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46 results on '"Csuk, Rene"'

1. An engineered microfluidic blood‐brain barrier model to evaluate the anti‐metastatic activity of β‐boswellic acid

Author

Vakilian, Saeid, primary, Alam, Khurshid, additional, Al‐Kindi, Juhaina, additional, Jamshidi‐Adegani, Fatemeh, additional, Rehman, Najeeb Ur, additional, Tavakoli, Rezvan, additional, Al‐Riyami, Khamis, additional, Hasan, Anwarul, additional, Zadjali, Fahad, additional, Csuk, Rene, additional, Al‐Harrasi, Ahmed, additional, and Al‐Hashmi, Sulaiman, additional

Published
2021
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46. Quantification of Incensole in Three Boswellia Species by NIR Spectroscopy Coupled with PLSR and Cross-Validation by HPLC.

Author

Al-Shidhani S, Rehman NU, Mabood F, Al-Broumi M, Hussain H, Hussain J, Csuk R, and Al-Harrasi A

Subjects
Anti-Inflammatory Agents analysis, Antidepressive Agents analysis, Least-Squares Analysis, Reproducibility of Results, Species Specificity, Boswellia chemistry, Chromatography, High Pressure Liquid methods, Diterpenes analysis, Spectroscopy, Fourier Transform Infrared methods, Spectroscopy, Near-Infrared methods
Abstract

Introduction: Incensole can be considered as a biomarker for Boswellia species which is a diterpene that has received remarkable pharmacological interest recently due to its potent anti-inflammatory and anti-depressant activity., Objective: Near-infrared (NIR) spectroscopy coupled with PLSR (partial least squares regression) as a robust, rapid and alternative method was used to quantify the content of incensole in three species namely B. papyrifera, B. sacra and B. serrata and cross-validated by high-performance liquid chromatography (HPLC)., Materials and Methods: NIR spectrophotometer was used for the quantification of incensole standards and Boswellia species in absorption mode in the wavelength range between 700 and 2500 nm. A PLSR model was built from the obtained spectral data using 70% of the incensole working standard solutions (training set), ranging from 0.5 to 100 ppm. The PLSR model obtained has a R 2 value of 98% with a correlationship of 0.99 and a good prediction with root mean square error for prediction (RMSEP) value of 3.2%., Results: The results indicated that the methanol (MeOH) extract of B. papyrifera resin has the highest concentration of incensole (18.4%) followed by n-hexane (13.5%) and ethyl acetate (3.6%) while trace amounts was detected in the fractions of B. sacra and no incensole was detected in the fractions of B. serrata., Conclusion: The findings are in total agreement with the HPLC analysis suggesting that NIR spectroscopy coupled with PLSR is a robust, rapid and non-destructive alternate method for the quantification of incensole in B. papyrifera. Copyright © 2018 John Wiley & Sons, Ltd., (Copyright © 2018 John Wiley & Sons, Ltd.)

Published
2018
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