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Your search keyword '"Correia, Ilídio J."' showing total 20 results
Start Over Author "Correia, Ilídio J." Publisher wiley
20 results on '"Correia, Ilídio J."'

19. IR780 loaded gelatin-PEG coated gold core silica shell nanorods for cancer-targeted photothermal/photodynamic therapy.

Author

Gonçalves ASC, Rodrigues CF, Fernandes N, de Melo-Diogo D, Ferreira P, Moreira AF, and Correia IJ

Subjects
Cell Survival drug effects, Gold chemistry, HeLa Cells, Humans, Neoplasms, Photothermal Therapy, Polyethylene Glycols chemistry, Silicon Dioxide chemistry, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Gelatin chemistry, Indoles chemistry, Nanotubes chemistry, Photochemotherapy
Abstract

Gold core silica shell (AuMSS) nanorods present excellent physicochemical properties that allow their application as photothermal and drug delivery agents. Herein, AuMSS nanorods were dual-functionalized with Polyethylene glycol methyl ether (PEG-CH 3 ) and Gelatin (GEL) to enhance both the colloidal stability and uptake by HeLa cancer cells. Additionally, the AuMSS nanorods were combined for the first time with IR780 (a heptamethine cyanine molecule) and its photothermal and photodynamic capacities were determined. The obtained results reveal that the encapsulation of IR780 (65 µg per AuMSS mg) increases the photothermal conversion efficiency of AuMSS nanorods by 10%, and this enhanced heat generation was maintained even after three irradiation cycles with a NIR (808 nm) laser. Moreover, the IR780-loaded AuMSS/T-PEG-CH 3 /T-GEL presented ≈2-times higher uptake in HeLa cells, when compared to the non-coated counterparts, and successfully mediated the light-triggered generation of reactive oxygen species. Overall, the combination of photodynamic and photothermal therapy mediated by IR780-loaded AuMSS/T-PEG-CH 3 /T-GEL nanorods effectively promoted the ablation of HeLa cancer cells., (© 2021 Wiley Periodicals LLC.)

Published
2022
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20. 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs.

Author

Nunes AS, Barros AS, Costa EC, Moreira AF, and Correia IJ

Subjects
Cell Line, Tumor, Humans, Antineoplastic Agents pharmacology, Drug Resistance, Neoplasm, Models, Theoretical, Spheroids, Cellular drug effects
Abstract

Three-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described., (© 2018 Wiley Periodicals, Inc.)

Published
2019
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