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Your search keyword '"David C. Hunden"' showing total 4 results
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4 results on '"David C. Hunden"'

1. The synthesis of the 14C and 2H-isotopomers of (R)-N-[2-(2′-ethoxyphenoxy)-ethyl]-N-2-[3-(4′-methoxy-3′-sulfonamido)-phenyl]-propylamine hydrochloride, an α1-adrenoreceptor antagonist

Author

David C. Hunden, William J. Wheeler, and Klaus K. Schmiegel

Subjects
Chemistry, Hydrochloride, Stereochemistry, Cyanide, Organic Chemistry, Antagonist, Propylamine, Biochemistry, Reductive amination, Analytical Chemistry, Isotopomers, Catalysis, chemistry.chemical_compound, Yield (chemistry), Drug Discovery, Radiology, Nuclear Medicine and imaging, Spectroscopy
Abstract

The synthesis of [14C]- and [2H]-labeled LY253351 (YM12617–1), a potent α1-receptor antagonist, which is potentially useful in the treatment of benign prostatic hypertrophy (BPH) is described. The [14C]-isotopomer was synthesized from [14C]-potassium cyanide in nine steps in 1.5% radiochemical yield. One of the key intermediates, [14C]-4-methoxyphenylacetone, was synthesized from [14C]-4-methoxyphenylacetyl chloride by a Pd(0)-catalyzed reaction with tetramethylstannane. The [2H]-labeled material was synthesized by a Pd/C catalyzed reductive amination with deuterium gas.

Published
1989
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2. ChemInform Abstract: AN IMPROVED SYNTHESIS OF β-TETRALONE

Author

David C. Hunden

Subjects
chemistry.chemical_compound, chemistry, Tetralone, General Medicine, Medicinal chemistry
Abstract

Aus dem Phenacetylchlorid (I) wird durch Umsetzung mit Aluminiumtrichlorid und anschliesendes Einleiten von Ethen (II) das β-Tetralon (III) hergestellt.

Published
1985
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3. ChemInform Abstract: Orally Absorbable Cephalosporin Antibiotics. Part 2. Structure-Activity Studies of Bicyclic Glycine Derivatives of 7-Aminodeacetoxycephalosporanic Acid

Author

David C. Hunden, Robin D. G. Cooper, Stjepan Kukolja, B. J. Graves, J. L. Pfeil, F. T. Counter, John L. Ott, and Susan E. Draheim

Subjects
7-aminodeacetoxycephalosporanic acid, Bicyclic molecule, Chemistry, Stereochemistry, Glycine, General Medicine, Cephalosporin Antibiotic
Published
1986
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4. ChemInform Abstract: Molecular Modeling of γ-Lactam Analogues of β-Lactam Antibacterial Agents: Synthesis and Biological Evaluation of Selected Penem and Carbapenem Analogues

Author

John K. Swartzendruber, Michael Dean Kinnick, Donald B. Boyd, Bennie Joe Foster, Jack B. Deeter, William Joseph Hornback, David C. Hunden, Jack B. Campbell, Lowell D. Hatfield, J. N. Jun. Hobbs, J. M. Jun. Morin, T. K. Elzey, Noel D. Jones, D. G. Vogt, John E. Munroe, and Norris E. Allen

Subjects
Carbapenem, chemistry.chemical_compound, chemistry, Molecular model, medicine, Lactam, General Medicine, Combinatorial chemistry, medicine.drug, Biological evaluation
Published
1989
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