung, K. F., additional, Ciprandi, G., additional, Cirule, I., additional, Cox, L., additional, Costa, D. J., additional, Custovic, A., additional, Dahl, R., additional, Dahlen, S. E., additional, Darsow, U., additional, De Carlo, G., additional, De Blay, F., additional, Dedeu, T., additional, Deleanu, D., additional, De Manuel Keenoy, E., additional, Demoly, P., additional, Denburg, J. A., additional, Devillier, P., additional, Didier, A., additional, Dinh-Xuan, A. T., additional, Djukanovic, R., additional, Dokic, D., additional, Douagui, H., additional, Dray, G., additional, Dubakiene, R., additional, Durham, S. R., additional, Dykewicz, M. S., additional, El-Gamal, Y., additional, Emuzyte, R., additional, Fabbri, L. M., additional, Fletcher, M., additional, Fiocchi, A., additional, Fink Wagner, A., additional, Fonseca, J., additional, Fokkens, W. J., additional, Forastiere, F., additional, Frith, P., additional, Gaga, M., additional, Gamkrelidze, A., additional, Garces, J., additional, Garcia-Aymerich, J., additional, Gemicioğlu, B., additional, Gereda, J. E., additional, González Diaz, S., additional, Gotua, M., additional, Grisle, I., additional, Grouse, L., additional, Gutter, Z., additional, Guzmán, M. A., additional, Heaney, L. G., additional, Hellquist-Dahl, B., additional, Henderson, D., additional, Hendry, A., additional, Heinrich, J., additional, Heve, D., additional, Horak, F., additional, Hourihane, J. O’. B., additional, Howarth, P., additional, Humbert, M., additional, Hyland, M. E., additional, Illario, M., additional, Ivancevich, J. C., additional, Jardim, J. R., additional, Jares, E. J., additional, Jeandel, C., additional, Jenkins, C., additional, Johnston, S. L., additional, Jonquet, O., additional, Julge, K., additional, Jung, K. S., additional, Just, J., additional, Kaidashev, I., additional, Khaitov, M. R., additional, Kalayci, O., additional, Kalyoncu, A. F., additional, Keil, T., additional, Keith, P. K., additional, Klimek, L., additional, Koffi N’Goran, B., additional, Kolek, V., additional, Koppelman, G. H., additional, Kowalski, M. L., additional, Kull, I., additional, Kuna, P., additional, Kvedariene, V., additional, Lambrecht, B., additional, Lau, S., additional, Larenas-Linnemann, D., additional, Laune, D., additional, Le, L. T. T., additional, Lieberman, P., additional, Lipworth, B., additional, Li, J., additional, Lodrup Carlsen, K., additional, Louis, R., additional, MacNee, W., additional, Magard, Y., additional, Magnan, A., additional, Mahboub, B., additional, Mair, A., additional, Majer, I., additional, Makela, M. J., additional, Manning, P., additional, Mara, S., additional, Marshall, G. D., additional, Masjedi, M. R., additional, Matignon, P., additional, Maurer, M., additional, Mavale-Manuel, S., additional, Melén, E., additional, Melo-Gomes, E., additional, Meltzer, E. O., additional, Menzies-Gow, A., additional, Merk, H., additional, Michel, J. P., additional, Miculinic, N., additional, Mihaltan, F., additional, Milenkovic, B., additional, Mohammad, G. M. Y., additional, Molimard, M., additional, Momas, I., additional, Montilla-Santana, A., additional, Morais-Almeida, M., additional, Morgan, M., additional, Mösges, R., additional, Mullol, J., additional, Nafti, S., additional, Namazova-Baranova, L., additional, Naclerio, R., additional, Neou, A., additional, Neffen, H., additional, Nekam, K., additional, Niggemann, B., additional, Ninot, G., additional, Nyembue, T. D., additional, O’Hehir, R. E., additional, Ohta, K., additional, Okamoto, Y., additional, Okubo, K., additional, Ouedraogo, S., additional, Paggiaro, P., additional, Pali-Schöll, I., additional, Panzner, P., additional, Papadopoulos, N., additional, Papi, A., additional, Park, H. S., additional, Passalacqua, G., additional, Pavord, I., additional, Pawankar, R., additional, Pengelly, R., additional, Pfaar, O., additional, Picard, R., additional, Pigearias, B., additional, Pin, I., additional, Plavec, D., additional, Poethig, D., additional, Pohl, W., additional, Popov, T. A., additional, Portejoie, F., additional, Potter, P., additional, Postma, D., additional, Price, D., additional, Rabe, K. F., additional, Raciborski, F., additional, Radier Pontal, F., additional, Repka-Ramirez, S., additional, Reitamo, S., additional, Rennard, S., additional, Rodenas, F., additional, Roberts, J., additional, Roca, J., additional, Rodriguez Mañas, L., additional, Rolland, C., additional, Roman Rodriguez, M., additional, Romano, A., additional, Rosado-Pinto, J., additional, Rosario, N., additional, Rosenwasser, L., additional, Rottem, M., additional, Ryan, D., additional, Sanchez-Borges, M., additional, Scadding, G. K., additional, Schunemann, H. J., additional, Serrano, E., additional, Schmid-Grendelmeier, P., additional, Schulz, H., additional, Sheikh, A., additional, Shields, M., additional, Siafakas, N., additional, Sibille, Y., additional, Similowski, T., additional, Simons, F. E. R., additional, Sisul, J. C., additional, Skrindo, I., additional, Smit, H. A., additional, Solé, D., additional, Sooronbaev, T., additional, Spranger, O., additional, Stelmach, R., additional, Sterk, P. J., additional, Sunyer, J., additional, Thijs, C., additional, To, T., additional, Todo-Bom, A., additional, Triggiani, M., additional, Valenta, R., additional, Valero, A. L., additional, Valia, E., additional, Valovirta, E., additional, Van Ganse, E., additional, van Hage, M., additional, Vandenplas, O., additional, Vasankari, T., additional, Vellas, B., additional, Vestbo, J., additional, Vezzani, G., additional, Vichyanond, P., additional, Viegi, G., additional, Vogelmeier, C., additional, Vontetsianos, T., additional, Wagenmann, M., additional, Wallaert, B., additional, Walker, S., additional, Wang, D. Y., additional, Wahn, U., additional, Wickman, M., additional, Williams, D. M., additional, Williams, S., additional, Wright, J., additional, Yawn, B. P., additional, Yiallouros, P. K., additional, Yusuf, O. M., additional, Zaidi, A., additional, Zar, H. J., additional, Zernotti, M. E., additional, Zhang, L., additional, Zhong, N., additional, Zidarn, M., additional, and Mercier, J., additional
Published: 2017
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6. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J., primary, Hellings, P. W., additional, Agache, I., additional, Bedbrook, A., additional, Bachert, C., additional, Bergmann, K. C., additional, Bewick, M., additional, Bindslev-Jensen, C., additional, Bosnic-Anticevitch, S., additional, Bucca, C., additional, Caimmi, D. P., additional, Camargos, P. A. M., additional, Canonica, G. W., additional, Casale, T., additional, Chavannes, N. H., additional, Cruz, A. A., additional, De Carlo, G., additional, Dahl, R., additional, Demoly, P., additional, Devillier, P., additional, Fonseca, J., additional, Fokkens, W. J., additional, Guldemond, N. A., additional, Haahtela, T., additional, Illario, M., additional, Just, J., additional, Keil, T., additional, Klimek, L., additional, Kuna, P., additional, Larenas-Linnemann, D., additional, Morais-Almeida, M., additional, Mullol, J., additional, Murray, R., additional, Naclerio, R., additional, O’Hehir, R. E., additional, Papadopoulos, N. G., additional, Pawankar, R., additional, Potter, P., additional, Ryan, D., additional, Samolinski, B., additional, Schunemann, H. J., additional, Sheikh, A., additional, Simons, F. E. R., additional, Stellato, C., additional, Todo-Bom, A., additional, Tomazic, P. V., additional, Valiulis, A., additional, Valovirta, E., additional, Ventura, M. T., additional, Wickman, M., additional, Young, I., additional, Yorgancioglu, A., additional, Zuberbier, T., additional, Aberer, W., additional, Akdis, C. A., additional, Akdis, M., additional, Annesi-Maesano, I., additional, Ankri, J., additional, Ansotegui, I. J., additional, Anto, J. M., additional, Arnavielhe, S., additional, Asarnoj, A., additional, Arshad, H., additional, Avolio, F., additional, Baiardini, I., additional, Barbara, C., additional, Barbagallo, M., additional, Bateman, E. D., additional, Beghé, B., additional, Bel, E. H., additional, Bennoor, K. S., additional, Benson, M., additional, Białoszewski, A. Z., additional, Bieber, T., additional, Bjermer, L., additional, Blain, H., additional, Blasi, F., additional, Boner, A. L., additional, Bonini, M., additional, Bonini, S., additional, Bosse, I., additional, Bouchard, J., additional, Boulet, L. P., additional, Bourret, R., additional, Bousquet, P. J., additional, Braido, F., additional, Briggs, A. H., additional, Brightling, C. E., additional, Brozek, J., additional, Buhl, R., additional, Bunu, C., additional, Burte, E., additional, Bush, A., additional, Caballero-Fonseca, F., additional, Calderon, M. A., additional, Camuzat, T., additional, Cardona, V., additional, Carreiro-Martins, P., additional, Carriazo, A. M., additional, Carlsen, K. H., additional, Carr, W., additional, Cepeda Sarabia, A. M., additional, Cesari, M., additional, Chatzi, L., additional, Chiron, R., additional, Chivato, T., additional, Chkhartishvili, E., additional, Chuchalin, A. G., additional, Chung, K. F., additional, Ciprandi, G., additional, de Sousa, J. Correia, additional, Cox, L., additional, Crooks, G., additional, Custovic, A., additional, Dahlen, S. E., additional, Darsow, U., additional, Dedeu, T., additional, Deleanu, D., additional, Denburg, J. A., additional, De Vries, G., additional, Didier, A., additional, Dinh-Xuan, A. T., additional, Dokic, D., additional, Douagui, H., additional, Dray, G., additional, Dubakiene, R., additional, Durham, S. R., additional, Du Toit, G., additional, Dykewicz, M. S., additional, Eklund, P., additional, El-Gamal, Y., additional, Ellers, E., additional, Emuzyte, R., additional, Farrell, J., additional, Fink Wagner, A., additional, Fiocchi, A., additional, Fletcher, M., additional, Forastiere, F., additional, Gaga, M., additional, Gamkrelidze, A., additional, Gemicioğlu, B., additional, Gereda, J. E., additional, van Wick, R. Gerth, additional, González Diaz, S., additional, Grisle, I., additional, Grouse, L., additional, Gutter, Z., additional, Guzmán, M. A., additional, Hellquist-Dahl, B., additional, Heinrich, J., additional, Horak, F., additional, Hourihane, J. O’. B., additional, Humbert, M., additional, Hyland, M., additional, Iaccarino, G., additional, Jares, E. J., additional, Jeandel, C., additional, Johnston, S. L., additional, Joos, G., additional, Jonquet, O., additional, Jung, K. S., additional, Jutel, M., additional, Kaidashev, I., additional, Khaitov, M., additional, Kalayci, O., additional, Kalyoncu, A. F., additional, Kardas, P., additional, Keith, P. K., additional, Kerkhof, M., additional, Kerstjens, H. A. M., additional, Khaltaev, N., additional, Kogevinas, M., additional, Kolek, V., additional, Koppelman, G. H., additional, Kowalski, M. L., additional, Kuitunen, M., additional, Kull, I., additional, Kvedariene, V., additional, Lambrecht, B., additional, Lau, S., additional, Laune, D., additional, Le, L. T. T., additional, Lieberman, P., additional, Lipworth, B., additional, Li, J., additional, Lodrup Carlsen, K. C., additional, Louis, R., additional, Lupinek, C., additional, MacNee, W., additional, Magar, Y., additional, Magnan, A., additional, Mahboub, B., additional, Maier, D., additional, Majer, I., additional, Malva, J., additional, Manning, P., additional, De Manuel Keenoy, E., additional, Marshall, G. D., additional, Masjedi, M. R., additional, Mathieu-Dupas, E., additional, Maurer, M., additional, Mavale-Manuel, S., additional, Melén, E., additional, Melo-Gomes, E., additional, Meltzer, E. O., additional, Mercier, J., additional, Merk, H., additional, Miculinic, N., additional, Mihaltan, F., additional, Milenkovic, B., additional, Millot-Keurinck, J., additional, Mohammad, Y., additional, Momas, I., additional, Mösges, R., additional, Muraro, A., additional, Namazova-Baranova, L., additional, Nadif, R., additional, Neffen, H., additional, Nekam, K., additional, Nieto, A., additional, Niggemann, B., additional, Nogueira-Silva, L., additional, Nogues, M., additional, Nyembue, T. D., additional, Ohta, K., additional, Okamoto, Y., additional, Okubo, K., additional, Olive-Elias, M., additional, Ouedraogo, S., additional, Paggiaro, P., additional, Pali-Schöll, I., additional, Palkonen, S., additional, Panzner, P., additional, Papi, A., additional, Park, H. S., additional, Passalacqua, G., additional, Pedersen, S., additional, Pereira, A. M., additional, Pfaar, O., additional, Picard, R., additional, Pigearias, B., additional, Pin, I., additional, Plavec, D., additional, Pohl, W., additional, Popov, T. A., additional, Portejoie, F., additional, Postma, D., additional, Poulsen, L. K., additional, Price, D., additional, Rabe, K. F., additional, Raciborski, F., additional, Roberts, G., additional, Robalo-Cordeiro, C., additional, Rodenas, F., additional, Rodriguez-Mañas, L., additional, Rolland, C., additional, Roman Rodriguez, M., additional, Romano, A., additional, Rosado-Pinto, J., additional, Rosario, N., additional, Rottem, M., additional, Sanchez-Borges, M., additional, Sastre-Dominguez, J., additional, Scadding, G. K., additional, Scichilone, N., additional, Schmid-Grendelmeier, P., additional, Serrano, E., additional, Shields, M., additional, Siroux, V., additional, Sisul, J. C., additional, Skrindo, I., additional, Smit, H. A., additional, Solé, D., additional, Sooronbaev, T., additional, Spranger, O., additional, Stelmach, R., additional, Sterk, P. J., additional, Strandberg, T., additional, Sunyer, J., additional, Thijs, C., additional, Triggiani, M., additional, Valenta, R., additional, Valero, A., additional, van Eerd, M., additional, van Ganse, E., additional, van Hague, M., additional, Vandenplas, O., additional, Varona, L. L., additional, Vellas, B., additional, Vezzani, G., additional, Vazankari, T., additional, Viegi, G., additional, Vontetsianos, T., additional, Wagenmann, M., additional, Walker, S., additional, Wang, D. Y., additional, Wahn, U., additional, Werfel, T., additional, Whalley, B., additional, Williams, D. M., additional, Williams, S., additional, Wilson, N., additional, Wright, J., additional, Yawn, B. P., additional, Yiallouros, P. K., additional, Yusuf, O. M., additional, Zaidi, A., additional, Zar, H. J., additional, Zernotti, M. E., additional, Zhang, L., additional, Zhong, N., additional, and Zidarn, M., additional
Published: 2016
Full Text: View/download PDF

7. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Bousquet, J., primary, Farrell, J., additional, Crooks, G., additional, Hellings, P., additional, Bel, E. H., additional, Bewick, M., additional, Chavannes, N. H., additional, de Sousa, J. Correia, additional, Cruz, A. A., additional, Haahtela, T., additional, Joos, G., additional, Khaltaev, N., additional, Malva, J., additional, Muraro, A., additional, Nogues, M., additional, Palkonen, S., additional, Pedersen, S., additional, Robalo-Cordeiro, C., additional, Samolinski, B., additional, Strandberg, T., additional, Valiulis, A., additional, Yorgancioglu, A., additional, Zuberbier, T., additional, Bedbrook, A., additional, Aberer, W., additional, Adachi, M., additional, Agusti, A., additional, Akdis, C. A., additional, Akdis, M., additional, Ankri, J., additional, Alonso, A., additional, Annesi-Maesano, I., additional, Ansotegui, I. J., additional, Anto, J. M., additional, Arnavielhe, S., additional, Arshad, H., additional, Bai, C., additional, Baiardini, I., additional, Bachert, C., additional, Baigenzhin, A. K., additional, Barbara, C., additional, Bateman, E. D., additional, Beghé, B., additional, Kheder, A. Ben, additional, Bennoor, K. S., additional, Benson, M., additional, Bergmann, K. C., additional, Bieber, T., additional, Bindslev-Jensen, C., additional, Bjermer, L., additional, Blain, H., additional, Blasi, F., additional, Boner, A. L., additional, Bonini, M., additional, Bonini, S., additional, Bosnic-Anticevitch, S., additional, Boulet, L. P., additional, Bourret, R., additional, Bousquet, P. J., additional, Braido, F., additional, Briggs, A. H., additional, Brightling, C. E., additional, Brozek, J., additional, Buhl, R., additional, Burney, P. G., additional, Bush, A., additional, Caballero-Fonseca, F., additional, Caimmi, D., additional, Calderon, M. A., additional, Calverley, P. M., additional, Camargos, P. A. M., additional, Canonica, G. W., additional, Camuzat, T., additional, Carlsen, K. H., additional, Carr, W., additional, Carriazo, A., additional, Casale, T., additional, Cepeda Sarabia, A. M., additional, Chatzi, L., additional, Chen, Y. Z., additional, Chiron, R., additional, Chkhartishvili, E., additional, Chuchalin, A. G., additional, Chung, K. F., additional, Ciprandi, G., additional, Cirule, I., additional, Cox, L., additional, Costa, D. J., additional, Custovic, A., additional, Dahl, R., additional, Dahlen, S. E., additional, Darsow, U., additional, De Carlo, G., additional, De Blay, F., additional, Dedeu, T., additional, Deleanu, D., additional, De Manuel Keenoy, E., additional, Demoly, P., additional, Denburg, J. A., additional, Devillier, P., additional, Didier, A., additional, Dinh-Xuan, A. T., additional, Djukanovic, R., additional, Dokic, D., additional, Douagui, H., additional, Dray, G., additional, Dubakiene, R., additional, Durham, S. R., additional, Dykewicz, M. S., additional, El-Gamal, Y., additional, Emuzyte, R., additional, Fabbri, L. M., additional, Fletcher, M., additional, Fiocchi, A., additional, Fink Wagner, A., additional, Fonseca, J., additional, Fokkens, W. J., additional, Forastiere, F., additional, Frith, P., additional, Gaga, M., additional, Gamkrelidze, A., additional, Garces, J., additional, Garcia-Aymerich, J., additional, Gemicioğlu, B., additional, Gereda, J. E., additional, González Diaz, S., additional, Gotua, M., additional, Grisle, I., additional, Grouse, L., additional, Gutter, Z., additional, Guzmán, M. A., additional, Heaney, L. G., additional, Hellquist-Dahl, B., additional, Henderson, D., additional, Hendry, A., additional, Heinrich, J., additional, Heve, D., additional, Horak, F., additional, Hourihane, J. O’. B., additional, Howarth, P., additional, Humbert, M., additional, Hyland, M. E., additional, Illario, M., additional, Ivancevich, J. C., additional, Jardim, J. R., additional, Jares, E. J., additional, Jeandel, C., additional, Jenkins, C., additional, Johnston, S. L., additional, Jonquet, O., additional, Julge, K., additional, Jung, K. S., additional, Just, J., additional, Kaidashev, I., additional, Kaitov, M. R., additional, Kalayci, O., additional, Kalyoncu, A. F., additional, Keil, T., additional, Keith, P. K., additional, Klimek, L., additional, Koffi N’Goran, B., additional, Kolek, V., additional, Koppelman, G. H., additional, Kowalski, M. L., additional, Kull, I., additional, Kuna, P., additional, Kvedariene, V., additional, Lambrecht, B., additional, Lau, S., additional, Larenas-Linnemann, D., additional, Laune, D., additional, Le, L. T. T., additional, Lieberman, P., additional, Lipworth, B., additional, Li, J., additional, Lodrup Carlsen, K., additional, Louis, R., additional, MacNee, W., additional, Magard, Y., additional, Magnan, A., additional, Mahboub, B., additional, Mair, A., additional, Majer, I., additional, Makela, M. J., additional, Manning, P., additional, Mara, S., additional, Marshall, G. D., additional, Masjedi, M. R., additional, Matignon, P., additional, Maurer, M., additional, Mavale-Manuel, S., additional, Melén, E., additional, Melo-Gomes, E., additional, Meltzer, E. O., additional, Menzies-Gow, A., additional, Merk, H., additional, Michel, J. P., additional, Miculinic, N., additional, Mihaltan, F., additional, Milenkovic, B., additional, Mohammad, G. M. Y., additional, Molimard, M., additional, Momas, I., additional, Montilla-Santana, A., additional, Morais-Almeida, M., additional, Morgan, M., additional, Mösges, R., additional, Mullol, J., additional, Nafti, S., additional, Namazova-Baranova, L., additional, Naclerio, R., additional, Neou, A., additional, Neffen, H., additional, Nekam, K., additional, Niggemann, B., additional, Ninot, G., additional, Nyembue, T. D., additional, O’Hehir, R. E., additional, Ohta, K., additional, Okamoto, Y., additional, Okubo, K., additional, Ouedraogo, S., additional, Paggiaro, P., additional, Pali-Schöll, I., additional, Panzner, P., additional, Papadopoulos, N., additional, Papi, A., additional, Park, H. S., additional, Passalacqua, G., additional, Pavord, I., additional, Pawankar, R., additional, Pengelly, R., additional, Pfaar, O., additional, Picard, R., additional, Pigearias, B., additional, Pin, I., additional, Plavec, D., additional, Poethig, D., additional, Pohl, W., additional, Popov, T. A., additional, Portejoie, F., additional, Potter, P., additional, Postma, D., additional, Price, D., additional, Rabe, K. F., additional, Raciborski, F., additional, Radier Pontal, F., additional, Repka-Ramirez, S., additional, Reitamo, S., additional, Rennard, S., additional, Rodenas, F., additional, Roberts, J., additional, Roca, J., additional, Rodriguez Mañas, L., additional, Rolland, C., additional, Roman Rodriguez, M., additional, Romano, A., additional, Rosado-Pinto, J., additional, Rosario, N., additional, Rosenwasser, L., additional, Rottem, M., additional, Ryan, D., additional, Sanchez-Borges, M., additional, Scadding, G. K., additional, Schunemann, H. J., additional, Serrano, E., additional, Schmid-Grendelmeier, P., additional, Schulz, H., additional, Sheikh, A., additional, Shields, M., additional, Siafakas, N., additional, Sibille, Y., additional, Similowski, T., additional, Simons, F. E. R., additional, Sisul, J. C., additional, Skrindo, I., additional, Smit, H. A., additional, Solé, D., additional, Sooronbaev, T., additional, Spranger, O., additional, Stelmach, R., additional, Sterk, P. J., additional, Sunyer, J., additional, Thijs, C., additional, To, T., additional, Todo-Bom, A., additional, Triggiani, M., additional, Valenta, R., additional, Valero, A. L., additional, Valia, E., additional, Valovirta, E., additional, Van Ganse, E., additional, van Hage, M., additional, Vandenplas, O., additional, Vasankari, T., additional, Vellas, B., additional, Vestbo, J., additional, Vezzani, G., additional, Vichyanond, P., additional, Viegi, G., additional, Vogelmeier, C., additional, Vontetsianos, T., additional, Wagenmann, M., additional, Wallaert, B., additional, Walker, S., additional, Wang, D. Y., additional, Wahn, U., additional, Wickman, M., additional, Williams, D. M., additional, Williams, S., additional, Wright, J., additional, Yawn, B. P., additional, Yiallouros, P. K., additional, Yusuf, O. M., additional, Zaidi, A., additional, Zar, H. J., additional, Zernotti, M. E., additional, Zhang, L., additional, Zhong, N., additional, Zidarn, M., additional, and Mercier, J., additional
Published: 2016
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8. Staphylococcal enterotoxin-specific IgE: a biomarker for a distinct phenotype of severe asthma?

Author: Chung, K. F., primary
Published: 2016
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9. The investigation of severe asthma to define phenotypes

Author: Gibeon, D., primary and Chung, K. F., additional
Published: 2012
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10. Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology

Author: Hew, M., primary and Chung, K. F., additional
Published: 2010
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11. Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma

Author: Macedo, P., primary, Hew, M., additional, Torrego, A., additional, Jouneau, S., additional, Oates, T., additional, Durham, A., additional, and Chung, K. F., additional
Published: 2009
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12. Molecular systematics of the trans-Pacific alpine genus Oreomyrrhis (Apiaceae): phylogenetic affinities and biogeographic implications

Author: Chung, K.-F., primary, Peng, C.-I, additional, Downie, S. R., additional, Spalik, K., additional, and Schaal, B. A., additional
Published: 2005
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13. H+/K+-ATPase (proton pump) inhibitors dampen increased cough reflex: more than gastric acid suppression

Author: Chung, K. F., primary
Published: 2005
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14. Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease

Author: Caramori, G, primary, Di Gregorio, C, additional, Carlstedt, I, additional, Casolari, P, additional, Guzzinati, I, additional, Adcock, I M, additional, Barnes, P J, additional, Ciaccia, A, additional, Cavallesco, G, additional, Chung, K F, additional, and Papi, A, additional
Published: 2004
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15. Maximal airway plateau responses and eosinophils in cough variant asthma

Author: Chung, K. F., primary
Published: 2004
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16. Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages

Author: Lim, S., primary, Caramori, G., additional, Tomita, K., additional, Jazrawi, E., additional, Oates, T., additional, Chung, K. F., additional, Barnes, P. J., additional, and Adcock, I. M., additional
Published: 2004
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17. Composite beams and floor systems fully integrated with building services

Author: Chung, K F, primary
Published: 2002
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18. Expression of respiratory mucins in fatal status asthmaticus and mild asthma

Author: Groneberg, D A, primary, Eynott, P R, additional, Lim, S, additional, Oates, T, additional, Wu, R, additional, Carlstedt, I, additional, Roberts, P, additional, McCann, B, additional, Nicholson, A G, additional, Harrison, B D, additional, and Chung, K F, additional
Published: 2002
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19. Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages

Author: Oliver, B., primary, Tomita, K., additional, Keller, A., additional, Caramori, G., additional, Adcock, I., additional, Chung, K. F., additional, Barnes, P. J., additional, and Lim, S., additional
Published: 2001
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20. Severe asthma: definition and mechanisms

Author: Stirling, R. G., primary and Chung, K. F., additional
Published: 2001
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21. Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease

Author: Di Stefano, A., primary, Capelli, A., additional, Lusuardi, M., additional, Caramori, G., additional, Balbo, P., additional, Ioli, F., additional, Sacco, S., additional, Gnemmi, I., additional, Brun, P., additional, Adcock, I. M., additional, Balbi, B., additional, Barnes, P. J., additional, Chung, K. F., additional, and Donner, C. F., additional
Published: 2001
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22. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

Author: ITO, K., primary, LIM, S., additional, CARAMORI, G., additional, CHUNG, K. F., additional, BARNES, P. J., additional, and ADCOCK, I. M., additional
Published: 2001
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23. Increased interleukin‐10 and macrophage inflammatoryprotein‐1α release from blood monocytes ex vivo duringlate‐phase response to allergen in asthma

Author: Lim, S., primary, John, M., additional, Seybold, J., additional, Taylor, D., additional, Witt, C., additional, Barnes, P. J., additional, and Chung, K. F., additional
Published: 2000
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24. Non-invasive biomarkers of asthma

Author: Chung, K. F., primary
Published: 1999
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25. The complementary role of glucocorticosteroids and long-acting β-adrenergic agonists

Author: Chung, K. F., primary
Published: 1998
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26. Adoptive transfer of allergen‐specific CD4+ T cells induces airway inflammation and hyperresponsiveness in Brown–Norway rats

Author: HACZKU, A., primary, MACARY, P., additional, HUANG, T.‐J., additional, TSUKAGOSHI, H., additional, BARNES, P. J., additional, KAY, A. B., additional, KEMENY, D. M., additional, CHUNG, K. F., additional, and MOQBEL, R., additional
Published: 1997
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27. Inhibition of inducible nitric oxide synthase expression by interleukin‐4 and interleukin‐13 in human lung epithelial cells

Author: BERKMAN, N., primary, ROBICHAUD, A., additional, ROBBINS, R. A., additional, ROESEMS, G., additional, HADDAD, E. B., additional, BARNES, P. J., additional, and CHUNG, K. F., additional
Published: 1996
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28. Expression of Th-2 cytokines interleukin-4 and −5 and of Th-1 cytokine interferon-γ in ovalbumin-exposed sensitized Brown-Norway rats

Author: HACZKU, A., primary, MACARY, P., additional, HADDAD, E.-B., additional, HUANG, T. J., additional, KEMENY, D. M., additional, MOQBEL, R., additional, and CHUNG, K. F., additional
Published: 1996
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29. Airway neuropeptides and neutral endopeptidase in asthma

Author: Chung, K. F., primary
Published: 1996
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30. Expression of RANTES in human airway epithelial cells: effect of corticosteroids and interleukin‐4, ‐10 and ‐13

Author: BERKMAN, N., primary, ROBICHAUD, A., additional, KRISHNAN, V. L., additional, ROESEMS, G., additional, ROBBINS, R., additional, JOSE, P. J., additional, BARNES, P. J., additional, and CHUNG, K. F., additional
Published: 1996
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31. Theophylline in chronic asthma-evidence for disease-modifying properties

Author: CHUNG, K. F., primary
Published: 1996
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32. beta2-adrenergic agonists, corticosteroids and IgE production

Author: Chung, K. F., primary
Published: 1995
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33. Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs

Author: HAYES, J. P., primary, DANIEL, R., additional, TEE, R. D., additional, BARNES, P. J., additional, CHUNG, K. F., additional, and NEWMAN TAYLOR, A. J., additional
Published: 1992
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34. Neutrophil influx into guinea‐pig airway lumen during cholinergic and non‐cholinergic bronchoconstriction

Author: LÖTVALL, J., primary, RABE, K., additional, TOKUYAMA, K., additional, LÖFDAHL, C.‐G, additional, BARNES, P. J., additional, and CHUNG, K. F., additional
Published: 1992
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35. Role for platelet-activating factor in asthma

Author: Chung, K. F., primary and Barnes, P. J., additional
Published: 1991
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36. Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig

Author: Lötvall, J. O., primary, Hui, K. P., additional, Löfdahl, C. G., additional, Barnes, P. J., additional, and Chung, K. F., additional
Published: 1991
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37. Mediators of bronchial hyperresponsiveness

Author: CHUNG, K. F., primary
Published: 1990
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38. Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air ® App

Author: Bédard, Annabelle, Antó, Josep, Fonseca, Joao, Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Cardona, Victoria, Cruz, Alvaro, Fokkens, Wytske, Garcia-Aymerich, Judith, Hellings, Peter, Ivancevich, Juan, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée, Melen, Erik, Monti, Ricardo, Mösges, Ralf, Mullol, Joaquim, Papadopoulos, Nikos, Pham-Thi, Nhan, Samolinski, Boleslaw, V Tomazic, Peter, Toppila-Salmi, Sanna, Ventura, Maria Teresa, Yorgancioglu, Arzu, Bousquet, Jean, Pfaar, Oliver, Basagana, Xavier, Bosnic‐Anticevich, Sinthia, Pham‐Thi, Nhân, Hellings, PW, Aberer, W., Agache, I., Akdis, Ca, Akdis, M., Aliberti, MR, Almeida, R., Amat, F., Angles, R, Annesi‐Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielle, S, Asayag, E, Asarnoj, A, Arshad, H, Avolio, F, Bacci, E, Baiardini, I, Barbara, C, Barbagallo, M., Baroni, I, Barreto, BA, Basagaña, X., Bateman, ED, Bedolla‐Barajas, M, Bewick, M., Beghé, B., Bel, EH, Bergmann, KC, Bennoor, KS, Benson, M, Bertorello, L, Białoszewski, AZ, Bieber, T., Bialek, S, Bindslev‐Jensen, Carsten, Bjermer, L., Blain, H., Blasi, F., Blua, A, Bochenska Marciniak, M, Bogus‐Buczynska, I, Boner, AL, Bonini, M., Bonini, S., Bosnic‐Anticevich, CS, Bosse, I., Bouchard, J., Boulet, LP, Bourret, R., Bousquet, Pj, Braido, F, Briedis, V, Brightling, CE, Brozek, J, Bucca, C, Buhl, R, Buonaiuto, R, Panaitescu, C, Burguete Cabañas, MT, Burte, E., Bush, A, Caballero‐Fonseca, F, Caillaud, D., Caimmi, D., Calderon, MA, Camargos, PAM, Camuzat, T., Canfora, G, Canonica, Gw, Carlsen, KH, Carreiro‐Martins, P, Carriazo, AM, Carr, W, Cartier, C., Casale, T., Castellano, G, Cecchi, L, Cepeda, AM, Chavannes, NH, Chen, Y., Chiron, R., Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciaravolo, MM, Ciceran, A, Cingi, C, Ciprandi, G, Carvalho Coehlo, AC, Colas, L, Colgan, E, Coll, J, Conforti, D, Constantinidis, J, de Sousa, J Correia, Cortés‐Grimaldo, RM, Corti, F, Costa, E, Costa‐Dominguez, MC, Courbis, AL, Cox, L, Crescenzo, M, Cruz, AA, Custovic, A., Czarlewski, W., Dahlen, Se, D’Amato, G, Dario, C, Da Silva, J., Dauvilliers, Y., Darsow, U, De Blay, F., De Carlo, G, Dedeu, T, de Fátima Emerson, M, De Feo, G., De Vries, G, De Martino, B, Motta Rubini, NP, Deleanu, D, Denburg, JA, devillier, P., Di Capua Ercolano, S, Di Carluccio, N, Didier, A., Dokic, D, Dominguez‐Silva, MG, Douagui, H, Dray, G., Dubakiene, R, Durham, Sr, Du Toit, G, Dykewicz, MS, El‐Gamal, Y, Eklund, P, Eller, E, Emuzyte, R., Farrell, J, Farsi, A, de Mello, J Ferreira, Ferrero, J, Fink‐Wagner, A, Fiocchi, A, Fokkens, WJ, Fonseca, JA, Fontaine, Jf, Forti, S, Fuentes‐Perez, JM, Gálvez‐Romero, JL, Gamkrelidze, A, Garcia‐Aymerich, Judith, García‐Cobas, CY, Garcia‐Cruz, MH, Gemicioğlu, B, Genova, S, Christoff, G, Gereda, JE, Van Wijk, R Gerth, Gomez, RM, Gómez‐Vera, J, González Diaz, S, Gotua, M., Grisle, I, Guidacci, M, Guldemond, NA, Gutter, Z, Guzmán, MA, Haahtela, T., Hajjam, J, Hernández, L, Hourihane, JO’B, Huerta‐Villalobos, YR, Humbert, M., Iaccarino, G., Illario, M, Ispayeva, Z, Ivancevich, JC, Jares, EJ, Jassem, E, Johnston, Sl, Joos, G, Jung, KS, Just, J., Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, AF, Karjalainen, J, Kardas, P, Keil, T, Keith, PK, Khaitov, M, Khaltaev, N, Kleine‐Tebbe, J, Kowalski, Ml, Kuitunen, M, Kull, I., Kupczyk, M, Krzych‐Fałta, E, Lacwik, P, Larenas‐Linnemann, Désirée, Laune, D., Lauri, D, Lavrut, J, Le, LTT, Lessa, M, Levato, G, Li, J., Lieberman, P, Lipiec, A, Lipworth, B, Lodrup Carlsen, KC, Louis, R, Lourenço, O, Luna‐Pech, JA, Magnan, A., Mahboub, B, Maier, D., Mair, A, Majer, I, Malva, J, Mandajieva, E, Manning, P, De Manuel Keenoy, E, Marshall, GD, Masjedi, MR, Maspero, JF, Mathieu‐Dupas, E, Matta Campos, JJ, Matos, AL, Maurer, M, Mavale‐Manuel, S, Mayora, O, Meco, C, Medina‐Avalos, MA, Melo‐Gomes, E, Meltzer, EO, Menditto, E., Miculinic, N, Mihaltan, F., Milenkovic, B, Moda, G, Mogica‐Martinez, MD, Mohammad, Y, Momas, I., Montefort, S, Mora Bogado, D, Morais‐Almeida, M, Morato‐Castro, FF, Mota‐Pinto, A, Moura Santo, P, Münter, L, Muraro, A, Murray, R, Naclerio, R., Nadif, R., Nalin, M, Napoli, L, Namazova‐Baranova, L, Neffen, H, Niedeberger, V, Nekam, K, Neou, A, Nieto, A, Nogueira‐Silva, L, Nogues, M., Novellino, E, Nyembue, TD, O’Hehir, RE, Odzhakova, C, Ohta, K., Okamoto, Y., Okubo, K, Onorato, GL, Ortega Cisneros, M, Ouédraogo, S., Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Park, HS, Papi, A., Passalacqua, G, Paulino, E, Pawankar, R, Pedersen, S, Pépin, JL, Pereira, AM, Persico, M, PHILLIPS, J, Picard, R., Pigearias, B, Pin, I., Pitsios, C., Plavec, D, Pohl, W, Popov, TA, Portejoie, F., Potter, P, Pozzi, AC, Price, D, Prokopakis, EP, Puy, R, Pugin, B, Pulido Ross, RE, Przemecka, M, Rabe, KF, Raciborski, F, Rajabian‐Soderlund, R, Reitsma, S, Ribeirinho, I, Rimmer, J, Rivero‐Yeverino, D, Rizzo, JA, Rizzo, MC, Robalo‐Cordeiro, C, Rodenas, F, Rodo, X, Rodriguez Gonzalez, M, Rodriguez‐Mañas, L, Rolland, C, Rodrigues Valle, S, Roman Rodriguez, M., Romano, A, Rodriguez‐Zagal, E, Rolla, G, Roller‐Wirnsberger, RE, Romano, M, Rosado‐Pinto, J, Rosario, N., Rottem, M, Ryan, D, Sagara, H, Salimäki, J, Sanchez‐Borges, M, Sastre‐Dominguez, J, Scadding, GK, Schunemann, HJ, Scichilone, N, Schmid‐Grendelmeier, P, Sarquis Serpa, F, Shamai, S., Sheikh, A., Sierra, M, Simons, FER, Siroux, V., Sisul, JC, Skrindo, I, Solé, D, Somekh, D, Sondermann, M, Sooronbaev, T, Sova, M, Sorensen, M, Sorlini, M, Spranger, O, Stellato, C, Stelmach, R, Stukas, R, Sunyer, J., Strozek, J, Szylling, A, Tebyriçá, JN, Thibaudon, M., To, T., Todo‐Bom, A, Tomazic, PV, Toppila‐Salmi, Sanna, Trama, U, Triggiani, M, Suppli Ulrik, C, Urrutia‐Pereira, M, Valenta, R, Valero, A., Valiulis, A., Valovirta, E., van Eerd, M, Van Ganse, E., van Hage, M, Vandenplas, O, Ventura, MT, Vezzani, G, Vasankari, T, Vatrella, A., Verissimo, MT, Viart, F., Viegi, G., Vicheva, D, Vontetsianos, T, Wagenmann, M, Walker, S, Wallace, D, Wang, DY, Waserman, S., Werfel, T, Westman, M, Wickman, M., Williams, DM, Williams, S, Wilson, N, Wright, J, Wroczynski, P, Yakovliev, P, Yawn, BP, Yiallouros, PK, Yusuf, OM, Zar, HJ, Zhang, L., Zhong, N, Zernotti, ME, Zhanat, I, Zidarn, M, Zuberbier, T., Zubrinich, C, Zurkuhlen, A, Mercier, Jacques, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, KYomed INNOV, Ghent University Hospital, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Odense University Hospital [Odense, Denmark], Woolcock Institute of Medical Research [Sydney], The University of Sydney, Vall d'Hebron University Hospital [Barcelona], ProAR - FMB, Federal University of Bahia School of Medicine, European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), University Hospitals Leuven [Leuven], Zentrum für Rhinologie und Allergologie [Wiesbaden, Germany], Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Vilnius University [Vilnius], Clínica de Alergia- Asma y Pediatría, Hospital Medica Sur, Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris] (IP), Medical University of Warsaw - Poland, Department of Pulmonology, Manisa Celal Bayar University, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Aix Marseille Université (AMU), Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), iQ4U consultants Ltd, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Department of Respiratory Medicine and Allergy, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, CHU Montpellier, Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Région Languedoc-Roussillon-Midi-Pyrénées, University of South Florida [Tampa] (USF), Chinese academy of sciences Sanya, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Laboratoire de Génie Informatique et d'Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Department of Paediatrics, UCB Pharma, Colombes, CHU Strasbourg, Università degli Studi di Salerno = University of Salerno (UNISA), Hôpital Foch [Suresnes], Service de pneumologie [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Informatique, Image, Intelligence Artificielle (I3A), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-IMT - MINES ALES (IMT - MINES ALES), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Center for Allergy and Immunology Research [Tbilisi], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Center for Turbulence Research [Stanford] (CTR), Stanford University, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Biomax Informatics AG, 'Federico II' University of Naples Medical School, Pneumology Department, Marius Nasta Institute of Pneumology, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Johns Hopkins University School of Medicine [Baltimore], CARSAT-LR, Montpellier, Dept. of Electronic Engineering, Chubu University, Institute for Solid State Physics, The University of Tokyo (UTokyo), Respiratory Medicine, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, University of Cyprus [Nicosia] (UCY), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Computer Science [Haifa], University of Haifa [Haifa], University of Edinburgh, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Réseau National de Surveillance Aérobiologique (RNSA), CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, University of Turku, Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), ASA (Advanced Solution Accelerator) (Data management : Développement Back-Office, hébergement…), 34830 Jacou, Consiglio nazionale delle ricerche, Instituto di fisiologia clinica, McMaster University [Hamilton, Ontario], Department of Molecular Medicine and Surgery, UMR CNRS 8179, Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), University Hospital of Cologne [Cologne], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ISGlobal, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, IMIM (Hospital del Mar Research Institute), Barcelona, Spain, CINTESIS, Center for Research in Health Technology and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal, Medida, Lda Porto, Porto, Portugal, KYomed INNOV, Montpellier, France, Upper Airways Research Laboratory, ENT Dept, Ghent University Hospital, Ghent, Belgium, MACVIA-France, Montpellier, France, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark, Woolcock Institute of Medical Research, University of Sydney and Woolcock Emphysema Centre and Sydney Local Health District, Glebe, NSW, Australia, Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain, ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Brasil and WHO GARD Planning Group, Salvador, Brazil, Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands, Euforea, Brussels, Belgium, Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina, Center for Rhinology and Allergology, Wiesbaden, Germany, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland, Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania, Clinic of Chest diseases and Allergology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius, Lithuania, Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico, Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Allergy and Clinical Immunology Unit, Department of Medical Sciences, University of Torino & Mauriziano Hospital, Torino, Italy, Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, Cologne, Germany, CRI-Clinical Research International-Ltd, Hamburg, Germany, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, University of Barcelona, Barcelona, Spain, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain, Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom, Allergy Department, Pasteur Institute, Paris, France, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland, Department of General ORL, H&NS, Medical University of Graz, Graz, Austria, Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland, Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey, University Hospital, Montpellier, France, INSERM U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, France, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles, France, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin Institute of Health, Berlin, Germany, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität, Marburg, Germany, Universidade do Porto, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut Pasteur [Paris], University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Università degli Studi di Salerno (UNISA), CHU Toulouse [Toulouse]-Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, University of Helsinki, Service d'Allergologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Cyprus [Nicosia], Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bedard, A., Anto, J. M., Fonseca, J. A., Arnavielhe, S., Bachert, C., Bedbrook, A., Bindslev-Jensen, C., Bosnic-Anticevich, S., Cardona, V., Cruz, A. A., Fokkens, W. J., Garcia-Aymerich, J., Hellings, P. W., Ivancevich, J. C., Klimek, L., Kuna, P., Kvedariene, V., Larenas-Linnemann, D., Melen, E., Monti, R., Mosges, R., Mullol, J., Papadopoulos, N. G., Pham-Thi, N., Samolinski, B., Tomazic, P. V., Toppila-Salmi, S., Ventura, M. T., Yorgancioglu, A., Bousquet, J., Pfaar, O., Basagana, X., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Bateman, E. D., Bedolla-Barajas, M., Bewick, M., Beghe, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Bialoszewski, A. Z., Bieber, T., Bialek, S., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabanas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Constantinidis, J., Correia de Sousa, J., Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, G., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fatima Emerson, M., De Feo, G., De Vries, G., De Martino, B., Motta Rubini, N. P., Deleanu, D., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gomez-Vera, J., Gonzalez Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzman, M. A., Haahtela, T., Hajjam, J., Hernandez, L., Hourihane, J. O. '. B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ispayeva, Z., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Kowalski, M. L., Kuitunen, M., Kull, I., Kupczyk, M., Krzych-Falta, E., Lacwik, P., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenco, O., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Meco, C., Medina-Avalos, M. A., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mota-Pinto, A., Moura Santo, P., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Manas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimaki, J., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Sarquis Serpa, F., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, J. N., Thibaudon, M., To, T., Todo-Bom, A., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hage, M., Vandenplas, O., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universidade do Porto [Porto], Kyomed, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Universitat Pompeu Fabra [Barcelona], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Service des Maladies Respiratoires, Hôpital Arnaud de Villeneuve-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Dermatology [Graz, Austria], Medical University Graz, University of Zürich [Zürich] (UZH), National Institute for Nuclear Physics (INFN), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA), University of South Florida (USF), University of Salerno (UNISA), CHU Toulouse [Toulouse]-Hôpital Larrey, Institut Mines-Télécom [Paris] (IMT), Center for Turbulence Research (CTR), Stanford University [Stanford], Service d'allergologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo, Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), RNSA, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bedard A., Anto J.M., Fonseca J.A., Arnavielhe S., Bachert C., Bedbrook A., Bindslev-Jensen C., Bosnic-Anticevich S., Cardona V., Cruz A.A., Fokkens W.J., Garcia-Aymerich J., Hellings P.W., Ivancevich J.C., Klimek L., Kuna P., Kvedariene V., Larenas-Linnemann D., Melen E., Monti R., Mosges R., Mullol J., Papadopoulos N.G., Pham-Thi N., Samolinski B., Tomazic P.V., Toppila-Salmi S., Ventura M.T., Yorgancioglu A., Bousquet J., Pfaar O., Basagana X., Aberer W., Agache I., Akdis C.A., Akdis M., Aliberti M.R., Almeida R., Amat F., Angles R., Annesi-Maesano I., Ansotegui I.J., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Bateman E.D., Bedolla-Barajas M., Bewick M., Beghe B., Bel E.H., Bergmann K.C., Bennoor K.S., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bosse I., Bouchard J., Boulet L.P., Bourret R., Bousquet P.J., Braido F., Briedis V., Brightling C.E., Brozek J., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillaud D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Canonica G.W., Carlsen K.H., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Casale T., Castellano G., Cecchi L., Cepeda A.M., Chavannes N.H., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Constantinidis J., Correia de Sousa J., Cortes-Grimaldo R.M., Corti F., Costa E., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Czarlewski W., Dahlen S.E., D'Amato G., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., De Carlo G., Dedeu T., de Fatima Emerson M., De Feo G., De Vries G., De Martino B., Motta Rubini N.P., Deleanu D., Denburg J.A., Devillier P., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Dykewicz M.S., El-Gamal Y., Eklund P., Eller E., Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Fontaine J.F., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., Christoff G., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Guzman M.A., Haahtela T., Hajjam J., Hernandez L., Hourihane J.O.'.B., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Illario M., Ispayeva Z., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Just J., Jutel M., Kaidashev I., Kalayci O., Kalyoncu A.F., Karjalainen J., Kardas P., Keil T., Keith P.K., Khaitov M., Khaltaev N., Kleine-Tebbe J., Kowalski M.L., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Laune D., Lauri D., Lavrut J., Le L.T.T., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Lourenco O., Luna-Pech J.A., Magnan A., Mahboub B., Maier D., Mair A., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Meco C., Medina-Avalos M.A., Melo-Gomes E., Meltzer E.O., Menditto E., Mercier J., Miculinic N., Mihaltan F., Milenkovic B., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Mora Bogado D., Morais-Almeida M., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Murray R., Naclerio R., Nadif R., Nalin M., Napoli L., Namazova-Baranova L., Neffen H., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Novellino E., Nyembue T.D., O'Hehir R.E., Odzhakova C., Ohta K., Okamoto Y., Okubo K., Onorato G.L., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Palkonen S., Panzner P., Park H.S., Papi A., Passalacqua G., Paulino E., Pawankar R., Pedersen S., Pepin J.L., Pereira A.M., Persico M., Phillips J., Picard R., Pigearias B., Pin I., Pitsios C., Plavec D., Pohl W., Popov T.A., Portejoie F., Potter P., Pozzi A.C., Price D., Prokopakis E.P., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Rajabian-Soderlund R., Reitsma S., Ribeirinho I., Rimmer J., Rivero-Yeverino D., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rodriguez-Zagal E., Rolla G., Roller-Wirnsberger R.E., Romano M., Rosado-Pinto J., Rosario N., Rottem M., Ryan D., Sagara H., Salimaki J., Sanchez-Borges M., Sastre-Dominguez J., Scadding G.K., Schunemann H.J., Scichilone N., Schmid-Grendelmeier P., Sarquis Serpa F., Shamai S., Sheikh A., Sierra M., Simons F.E.R., Siroux V., Sisul J.C., Skrindo I., Sole D., Somekh D., Sondermann M., Sooronbaev T., Sova M., Sorensen M., Sorlini M., Spranger O., Stellato C., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., To T., Todo-Bom A., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., Valero A., Valiulis A., Valovirta E., van Eerd M., van Ganse E., van Hage M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi G., Vicheva D., Vontetsianos T., Wagenmann M., Walker S., Wallace D., Wang D.Y., Waserman S., Werfel T., Westman M., Wickman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zhang L., Zhong N., Zernotti M.E., Zhanat I., Zidarn M., Zuberbier T., Zubrinich C., and Zurkuhlen A.
Subjects: 0301 basic medicine, SYMPTOMS, Smart phone, Allergy, Escala visual analógica, INNOVATION, [SDV]Life Sciences [q-bio], Medical and Health Sciences, Correlation, visual analogue scale, 0302 clinical medicine, Quality of life, Visual analogue scale, QUALITY-OF-LIFE, Màscares, Immunology and Allergy, score, Nose, Rinitis, Rhinitis, PRODUCTIVITY COSTS, asthma, MASK, rhinitis, Score, Explained variation, Response Variability, Mobile Applications, ALLERGIC RHINITIS, rhiniti, medicine.anatomical_structure, TRIALS, Rinite, 1107 Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Smartphone, medicine.medical_specialty, MASK study group, Immunology, MACVIA-ARIA, 03 medical and health sciences, Allergic, medicine, Humans, TECHNOLOGY, IMMUNOTHERAPY, Asma, Asthma, business.industry, Rhinitis, Allergic, medicine.disease, RHINOCONJUNCTIVITIS, 030104 developmental biology, 030228 respiratory system, 3121 General medicine, internal medicine and other clinical medicine, Physical therapy, Clinical Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Background: In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK-air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom-medication scores obtained concurrently. Methods: All consecutive MASK-air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self-assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom-medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra-individual response variability (IRV) index was calculated. Results: A strong correlation was observed between VAS work and other VAS. The highest levels for correlation with VAS work and variance explained in VAS work were found with VAS global, followed by VAS nose, eye and asthma. In comparison with VAS global, the mCSMS and MASK control score showed a lower correlation with VAS work. Results are unlikely to be explained by a low quality of data arising from repeated VAS measures. Conclusions: VAS work correlates with other outcomes (VAS global, nose, eye and asthma) but less well with a symptom-medication score. VAS work should be considered as a potentially useful AR outcome in intervention studies. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Published: 2020

39. Extracellular matrix degradation pathways and fatty acid metabolism regulate distinct pulmonary vascular cell types in pulmonary arterial hypertension.

Author: Mumby S, Perros F, Hui C, Xu BL, Xu W, Elyasigomari V, Hautefort A, Manaud G, Humbert M, Chung KF, Wort SJ, and Adcock IM
Abstract: Pulmonary arterial hypertension describes a group of diseases characterised by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles. Left untreated, patients die from right heart failure. Pulmonary vascular remodelling involves all cell types but to date the precise roles of the different cells is unknown. This study investigated differences in basal gene expression between pulmonary arterial hypertension and controls using both human pulmonary microvascular endothelial cells and human pulmonary artery smooth muscle cells. Human pulmonary microvascular endothelial cells and human pulmonary artery smooth muscle cells from pulmonary arterial hypertension patients and controls were cultured to confluence, harvested and RNA extracted. Whole genome sequencing was performed and after transcript quantification and normalisation, we examined differentially expressed genes and applied gene set enrichment analysis to the differentially expressed genes to identify putative activated pathways. Human pulmonary microvascular endothelial cells displayed 1008 significant ( p ≤ 0.0001) differentially expressed genes in pulmonary arterial hypertension samples compared to controls. In human pulmonary artery smooth muscle cells, there were 229 significant ( p ≤ 0.0001) differentially expressed genes between pulmonary arterial hypertension and controls. Pathway analysis revealed distinctive differences: human pulmonary microvascular endothelial cells display down-regulation of extracellular matrix organisation, collagen formation and biosynthesis, focal- and cell-adhesion molecules suggesting severe endothelial barrier dysfunction and vascular permeability in pulmonary arterial hypertension pathogenesis. In contrast, pathways in human pulmonary artery smooth muscle cells were mainly up-regulated, including those for fatty acid metabolism, biosynthesis of unsaturated fatty acids, cell-cell and adherens junction interactions suggesting a more energy-driven proliferative phenotype. This suggests that the two cell types play different mechanistic roles in pulmonary arterial hypertension pathogenesis and further studies are required to fully elucidate the role each plays and the interactions between these cell types in vascular remodelling in disease progression., (© The Author(s) 2021.)
Published: 2021
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40. Acupuncture for insomnia.

Author: Cheuk DK, Yeung WF, Chung KF, and Wong V
Subjects: Acupressure methods, Humans, Randomized Controlled Trials as Topic, Acupuncture Therapy methods, Sleep Initiation and Maintenance Disorders therapy
Abstract: Background: Although conventional non-pharmacological and pharmacological treatments for insomnia are effective in many people, alternative therapies such as acupuncture are widely practised. However, it remains unclear whether current evidence is rigorous enough to support acupuncture for the treatment of insomnia., Objectives: To determine the efficacy and safety of acupuncture for insomnia., Search Methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, Dissertation Abstracts International, CINAHL, AMED, the Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS), the World Health Organization (WHO) Trials Portal (ICTRP) and relevant specialised registers of the Cochrane Collaboration in October 2011. We screened reference lists of all eligible reports and contacted trial authors and experts in the field., Selection Criteria: Randomised controlled trials evaluating any form of acupuncture for insomnia. They compared acupuncture with/without additional treatment against placebo or sham or no treatment or same additional treatment. We excluded trials that compared different acupuncture methods or acupuncture against other treatments., Data Collection and Analysis: Two review authors independently extracted data and assessed risk of bias. We used odds ratio (OR) and mean difference for binary and continuous outcomes respectively. We combined data in meta-analyses where appropriate., Main Results: Thirty-three trials were included. They recruited 2293 participants with insomnia, aged 15 to 98 years, some with medical conditions contributing to insomnia (stroke, end-stage renal disease, perimenopause, pregnancy, psychiatric diseases). They evaluated needle acupuncture, electroacupuncture, acupressure or magnetic acupressure.Compared with no treatment (two studies, 280 participants) or sham/placebo (two studies, 112 participants), acupressure resulted in more people with improvement in sleep quality (compared to no treatment: OR 13.08, 95% confidence interval (CI) 1.79 to 95.59; compared to sham/placebo: OR 6.62, 95% CI 1.78 to 24.55). However, when assuming that dropouts had a worse outcome in sensitivity analysis the beneficial effect of acupuncture was inconclusive. Compared with other treatment alone, acupuncture as an adjunct to other treatment might marginally increase the proportion of people with improved sleep quality (13 studies, 883 participants, OR 3.08, 95% CI 1.93 to 4.90). On subgroup analysis, only needle acupuncture but not electroacupuncture showed benefits. All trials had high risk of bias and were heterogeneous in the definition of insomnia, participant characteristics, acupoints and treatment regimen. The effect sizes were generally small with wide confidence intervals. Publication bias was likely present. Adverse effects were rarely reported and they were minor., Authors' Conclusions: Due to poor methodological quality, high levels of heterogeneity and publication bias, the current evidence is not sufficiently rigorous to support or refute acupuncture for treating insomnia. Larger high-quality clinical trials are required.
Published: 2012
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41. Acupuncture for insomnia.

Author: Cheuk DK, Yeung WF, Chung KF, and Wong V
Subjects: Acupressure methods, Humans, Randomized Controlled Trials as Topic, Acupuncture Therapy, Sleep Initiation and Maintenance Disorders therapy
Abstract: Background: Although conventional non-pharmacological and pharmacological treatments for insomnia are effective in many people, alternative therapies such as acupuncture are still widely practiced. However, it remains unclear whether the existing evidence is rigorous enough to support its use., Objectives: To determine the efficacy and safety of acupuncture in people with insomnia., Search Strategy: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, Dissertation Abstracts International, CINAHL, AMED (the Allied and Complementary Medicine Database), TCMLARS (Traditional Chinese Medical Literature Analysis and Retrieval System), National Center for Complementary and Alternative Medicine, the National Institute of Health Clinical Trials Database, the Chinese Acupuncture Trials Register, the Trials Register of the Cochrane Complementary Medicine Field, from inception to 2006, and the sleep bibliography, which is available at www.websciences.org/bibliosleep. We searched reference lists of retrieved articles, and contacted trial authors and experts in the field for information on ongoing/completed trials., Selection Criteria: Randomised controlled trials evaluating any form of acupuncture involving participants of any age with any type of insomnia were included. Included trials compared acupuncture with placebo or sham or no treatment, or acupuncture plus other treatments compared with the same other treatments. Trials that compared only acupuncture methods or compared acupuncture alone against other treatments alone were excluded, since they did not yield the net effect of acupuncture., Data Collection and Analysis: Two review authors independently extracted data and assessed quality according to a set of criteria for risk of selection bias, performance bias, attrition bias and detection bias. Relative risk (RR) and standardised mean difference (SMD) with 95% confidence intervals were used for binary and continuous outcomes respectively. Data were combined in meta-analyses (on an intention-to-treat basis), where more than one trial without significant clinical heterogeneity presented the same outcome., Main Results: Seven trials met the inclusion criteria. The studies included 590 participants with insomnia, of whom 56 dropped out. Participant age ranged from 15 to 98 years, and the duration of insomnia varied from 6 months to 19 years. Co-existing medical conditions contributing to insomnia included stroke, end-stage renal disease and pregnancy. Apart from conventional needle acupuncture, different variants of acupuncture such as acupressure, auricular magnetic and seed therapy, and transcutaneous electrical acupoint stimulation (TEAS) were evaluated. Meta-analysis was limited because of considerable heterogeneity between comparison groups and between outcome measures. Based on the findings from individual trials, the review suggested that acupuncture and acupressure may help to improve sleep quality scores when compared to placebo (SMD = -1.08, 95% CI = -1.86 to -0.31, p=0.006) or no treatment (SMD -0.55, 95% CI = -0.89 to -0.21, p=0.002). TEAS also resulted in better sleep quality score in one trial (SMD = -0.74, 95% CI = -1.22 to -0.26, p=0.003). However, the efficacy of acupuncture or its variants was inconsistent between studies for many sleep parameters, such as sleep onset latency, total sleep duration and wake after sleep onset. The combined result from three studies reporting subjective insomnia improvement showed that acupuncture or its variants was not more significantly effective than control (RR = 1.66, 95% CI = 0.68 to -4.03) and significant statistical heterogeneity was observed. Only one study reported an adverse event, with one out of 16 patients (6.3%) withdrawing from acupuncture because of pain., Authors' Conclusions: The small number of randomised controlled trials, together with the poor methodological quality and significant clinical heterogeneity, means that the current evidence is not sufficiently extensive or rigorous to support the use of any form of acupuncture for the treatment of insomnia. Larger high quality clinical trials employing appropriate randomisation concealment and blinding with longer follow-up are needed to further investigate the efficacy and safety of acupuncture for the treatment of insomnia.
Published: 2007
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42. Interleukin-5 in growth and differentiation of blood eosinophil progenitors in asthma: effect of glucocorticoids.

Author: Kuo HP, Wang CH, Lin HC, Hwang KS, Liu SL, and Chung KF
Subjects: Adult, Antibodies, Monoclonal pharmacology, Antigens, CD34 immunology, Asthma pathology, DNA, Antisense pharmacology, Dexamethasone pharmacology, Eosinophils cytology, Eosinophils immunology, Female, Gene Expression, Glucocorticoids pharmacology, Humans, Interleukin-5 genetics, Interleukin-5 physiology, Leukocytes, Mononuclear cytology, Leukocytes, Mononuclear drug effects, Leukocytes, Mononuclear immunology, Male, RNA, Messenger genetics, RNA, Messenger metabolism, Receptors, Interleukin immunology, Receptors, Interleukin-5, Stem Cells drug effects, Asthma physiopathology, Cell Differentiation drug effects, Cell Division drug effects, Eosinophils drug effects, Interleukin-5 pharmacology
Abstract: 1. There are increased numbers of circulating CD34(+) progenitor cells for eosinophils in patients with atopic asthma, with a further increase following allergen exposure or spontaneous worsening of asthma. We investigated the expression of IL-5 and IL-5Ralpha receptor in circulating CD34(+) progenitor cells in allergic asthmatics and the effects of corticosteroids. 2. Using double-staining techniques, up to 50% of CD34(+) cells expressed intracellular IL-5, and by RT - PCR, there was significant expression of IL-5 mRNA. When cultured in a semi-liquid methylcellulose medium, there were more eosinophil colony-forming units grown from asthmatic non-adherent mononuclear cell depleted of T cells in the presence of the growth factors GM-CSF, SCF and IL-3, but not of IL-5. 3. An anti-IL-5Ralpha receptor antibody and an anti-sense IL-5 oligonucleotide reduced the number of eosinophil colony forming units. No IL-5 mRNA or protein expression on T cells was observed in asthmatics or normal subjects. In the presence of growth factors including IL-5, there were significantly greater colony numbers with eosinophilic lineage grown from either asthmatics or normal subjects. 4. Dexamethasone (10(-6) M) suppressed IL-5 mRNA and protein expression in CD34(+) cells, and reduced eosinophil colony-forming units in asthmatics, but not in normal subjects. Dexamethasone did not change the expression of IL-5Ralpha on CD34(+) cells. 5. We conclude that there is increased expression of IL-5 on blood CD34(+) cells of patients with asthma and that this expression may auto-regulate eosinophilic colony formation from these progenitor cells. Corticosteroids inhibit the expression of IL-5 in circulating CD34(+) progenitor cells.
Published: 2001
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43. A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat.

Author: Huang TJ, Adcock IM, and Chung KF
Subjects: Animals, Blotting, Western, Bronchial Hyperreactivity genetics, Bronchial Hyperreactivity immunology, Bronchoalveolar Lavage Fluid cytology, CD2 Antigens analysis, CD4 Antigens analysis, CD8 Antigens analysis, Eosinophils cytology, Eosinophils drug effects, Eosinophils immunology, Gene Expression Regulation drug effects, Immunohistochemistry, Interferon-gamma genetics, Interleukin-10 genetics, Interleukin-2 genetics, Interleukin-4 genetics, Interleukin-5 genetics, Lung drug effects, Lung metabolism, Lymphocytes cytology, Lymphocytes drug effects, Lymphocytes immunology, Macrophages cytology, Macrophages drug effects, Macrophages immunology, Male, NF-kappa B antagonists & inhibitors, Neutrophils cytology, Neutrophils drug effects, Neutrophils immunology, Organic Chemicals, Ovalbumin immunology, Proto-Oncogene Proteins c-jun drug effects, Proto-Oncogene Proteins c-jun metabolism, Pulmonary Eosinophilia genetics, Pulmonary Eosinophilia immunology, RNA, Messenger drug effects, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Rats, Inbred BN, Respiratory Mucosa drug effects, Respiratory Mucosa immunology, Respiratory Mucosa pathology, Specific Pathogen-Free Organisms, Transcription Factor AP-1 antagonists & inhibitors, Allergens immunology, Bronchial Hyperreactivity prevention & control, Cytokines genetics, Immunosuppressive Agents pharmacology, Pulmonary Eosinophilia prevention & control, Transcription Factors antagonists & inhibitors
Abstract: 1. We examined the effect of SP100030, a novel inhibitor of activator protein-1 (AP-1) and nuclear factor (NF)-kappa B transcription factors, in a rat model of asthma. 2. Sensitized Brown-Norway rats were treated with SP100030 (20 mg kg(-1) day(-1) for 3 days) intraperitoneally prior to allergen challenge. Allergen exposure of sensitized rats induced bronchial hyperresponsiveness (BHR), accumulation of inflammatory cells in bronchoalveolar lavage (BAL) fluid, and also an increase in eosinophils and CD2(+), CD4(+) and CD8(+) T-cells in the airways together with mRNA expression for IL-2, IL-4, IL-5, IL-10, and IFN-gamma. 3. Pre-treatment with SP100030 inhibited BAL lymphocyte influx (P<0.03), specifically reduced CD8(+) T-cell infiltration in the airway submucosa (P<0.03), and mRNA expression for IL-2, IL-5, and IL-10 (P<0.05). Neutrophil, eosinophil, and CD4(+) T-cells accumulation in the airways and BHR were not affected by SP100030. 4. Our results indicate that suppression of IL-2 and IL-5 mRNA expression may not necessarily lead to suppression of BHR. The expression of IL-5 mRNA may contribute to the airway accumulation of eosinophils, but does not correlate with the extent of eosinophilia. 5. The joint AP-1 and NF-kappa B inhibitor, SP100030, selectively inhibits CD8(+) T-cells, and mRNA expression of both Th1 and Th2 cytokines in vivo, but does not inhibit allergen-induced airway eosinophilia and BHR.
Published: 2001
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44. IL-17-induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen-activated protein (MAP) kinases.

Author: Laan M, Lötvall J, Chung KF, and Lindén A
Subjects: Bronchi cytology, Bronchi enzymology, Bronchi metabolism, Cell Division drug effects, Cell Line, Transformed, Enzyme Inhibitors pharmacology, Epithelial Cells cytology, Epithelial Cells enzymology, Epithelial Cells metabolism, Humans, Interleukin-6 metabolism, Interleukin-8 metabolism, MAP Kinase Kinase 1, MAP Kinase Signaling System drug effects, Mitogen-Activated Protein Kinase Kinases antagonists & inhibitors, Mitogen-Activated Protein Kinase Kinases metabolism, Mitogen-Activated Protein Kinases antagonists & inhibitors, Phosphatidylinositol 3-Kinases metabolism, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase C antagonists & inhibitors, Protein Kinase C metabolism, Protein Serine-Threonine Kinases antagonists & inhibitors, Protein Serine-Threonine Kinases metabolism, p38 Mitogen-Activated Protein Kinases, Bronchi drug effects, Cytokines metabolism, Epithelial Cells drug effects, Interleukin-17 pharmacology, Mitogen-Activated Protein Kinases metabolism
Abstract: 1. Recent data indicate that interleukin (IL)-17 may contribute to neutrophilic airway inflammation by inducing the release of neutrophil-mobilizing cytokines from airway cells. The aim of this study was to evaluate the role of mitogen activated protein kinases in IL-17 induced release of IL-8 and IL-6 in bronchial epithelial cells. 2. Transformed human bronchial epithelial cells (16HBE) were stimulated with either IL-17 or vehicle. Both groups were treated either with SB202190 (inhibitor of p38 MAP kinase), PD98059 (inhibitor of extracellular-signal-regulated kinase [ERK] pathway), Ro-31-7549 (protein kinase C [PKC] inhibitor), LY 294002 (a phosphatidylinositol 3-kinase [PI 3-kinase] inhibitor) or vehicle. IL-6 and IL-8 levels were measured in conditioned media by ELISA. 3. The IL-17-induced release of IL-6 and IL-8 was concentration-dependently inhibited by SB202190 and by PD98059 in bronchial epithelial cells without affecting cell proliferation or survival. 4. Ro-31-7549 and LY294002 had no significant effect on IL-17-induced IL-6 or IL-8 release in bronchial epithelial cells. 4. Taken together, these data indicate a role for p38 and ERK kinase pathways in IL-17-induced release of neutrophil-mobilizing cytokines in human bronchial epithelial cells. These mechanisms constitute potential pharmacotherapeutical targets for inhibition of the IL-17-mediated airway neutrophilia.
Published: 2001
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45. Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids.

Author: Chung KF, Patel HJ, Fadlon EJ, Rousell J, Haddad EB, Jose PJ, Mitchell J, and Belvisi M
Subjects: Adolescent, Adult, Cells, Cultured, Chemokine CCL11, Chemokine CCL5 biosynthesis, Child, Cytokines genetics, Female, Humans, Interferon-gamma pharmacology, Male, Middle Aged, RNA, Messenger analysis, Bronchi metabolism, Chemokines, CC, Cytokines biosynthesis, Dexamethasone pharmacology, Interleukin-1 pharmacology, Interleukin-10 pharmacology, Muscle, Smooth metabolism, Trachea metabolism, Tumor Necrosis Factor-alpha pharmacology
Abstract: Eotaxin is a novel C-C chemokine with selective chemoattractant activity for eosinophils. We determined whether eotaxin could be produced by human airway smooth muscle (HASM) cells in culture and examined its regulation by interleukin-10 (IL-10) and the corticosteroid, dexamethasone. Stimulation of the cells with interleukin-1beta (IL-1beta) or tumour necrosis factor (TNFalpha) each at 10 ng ml(-1) induced the release of eotaxin protein with maximal accumulation by 24 h. Interferon-gamma (IFNgamma) alone at 10 ng ml(-1) had no effect and there was no synergy between these cytokines on the release of eotaxin. Reverse phase high performance liquid chromatographic (HPLC) analysis of supernatents from cells treated with TNFalpha (10 ng ml(-1) for 96 h showed immunoreactivity to eotaxin which eluted with the expected retention time of 34.5-35 min. Both IL-1beta and TNFalpha-induced release of eotaxin was not inhibited by dexamethasone (1 microM), however IL-10 (10 ng ml(-1)) had a significant inhibitory effect. Dexamethasone and IL-10 did not inhibit the induction of eotaxin mRNA induced by IL-1beta or TNFalpha. Thus, human airway smooth muscle cells can release eotaxin and could be an important source of chemokine production during airway inflammatory events.
Published: 1999
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46. Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats.

Author: Salmon M, Walsh DA, Huang TJ, Barnes PJ, Leonard TB, Hay DW, and Chung KF
Subjects: Acetylcholine pharmacology, Animals, Arachidonate 5-Lipoxygenase physiology, Bronchi drug effects, Cell Count, Eosinophils physiology, Male, Rats, Rats, Inbred BN, Allergens immunology, Bronchi metabolism, Cysteine physiology, DNA biosynthesis, Leukotrienes physiology, Muscle, Smooth metabolism
Abstract: Airway smooth muscle thickening is a characteristic feature of airway wall remodelling in chronic asthma. We have investigated the role of the leukotrienes in airway smooth muscle (ASM) and epithelial cell DNA synthesis and ASM thickening following repeated allergen exposure in Brown Norway rats sensitized to ovalbumin. There was a 3 fold increase in ASM cell DNA synthesis, as measured by percentage bromodeoxyuridine (BrdU) incorporation, in repeatedly ovalbumin-exposed (4.1%, 3.6-4.6; mean, 95% c.i.) compared to chronically saline-exposed rats (1.3%, 0.6-2.1; P<0.001). Treatment with a 5-lipoxygenase enzyme inhibitor (SB 210661, 10 mg kg(-1), p.o.) and a specific cysteinyl leukotriene (CysLT1) receptor antagonist, pranlukast (SB 205312, 30 mg kg(-1), p.o.), both attenuated ASM cell DNA synthesis. Treatment with a specific leukotriene B4 (BLT) receptor antagonist (SB 201146, 15 mg kg(-1), p.o.) had no effect. There was also a significant, 2 fold increase in the number of epithelial cells incorporating BrdU per unit length of basement membrane after repeated allergen exposure. This response was not inhibited by treatment with SB 210661, pranlukast or SB 201146. A significant increase in ASM thickness was identified following repeated allergen exposure and this response was attenuated significantly by SB 210661, pranlukast and SB 201146. Rats exposed to chronic allergen exhibited bronchial hyperresponsiveness to acetylcholine and had significant eosinophil recruitment into the lungs. Treatment with SB 210661, pranlukast or SB 201146 significantly attenuated eosinophil recruitment into the lungs, whilst having no significant effect on airway hyperresponsiveness. These data indicate that the cysteinyl leukotrienes are important mediators in allergen-induced ASM cell DNA synthesis in rats, while both LTB4 and cysteinyl leukotrienes contribute to ASM thickening and eosinophil recruitment following repeated allergen exposure.
Published: 1999
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47. Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung.

Author: Liu SF, Haddad EB, Adcock I, Salmon M, Koto H, Gilbey T, Barnes PJ, and Chung KF
Subjects: Animals, Cytokines biosynthesis, Enzyme Induction, Male, NF-kappa B metabolism, RNA, Messenger analysis, Rats, Rats, Inbred BN, Allergens immunology, Lung enzymology, Nitric Oxide Synthase biosynthesis
Abstract: 1. We studied the effects of ovalbumin (OA) sensitization and challenge on inducible nitric oxide synthase (iNOS) gene and protein expression in Brown-Norway rats in vivo. 2. By use of Northern analysis, a 4.4-kb iNOS mRNA transcript was weakly observed in control rat lung but there was a 3 fold increase in lungs sensitized to OA alone (P<0.05). In sensitized rats, four hours after exposure to OA aerosol, there was a 6 fold increase in iNOS mRNA transcript (P<0.05), which returned to baseline at 24 h. 3. Immunostaining with an anti-mouse iNOS antibody revealed some patchy staining of airway epithelium in naive rats. There were no changes in sensitized rats exposed to saline, but sensitized and OA-exposed rats showed increased expression in iNOS staining in macrophages. 4. Electrophoretic mobility shift assays of lung nuclear extracts showed a marked increase in nuclear factor-kappaB (NF-kappaB)-binding activity at 2 h after allergen exposure with return to baseline at 6, 12 and 24 h. 5. We concluded that there is increased iNOS gene and protein expression associated with increased NF-kappaB DNA-binding in lungs of sensitized and challenged rats. The increase in iNOS expression may underlie the increase in exhaled NO found after allergen challenge and may contribute to the development of allergen-induced airway hyperresponsiveness.
Published: 1997
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48. Effect of sodium metabisulphite on bronchial blood flow in conscious sheep: pharmacological modulation.

Author: Nichol GM, Parsons GH, and Chung KF
Subjects: Administration, Inhalation, Aerosols, Animals, Cholinergic Antagonists, Consciousness, Dose-Response Relationship, Drug, Furosemide pharmacology, Histamine H1 Antagonists pharmacology, Histamine H2 Antagonists pharmacology, Nedocromil pharmacology, Sheep, Sulfites pharmacokinetics, Tachyphylaxis, Vascular Resistance drug effects, Bronchi blood supply, Pulmonary Circulation drug effects, Sulfites pharmacology
Abstract: 1. Sodium metabisulphite (MBS) can induce bronchoconstriction in patients with asthma. We investigated the effects of MBS aerosol on bronchial blood velocity (Vbr) and pulmonary resistance in intubated conscious sheep. 2. Bronchial blood velocity was measured by implanting a 20 MHz ultrasonic Doppler flow probe on the common bronchial branch of the bronchoesophageal artery. 3. Inhaled MBS induced a dose-dependent, transient increase in Vbr lasting for a few minutes without any changes in aortic and pulmonary artery pressures. There was some tachyphylaxis of the Vbr response to successive inhalations of MBS. 4. The cholinoceptor antagonist, ipratropium bromide and the H1 and H2 histamine antagonists, chlorpheniramine and cimetidine, had no significant effect on MBS-induced increase on Vbr. The loop diuretic, frusemide, and the anti-inflammatory drug, nedocromil sodium, which both inhibit MBS-induced bronchoconstriction in patients with asthma, were also without effect. 5. We conclude that MBS induces bronchial vasodilatation in conscious sheep, and that this effect is not dependent on the release of histamine or other mediators, or an activation of cholinergic pathways.
Published: 1994
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49. Pharmacological modulation of inhaled sodium metabisulphite-induced airway microvascular leakage and bronchoconstriction in the guinea-pig.

Author: Sakamoto T, Elwood W, Barnes PJ, and Chung KF
Subjects: Administration, Inhalation, Animals, Anti-Inflammatory Agents, Non-Steroidal, Atropine pharmacology, Bronchi blood supply, Capsaicin pharmacology, Female, Furosemide pharmacology, Guinea Pigs, Nedocromil, Quinolones pharmacology, Sulfites administration & dosage, Bronchi drug effects, Bronchoconstriction drug effects, Capillary Permeability drug effects, Chlorpheniramine pharmacology, Solanaceous Alkaloids pharmacology, Sulfites pharmacology
Abstract: 1. We have investigated the effects of chlorpheniramine, atropine and capsaicin pretreatment on inhaled sodium metabisulphite (MBS)-induced airway microvascular leakage and bronchoconstriction in anaesthetized guinea-pigs in order to clarify the mechanisms involved in these responses. The effects of frusemide and nedocromil sodium were also examined. 2. Lung resistance (RL) was measured for 6 min after inhalation of MBS (20, 40, 80 and 200 mM; 30 breaths), followed by measurement of extravasation of Evans blue dye into airway tissues, used as an index of airway microvascular leakage. MBS caused an increase in RL and leakage of dye at all airway levels in a dose-dependent manner. 3. Chlorpheniramine (10 mg kg-1, i.v.), atropine (1 mg kg-1, i.v.), their combination or inhaled nedocromil sodium (10 mg ml-1, 7 min) had no effect against the airway microvascular leakage induced by 80 mM MBS (30 breaths). Capsaicin pretreatment (50 mg kg-1, s.c.) caused a significant decrease in the leakage of dye in the main bronchi and inhaled frusemide (10 mg ml-1, 7 min) also in the main bronchi and proximal intrapulmonary airway. 4. Chlorpheniramine, atropine, their combination, capsaicin pretreatment and frusemide, but not nedocromil sodium, inhibited significantly the peak RL induced by 80 mM MBS (30 breaths) by approximately 50%. 5. We conclude that a cholinergic reflex and neuropeptides released from sensory nerve endings may participate in the mechanisms of MBS-induced airway responses. Frusemide but not nedocromil sodium may have an inhibitor effect on these neural mechanisms. The inhibitory effect of nedocromil sodium against lower doses of MBS is not excluded.
Published: 1992
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50. Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs.

Author: Hayes JP, Lotvall JO, Barnes PJ, Newman Taylor AJ, and Chung KF
Subjects: Animals, Antibodies analysis, Arachidonate 5-Lipoxygenase metabolism, Asthma etiology, Asthma immunology, Enzyme-Linked Immunosorbent Assay, Female, Guinea Pigs, Histamine Release, Immunization, Immunoglobulin G analysis, Occupational Diseases etiology, Occupational Diseases immunology, Phthalic Anhydrides adverse effects, Platelet Activating Factor physiology, Respiratory System drug effects, Serum Albumin immunology, Allergens, Bronchoconstriction immunology, Phthalic Anhydrides immunology, Respiratory System immunology
Abstract: 1. We examined the effect of various pharmacological agents on the acute bronchoconstrictor response and airway microvascular leakage in a model of guinea-pig sensitization to trimellitic anhydride (TMA) a cause of low molecular weight occupational asthma in man. 2. Guinea-pigs were given intradermal injections of 0.1 ml of 0.3% TMA in corn oil; 21-28 days later, anaesthetized guinea-pigs were challenged with TMA conjugated to guinea-pig albumin by tracheal instillation. Changes in lung resistance were measured and airway microvascular leakage was quantified by measuring the extravasation of Evans blue dye into the airway tissue. 3. Sensitized guinea-pig (n = 9 in each group) were pretreated with chlorpheniramine (2.5 mg kg-1, i.v.), WEB 2086 (10 micrograms kg-1, i.v.), BW 4AC (50 mg kg-1, i.p.), nedocromil sodium (2% aerosol for 60 s) or vehicle alone. 4. Pretreatment with chlorpheniramine inhibited both the acute bronchoconstrictor response and the increase in airway microvascular leakage. WEB 2086 and nedocromil sodium partially inhibited the bronchoconstrictor response but had no significant effect on airway microvascular leakage. BW 4AC caused a non-significant reduction of the bronchoconstrictor response and airway microvascular leakage. 5. These results indicate that both the bronchoconstrictor response and the airway microvascular response in this model of sensitization is mediated to a large extent by histamine. PAF but not 5-lipoxygenase products also partially mediates the bronchoconstrictor response but not the airway microvascular leakage. Nedocromil sodium partially inhibits the bronchoconstrictor response only.
Published: 1992
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